Speaking of UKRI, this was a really interesting analysis by @johnwomersley.bsky.social of the political factors that have shaped the agency and its new direction. www.researchprofessionalnews.com/rr-news-uk-v...

Additionally, the functional evidence for 275 SCN5A variants from our recent SCN5A automated patch-clamp study is now accessible in ClinVar.

Excited to share our work engineering caveolin-derived nanoparticles “caveospheres”. We show their use for targeted transfection in cultured cells and effective targeted delivery and tumor killing in vivo. pubs.acs.org/doi/full/10....

Are you looking for a reason to bring you to Italy this May? Register for the Pain Mechanisms and Therapeutics Conference, taking place this May in Verona bit.ly/45Gk3ew #PRF

Our latest preprint. More evidence that diabetic neuropathy is a neuro degenerative disease. Very proud of @ish1789.bsky.social and our whole PRECISION group who made this work possible. #HEALinitiative funded

Now reading: "From this atlas, we found that the neuron composition of the developing and regenerating spinal cord differ. So do the strategies employed, which favor waves of cell-type specific neuron morphogenesis, proliferation, .." #devbio 🧪 And they found some frog Rohon-Beard neurons!

Such fun and a real privilege to write this Journal Club article in @natrevneuro.nature.com. Introducing a fascinating creature and what it teaches us about behavioural coordination rdcu.be/eZnKn

Thank you @ucdlibrary.bsky.social for sourcing this fantastice read by @steveroyle.bsky.social for me. Highly recommended for anyone interested in learning more about #cellbiology #biologicalimaging #imageanalysis #datavis also more people should read the #quantixed blog.

A beautiful, informative and perceptive review of neuronal ER, and how its form relates to its function. Nice work from @marijnkuijpers.bsky.social and colleagues. #ER_Literature

'Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection' - but isn't still wonderful??? This is a fantastic read. journals.biologists.com/jcs/article/...

🧪 An EMBO Meeting on Axon Biology in Okinawa, Japan Iconic science at an amazing venue. Please join us! EMBO | COB Workshop on Axonal degeneration and regeneration meetings.embo.org/event/26-axo...

We can neither confirm nor deny the existence of big pain relief news next week.

Perhaps the greater challenge: conveying that uncertainty is a *fundamental* aspect of knowledge.

Delighted to have been part of this exciting project uncovering how MSC-derived extracellular vesicles modulate NGF-induced neuronal sensitisation. Don’t miss our new pre-print exploring the role of miRNAs and nanoparticle-based delivery! www.biorxiv.org/content/10.6...

If pain & peptides are your thing, then this session is for you: 17:00 UK time today 👇

Thus, in this #PainResearch www.biorxiv.org/content/10.6... we found that MSC-EVs deliver miRNAs that counteract NGF-induced sensitisation, next steps: 1) working out molecular mechanisms by which miRNAs of interest work 2) examining roles in vivo, e.g. does miR-21-5p ameliorate joint pain in 🐭?

Excited to share @rbrianroome.bsky.social ‘s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down. www.science.org/doi/10.1126/...

I guess I should re-post from the Bird Site "The Rules For Academic Success here": I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses... This list gets longer all the time

In case anyone needs it for their syllabi, my statement in gen-Ai from the minicomic I made as a syllabus for class last semester. All online and printable here spinweaveandcut.com/fall-2025-sy...

In honour of my new job as Director of the University Museum of Zoology at Cambridge University, this is the first of a series of weekly posts celebrating our amazing collection. And what better to start with than the Fin Whale, who will welcome you when you come to visit! @zoologymuseum.bsky.social

UCL spinout EpilepsyGTx has raised $33M Series A to advance its gene therapy EPY201 into clinical trials, offering hope for millions with refractory epilepsy. We are pleased to have supported this lab-to-market journey from the early stage. Details: bit.ly/4qXYGxJ

Why should scientists write op-eds? It's tempting to say the facts ought to speak for themselves. But the facts are largely whispering among themselves in the scientific literature. They need us to give them a voice. How? Advice in my latest @natchem.nature.com Thesis rdcu.be/eJlGL #chemsky 1/3

The scikit-bio paper in online in Nature Methods! Many thanks to our collaborators, community contributors and reviewers! We couldn’t have done it without you. www.nature.com/articles/s41... #Bioinformatics #OpenSource

We all should remember that by publishing in a journal, we financially support their existence, and intellectually support their values and approach to publishing. Publish in journals that give back to your discipline, that give back to science. Such as Development and Developmental Biology

Blackademics U.K starter pack is here!! Let me know if you would like to be added. Please help me spread the word by reposting 🫶🏽 #Blackademics #BlackSky #AcademicSky #HiSciSky go.bsky.app/9SZqevC

Until then, @biologyopen.bsky.social will continue running Fast & Fair: paid peer review, decisions with reviews in 7 working days. Data > vibes. Happy New Year. 🎉 journals.biologists.com/bio/pages/fa...

Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2

For every trainee who succeeds at getting some super difficult experiment to yield interesting results, there are another dozen who fruitlessly spun their wheels for years. My advice: explore many technically feasible experiments and follow up on interesting leads

Excited to finally share this story with you! We generated a temporal atlas of the joint-DRG axis during arthritis-induced pain to probe neuroimmune interactions. This revealed OSM and SEMA4D as mediators of neutrophil-neuronal signaling. Many thanks to all coauthors! www.biorxiv.org/content/10.6...

A new story at The Transmitter about the PRECISION Human Pain Network's new DRG cell atlas: www.thetransmitter.org/peripheral-n... So rewarding to hear about colleagues who are already using our datasets in their own work.

Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...

Neurovascular compression of the trigeminal root, which undergoes major morphological changes, and focal demyelination of primary trigeminal afferents are key aetiological factors in #Trigeminal #neuralgia https://www.nature.c...

Do YOU live with joint pain? Do YOU experience poor pain management? Have you got 2-minutes to tell pain researchers about it? If yes 👉 forms.gle/7NTwma2gnVN1... We hope to gain insight into lived experience for those with joint pain & involve people in our #PainResearch 😃

It feels like we're hitting an inflection point in the infiltration of AI slop (both papers and journals) into the peer-reviewed literature - the anecdotes just keep getting wilder. This is truly the very last thing we need when science and evidence-based decision-making are already under attack.

All research is exploratory if you’re confused enough

Would it be terribly annoying if I posted about things that have made my academic work more... efficient?

“We need to take on the defence of science for the world.” In a wide-ranging and frank conversation, Paul Nurse reflects on his years leading the Francis Crick Institute with our new director, Edith Heard. www.crick.ac.uk/news/2025-12...

In January, it’ll be 10 years since I got the call that I had a PhD spot in Geoff’s lab. Grateful every day since, but especially the days I get to poke around and learn something new about sensory neurons 🤩

Excited to share our preprint: “Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia Risk!” We performed ~50,000 experimental measurements of KCNQ1 variants. www.medrxiv.org/content/10.64898/2025.12.15.25341924v1

A preprint from my lab @yalepharm.bsky.social: doi.org/10.1101/2025... show molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling, offering a clear blueprint to target this long sought-after pathway!

A growing list of medications—such as zuranolone for postpartum depression, suzetrigine for pain, and the gepants class of migraine medicines—exist because of insights from basic research, writes @alexkwan.bsky.social. www.thetransmitter.org/drug-develop... #neuroskyence

This is one of those stories where every interview had me like 🤯🤯🤯. For @nature.com Outlook, I dove into the surprising field of cancer neuroscience. Edited by the amazing @scchak.bsky.social www.nature.com/articles/d41... #neuroskyence

On neuronal Golgi - including axons and dendrites

My team are running the Peripheral Nerve Society's Instagram account this week: www.instagram.com/pnsociety1 If you like images of the nervous system, please check it out! #FluorescenceFriday @uclqsneuromuscular.bsky.social @uclqsion.bsky.social

Leaders at @ukri.org should be seriously looking at the lottery first idea. 68% lower economic costs, increase in diversity of award holders and well received. www.nature.com/articles/s41...

Motivational quote of the day from Thomas' PhD mentor, Dr Marius Wernig - "There's no speed limit on the Autobahn" - i.e., (with the right tools) there's nothing stopping you going after big questions 💡

Rivero-Ríos, Sutton, Weisman and colleagues show that PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity. rupress.org/jcb/article/... 📕 From The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025

We have some very crafty staff here at CIMR! Thanks to the amazing reception team for the beautiful hand-made decorations and to the labs who contributed science themed wreaths to brighten up our building

Came across the phrase “a mutation can alter the character of a protein” and now I can’t stop thinking about an alignment grid with types of genetic regulation/variation. Synonymous substitutions as True Neutral? Splicing variants as Lawful Good? Structural mutations as Chaotic Evil? 🧬

some people have security blankets i have the 40 hidden slides in my presentation just in case i get asked specific obscure questions