Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it. PhD students: choose someone you like to talk to!

Lesion-remote astrocytes govern microglia-mediated white matter repair www.nature.com/articles/s41...

Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons www.nature.com/articles/s41... @natneuro.nature.com

Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation. Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

New preprint from the lab! For those who love astrocytes 🤩. We welcome feedback! #preprint #openaccess #astrocytes #autism

Update: a Targetome commentary by Zhao, Agarwal & Bai discusses our Cell paper as part of a broader paradigm of glia–glia coordination—linking microglia–astrocyte signaling in synaptic pruning to cooperative glial mechanisms in processes such as myelination. www.maxapress.com/article/doi/...

Another great preprint on neuronal APOE4 from the Huang lab!

#NatMetabPicks | In @natcellbio.nature.com led by @olzmannlab.bsky.social ( @ucberkeleyofficial.bsky.social ) FSP1, localized to lipid droplets, protects stored lipids from oxidative damage and prevents ferroptosis. www.nature.com/articles/s41...

Our new review is out today! 𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀 We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility. onlinelibrary.wiley.com/doi/10.1111/...

The Cummings Lab is hiring a postdoc to work in the areas of reward and addiction! Please see the ad below:

#astrocytes #endothelium #cerebrovascular 😱🤩🤩

Thrilled to publish our new study on #mitochondrial ROS coming from complex III, revealing this key site in #astrocytes 🎯as a crucial immunometabolic signal transducer🤯 and potential therapeutic target for #dementia #FTD 💊 rdcu.be/eOc0m 👈💪 Great commentary by H. Pan and F. Yin🤩! tinyurl.com/4hdytw4c

Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social. www.cell.com/neuron/fullt...

TT faculty job opening in #Neuroscience! We are looking for a colleague to join us in our fantastic Biology Department and Neuroscience Program at Brandeis. We are a group of *very* collaborative, supportive, and productive scientists (& humans!) so please apply academicjobsonline.org/ajo/jobs/30961

ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline. Apply here: hr.umn.edu/jobs/Find-Job Assistant Prof job code: 364920 Associate/Full Prof job code: 364921

If you’re interested in glia and you’ll be at SfN in San Diego, please join us!

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

We are #hiring for a Tenure Track Assistant Professor position in the Department of Molecular&Cellular Physiology (med.stanford.edu/mcp.html) at @stanfordmedicine.bsky.social. Please apply or forward the opportunity to anybody who might be interested. facultypositions.stanford.edu/en-us/job/49...

💡 Research Spotlight: Primary cilia in astrocytes are key for their development, metabolism & synaptic regulation. Defects lead to neuronal and behavioral issues in mice, offering new insights into neurodevelopment & ciliopathies. 🔗 https://www.nature.com/articles/s41593-024-01726-z

what Piali said! Looking to recruit a new assistant professor to our fabulous neuroscience group and department at Brandeis. Please circulate far and wide and alert anyone you know who is on the job market! #neuroscience

It’s official: ChatGPT can't draw a GPCR, but you’ll master them in the Filizola Lab 😜 Join Us! (send your CV and the names of at least two references to my institutional email) #Postdoc #scientist #research

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8

A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science. www.sciencedirect.com/science/arti...

I started my own lab about 6 months ago at Ohio State where we’re continuing to look at ways to manipulate astrocyte biology to improve brain repair. We’re also generating new viral tools along the way, for use in research and hopefully in gene therapies for patients down the line.

Huge congrats @amygleichman.bsky.social on this phenomenal study, demonstrating regional differences in astrocyte responses to stroke and a key role for astrocytes in post-stroke angiogenesis and repair! (see also - gorgeous astrocytes for fluorescence Friday) www.sciencedirect.com/science/arti...

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...

Mitochondrial diseases have seemed intractable, but last month the Food and Drug Administration OK’d the first treatment targeting a mitochondrial flaw. https://scim.ag/4q3Ymxz

Obituary: Jane Goodall (1934-2025) Pioneer primatologist who inspired generations of scientists go.nature.com/48aWjRU

Intriguing new insights on axonal TDP-43 in ALS from @labperlson.bsky.social and colleagues www.nature.com/articles/s41...

Postdoctoral Researcher Vacancy at VIB-CMN Antwerp with Dr Rosa Rademakers. Focus on genetics of FTLD using advanced sequencing, bioinformatics, and integrative analysis. Closing date: 24th November www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

Link to HHMI preprint mandate hhmicdn.blob.core.windows.net/policies/Imm...

We have several positions open at various levels (Research Assistant, Research Associate, Postdoctoral Fellow) across our highly interactive teams in the Division of Translational Neuroscience 🧠🔬🧪 @lieberinstitute.bsky.social www.libd.org/careers/ Links to individual positions in the thread below.

Mental and metabolic health are closely linked - but what drives this connection? In our new theory paper, we (w/ @camillanord.bsky.social & @hugofleming.bsky.social g.bsky.social) propose dysregulation of interoceptive energy allostasis as a key mechanism. www.science.org/doi/10.1126/... 🧵 1/n

I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Thrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025

🤩Additional funding for AD & ADRD Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research www.nia.nih.gov/about/budget...

Sensory neurons shape local macrophage identity via TGF-β signaling @cp-immunity.bsky.social www.cell.com/immunity/ful...

A potential trauma-related astrogliopathy? Subpial tau astrogliopathy is frequently seen alongside CTE lesions and we also see it in our repeated head impact cases that don't have CTE. It's exciting to see new data exploring this.

Astrocytes are connected by gap junctions in large, plastic networks that link brain regions not connected by neurons, a new preprint shows. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/astrocytes/a...

Submissions for late-breaking abstracts are now open!   Share your most recent and exciting research with a global audience at #SfN25.  Submit your late-breaking abstract by Wednesday, September 10.  🔗 vist.ly/45gzc #neurosky #neuroskyence #academicchatter

#APOE genotype influences on the brain #metabolome of aging mice – role for #mitochondrial energetics in mechanisms of #resilience in APOE2 genotype Kamil Borkowski, Nuanyi Liang, Na Zhao..Rima Kaddurah-Daouk @dukemedschool.bsky.social @metabolomics-wcmc.bsky.social @mayoclinic.org bit.ly/4g0otRm

Our Salon webinar recording release brings Dr Ella Moonan-Howard from Alzheimer's Society and Professor Richard Unwin from The University of Manchester to explore what is means for Researchers to be 'Innovation Minded' youtu.be/pLssuT6A8W0

Katz has been a game changer for me and my lab, so happy to see it reissued!

Ever wanted to do a CRISPR screen directly in the mammalian brain? While perturbing thousands of genes in parallel? All while targeting specific cell types? Check out our latest paper describing CrAAVe-seq, a powerful new functional genomics tool for massively parallel neuroscience research