Robert Screaton
@roblab.bsky.social
📤 213
📥 57
📝 69
scientist. regeneration. mitochondria. diabetes. cancer. views my own.
reposted by
Robert Screaton
Richard Sever
2 days ago
HHMI adopts Plan U
journals.plos.org/plosbiology/...
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reposted by
Robert Screaton
Elizabeth Rideout
6 days ago
I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out!
www.cell.com/cell-reports...
Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.
add a skeleton here at some point
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Three word wine review: a bit soapy
8 days ago
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reposted by
Robert Screaton
CIRTN-R2FIC
14 days ago
Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes. Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.
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reposted by
Robert Screaton
Daniel Durocher
30 days ago
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at
@sinaihealth.bsky.social
. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
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reposted by
Robert Screaton
Christian Frezza
29 days ago
Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity
www.biorxiv.org/content/10.1...
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Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity
The brain is a metabolically demanding organ as it orchestrates and stabilizes neuronal network activity through plasticity. This mechanism imposes enormous and prolonged energetic demands at synapses...
https://www.biorxiv.org/content/10.1101/2025.08.27.672715v1
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Check on your Yankee fan friends
about 1 month ago
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Friendly reminder that no one likes the Yankees.
about 1 month ago
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goodnight, tommy pham
#bluejays
about 1 month ago
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reposted by
Robert Screaton
Vincent Poitout 🇨🇦
about 1 month ago
It was great fun to write this review with friends and colleagues Melkam Kebede, Belinda Yau,
@jinghughes.bsky.social
and Julien Ghislain
add a skeleton here at some point
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A road map for using stem cell-derived islet cells to treat (cure?) T1D
diabetesjournals.org/diabetes/art...
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Future Directions and Clinical Trial Considerations for Novel Islet β-Cell Replacement Therapies for Type 1 Diabetes
Type 1 diabetes results from the immune-mediated loss of insulin-producing pancreatic islet β-cells, rendering those affected dependent on exogenous insuli
https://diabetesjournals.org/diabetes/article/doi/10.2337/dbi24-0037/162981/Future-Directions-and-Clinical-Trial
about 1 month ago
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"Why biological replication is more important than sequencing depth"
www.nature.com/articles/s41...
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How thoughtful experimental design can empower biologists in the omics era - Nature Communications
Here, the authors discuss principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches, highlighting common expe...
https://www.nature.com/articles/s41467-025-62616-x
about 1 month ago
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reposted by
Robert Screaton
Dylan MacKay
about 2 months ago
If you are an adult with
#t1d
in Canada please check out
CommuniT1D.ca
It is an online peer support program for people with T1D and I'm also really excited as a health researcher who lives with type 1 diabetes to be involved in its creation and evaluation. Also please share with all your DiaBuddies!
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It's been a while - what's new with Coldplay?
2 months ago
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www.instagram.com/reel/DL8VGB_...
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Login • Instagram
Welcome back to Instagram. Sign in to check out what your friends, family & interests have been capturing & sharing around the world.
https://www.instagram.com/reel/DL8VGB_yVsp/?igsh=dXAwM2VlZWlqeTZ4
2 months ago
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reposted by
Robert Screaton
Alexey Amunts
2 months ago
Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature
@nature.com
www.nature.com/articles/s41...
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reposted by
Robert Screaton
Nature Reviews Endocrinology
2 months ago
New content online: The role of GLP1 receptor agonists in adult-onset type 1 diabetes mellitus
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The role of GLP1 receptor agonists in adult-onset type 1 diabetes mellitus
Nature Reviews Endocrinology, Published online: 16 July 2025; doi:10.1038/s41574-025-01154-4Adult-onset type 1 diabetes mellitus differs from the early onset form in terms of residual endogenous insulin secretion, comorbidities and baseline cardiorenal risk. Adjunct therapy with glucagon-like peptide 1 receptor agonists could offer benefits in this population of patients by preserving β-cell mass and function while also contributing to cardiorenal risk mitigation.
https://www.nature.com/articles/s41574-025-01154-4?utm_source=bluesky&utm_medium=social&utm_campaign=nrendo
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reposted by
Robert Screaton
Nature
2 months ago
Long-awaited results suggest that mitochondrial donation can prevent babies from inheriting diseases caused by mutant mitochondria
go.nature.com/4nUQHAq
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‘Landmark’ study: three-person IVF leads to eight healthy children
Long-awaited results suggest that mitochondrial donation can prevent babies from inheriting diseases caused by mutant mitochondria.
https://go.nature.com/4nUQHAq
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Home Run Derby X WWE crossover happening rn on a tv near you
2 months ago
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Evidence accumulating that Heineman is on the
#athletics
payroll
#bluejays
3 months ago
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Awesome to see Sunnybrook veterans at the
#bluejays
game today!
3 months ago
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reposted by
Robert Screaton
Minor Leaguer x
3 months ago
The 2025 Blue Jays have been so much better for my mental health than the 2024 Blue Jays.
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reposted by
Robert Screaton
bioRxivpreprint
3 months ago
Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes
https://www.biorxiv.org/content/10.1101/2025.06.25.661601v1
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José, José José José Perfect timing ⚾️
#bluejays
3 months ago
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🍿
www.nature.com/articles/d41...
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Transparent peer review to be extended to all of Nature’s research papers
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.
https://www.nature.com/articles/d41586-025-01880-9
3 months ago
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reposted by
Robert Screaton
Peter Thompson
4 months ago
Very excited to share new work on the origins of beta cell senescence in
#T1D
led by talented PhD student Jasmine Pipella! 🥂🎉 online today!
diabetesjournals.org/diabetes/art...
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Autoreactive T Cells and Cytokine Stress Drive β-Cell Senescence Entry and Accumulation in Type 1 Diabetes
Type 1 diabetes (T1D) results from a complex dialogue between the immune system and islets characterized by T cell–mediated autoimmune destruction of pancr
https://diabetesjournals.org/diabetes/article/doi/10.2337/db24-1122/160590/Autoreactive-T-Cells-and-Cytokine-Stress-Drive
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reposted by
Robert Screaton
Vincent Poitout 🇨🇦
4 months ago
On the consequences of NIH funding cuts for Canada 🧪:
www.nature.com/articles/d41...
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‘A funeral for our careers’: Trump’s science cuts spill onto Canadian turf
Researchers in Canada prepare for turbulence in the wake of US funding changes — but there’s a silver lining.
https://www.nature.com/articles/d41586-025-01439-8?WT.ec_id=NATURE-202505
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reposted by
Robert Screaton
Gareth Lim
4 months ago
There is still a spot for a PhD student or Postdoc in the Lim Lab! If you are interested in metabolism, 14-3-3 proteins, adipocytes, or beta-cells, please email me (details at
www.limlab.ca
). International applicants are welcome! Positions are fully funded. Looking forward to working with you!
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Lim Lab
Exploring how 14-3-3 proteins contribute to metabolism and metabolic diseases
https://www.limlab.ca
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reposted by
Robert Screaton
Francis Lynn 🇨🇦
4 months ago
Promoted! This one's for you Dad, miss you. A huge thanks to all my wonderful and supportive colleagues, some anonymous, that helped with this!
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Oh hi Instagram: I promise you I do not want to follow your broadcast channels now or ever.
4 months ago
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reposted by
Robert Screaton
Journal of Cell Science
4 months ago
In our Special Issue: Cell Biology of Mitochondria we interview Guest Editor Heidi McBride
@mitodynamics.bsky.social
Heidi discusses her career path, the past, present & future of
#mitochondria
research & her role as guest editor at JCS.
journals.biologists.com/jcs/article/...
#JCSMitoSI
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reposted by
Robert Screaton
Ebrahim Lab
4 months ago
Early for
#MicroscopyMonday
:
#Hemifusomes
- Newly discovered ESCRT-independent intermediates of intraluminal vesicle and multivesicular body formation! In collaboration with the Kachar Lab at the NIH and out today in
@natcomms.nature.com
:
rdcu.be/emtQu
#cryoET
#trafficking
#organelle
#hemifusion
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Perfect game for the
#bluejays
to rediscover bunting
4 months ago
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In
@elife.bsky.social
: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
doi.org/10.7554/eLif...
from
@carolschuurmans.bsky.social
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Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
https://doi.org/10.7554/eLife.100604
4 months ago
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reposted by
Robert Screaton
Dylan MacKay
5 months ago
Just 13 days left until I walk the runway for Diabetes Canada Pump Couture Fashion show, please buy a ticket ( I will guarantee a good show) or if you can't attend you can support one of the models here
crm2.diabetes.ca/site/SPageSe...
add a skeleton here at some point
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reposted by
Robert Screaton
Lara Green
5 months ago
Yesterday, Health Canada approved the first disease-modifying therapy for type 1 diabetes
#T1D
. This is a ‘preventative’ (actually ‘delaying’) therapy that addresses autoimmunity *before* someone is diagnosed and requiring insulin.
breakthrought1d.ca/news/health-...
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Health Canada approves Tzield – the first ever disease modifying therapy for type 1 diabetes | Breakthrough T1D
On May 5, 2025, Sanofi announced Health Canada approval of Tzield, the first disease-modifying therapy for type 1 diabetes (T1D). This is a huge win for the T1D community in that it is the first medic...
https://breakthrought1d.ca/news/health-canada-approves-tzield-the-first-ever-disease-modifying-therapy-for-type-1-diabetes/
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reposted by
Robert Screaton
Elizabeth Rideout
5 months ago
Really looking forward to this today! Grateful to Erin Mulvihill and
@roblab.bsky.social
for the opportunity to share a little about how biological sex affects islets!
add a skeleton here at some point
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Excited for experts
@ejrideout.bsky.social
and Jeeyeon Cha to join us later today in the 🇨🇦
#Islet
and
#Diabetes
grad course
@uoft.bsky.social
to discuss sex differences in
#diabetes
and the implications for health care
5 months ago
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reposted by
Robert Screaton
Francis Lynn 🇨🇦
5 months ago
Thrilled to share our latest work, which was the outstanding doctoral work of
@samanthajsyoon.bsky.social
academic.oup.com/endo/advance...
1/12
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NPAS4 depletion in POMC neurons protects from obesity and alters the feeding-regulated transcriptome in male mice
Abstract. Immediate Early Genes (IEGs), such as Neuronal PAS domain protein 4 (Npas4), are induced as part of the response to environmental stimuli. In the
https://academic.oup.com/endo/advance-article/doi/10.1210/endocr/bqaf083/8121611?utm_source=authortollfreelink&utm_campaign=endo&utm_medium=email&guestAccessKey=5f7be493-2871-45d6-bc3d-5195230c2d09&login=false
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WHYYYYYYYY
#bluejays
5 months ago
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go sens go
5 months ago
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reposted by
Robert Screaton
Rebecca Hull-Meichle
5 months ago
Thanks
@roblab.bsky.social
! Always a pleasure to participate in this course ☺️
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Fantastic talks just now from experts
@teresamastracci.bsky.social
and
@rlhull-meichle.bsky.social
on crosstalk between the
#islet
and the surrounding
#acinar
and vascular tissue... are there novel pancreatic targets outside the islet to treat
#T1D
and
#T2D
? 🇨🇦 Nat'l Grad Course
@uoft.bsky.social
5 months ago
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reposted by
Robert Screaton
Islet Biology Lab - UMH
5 months ago
Preza et al. show that a circadian transcription factor specific to maturing stem cell-derived-β cells, DEC1, regulates insulin responsiveness to glucose. 🧪
#PancSky
#StemCells
www.biorxiv.org/content/10.1...
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DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm
Stem cell-derived islet (SC-islet) organoids offer hope for cell replacement therapy in diabetes, but their immature function remains a challenge. Mature islet function requires the β-cell circadian c...
https://www.biorxiv.org/content/10.1101/2025.04.03.647023v1.full
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reposted by
Robert Screaton
Krista Lamb
5 months ago
Pretty awesome line-up!! Lucky trainees.
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Leading islet and stem cell-derived islet transplant scientists Andrew Pepper
@ualberta.bsky.social
and Tim Kieffer
@ubcmedicine.bsky.social
join us today in the 🇨🇦
#islet
and
#diabetes
grad course
@uoft.bsky.social
for the latest in islet replacement therapies, encapsulation, trials, and more!
5 months ago
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ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1: Cell
www.cell.com/cell/fulltex...
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ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1
A membrane-associated pool of NADH confers protection against ferroptosis.
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900292-2
5 months ago
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reposted by
Robert Screaton
Dylan MacKay
6 months ago
Dear Canadian researchers, faculty, RAs, PDFs and grad students, this letter is for the federal party leaders asking them to defend and expand Canadian research sovereignty with a historic investment in science, please sign and share
docs.google.com/document/d/1...
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National Letter
Open Letter from Canadian Researchers to the Federal party leaders Click here to sign this letter See who has signed - version française se trouve à page 3 - Dear Party Leaders We, the undersigne...
https://docs.google.com/document/d/1Gz8gql8YivQjiUG57W0FEaEyE6LtbdzPxufAbP9izww/edit?usp=sharing
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Looking forward to discussing all things beta cell states with expert
@thompsonisletlab.bsky.social
today! Regeneration, quiescence, senescence, screening and more! 🇨🇦
#islet
and
#diabetes
course
@uoft.bsky.social
6 months ago
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wut "We provide evidence that GDM often represents detection of chronic and progressive β-cell dysfunction that is temporally, but not mechanistically related to pregnancy"
diabetesjournals.org/diabetes/art...
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What is Gestational Diabetes – Really?
Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. It is generally defined as glucose intolerance with onset
https://diabetesjournals.org/diabetes/article/doi/10.2337/dbi24-0041/158091/What-is-Gestational-Diabetes-Really
6 months ago
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