How do different tissues respond to mitochondrial dysfunction? @candrewfrank.bsky.social &co show that Complex I depletion triggers ROS-driven compensatory signaling in #MotorNeurons, but degeneration in muscles, with implications for #MitochondrialDisease @plosbiology.org 🧪 plos.io/4nLUIGJ

Please help me to celebrate Mei Zhen, an innovator and tremendous collaborator, named to the Royal Society of Canada Academy of Science on September 4, 2025

'Herein, we present a family of time-resolved fluorescent proteins (tr-FPs) with rationally controlled lifetimes. Using a strategy that regulates lifetime without affecting the spectra of FPs, we have developed a series of tr-FPs that cover the visible spectrum and a wide range of lifetimes.'

Ed Kravitz passed away yesterday. He was a remarkable scientist and mentor- brilliant, curious, creative, and kind. I am grateful to have learned from him. His legacy will endure through his science and through the many people he inspired. We will miss you, Ed.

Why did not one tell me we were having a Rapture? I would've ... well, I'm not sure what I would've done. But I'd have figured something out.

Excellent work from @candrewfrank.bsky.social's lab out now!

Very unexpectedly, we had to say goodbye to this beautiful lady last week. The world is a little less brighter these days.

🚨🚨🚨🧪 H1B scientists who are traveling outside the USA. Please be aware that current advice is to return to the USA IMMEDIATELY

Thrilled to be tuning in to Ben's lecture today at the 5th Lucy Cherbas Lecture. Ben White is a fantastic Drosophila researcher who does incredible work and taught me everything I know!

We are excited to announce our 2025 SPINE Fellows! We also appreciate everyone who submitted applications this year - it was great to read about everyone's awesome science! If you have not already, please register for SPINE by 9/24 and submit poster abstracts by 9/22 (extended) at spinephilly.org!

Acetaminophen/Tylenol use during pregnancy was not associated with children’s risk of autism, ADHD, or intellectual disability in sibling control analysis. This suggests associations observed in other, less rigorous analyses may have been attributable to familial confounding (aka erroneous finding):

Oh, for the love of fucking hell ... www.cnn.com/2025/09/05/h...

Grant writing is like songwriting for nerds. We all tell stories and we all dream of hitting #1 on the charts.

Not the best optics, but we were visited by a beautiful Orb Weaver last night. Absolutely stunning.

Fly labs — Now is the time to show some solidarity and chip in support for this vital resource!

Taylor Swift and Travis Kelce are engaged. “Your English teacher and your gym teacher are getting married,” the couple captioned a joint post on Instagram announcing the news on Tuesday. nyti.ms/4lHtQWR

🚨| CNN is reporting the engagement of Taylor Swift & Travis Kelce. BREAKING NEWS: Taylor Swift and Travis Kelce announce engagement

So, I've been in a meeting for the last two hours ... did anything interesting happ-OH MY GOD IT'S HAPPENING. IT'S REALLY HAPPENING!!!! www.instagram.com/p/DN02niAXMM...

I cannot agree more with this! I live for the nodders. The nodders make things better for everyone.

<DEEP sigh> share.inquirer.com/4FvNNE

Reminds me of my response to my PCP every year during my physical when he says, "Can you do things to reduce your stress ... ?" and then he has to give me a referral for pulling every eye rolling muscle in my body.

Fly folk: The Amazing and essential @flybase.bsky.social is in existential need due to Trump termination of the grant that supports this vital resource. Please donate to help keep Flybase alive. I just did. Info here on how to make a tax deductible donation: wiki.flybase.org/wiki/FlyBase...

Please please please, if you are able, consider supporting Flybase fiscally. They need our help! I donated this evening. They are in danger of closing and any amount will help. We cannot allow this critical pillar of science to collapse!

This seems like a lovely update!

Old and common #NIHGrant seeker advice, I know. But now more than ever. Diversify your study sections. Even if one is the seeming perfect fit. Spread your precious six apps per year around.

Well. This is just fucking terrible.

Call me crazy, but if a business says that there is no earthly way to determine how much money was made in a single fiscal year, that no one will ever have an accurate budget, and that useful projections can just never be provided ... it's not a good business at all.

ATTN: Robert Wood Johnson has money to support “canceled” research on racial-indigenous health equity www.rwjf.org/en/grants/ac...

🧠PHILLY: Join @brockkirwan.com, Joseph Kable, Mikaela Belle Martin and special guest Councilmember Nina Ahmad for a Teach-In TOMORROW! Info below, spots are still available! Register here: actionnetwork.org/events/be-a-... #StandUpForScience #Philly #TeachIn #Neuroscience

It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit. You all have my sympathies. Unfair doesn’t even begin to describe it.

What a sad loss. A titan of neurobiology discovery.

To the student who wrote in their evaluation, "Dr. Mosca should teach every lecture in this course!" ... thank you, you are too kind and I love you to pieces, but I'm gonna need you to shut your filthy mouth. DO NOT GIVE THE ADMINS ANY IDEAS.

Not a single person on the SRT at 4 PM on a sunny Sunday afternoon might not have been the first clue that it was a bad idea to run today ... but it was the loudest. #cityrunner

Flybase is free to use but not free to make. It takes large teams of people and millions of dollars a year to create the knowledgebas and tools for fly research. Please donate generously.

A great interview!!!!

Caterpillar waking up halfway through metamorphosis: I'm goo. Shit. Shit. Calm down. Go back to sleep. I'm really straight-up goo right now. Fuck

A palate cleansing question, Philly. Where can I get a good lobster roll in or around the city? I know I can go down the shore, but I want closer. Whaddya say?

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

I would not restrict to 'fly research', which may sound little important to the uninformed reader. FlyBase is the most elaborate, detailed and precise model organism data base we have and of use to many far beyond the Drosophila community - whilst being a role model setting helpful standards.

Amazing work from The Hart Lab!!

An absolutely awful turn of events. I am heartbroken over the firing of the Flybase staff. Thanks to @claudia-lopez.bsky.social for covering this important story.

I do enjoy running north from time to time. Even if I'm definitely going to spend the way back in a storm. Worth it. #cityrunner

Of 2025, my most favorite phrase I've learned is "reheating one's nachos" because it has become a great way to refer to a paper that does exactly the same thing as a previous paper but without citing it.

This is really a spectacular thing. Developmental neurobiology is absolutely essential to the future of neuroscience.

A Slight Disturbance at the Disco

Yeah ... my girlfriend and I reference the Honmoon at LEAST once a week these days.

Hmm. Looks like my rage about people being mistreated and vowing to fight against that is what's going to bring me back to Bluesky after months of depression. Didn't have that on my Bingo card! So hello again everyone. I missed you all. :)

Just when I think some folks hit the lowest one could possibly go ... they surprise me by finding greater depths. On the bright side, the horror motivates me to be even better and more supportive. It's my own little way of trying to even out the world.