That’s a fascinating discovery, congrats!

Happy to share a new preprint from our group. In studying lung T cell responses in humans, we wondered if the method of sampling matters. Here we isolated paired BAL and endobronchial brushing T cells followed by scRNA- and TCR-seq, finding surprising differences #Immunology

'Here, we generated sST2-deficient mice with intact ST2L and showed that constitutively high levels of endogenous sST2 inhibit the development of food allergies, in which among nonhematopoietic cells, fibroblasts possibly play an important role as the source of sST2.' #Immunology #Allergy

IL-17a induces age-related olfactory dysfunction by impairing olfactory epithelium regeneration www.nature.com/articles/s41... @natcomms.nature.com

What maintains ILC2s in airway allergy? We report a complement-producing stromal niche forming an IL-33 alarmin hub sustaining ILC2s. Thanks to the JHU Catalyst Award for the support!! cc @deniswirtz.bsky.social @cp-cellreports.bsky.social @hopkinsmedicine.bsky.social www.cell.com/cell-reports...

Temporal single-cell profiling uncovers age-associated delays in immune resolution to respiratory viral infection @biorxivpreprint.bsky.social @jie-immunology.bsky.social www.biorxiv.org/content/10.6...

Novel study reveals that IgM drives airway hyperresponsiveness in allergic asthma via the Baiap2l1 pathway in human airway smooth muscle, uncovering a novel target for future therapies 💊 #Immunology #asthma #Th2 🔗 doi.org/10.7554/eLif...

@biorxivpreprint.bsky.social comprehensive cell type-resolved transcriptional screen of human cytokine responses www.biorxiv.org/content/10.6... @helmholtzmunich.bsky.social

Who controls type-2 immunity? Turns out fibroblasts do , via a C3–IL-33–ILC2 axis that shapes allergic inflammation in vivo. @atakkatan.bsky.social Our new work highlighted by @cellreports.bsky.social #Immunology #StromalBiology #Allergy #Asthma #ILC2 #IL33 #Complement

Why do heart attacks during the night cause less damage than during daytime? The role of neutrophils and circadian clock genes in reducing inflammation and injury in experimental model rupress.org/jem/article/...

Nice to see work on poorly understood IL-13Ra2

Erythropoietin receptor on cDC1s dictates immune tolerance @nature.com @stanforduniversity.bsky.social www.nature.com/articles/s41...

In this study, Panda, Colonna et al. @washumedicine.bsky.social highlight a previously unknown role for SLC7A8 in Th2 cells, with potential implications for understanding and treating type 2 immune-related diseases. rupress.org/jem/article/... #MucosalImmunology #InfectiousDisease #inflammation

#newPI feels

Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy @cp-cellreports.bsky.social @atakkatan.bsky.social @hopkinsmedicine.bsky.social www.cell.com/cell-reports...

New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social

Preprint: Chikungunya virus persists in joint associated macrophages and promotes chronic disease www.researchsquare.com/article/rs-6...

#WeekendRead! #ImmuneMechanosensing! Zhou &co show @cp-cellreports that rigid pathogenic candida hyphae are sensed in phagocytes by Piezo1 which upregulates Dectins & other CLRs via CREB-C/EBPb & drives antifungal NLRP3 activation via NDR1/2! www.cell.com/cell-reports...

Fonta et al. show that #oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS #autoimmunity. IL-33 ablation reduces persistence & TCF-1low effector T cell generation. rupress.org/jem/article/... 📘 In #Neuroimmunology & #Neurodegeneration 2025: rupress.org/jem/collecti...

Online now: A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction

This is cool! #Immunology 🧪

Experimental contact lenses now allow humans (and mice) to see near-infrared light by converting it into visible wavelengths. No power source needed! 🧪 www.cell.com/cell/fulltex...

Closed-loop vagus nerve stimulation aids recovery from spinal cord injury @nature.com www.nature.com/articles/s41...

A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma www.nature.com/articles/s41... @natimmunol.nature.com @regisjoulia.bsky.social

Cholinergic regulation of thymocyte negative selection www.nature.com/articles/s41... @natimmunol.nature.com

When a Decision on Manuscript email arrives a minute before you go out to celebrate your birthday

Neutrophils: not just infection fighters! 🧬 New review connects them to food allergies, eczema, and asthma. Could they be future targets for therapy? 🔗 bit.ly/3GReFeX #FoodAllergyAwarenessWeek

Our work featured on the cover of this month's J Exp Med!

Its enriching to see young talent develop! Proud mentor moments-all 3 of my Ph.D students @aishwaryamagesh.bsky.social @atakkatan.bsky.social and IanMcKnight got selected for podium presentations at #AAI2025 @johnshopkinsmmi.bsky.social @jhu.edu

Had a wonderful time presenting at the international complement society guest symposium at #AAI2025. A big shoutout 👏👏👏to my 2 very talented Ph.D students @aishwaryamagesh.bsky.social and @atakkatan.bsky.social for making this work possible! @johnshopkinsmmi.bsky.social

Honored to have been invited to the #AAI2025 International Complement Society (ICS) Guest Symposium. Big shout out to Claudia Kemper and Jessy J Alexander for organizing the symposium.

Enjoying #AAI2025 and learning a bunch of new science with folks from the lab ! #immunology2025

If you are looking to COMPLEMENT your knowledge of Th2 immunity, please read our latest review.

It’s #CRSwNPAwarenessDay! We’re honored to team up with microscopy artist 𝐒𝐭𝐞𝐯𝐞 𝐆𝐬𝐜𝐡𝐦𝐞𝐢𝐬𝐬𝐧𝐞𝐫 to show CRSwNP like you’ve never seen it before. More here: theworldcloseup.com Images are copyright protected—view & license at: www.sciencephoto.com/search?q=chr... #AirwayHealth #CRSwNP #ScienceArt

Review @jimmunol.bsky.social Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease academic.oup.com/jimmunol/adv...

🥼A new tissue expansion method developed by researchers in the Wang & Tillberg labs & collaborators @uwmadison.bsky.social enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules at the single cell level in their native locations ➡️ hhmi.news/4ixHOZZ

Tissue-geometry-regulated cellular traction forces trigger the activation of Piezo1 and its co-localization with bacteria to facilitate the formation of specific bacterial invasion patterns to promote infection @cellcellpress.bsky.social www.cell.com/cell/fulltex...

#immunosky Obsessed with our robotic arm loading plates to our Sony ID7000 spectral analyser to dramatically increase our flow throughput. This cytometer literally never blocks so we have complete trust in the whole system to run samples overnight whilst we sleep 😴

#TickTock⏰! Udeehardt, LaiGuan NG, @drusqui.bsky.social &co show @nature.com that skin #neutrophils produce in a circadian manner extracellular matrix potentiating skin barrier & that after injury they create TGFb-dependent rings of matrix shielding pathogens & foreign molecules!

That’s gold!

Meeting the person you suspect is reviewer #2 in a conference

can you explain this 3 year gap in your resume? yeah the paper was under review

#InterferonFriendOrFoe?! Joe Sun, Xiaoqin Wei &co show @science.org that lung macrophage peroxisomes instruct repair programs after virus infections favoring AT2 cell renewal & recovery! IFNgamma drives pexophagy, increasing mitochondrial ROS & activating inflammasomes driving KRT8 cells & fibrosis!

Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth www.nature.com/articles/s41... @naturecomms.bsky.social

GABA production by enteric neurons suppresses ILC3 activation to prevent inflammation and maintain gut homeostasis @natimmunol.bsky.social N&V by @hepworth-lab.bsky.social www.nature.com/articles/s41... on www.nature.com/articles/s41...

Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM www.cell.com/cell-genomic...

#WeekendRead! #WeAreWhatWeEat! Lesbats, Garaude &co show @nature.com that macrophages recycle phagocytosed bacteria to fuel their metabolism but that dead, compared to live, bacteria still feed macrophages but reduce the induction of ROS & the secretion of IL1b! www.nature.com/articles/s41...

Acute Exercise Rewires the Proteomic Landscape of Human Immune Cells papers.ssrn.com/sol3/papers....

Recent advancements in type 2 immunity reveal its crucial role in allergic diseases like #asthma, chronic rhinosinusitis, and atopic dermatitis, with key cellular and molecular mechanisms involving epithelial cells, ILCs, cytokines, and IgE. #Immunology #ImmunoSky www.nature.com/articles/s41...

Mater of time