New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.

Exciting News! 🚀 Registration Open! | Loke CTR Annual Meeting 2026 🎉 📅 16-17 July 2026 📍 St John’s College, Cambridge | 💻 Hybrid conference (in-person & online) 🔬 Epigenetics of embryogenesis and placentation 📌 To find out more and to register www.trophoblast.cam.ac.uk/ctrconferenc...

This went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...

When people celebrate the individual genius of folks in science, they should also mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)

Applications close tomorrow!! Fully funded 4-year PhD studentships in reproductive and placental biology. Last chance to apply go to trophoblast.cam.ac.uk/phd-studentships

Sad to hear of the death of John Gurdon this morning, aged 92.

Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

[please retweet] I’m #hiring! The Millman Lab is looking for a postdoctoral researcher to lead an exciting new project focused on vascularized #stemcell-derived islets for #diabetes disease modeling and cell replacement therapy. Email me your CV and cover letter.

A very nice paper in the developmental programming field, linking childhood eczema to maternal stress during pregnancy. rdcu.be/eCKOI

Glad to see this review out. Epigenetic Changes Associated With Obesity-related Metabolic Comorbidities url: academic.oup.com/jes/article/...

🚨 New paper alert 🚨 I am excited to share our new work on epigenetic enhancer priming in early mammalian development genomebiology.biomedcentral.com/articles/10.... Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd. Short 🧵

How do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...

1/n Very excited to share our recent paper published on @ScienceAdvances where we dissect the gene regulatory landscape guiding mouse sex determination! science.org/doi/10.1126/... A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!

Also, check out the News & Views summarizing our findings, written by Youjia Guo & @themodzlab.bsky.social 🤩🤩 www.nature.com/articles/s41...

Are you passionate about data and do you enjoy coding in Stata? Come and work with me at the Department of Obstetrics & Gynaecology in Cambridge! Please share with anyone who might be interested, and feel free to reach out if you have any questions. www.jobs.cam.ac.uk/job/51739/

Very cool paper connecting nutrition, epigenetics and developmental biology. rdcu.be/eptl7

Happy to see this paper from David Grattan’s lab (@prolactinguy.bsky.social). And glad to have made a small contribution. Loss of choroid plexus‐derived insulin‐like growth factor 2 (IGF2) leads to hyposmia, while retaining post‐partum mood resilience in mice. onlinelibrary.wiley.com/doi/10.1111/...

We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵

🎉 Huge congratulations to Prof. Kathy Niakan on receiving the 2025 Mary Lyon Medal! @niakanlab.bsky.social's Mary Lyon Medal lecture is on the genetic approaches to study early lineage specification in human embryos. #Epigenetics2025

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

Wondering whether your cancer risk might start before you are born? Our latest work published in #Nature Cancer suggests it does, through regulation by Trim28 and #epigenetic silencing. Congratulations to @ilariapanzeri.bsky.social for spearheading! Read it here: www.nature.com/articles/s43...

We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬 What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬 www.science.org/doi/full/10....

Small but mighty: multiple Y chromosome contributions to mouse spermatogenesis @lab-turner.bsky.social www.science.org/doi/10.1126/...

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.

Meet our excellent speakers joining us for #GenomicImprinting25: @arburga.bsky.social @cwhanna.bsky.social @daannoordermeerlab.bsky.social @eddaschulz.bsky.social Join us for an exploration into how the latest #ImprintingResearch is advancing the clinical treatment of imprinting disorders 🔽

Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!

Excited to share our most recent work in Cell Stem Cell, led by @georgiaplea.bsky.social, characterising determinants of DNA methylation patterning in human trophoblast stem cells! A great collaboration with @vpglab.bsky.social. tinyurl.com/93mchcd2 @loke-ctr.bsky.social @cam-repro.bsky.social

🚨PhD opportunity in my lab🚨 I am thrilled to announce that I’m offering a fully funded PhD position in the prestigious BBSRC MIBTP (Midlands Integrative Biosciences Training Partnership) program! 💡Project Focus: The pregnant brain and the effects of high fat diet👇🏼 warwick.ac.uk/fac/cross_fa...

A Nature Aging paper identifies 13 proteins linked to brain aging. Changes in the concentrations of these blood proteins may peak at 57, 70, and 78 years old, and suggest that these ages may be important for potential interventions in the brain aging process. https://go.nature.com/3ZvGLSy 🧪

We’re recruiting a PhD student to use comparative omics to investigate why some viruses can efficiently infect both human and mosquito cells, but lead to different infection outcomes. Fully funded position by @evomg-bcn.bsky.social at our lab at UPF-CRG and the Diez lab. www.crg.eu/en/content/t...

Decoding aging clocks: New insights from metabolomics www.cell.com/cell-metabol...

Interested in a #postdoc in Edinburgh working on #interdisciplinary #epigenetics and having this view on your morning commute? Upcoming opportunities to apply for funding below 🧵 1/3. Get in touch if you are interested.

Postdoc positions in epigenetics! We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️ See👇or contact me for other options. Pls RS

www.cell.com/cell/fulltex... Looks like an interesting resource

Congratulations to Prof. Kathy Niakan on being awarded the Mary Lyon Medal🏅 for their pioneering research on the function of genes that regulate early human development and the molecular mechanisms that direct cell fate in human embryos. genetics.org.uk/medals-and-p...

Brilliant perspective from Herve Seitz on miRNA targeting expressing in a super-clear way how miRNAs may have many biochemical targets, but only a few 'biological' ones. Cf great recent work from @lcochella.bsky.social , @labgrosshans.bsky.social & Katherine McJunkin academic.oup.com/nar/article/...

Check out our updated database of 189 PhD fellowships and funding opportunities. For each fellowship, we provide a description, $ amount, deadline, link to funder and eligibility criteria (such as citizenship). Good luck! Download freely here: research.jhu.edu/rdt/funding-...

🧬 New in @Nature: Our team found that fat cells keep a “memory” of their previous obese state even after weight loss, helping explain why maintaining weight loss is so challenging. Excited to share this work!! www.nature.com/articles/s41...

🚨 #Postdoc position 🚨 Join our lab at the #IJC in #Barcelona to lead innovative #Epigenetics & #SingleCell #Omics research on #SecondaryImmunodeficiency in #Leukemia patients, funded by #Grifols. institut-josep-carreras-ijc.jobs.personio.com/job/1760907?...

First impressions on this new environment are rather good! I hope it stays that way!