I felt very moved by this too. Not because we yet have a cure, but because of the reminder of the passionate and humane commitment that goes into such research, contrasted with the vicious idiocy with which medical research is being treated right now by the US administration.

Really cool, conceptually simple approach here: cross-referencing grant proposal scores with literature citations and explicit acknowledgments in drug patents to identify patents linked to projects that wouldn't have been funded given a smaller budget

*job alert** Wanted - 2 enthusiastic postdocs to join me @thecimr.bsky.social and Emma Rawlins @labrawlins.bsky.social to build complex models and use -omic approaches to understand mechanisms in human lung disease in collaboration with GSK. Contact us for more info! www.jobs.cam.ac.uk/job/52936/

Paradoxically it is very simple: Building (growing) the most complex organ from a handful of cells is a very complex process. Slightest thing goes awry somewhere along the way, you'll end up with a different system. And because it's complex there are lots of parts & things that can go another way.

This is positive. An anti-pollution movement is growing. We need to stop calling ourselves 'consumers'. Most people dont want to consume the planet, so why refer to ourselves as if thats the sole economic role of a person.

Professor Paola Giunti (Head of the Ataxia Centre, UCL Queen Square Institute of Neurology) and her team at UCLH have collaborated with pharmaceutical company Biogen to progress the first ever treatment for a rare genetic disease called Friedreich’s ataxia.

Are you planning on a project collaborating between international basic, translational, and clinical scientists? Apply for the @IASPpain’s Collaborative Research Grant! Find more information and how to apply here bit.ly/46gTkoc

🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research. @uclqsion.bsky.social @ucl-hd.bsky.social www.bbc.co.uk/news/article...

Have you read Neurotribes?!? If you want to know what autism is and why it is diagnosed more, Neurotribes explains the whole history. www.penguinrandomhouse.com/books/310415...

🔥 New episode of the Night Science Podcast with Akiko Iwasaki @virusesimmunity.bsky.social Yale & HHMI professor, and one of Time Magazine’s 100 most influential people in 2024! Akiko explains how leading large collaborations requires managing expectations, not micromanaging the research.

Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID

It's such a good week for preprints! Looking forward to reading this one www.biorxiv.org/content/10.1... #PainResearch

Congratulations @amapruns.bsky.social and all! Can't wait to dig in to this dataset #PainResearch

I will give the UCL Prize Lecture in Life and Medical Sciences. If you are in London on December 3, come say hello. Registration is required but free: www.eventbrite.co.uk/e/ucl-prize-...

New research from @danafarber.bsky.social! Satellite glial contact enhances differentiation and maturation of human iPSC-derived sensory neurons providing a better model for investigating human peripheral neuropathies #neuropathy #neuron #glia ow.ly/zv6X50WZpnh @harvardmed.bsky.social @isscr.org

Looking at different places along the axon, we found most of the spontaneous exocytosis occurring in… the axon initial segment! In addition, acute perturbation of the actin-spectrin scaffold could up-regulate shaft exocytosis vs presynaptic release. 6/11

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons www.biorxiv.org/content/10.1...

Really exciting new paper from collaborator extraordinaire @neurobender.bsky.social on CRISPRa-mediated rescue of Scn2a loss-of-function. Happy to contribute a tiny bit to this behemoth of a story. Congrats, Kevin, Nadav, and everyone else!

Question for the molbio crowd: does plasmid promoter strength refer to efficiency of polymerase binding, or number of transcription events per plasmid copy?

Question for the molbio crowd: does plasmid promoter strength refer to efficiency of polymerase binding, or number of transcription events per plasmid copy?

This is true, and funny because it's true, and also an argument for "early writing" - you can write much of your paper, even most of it, well before the work is complete and thus before you're too late for "should have done".

Lovely to see David Stephens highlighted in 100 years of cell biologists at J. Cell Sci., alongside Linda Amos, Peter Medawar, Juan Bonifacino, and others journals.biologists.com/jcs/article/...

Trafficking biology is wild - who will win out in the diligent workers vs loose bucket brigade battle of the motor proteins?

New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub

Excited to share our preprint, now available online on BioRxiv! biorxiv.org/content/10.1.... We uncovered the coupling of translation and secretion machineries at the #axonalER to promote local delivery of axonal transmembrane proteins (TMPs) to the plasma membrane.

Nociceptors use multiple neurotransmitters to drive pain https://www.biorxiv.org/content/10.1101/2025.09.09.675093v1

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Membrane protein export in developing axons, via axonal ERES and Golgi bypass #ER_Literature

Load and lock: An emerging class of therapeutics that influence macromolecular dissociation

Tee-shirt from Noma. What is true for cooking is even truer for research: Try new things!

ICYMI: Simplifying access to MRC applicant-led funding #MRC #AcademicSky

This is ... just brilliant. Another ncRNA gene involved in rare developmental diseases, and these are a meaningful number of new cases - also interesting the dominance/linear/recessive differences

After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻‍♀️

I've been inspired by a lot of talks this year at #flux2025 @fluxsociety.bsky.social We've discussed adversity, diversity, loneliness, disinformation, attacks on science, autocracy and right-wing populism, but one thing not mentioned, which is sown into all aforementioned topics is Palestine. 1/8

Non-profits wade in where for-profit life science investment fears to tread nature.com/articles/s41... rdcu.be/eyzXy

Tear down of air pods at iFixit 2025. They are currently a disposable product but will have to have user replaceable batteries by 2027 by law in the EU.

Pick an idiom: "more than meets the eye", "beauty more than skin [feather] deep" etc. In work led by Rosalyn Price-Waldman, we describe a hidden (and ignored!) black or white layer found below the visible surface of bird feathers which helps make bird colours so striking! 🧪 🪶 #colsci

Wagner, Silva et al. @washuengineers.bsky.social show that deleting large sections of the Nav1.5 I–II linker does not affect voltage-dependent gating. But changes to the protein sequence does affect gating, showing how certain variants can alter channel function. rupress.org/jgp/article/...

Brain postdoc fellowships now open guarantorsofbrain.org/grants/post-...

So ready for Benoit Blanc’s return!

📝Check out our review “Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine”, out in @natrevcardiol.nature.com. We review the use of Multiplexed Assays of Variant Effect and variant effect predictors in cardiovascular disease.

An absolutely golden thread on planning and executing a research budget for anyone new to grant writing, huge thanks for sharing your knowledge @labliston.bsky.social!

Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti... #Reproducibility

New approach methodologies offer the promise of greater predictivity of safety risks of drug candidates than animal models. Find out about progress in their application in drug development in this article in the September issue www.nature.com/articles/s41... rdcu.be/eDV1s

Hello world! We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.

Another year older, another year a little wiser. If turning 30 was about finding joy, 31 was about being brave - thanks to the support of some amazing colleagues that made this year so scientifically exciting! Ready to keep building and see what lessons 32 has in store 🔬🥳🥂

A thoughtful end to this series on AI in research writing and science communication: "The path forward means acknowledging that efficiency isn’t always progress, that removing friction isn’t always improvement, and that tools designed to make us more productive might sometimes make us less capable."

How multispecific molecules are transforming pharmacotherapy

My editor’s pick: painresearchforum.org/paper/mitoch... “...the findings suggest that nociceptors have evolved to “dial down” the ETC pathway, enabling them to be unusually resilient to oxidative and other intracellular stresses.“

2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026. 🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others. 💡 Submit abstracts by the 26th of September, 2025: lnkd.in/eDhPUVKd 💻 More info: lnkd.in/eJw9pfMz