☔ April showers bring May flowers and this past month, Vancouver researchers were absolutely showered with success! We've highlighted Dr. Nicole Krentz @nkrentz.bsky.social, who was awarded a Breakthrough T1D Career Development Award. Check out the full April Award Summary: https://bit.ly/4uJ7DMX

It’s an honor to be a candidate for @endosocjournals.bsky.social President-Elect, and to have the opportunity to advocate for patients, physicians, and scientists in #Endocrinology around the world. Voting is open until March 4: bit.ly/4qdrySB

Happy New Year ! 🎆 We hope everyone had a wonderful winter holiday. We have uploaded our fourth Islets in a Pod episode. Here we interview Dr. Andrew Pepper from the University of Alberta. youtu.be/Z2i0-C0KkaU

Our latest now published in @natcomms.nature.com, where we found a new role for mitochondrial programming of SC-β cell fate through PPARα. We're excited for the potential to target mitochondria to improve SC-islets to treat #T1D! www.nature.com/articles/s41...

Hey Mom, wanna do something spontaneous?

🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.

CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta. youtu.be/UlHn_1Fz3ck?...

Apply for the 'Dr. Connie Eaves Chair in Cancer Cell Research' at UBC. Come join the dynamic research community in Vancouver 🇨🇦!

Very proud to see the main thesis work of the intrepid Dr. Mohammad Pourhosseinzadeh come out in @pnas.org today! In this paper, Mohammad assesses how crosstalk between insulin-secreting beta and somatostatin-secreting delta cells in the islet actually happens, in near real-time. A quick thread 1/10

Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes. Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.

Our department at The University of British Columbia in Vancouver (Canada) is running two faculty searches. One is a joint hire with the Institute for Healthy Aging, one a cohire with the Math Dept cps.med.ubc.ca/careers-2/ Click on “Faculty Positions” on the page. Please help spread the word!

Official posting coming soon, but here's a heads-up: #Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome! www.bcell.org

Bringing this thread back since this paper is currently featured as the Endocrinology Article of the Week! 🎉This paper was the result of years of hard work during my PhD and it wouldn't have been possible without the excellent mentorship from Francis and the collaborative efforts of all co-authors.

We are launching a new initiative to support experimental design, data management/analysis and bioinformatics. Early days yet, but check it out here. www.bcell.org/adi-datasci....

Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...

It was a pleasure to be able to contribute to this paper on a novel cause of transient neonatal diabetes. Check it out👇🏻

Homozygous loss-of-function variants in PAX4 are a novel genetic cause of transient neonatal #diabetes www.sciencedirect.com/science/arti...

I will be opening my new lab in September at UBC! if you’re coming to #Worm25 and are looking for graduate studies or a postdoc position, let’s meet! Vancouver + worms = perfect vibes. www.zoology.ubc.ca/~yeecs/labsi... Please share! 🙌

Pharmacological targeting of SOS1-RAS interaction triggers pancreatic β-cell proliferation and sustainably reverses diabetic hyperglycemia https://www.biorxiv.org/content/10.1101/2025.06.03.657628v1

I'm very excited to share that I'll be starting as an Assistant Professor at the University of Alberta this fall 🎉 !! I'm very grateful to mentors, colleagues, friends, and family who have supported me along the way ❤️. www.ualberta.ca/en/physiolog...

Wang et al. show that, unlike other stem cell-derived endocrine cells, there is a progressive loss of cell identity and metabolic function in stem cell-derived β cells when exposed to hypoxia. 🧪 #PancSky www.nature.com/articles/s41...

Congratulations, @annagloyn.bsky.social! A very well-deserved recognition of a brilliant scientist and mentor 🎉

Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal! Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵 🔗 doi.org/10.1242/dev....

New study from @mayoclinic.org uses #stemcells to model diabetic alpha cell dysfunction. SC-α cells mimic glucagon hypersecretion and sunitinib (tyrosine kinase inhibitor) protects against ER stress-induced dysfunction ow.ly/CWmV50VPsVt @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social

Excited to announce our newest #Immunology recruitment 🎉🥳 This is for a Canada Research Chair (Tier 1)🇨🇦, a position that isnt offered often when 7yr term incl full salary (+renewable)! Please share widely when broad immunology focus. Happy to answer any dept Q & note date 👇 @umanitoba.bsky.social

Thrilled to share our latest work, which was the outstanding doctoral work of @samanthajsyoon.bsky.social academic.oup.com/endo/advance... 1/12

A group of scholars and I had a chance to share our experiences with the MOSAIC program being terminated 🧪 www.npr.org/sections/sho...

GLP-1-based therapies for diabetes, obesity and beyond tinyurl.com/ph3fn4eh rdcu.be/ejIM2 This new review by @danieljdrucker.bsky.social profiles GLP-1-based medicines, discussing optimization of pharmacokinetics and tolerability, engagement of new therapeutically useful pathways and safety aspects

“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is” https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y

I very much enjoyed my first trip to Spain. I started with great science at the EMBO Pancreas and Liver Workshop and finished with two weeks travelling around the country.

A reminder about this starter pack on the Canadian diabetes research community. I continue to add and update - please let me know if there are people or lab accounts that are missing!

Here's a Starter Pack I made to highlight Biomedical Researchers working in Canada 🧪🇨🇦 Please let me know if you'd like other be added! go.bsky.app/6aMSMpy

Canadian Diabetes Job! www.nature.com/naturecareer...

1 day left to apply!

There are fewer than 10 documented genetic causes of Transient Neonatal Diabetes (TNDM) and now PAX4 is one of them! Really proud of this collaborative work done between the Neonatal Diabetes Research Team at Exeter and the Translational Genomics of Diabetes Lab in Stanford.

More genetic evidence of the importance of PAX4 in diabetes.

Come join us at beautiful UBC! The King Lab is recruiting a Post-doc Fellow to develop mathematical theory on infectious disease evolution and emergence, together with Ben Ashby (SFU) #zoonoses #biodiversity www.zoology.ubc.ca/kinglab/join...

Come by my colleague!! Assistant professor position in molecular neurobiology at @mcgill.ca and the Lady Davis Institute! mcgill.wd3.myworkdayjobs.com/McGill_Caree... Montreal is an amazing city and the Lady Davis is a great institute to work at!

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...

It was a pleasure to co-author this article alongside amazing folks at Carleton. Please check out our EDI resources! Tools for transformation: a teaching toolkit and research pocket guide for advancing equity, diversity, and inclusion in science and engineering www.facetsjournal.com/doi/10.1139/...

Become Our New Faculty Colleague! We are looking for a junior Principal Investigator to expand their stem cell research towards translational outcomes. reNEW Copenhagen @ucph.bsky.social #stemcell #diversity #faculty #regenerativemedicine shorturl.at/m9Zko

An overview of the progress and contributions made by the Type 1 #Diabetes #Genetics Consortium #T1D academic.oup.com/jcem/advance...

Proud to share a new preprint from my lab that is the product of hard work from several talented lab members and collaboration with valued colleagues: www.biorxiv.org/content/10.1...

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction. https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1

It was a pleasure for our team to be able to contribute to this manuscript on Vimentin+ alpha cells in CF 👇🏻 joe.bioscientifica.com/view/journal...

Shout out to @bcellorg.bsky.social and the team at the Alberta Diabetes Institute's IsletCore for the fantastic website with so many resources. IsletCore is an amazing asset to diabetes research programs globally. #Islets #DiabetesResearch www.bcell.org/adi-isletcor...

Are you applying for the J. Andrew McKee Fellowship in Type 1 Diabetes?    Supported by SCN and Breakthrough T1D (formerly JDRF), this is your chance to join UBC’s Breakthrough T1D Centre of Excellence. Submit your application by February 27, 2025. ➡️ stemcellnetwork.ca/training/exc...

We are recruiting for the Head of the Division of Endocrinology at BC Children’s Hospital, @bcchresearch.bsky.social and @ubcmedicine.bsky.social. Please apply! https://jobs.phsa.ca/job/vancouver/head-division-of-endocrinology-bc-children-s-hospital-and-university-of-british-columbia/909/76783745776

A post over a decade in the making… 🙌beyond excited to share our work out today in @science.org. We found that retrograde (mitonuclear) signaling regulates the identity and maturity of metabolic tissues.🧵 1/6 www.science.org/doi/10.1126/...

Snow day