A really interesting screen. Axon diameter is an under-appreciated parameter for axon function, and not only conduction speed.

If it’s 0-0 at the end of regular time they should bring England and France back

Tuchel passing out knuckle dusters and nunchucks at the hydration break #ENGARG

HANG IT IN THE LOUVRE #EngArg

We are heartbroken to have lost our founder, who provided so much inspiration, but we are all honored to carry on the science he loved so much. picower.mit.edu/news/picower... #neuroscience #biology

Wishing England good juju and maybe some jiu jitsu to get through this game 😬🙏

Demis Hassabis says a lot of very strange things, not least about my own field of drug discovery. I go on at length here:

In our latest pre-print, we show that mice with the neuropathy-causing GARS1 ∆ETAQ mutation display robust pathology in subsets of peripheral nerves: www.biorxiv.org/content/10.6... Well done @beccasimkin.bsky.social and Aurélie Paulo-Ramos! @uclqsneuromuscular.bsky.social @uclqsion.bsky.social

Can only laugh but I think I’ve discovered a new form of impostor syndrome à la Nick Miller: “I’m not convinced I know what I’m doing, I’ve just memorised a lot of facts”

Delighted to see this paper finally published. New insights into the impact of aging on the human NMJ (hint: it’s NOT denervation!): JCI - Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition www.jci.org/articles/vie...

Very timely review as we find more and more links between DPN pathology and CNS neurodegenerative conditions #PainResarch onlinelibrary.wiley.com/doi/10.1002/...

Me relentlessly harassing my colleagues for feedback at every step of grant writing

🚨 Early bird registration deadline for NeuroBioUK26 is fast approaching! Register by July 17th to secure your discounted rate (£35) AND remember to submit your abstract to be in the running for a talk slot. You're faithful organising committee have some hard deadlines this year, so please submit!

Happy 78th Birthday to the NHS 🥳 Nye Bevan’s vision of universal healthcare became reality on 5 July 1948 "Illness is neither an indulgence for which people have to pay, nor an offence for which they should be penalised, but a misfortune, the cost of which should be shared by the community"

Some thoughts on the planned closure of @resprofnews.bsky.social . And what the lack of media coverage on the planned closure of Research Professional News tells us about what life might look like without a functioning trade media.

We are celebrating 75 years of research, innovation and education with global patient impact! Watch how Queen Square’s unique combination of research, clinical care and collaboration has shaped major neurological breakthroughs and continues to drive future treatments youtu.be/QbgSKrvgQXw

Are you impacted by pain? Has it been so bad that you have had to go to A&E? If so, you may want to take part in this study. Scan the code to take part. (And we are also interested in how many people have had to go through A&E due to pain, so please comment below if this has been you)

This is really rough news for everyone who works at RP. I'm so sorry to read this and hope impacted colleagues have good support networks to lean on. It will create a huge hole in a sector for which the timing couldn't be worse. www.researchprofessionalnews.com/rr-news-uk-o...

Join THE NEW-ROTROPHIN and stay on top of the last literature about neurotrophic factors in health and disease, from molecular genetics and cell biology to clinical trials in cancer and neuroscience. It's free and community-driven. thenewrotrophin.base44.app/Newsletter

This is cultural suicide and intellectual vandalism. In an era where humanities-illiterate tech bros have unearned god-like powers, we need historians, philosophers, ethicists, classicists more than ever.

'Our results identify a mechanism for cortical excitatory and inhibitory neurogenesis involving SCN2A, and reveal that early neurogenesis deficits precede postnatal neural circuit dysfunction in SCN2A-associated disorders' www.biorxiv.org/content/10.1...

I gave a workshop on AlphaFold & related programs @ the University of Utah. Part 1 covers protein structure prediction before/after AlphaFold & deep learning neural networks. Part 2 covers the math behind the scores. Part 3 covers PyMOL & the webservers. youtube.com/@rolanddunbr...

Periodic reminder that publishing papers is not the goal in and of itself. The paper is a mechanism for sharing what you have learned--sharing processes and outcomes that others should be aware of/should think about too. 1/3

🎉 50 years of #Clathrin! The second article in Traffic's Special Issue is now online. #CellBiology #MembraneTrafficking #Endocytosis #TrafficJournal Edited by Emanuele Cocucci, Jeanne Stachowiak & Margaret Robinson. onlinelibrary.wiley.com/doi/10.1111/...

Longterm, meticulous science 1970s mutation identified 2000s lentiviral vectors made reliable 2012 CRISPR makes editing feasible 2017 first durable lentiviral cures 2020 first CRISPR‑edited SCD patients 2023–24 first approved gene‑addition & CRISPR cures pmc.ncbi.nlm.nih.gov/articles/PMC...

📣Excited to share our new preprint! We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models. www.biorxiv.org/content/10.6...

Really excited to share out latest preprint! We’ve been studying how the proton-sensing GPCR GPR65 drives inflammatory pain – and found that *where* it signals matters! Huge thanks to support from @mayadannawi.bsky.social and @psalmotoxin.bsky.social! Read here: www.biorxiv.org/content/10.6...

🚀 Exciting opportunity for early career researchers in Cell & Developmental Biology! 🔗 Learn more and apply: www.ucl.ac.uk/life-science... Please share with your networks or tag someone who should apply! 👇

10 colour palettes I reach for in research charts — curated, and most are colourblind-safe. Categorical + sequential: Okabe-Ito, Paul Tol, Tableau 10, viridis, cividis, magma. Skip default tab10 and rainbow/jet. Which do you swear by? Anything I'm missing? #DataViz #ColorPalette #SciComm

“MyoD is not powerful because it commands other genes from above. It is powerful because its position in the regulatory network is such that its presence or absence reshapes the entire downstream landscape. Adding it to a fibroblast doesn’t just flip a switch; it reorganizes what the cell is." 💡

big news for us today: www.prnewswire.com/news-release...

Our latest review is out. We take a deep dive into the human mutations in microtubule motors that drive devastating neurodevelopmental and neurodegenerative diseases. Taking in motor protein biophysics, animal models of disease as well as patient phenotypes. onlinelibrary.wiley.com/doi/full/10....

Having been someone calling for UKRI to give the community greater notice on call deadlines, I welcome this. Drawing on the kids primary school feedback mechanism, here some feedback on today's announcement: 🧵

Many women may not be using the best pain relief for period cramps, a big study of supermarket receipts suggests. Paracetamol/acetaminophen was most commonly bought with tampons & sanitary towels, but Ibuprofen/Advil more effectively deals with muscle cramps. 🧪💊 www.bbc.co.uk/news/article...

According to @edvardmoser.bsky.social, director of the Kavli Institute for Systems Neuroscience, the four recipients of the Kavli Prize in Neuroscience challenged what had long been regarded as a central dogma in neuroscience. By Alissa de Chassey www.thetransmitter.org/awards/four-...

“We have enjoyed strong cross-party support for R&D, but we can’t assume that’s going to continue. If the public aren’t seeing the value when there are difficult choices to be made with public finances, I think that’s a real threat,” Welham told @isaacbarbosa1.bsky.social Full piece here:

Check out the paper in @stemcellreports.bsky.social www.cell.com/stem-cell-re... A collaborative effort between researchers at @fraunhoferitmp.bsky.social, @eu-openscreen.bsky.social, @mdc-berlin.bsky.social, and @hhu.de

Molecular Origami: Build 3D Paper Models of Protein Domains Download printable alpha helices and beta strand templates for hands-on exploration of protein folding domains, including a TIM Barrel and a Beta Sandwich

Come and join us @phar.cam.ac.uk for a PhD with Maxion Therapeutics www.findaphd.com/phds/project... Deadline: July 30th Funding: Home Fee status only

Leftover lab decor in our lab, from inheriting a graduated PhD student's bench

This is sad and shocking news - Raúl always worked tirelessly to help early career researchers navigate the complexities of academia, and was a generous and selfless advocate for stronger standards in pedagogy and higher education access. We need more Raúls in academia. Sincere condolences

I took part in the launch of Dr Martin's repair and remanufactured boots service. You really can have a pair of boots that will last you a lifetime. Here is the video of the fascinating panel event about the growth of reuse/repair services in fashion: youtube.com/live/3KYcowf...

Wow! It was not simple, but we managed to package and ship 3 confocal microscopes from @thecimr.bsky.social to the Sena Institute of Technology in Penyi, Ghana. A massive thanks to all the amazing people at CIMR who helped out, and can’t wait to see these scopes running and producing data at SIT!

Giving a talk? Don't waste time with "practice talks". Stay in slide sorter view & practice 3 things for each slide: 1. What point/s do I want to convey with this slide (</=3). 2. What's the 1-line summary of this slide? 3. What is the transition to the next slide? Something doesn't fit? FIX IT

Wu and Hegde annotate and analyze the topology of 4,863 human endoplasmic reticulum–inserted membrane proteins and their 20,546 transmembrane domains, showing that transmembrane domains inserted by different pathways can tolerate different biophysical properties. rupress.org/jcb/article/...

UK-based cell biologist? Interested in membrane trafficking? Want to find a conference? Looking for a job (PI, postdoc...)? Do link to www.ukmembranetraffic.com, where @jezcarlton.bsky.social and Chris Stefan (not here?) do sterling work

@drsusanna.bsky.social paper is now out in its final form. Relative to the original preprint, we now show additional mutant data and a better way to display heat maps of gene activation. www.cell.com/current-biol...

By the way, @dshb-antibodies.bsky.social is a non-profit that sells quality antibodies to many proteins at exceptionally reasonable prices, without AI generated faux-validation images. Check them out. dshb.biology.uiowa.edu

A few final views from high places 🌳