New preprint! In collaboration with the Steinmetz Lab at PSI we report cryo-EM structures of microtubules at up to 1.9 Å (!) resolution & in different nucleotide state mimics, suggesting a mechanism for lattice-induced GTP hydrolysis and why it leads to catastrophe: tinyurl.com/7cjrf863

🚨 I am very happy to share the first preprint from our lab! www.biorxiv.org/content/10.6...

🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1

Miao Gui and @orbachron.bsky.social summarise current structural and functional insights into conserved and lineage-specific MIPs, their roles in shaping ciliary architecture, and the consequences of their disruption on ciliary motility. #JCSciliaSI journals.biologists.com/jcs/article/...

Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together. Happy reading! #cilia #flagella journals.biologists.com/jcs/issue/13...

Ever wondered what microtubule inner proteins (MIPs) are and what they actually do? Or perhaps you already know about them, but find it hard to keep track of which ones are conserved across species and how they support ciliary structure and function? journals.biologists.com/jcs/article/...

Congratulations to our ISF 2025–2026 grant recipients from Bar Ilan’s Azrieli Faculty of Medicine in the Galilee: Dr. Liron Rosenkrantz, Prof. David Karasik, and Prof. Chaim Putterman.

Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀 Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link: journals.biologists.com/jcs/article/...

✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social‬ & ALMF @embl.org ✨ 👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8

📣 Happy to share our review on host-microbiome genomics! We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes Out now in Nature Reviews Genetics👇 www.nature.com/articles/s41...

Can we break past the usual limits of #SuperResolution #Microscopy—achieving deep-imaging, high-res, large FOV imaging without the trade-offs? 🧬🔬 YES: with #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC-OPR)! 📄 www.nature.com/articles/s41... @natcomms.nature.com! 🧵👇

Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...

What a treat! After far too long, the lab finally took a break for some well-earned fun. We spent the morning biking through Agamon Hula, surrounded by beautiful scenery and nesting birds, and wrapped up with a delicious lunch. Here's to more outings like this in the future! 🚲

The Orbach Lab had a great time at the Annual Meeting of the Israel Society for Microscopy at Expo Tel Aviv. Mohammed presented a poster full of exciting microscopy data and got some great feedback from the community. Big thanks to the organizers and everyone who stopped by!

🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share

It was a real pleasure to present our work at The Biophysics of Motile Cilia – from Structure to Function meeting at the Physikzentrum Bad Honnef. Grateful for the fruitful discussions with both biologists and physicists, and for the opportunity to meet so many inspiring new colleagues.

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

I am super excited to share our latest work on the structures of doublet microtubules from trypanosomatid parasites, the causative agents of leishmaniasis, Chagas disease, and African sleeping sickness. tinyurl.com/48sh3xn5

Lab's first published paper!! 🚨 We introduce Perceived Immunity (PI) - a new construct capturing perceived immune efficacy. Using a novel scale, we show that PI prospectively predicts physical symptoms up to 14 months later, beyond baseline symptoms. Why is this important? Read on… 🧵

The world is full of crazy and sad news, but here is a protein that localizes to only one of the two flagella

Dr. Moran Yadid is leading a groundbreaking international consortium with experts from Finland & Germany to develop an innovative personally tailored approach for treating heart muscle enlargement caused by a genetic mutation. The consortium operates under grant from the European Union.

‏How Do We Teach Doctors to Teach? We concluded a new & unique year-long course in medical education aimed to develop the teaching methods of clinical faculty. The course focused on teaching and assessment, emphasizing active learning, integrating theoretical knowledge, and working in small groups

‏Introducing the Tzafon Data and Bio-Bank - Israel’s first-ever bio-bank integrating biological samples and bacteria! this transformative bio-bank fueling both research and industry, is a collaboration with Tzafon Medical Center,To be led by Prof. Avi Peretz, Dr. Hagar Tadmor, and Dr. Maya Azrad.

1/3 Our paper about miRNA target complementarity in Cnidaria is finally published in @emboreports.bsky.social This work was led by the talented Yael Admoni with help from Arie and Rubi in collaboration with the labs of @thecocodium.bsky.social and Michal Rabani www.embopress.org/doi/full/10....

Dr. Sivan Spitzer has achieved an extraordinary achievement: securing Bar-Ilan University's first-ever prestigious €22M EU-IHI grant from the European Union. The grant is for developing an innovative platform to improve medication adherence among patients with cardio-metabolic conditions

Join us for the fantastic annual @cshlnews.bsky.social #Xenopus cell & developmental Biology course. Deadline for application is Jan 31st. meetings.cshl.edu/courses.aspx...

💥Finally out! Answering a two-centuries old question about a membraneless organelle that forms in #oocytes from insects to humans: the Balbiani body (Bb). Now in @currentbiology.bsky.social : cell.com/current-biol... >

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇

A reminder that the Brown lab has an opening for a postdoc fellow: brown.hms.harvard.edu/jobs/242. This might suit someone from the #cilia community interested in learning structural biology. Deadline extended to the 10th Jan.

Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with Tzviya Zeev-Ben-Mordehai and @alanbrownhms.bsky.social www.nature.com/articles/s41...

Mahamid and Woodruff labs use cryo-ET to look at mitotic centrosomes: Stunned to see the pericentriolar matrix taking shape, and what seem to be ‚S size’ gamma-tubulin complex oligomers capping the end of 11-pf microtubules. www.cell.com/developmenta...

From the Orbach Lab, we send our warmest Hanukkah wishes. May this season of light bring hope, strength, and small moments of joy, even in the face of challenges. 🕎✨

For this #FluorescenceFriday, let's watch an axonal growth cone (for a change) displaying its most beautiful filopodia (this time)! 🤩 They are so dynamic! 1 image taken every 500 ms for 5 min played at 15 fps. 🧪

#notthecover Friction (rather than density of motors) guides actin network contraction. #resistance ✊ by @alexandra-colin.bsky.social www.pnas.org/doi/10.1073/...

Ever wondered about how accessible the tubulin C-terminal tails (CTTs) are within the microtubule lattice? Takashi Hotta (Puck Ohi lab) will present our work at a poster Tuesday 1:30pm (P2401, B8) and in a talk Tuesday 6:15pm (room 30C). #cellbio24 #CellBio2024 #cytoskeleton

Proudly present our new preprint on my first post here. We performed SPA on the ciliary tip and identify 7 proteins. Among them, we found the conserved protein SPEF1 at the microtubule seam. In vitro assays show that SPEF1 binds to the seam and stablizes microtubules. www.biorxiv.org/content/10.1...

Congratulations to Dr. Nir Qvit for winning a prestigious research grant from the Israel Innovation Authority! Dr. Qvit’s research identified a novel mechanism affecting mitochondrial division, which supplies energy for normal heart activity and under stress conditions.

Mix two motors of opposite polarity with microtubules and they will partition space ! Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns. #morphogenesis doi.org/10.1073/pnas... (1/n)

Here we are! To celebrate our arrival, here is a #trypanosome expanded ~13 times & stained for tubulin, individual cortical #microtubules can be recognised, what was only achievable by EM before. Images: Christine Girard-Blanc & Thierry Blisnick. Many thanks to @centriolelab.bsky.social for training

#Microtubules flow retrogradely in all neurites before axon specification - labeled CAMSAP3 on the right. After axon outgrowth, this retrograde flow slows down - to enable stable axon growth. Could this retrograde flow also exist in #microglia, #astrocytes & #cancer cells? #FluorescenceFriday 🧪 🧠📈

Deadline alert: "Biophysics of Motile Cilia": Apply before Dec 1st for consideration for contributed talks! Topics: #axoneme mechanics, #synchronization, #navigation, #ciliopathies, ... Meet us in Bad Honnef, Germany, 30.03.-02.04.2025 we-heraeus-stiftung.de/veranstaltun... Please re-sky!

I'm excited to rebuild this #science community over here on Bluesky! In honor of this clean slate, here's a repost of my favorite #epithelial cell building its brush border. @tyskalabactual.bsky.social

A few more from my "wrong ciliates" folder. Was looking at ciliates associated with purple sulfur bacteria (which can be seen in some of the images as reddish/purplish particles!). I don't have IDs for all of the ciliates, I just find them beautiful, but I welcome comments! #protistsonsky

Congrats to Prof. @omrykoren.bsky.social who has been selected by Clarivate as Most Frequently Cited Researcher. This is his seventh year in a row! #HighlyCited2024 clarivate.com/highly-cited...

Really looking forward to the Crick BioImage Analysis Symposium 2024 next week www.crick.ac.uk/whats-on/cri... Anyone going?

We found something interesting in the evolution of plant microbiota. It is under review and we published the preprint today. Avi Bograd from my lab analyzed the genomes of 38,912 bacteria and identified a clear depletion of all MGE types in plant-associated bacteria vs. non-plant associated bacteria

Happy to join this platform. it is probably makes sense to first introduce our group! We love bacteria and we love RNA! We focus on the role regulatory RNA play in the interaction of bacteria with their surroundings. You can read more about it in our website or here: www.cell.com/molecular-ce...