We have recently updated FlyCyc biocyc.org/DMEL/organis..., the pathway-genome database representing Drosophila metabolism, to include enzymatic complexes as well as further improvements to enzyme annotations. #FlyCyc is now classed as a ‘Tier 1 Highly Curated Organism Database’.

Now published as version of record at @elife.bsky.social ! Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️) elifesciences.org/articles/107... shop.vbc.ac.at/vdrc_store/d... #Drosophila #IDsky #SymbioSky #Infection #Immunology

✨A gut feeling you’ll love this one 🐛 The anterior midgut of a Drosophila melanogaster 🪰larva puts on a confocal glow show! 🟢 Adult midgut progenitors 🔴 Actin 🔵 Nuclei 📸Image by Sapna Krishnakumar #FluorescenceFriday #Microscopy #DevBio

Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social

🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off. Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2 tinyurl.com/FlyBase

📣Tomorrow is International #DayoftheGirl & 30 years since the Beijing Declaration on advancing equity, development & peace for all women & girls 📈We must scale investment in girls — including through research, health, education & empowerment- -a commitment we make in our lab #GenerationEquality

Burgmer, S., Meyer Zu Altenschildesche, F., Gyenis, A., Lee, H., Vilchez, D., Giavalisco, P., Fichant, A., Uhlirova, M., Storelli, G. (2025). Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling. Cell Rep, 44(6):115811 www.cell.com/cell-reports...

Another amazing achievement from the fly community 🤩

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth. bit.ly/4gX6njF

🪰 More than 750 scientists from 40+ countries gathered in Alicante for the XXVIII European Drosophila Research Conference #EDRC2025. For 4 days, the fruit fly took center stage as a model to study health, aging, and disease👏 @edrc2025.bsky.social @csic.es @dicv.csic.es @umh.es

Thank you to all #EDRC2025 participants and a big applause to the organizing committee for this great #Drosophila meeting! See you all in Bonn for #EDRC2027

#edrc2025 European #drosophila Society meeting announces the 2029 meeting location : see you all in Szeged (and Bonn in 2027 of course)!

Beautiful location, fabulous science, and wonderful people 🤩 Thanks to the organizers for all your hard work in bringing us together!

Interesting episode of short wave about the origin of endometriosis. I really appreciate that they end with how uncertainty in NIH funding affects the future of their work. www.npr.org/2025/09/26/n...

2nd paper outta my PhD is NOW PUBLISHED😭 🧬🖥️ 🦑Here we show how comparative #genomics 🧬 is a powerful tool to detect putative #SexDetermination genes: Dmrt1L & SoxH from #bivalves 🦪 share evolutionary patterns with Sry from #mammals 🐗 but not with genes from #drosophila 🪰 doi.org/10.1111/mec....

Taking in my favorite part of Vancouver airport on the way to EDRC in Alicante - excited to see folks there for all things Drosophila!

Dear JEDIs, the #EDRC meeting is coming soon! Who is joining? Looking forward to meeting everyone next week!

Studies of prohormone convertase knockouts in mouse islets reveal plasticity in proglucagon processing to support intra-islet α cell-to-β cell communication, normally dominated by glucagon secretion www.science.org/doi/10.1126/...

Very proud of Celena Cherian in the lab, who contributed data to www.biorxiv.org/content/10.1... Briefly, Celena showed female fat body cells have higher ribosomal protein expression and more protein synthesis than males. This difference persists even after cell size is accounted for!

The next paper from @pujabiswas.bsky.social PhD has been posted! www.biorxiv.org/content/10.1... Puja found a sex difference in levels of hormones produced by gut enteroendocrine cells.

I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.

In our Forest of Biologists we fund the restoration and preservation of ancient woodland and dedicate these trees to our peer reviewers. There are now over 10,000 trees for peer reviews! Thank you to all our peer reviewers. Find out more: forest.biologists.com #PRW2025 @peerreviewweek.bsky.social

Congratulations to my PhD student, Ujjayita for being awarded the DBT-CTEP international travel support grant to attend @edrc2025.bsky.social in Alicante, Spain. Ujjayita will be giving a talk at EDRC. Looking forward to EDRC 2025 :) Spain here we come!! #Drosophila #EDRC2025

Very proud of former Kumar lab PhD student, Alison Ordway, for receiving a K99 award from the National Eye Institute on her work describing photoreceptor patterning in Drosophila and mosquito compound eyes. Keep your eyes out for Alison when she goes out on the job market.

Geronazzo, J., Heimerl, A., Lindell, L., McCrimmon, S., Stormer, C., Horvai, B., Johnson, I. P., Peterson, T. M., Zuckerman, J., Scott, A. I., Course, M. M. (2025). Characterizing fatty acid oxidation genes in #Drosophila. G3 (Bethesda), academic.oup.com/g3journal/ar...

Studies of pancreatic slices from organ donors reveals beta cell dysfunction in #T1D occurs independently of local autoimmunity www.cell.com/cell-reports...

Dear GenZ members of the #Drosophila community! You are needed to make cool fly research viral in your social media world! As a boomer I do not understand that sphere, but I can consult and contribute our enormous fund of outreach resources: droso4public.wordpress.com. Please, get in contact!

Are you an early-career researcher using Drosophila in your research? Sign up to be matched with a mentor as part of FlyCROSS 2025-26. Apply by 1 September 2025. thenode.biologists.com/mentees-flyc... #Drosophila #DevelopmentalBiology #Mentor #Career #Biology #FlyCross

In case folks missed this post the first time - join us in Vancouver at The University of British Columbia. Two faculty positions are available (see links in original post), and views like this will be close at hand:

My lab’s newest preprint is now available. www.biorxiv.org/content/10.1...

I mentioned to a couple of people that I had a surprise waiting to be shared when Moderna got approval for its updated COVID-19 vaccine. It’s approved, and the big news??? Completely produced domestically!!!!! 🥳🤩 Approved as usual for all aged 6mo+!

Check out our cover article in @evolletters.bsky.social, Size in the city: morphological differences between city and forest great tits have a genetic basis. By @babimt.bsky.social @keesvanoers.bsky.social @mevisser.bsky.social. academic.oup.com/evlett/artic...

Please please please, if you are able, consider supporting Flybase fiscally. They need our help! I donated this evening. They are in danger of closing and any amount will help. We cannot allow this critical pillar of science to collapse!

I watched the video and donated - it was super easy! Please donate if you’re able, and help spread the word so that we can keep this essential resource going.

Yours truly amongst the Fellows. Great group of people, meeting in person in December in a British Pub. This will be remembered as an infamous day in the Dev Bio field, mark my words! 🧪

big one! a decade in the making. nadler & team develop tools to track lipid transport in living cells at single-species resolution. turns out non-vesicular, asymmetry-driven transport is the main architect of organelle identity. feels like the dawn of a golden era for lipid biology. rdcu.be/eBGJv

Summer camps schedule for kids means I can bike to work. So grateful for this scenic commute!

Pilgrimage with @ereynaud.bsky.social to the #Blaschka’s grave in Hosterwitz near #Dresden. Emmanuel came to show them the gorgeous book of photographs of their world famous glass models of marine animals. Bringing a #Czech along was a bonus. I think they would have been proud of the book.

Growth arrest in the developing wing occurs during the pupal stage #Drosophila

Redefining insulin signalling and its dysfunction, highlighting new therapeutic opportunities. www.nature.com/articles/s42...

I think the "embodiment" of this connectome is going to be such a hit: For instance take the interactive "body part" maps on Codex, where you can simply click on your favorite external or visceral part and it will show you all of the neurons associated it! codex.flywire.ai/app/body_par...

🐝 #CanFly2023 Throwback! Explore top-tier Canadian #Drosophila research in our #CanFly2023 collection—genetics, neuro, evo, development & more! 🧬🧠 ow.ly/XUvC50WqbAx 🗨️ Came to #CanFly2025? Submit to the new collection—NO #OA FEES! 📝 #ModelOrganisms

Fly folks - want to do RNAi in embryos to look at patterning. Haven't delved into this before - any suggestions of good Gal4 drivers? #Drosophila

Woodling, N. (2024). Sex- and strain-dependent effects of ageing on sleep and activity patterns in #Drosophila. PLoS One, 19(8):e0308652 journals.plos.org/plosone/arti...

Thankyou @asbmb.bsky.social for helping us spread the word ! #Drosophila #earlycareer researchers including #grads #postdoc & #pretenure #faculty are welcome to participate as mentees in #FlyCROSS. Fill up the mentee survey by Sept 1 ! 👇🏽 docs.google.com/forms/d/e/1F... #academia

This thread below is criminally under-liked and under-shared! Young #Drosophila researchers (PhDs, postdocs, and early-career Drosophilists): fill out the survey by Sept 1st to get matched with a mentor who can support you with your career. Established Drosophilists, like/share Shefali's Thread ;)

How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ www.nature.com/articles/s41...

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

I should have said too that our department welcomes applications from people that use experimental systems including (but not limited to) worms, flies, and mice to study these questions!!

Our department at The University of British Columbia in Vancouver (Canada) is running two faculty searches. One is a joint hire with the Institute for Healthy Aging, one a cohire with the Math Dept cps.med.ubc.ca/careers-2/ Click on “Faculty Positions” on the page. Please help spread the word!