Today in the 🇨🇦 National grad course in #islet biology and #diabetes, experts Matt Merrins and Dick Kibbey from @yalepress.bsky.social stop by to discuss the latest in mechanisms of glucose coupling in the beta cell - it's all about the ATP! @utoronto.ca

Two cells isolated from a fish scale videoed through a DIC microscope. The cells are cool but now all I see are extracellular vesicles floating by in the media and stuck to the substrate....... #CellBiology

Beta cell stress in #T1D and #T2D with experts @bruceverchere.bsky.social @thompsonisletlab.bsky.social and @mathieuferron.bsky.social coming in today for the 🇨🇦 #Islet biology and #diabetes grad course @utoronto.ca - defining metrics for beta cell recovery

Thanks Rob! Super fun class as always! Good to see some familiar faces too

Today in the 🇨🇦 #Islet biology and #diabetes grad course we welcome experts @nkrentz.bsky.social and @drprentice.bsky.social who will discuss the pros and cons of common islet models as well as tissue crosstalk in #T1D and #T2D.

Join us in Toronto, July 13–16 for the inaugural International Conference on Neurogenesis & Repair! Featuring keynote Jeffrey Macklis (Harvard) + global speakers. 13 competitive short talks, poster sessions, and separate trainee awards. Early‑bird deadline: March 31.

Queued up in the 🇨🇦 National Graduate Course in #Islet Biology and #Diabetes today: experts @chrisadoucette.bsky.social and @theodoreds.bsky.social who will be discussing our current knowledge (and gaps!) on how #insulin actually gets out of a beta cell! Glucose coupling, circadian effects, and more!

🧬What if #betacells aren’t all the same? Professor Andrew Pospisilik shares new epigenetic evidence that could reshape our understanding of #diabetes and #heterogeneity - from beta cell subtypes to #obesity endotypes. 📺Watch now:🔗 easd-elearning.eu/episode/359/...

This week FRIDAY JAN23 at NOON CST we are thrilled to welcome @glim2016.bsky.social from @umontreal.ca @crchum.bsky.social to the pharmacology seminar series speak "Can we identify 14-3-3 zeta inhibitors to treat type 1 #diabetes" @dream-diabetes.bsky.social Join us Via ZOOM: 660 7073 7150 PW:594459

Today in the 🇨🇦 National Grad course in #Islet Biology and #Diabetes we welcome superstars Cristina Nostro and @yassiag.bsky.social to discuss the latest on using #stemcell derived islet cells as a strategy to treat (cure?) #T1D!

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Will be discussing science communication today in the 🇨🇦 National #Islet and Diabetes graduate course - using the #betacell secretion coupling debate as a case study! @utoronto.ca

The 6th Annual 🇨🇦 National Graduate Course in #Islet Biology and #Diabetes hosted at @utoronto.ca kicks off today with 21 students and 30 outstanding lecturers from around the world. Today Drs. Wicklow and Gerstein will talk about #T2D and GDM in indigenous populations and the latest on #remission.

Study shows that neonatal #betacells sense gut microbiota-derived #bileacids via #FXR, limiting their development. Declining postnatal beta cell FXR expression allows normal neonatal beta cell growth and reduces #diabetes risk link.springer.com/article/10.1...

(please share) Immediate #postdoc job opening in the Millman lab at WashU Med (St. Louis, MO). Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply sites.wustl.edu/millmanlab/

Lietzke et al. demonstrate that pluripotent stem cell-derived β cells exhibit reduced oxidative and mitochondrial fatty acid metabolism compared to primary human islets, which is related to limitations in key mitochondrial transcriptional networks. 🧪 #PancSky www.nature.com/articles/s41...

Download our large database of postdoc fellowships in all fields of research. Database freely available to all; 281 fellowships. Download here: research.jhu.edu/rdt/funding-...

Spatial and morphological organization of mitochondria in neurons across a connectome | Science www.science.org/doi/10.1126/...

Our Novo Nordisk Research Chair in Equitable Care of Diabetes and Related Conditions, Dr. Baiju Shah, was interviewed about the importance of including diverse populations in research. Check out this video podcast from the T2D Network and @kristalamb.bsky.social! www.youtube.com/watch?v=SGIG...

How is #insulin production affected in residual beta cells in type 1 #diabetes? Préfontaine et al show unexpectedly that stressed senescent beta cells continue to produce mature insulin in the context of type 1 diabetes #DiabetesResearch #T1D #Islets link.springer.com/article/10.1... 🔓

Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social

Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine. If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again. #sciencematters

Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy link.springer.com/article/10.1... 🔓

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

A future star in 🇨🇦 diabetes research

Diabetologia supports this year’s #WorldDiabetesDay focus on diabetes and well-being. Well-being is key to people’s lived experiences of diabetes around the world, and we were honoured to explore this through the voices of PLWD in our recent special issue link.springer.com/article/10.1...

🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100… Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social @cirtn.bsky.social

During the workday, people living with #diabetes may need time for blood sugar checks, insulin and breaks. Remember: 💬Ask how you can support. 👂Listen to what they need, or do not need, from you. 🙅‍♀️Blaming and shaming is never helpful. Learn more🔗bit.ly/4844grn#diabetes#WorldDiabetesDay

Happening TODAY! Join us in 500 JBRC for the 7th Annual DREAM Trainee Lectureship, where Dr. Hertzel Gerstein (@mcmasteruniversity.bsky.social) will present on "Type 2 Diabetes Remission: The Quest" from 12 - 1 p.m. Don't miss this! @chrimanitoba.bsky.social @um-radyfhs.bsky.social

Can we prevent Type 1 Diabetes in Canada? Join the CanScreen T1D Symposium at @diabetescanada.bsky.social's preconference! 📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto ✅ Screening, prevention, family insights, and how to get involved 🔗 Register: bit.ly/4nyxy79 #Diabetes #Type1Diabetes #Symposium

What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.

Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️ Learn more: www.myroadplatform.ca/en Contact: [email protected]

this is why we put a runner on second

but the dodgers are better 😛

The Dome is going to collapse. After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th. It’s 11-2 #BlueJays

the TTC gets it

Metabolomics study indicates that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a #diabetes diagnosis #DiabetesResearch

“People with advanced lung or skin cancer who received a COVID-19 mRNA vaccine within 100 days of beginning immunotherapy lived considerably longer than those who did not… .” www.sciencedaily.com/releases/202...

New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org. rdcu.be/eKKz1 🇨🇦

Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science www.science.org/doi/10.1126/...

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔 In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n www.science.org/doi/10.1126/...

front 3 rows half empty for an elimination game, guess they know who's going to win 📝

A genetic map of human metabolism across the allele frequency spectrum www.nature.com/articles/s41...

In this week's mitophagy news 🪫🗑️ biomed.news/bims-tofagi/... ⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡ -Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway Thanks to @biomednews.bsky.social

🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!

On Truth and Reconciliation Day, we wear orange to honour survivors of residential schools and remember those who we lost. Reconciliation is ongoing work, and we remain committed to listening, learning, and walking together with respect. #EveryChildMatters #OrangeShirtDay #TruthAndReconciliation

Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...