As 2025 comes to a close, my university (Dalhousie U in Halifax, Canada) is recruiting faculty, including outstanding early career researchers, and Canada Research Chairs. Applications are due January 19 2026 (was just notified today!). Please repost.

Talin didn’t evolve for integrins... integrins evolved for talin 🤯 pN force coupling via talin is ancient, conserved from amoebae to humans; signaling came later. Read this amazing paper here 👇🏽 www.nature.com/articles/s41...

We have recently updated FlyCyc biocyc.org/DMEL/organis..., the pathway-genome database representing Drosophila metabolism, to include enzymatic complexes as well as further improvements to enzyme annotations. #FlyCyc is now classed as a ‘Tier 1 Highly Curated Organism Database’.

The homeodomain-interacting protein kinase Hipk promotes apoptosis by stabilizing the active form of Dronc #Drosophila

Who wants to come to a bug conference on the east coast? Save the date for the Acadian Entomological Society's 2026 meeting, June 18-20, to be held right here in Antigonish @stfx-university.bsky.social @davidawde.bsky.social

An energy-based model of protein conformational space can be used to predict structure from sequence, sample from the conformational landscape, rank structures, and predict mutation effects. @sokrypton.org www.biorxiv.org/content/10.6...

Aaand... my first cover!! RpS6 phosphorylation (magenta) in a Udd (ribosome biogenesis factor) mutant ovary 🔬

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park! “Specialized gas-exchange endothelium of the zebrafish gill” — www.biorxiv.org/content/10.6... Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

From January 1st 2026, the CNRS will cut access to one of the largest commercial bibliometric databases, Clarivate Analytics' Web of Science, along with the Core Collection and Journal Citation Reports.

ROS heal the cricket leg This Research Highlight showcases the work from Misa Okumura-Hirono, Tetsuya Bando and colleagues journals.biologists.com/dev/article/...

thanks, @coastalseaside.bsky.social for the delicious w[1118] #Drosophila cookie!

dFlpTag, a RMCE-based tool for simultaneous endogenous protein tagging and cell labeling in Drosophila #Drosophila

Reliable Identification of Homodimers Using AlphaFold https://www.biorxiv.org/content/10.1101/2025.11.27.691011v1

Daniel Smith, Sanford Bernstein and colleagues @sdsuresearch.bsky.social uncover the distinct impacts of human co-chaperone UNC45 paralogs on Drosophila muscle development and function. journals.biologists.com/jcs/article/...

Just gonna put this here for now www.science.org/doi/10.1126/... bsky.app/profile/jlst...

Thrilled to share our new paper! With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste. Link @nature.com: www.nature.com/articles/s41...

Mameli, Samantsidis, Viswanatha, Kwon, Hall, Butnaru, Hu., Y., Mohr, Perrimon and Smith (2025) A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes. 16(1):10323. doi: 10.1038/s41467-025-65304-y. PMID: 41285753

An open webinar on our reproducibility project 'WHAT 400 DROSOPHILA PAPERS Teach Us about Doing Better Science' on December 9th 2PM EEST time (1PM Swiss time). Registration below

Latest work out today in @currentbiology.bsky.social We find the fly development gene bicoid is much older than previously thought (~20 million yrs older!) 🪰🧬 To pinpoint its origins we tackled the Diptera phylogeny, providing some resolution (many open questions remain). 🔗 tinyurl.com/2vyuevpy

Another AI cover art. Sigh

The law of the jungle. Interactions of cells in a collective lead to global rotation. In 80% of the case HUVEC cells turn clockwise. How many cells does it take for this to happen?

Dear #Neuroscience researchers, I am Guest Editing an issue in @devdynamics.bsky.social on NEURAL MIGRATION. Due date: March 31, 2026. Great opportunity to showcase your findings on neural migration. #DevBio Please reskeet 🙏 anatomypubs.onlinelibrary.wiley.com/journal/1097...

Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2) forum.image.sc/t/bigvolumeb...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...

OMG--read this thread. Remarkable clever use of a trick to visualize plasmid competition that reveals key insights into evolution!!!! 🧪

How the Avalanche of Academic Papers Threatens Scientific Research, by Vince Bielski 'Editor-in-Chief Anna Stilz at @ucberkeleyofficial.bsky.social led a revolt that culminated in the mass resignation of the journal’s entire editorial staff and board.' www.realclearinvestigations.com/articles/202...

A remarkable scientist, innovator, and role model--well worth a read. 🧪

NEW! We are hiring a Scientific Editor to join our amazing #PeerReview team. In this role, you'll help uphold rigorous peer review and support our editors, reviewers, and authors. Applications are now open. Details here 📚▶️ https://ow.ly/X6WV50Xujv1#PeerReview #NowHiring #ScienceJobs #AcademicPublishing

Check out this tick I collected ;-) And by collected, I mean pulled off my pant leg after a walk in the woods

📢Check out our latest #preprint list on FocalPlane This list focusses on the latest research on bioimage analysis and data management. Let us know if there are any preprints that we should add to our list and send us recommendation for the next one! focalplane.biologists.com/2025/11/14/m...

You must have been looking forward to... October in preprints! Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀 thenode.biologists.com/october-in-p...

Poniendo los puntos sobre las íes 👏 Beigel, F., Brockington, D., Crosetto, P., Derrick, G., Fyfe, A., Barreiro, P. G., Hanson, M. A., Haustein, S., Larivière, V., Noe, C., Pinfield, S., & Wilsdon, J. (2025). The Drain of Scientific Publishing (No. arXiv:2511.04820). arXiv. doi.org/10.48550/arX...

Glad to share our latest work showing that #drosophila epigenetic enzyme TET controls muscle development independently of its catalytic activity but prevents muscle aging in a catalytic-dependent manner! Congratulations to Vincent and Emilie @igred.fr ! links.springernature.com/f/a/L1ogzL3H...

Latest from the lab by @longweibai.bsky.social www.biorxiv.org/content/10.1... 1/6

Nope. Read his words compiled by @lpachter.bsky.social and say that again. He was a stain on science from day 1 liorpachter.wordpress.com/2018/05/18/j...

lol so true

A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration Read this #LifelongDevSI #OA Research Article by John W. Quinn, Robin E. Harris and colleagues in our Stem Cells and Regeneration section doi.org/10.1242/dev....

We desperately needed a cooling dry bath, but the typical brands are crazy expensive. So we got ourselves a

PAPER OUT ✨ What if you could use your microscope as a 3D printer? Prototype microfluidics in-house, <5$ in material costs per chip. From idea to experiment within a day. Now published in Lab-on-a-Chip (open-access): doi.org/10.1039/D5LC...

Nature Communications will publish ~10K papers in 2025 pubmed.ncbi.nlm.nih.gov?term=%22Natu... That's ~$70M in revenue, while many of the non-profit journals that used to occupy that slot in the journal hierarchy have seen a precipitous decline in submissions in the 15 years it's existed.

Meet Dr. Angelo Iulianella! @aineurolab.bsky.social "My interests are varied, perhaps a bit too varied, but my curiosity is always tickled by some new facts revealed to me by my fellow members at the AAA." Want to be featured? Fill out this form 👉 ow.ly/iLiu50XcC6Q #AAA #FacesofAnatomy

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Plant bioengineering is so cool.

- "Raise the East Wing" ! (only for ♂♂)(and drosophilists).

What are these? You are looking at embryos of a sea squirt. Each of the 'soap bubbles' is a living cell, about a fourtieth of a millimetre in size. The outlines of the cells are visible thanks to fluorescent markers identified by Hitoyoshi Yasuo @hitoyas.bsky.social see doi.org/10.1101/2024... 🧵

obviously a very bad metric. but why is nature publishing click-bait news like this?

www.nature.com/articles/s41... Probably has been shared a few times already, but I just read this beautiful work. The tip of the Malpighian tubules is the calcium storage in #Drosophila (and insects?), and the hormone that regulates the release is called Capability (Capa).

Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration Read this #LifelongDevSI #OA Research Article by Rachel Forman-Rubinsky, Michael Tsang and colleagues from the University of Pittsburgh doi.org/10.1242/dev....

Dick is one of the most thoughtful folks in cell biology--this is a must read for anyone interested in microtubules!