How is #insulin production affected in residual beta cells in type 1 #diabetes? Préfontaine et al show unexpectedly that stressed senescent beta cells continue to produce mature insulin in the context of type 1 diabetes #DiabetesResearch #T1D #Islets link.springer.com/article/10.1... 🔓

Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social

Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine. If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again. #sciencematters

Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy link.springer.com/article/10.1... 🔓

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

A future star in 🇨🇦 diabetes research

Diabetologia supports this year’s #WorldDiabetesDay focus on diabetes and well-being. Well-being is key to people’s lived experiences of diabetes around the world, and we were honoured to explore this through the voices of PLWD in our recent special issue link.springer.com/article/10.1...

🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100… Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social @cirtn.bsky.social

During the workday, people living with #diabetes may need time for blood sugar checks, insulin and breaks. Remember: 💬Ask how you can support. 👂Listen to what they need, or do not need, from you. 🙅‍♀️Blaming and shaming is never helpful. Learn more🔗bit.ly/4844grn#diabetes#WorldDiabetesDay

Happening TODAY! Join us in 500 JBRC for the 7th Annual DREAM Trainee Lectureship, where Dr. Hertzel Gerstein (@mcmasteruniversity.bsky.social) will present on "Type 2 Diabetes Remission: The Quest" from 12 - 1 p.m. Don't miss this! @chrimanitoba.bsky.social @um-radyfhs.bsky.social

Can we prevent Type 1 Diabetes in Canada? Join the CanScreen T1D Symposium at @diabetescanada.bsky.social's preconference! 📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto ✅ Screening, prevention, family insights, and how to get involved 🔗 Register: bit.ly/4nyxy79 #Diabetes #Type1Diabetes #Symposium

What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.

Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️ Learn more: www.myroadplatform.ca/en Contact: [email protected]

this is why we put a runner on second

but the dodgers are better 😛

The Dome is going to collapse. After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th. It’s 11-2 #BlueJays

the TTC gets it

Metabolomics study indicates that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a #diabetes diagnosis #DiabetesResearch

“People with advanced lung or skin cancer who received a COVID-19 mRNA vaccine within 100 days of beginning immunotherapy lived considerably longer than those who did not… .” www.sciencedaily.com/releases/202...

New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org. rdcu.be/eKKz1 🇨🇦

Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science www.science.org/doi/10.1126/...

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔 In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n www.science.org/doi/10.1126/...

front 3 rows half empty for an elimination game, guess they know who's going to win 📝

A genetic map of human metabolism across the allele frequency spectrum www.nature.com/articles/s41...

In this week's mitophagy news 🪫🗑️ biomed.news/bims-tofagi/... ⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡ -Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway Thanks to @biomednews.bsky.social

🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!

On Truth and Reconciliation Day, we wear orange to honour survivors of residential schools and remember those who we lost. Reconciliation is ongoing work, and we remain committed to listening, learning, and walking together with respect. #EveryChildMatters #OrangeShirtDay #TruthAndReconciliation

Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions. www.nature.com/articles/s41...

HHMI adopts Plan U journals.plos.org/plosbiology/...

I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.

Three word wine review: a bit soapy

Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes. Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity www.biorxiv.org/content/10.1...

Check on your Yankee fan friends

Friendly reminder that no one likes the Yankees.

goodnight, tommy pham #bluejays

It was great fun to write this review with friends and colleagues Melkam Kebede, Belinda Yau, @jinghughes.bsky.social and Julien Ghislain

A road map for using stem cell-derived islet cells to treat (cure?) T1D diabetesjournals.org/diabetes/art...

"Why biological replication is more important than sequencing depth" www.nature.com/articles/s41...

If you are an adult with #t1d in Canada please check out CommuniT1D.ca It is an online peer support program for people with T1D and I'm also really excited as a health researcher who lives with type 1 diabetes to be involved in its creation and evaluation. Also please share with all your DiaBuddies!

It's been a while - what's new with Coldplay?

Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com www.nature.com/articles/s41...

New content online: The role of GLP1 receptor agonists in adult-onset type 1 diabetes mellitus