Our latest work on PAM is out #GenomeMedicine We show that PAM-T2D risk alleles result in "GLP-1 resistance". I am so proud of this collaborative work championed by two incredible early career academics - Mahesh Umpathysivam & Elisa Araldi (not on BlueSky) link.springer.com/article/10.1...

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Tracking the details of an experiment in successively cited Methods sections

Congratulations Professor Gloyn! @Stanford @TheEndoSociety endocrinenews.endocrine.org/anna-gloyn-w... @annagloyn.bsky.social 🧪

Anna Gloyn (@annagloyn.bsky.social), Jie Liu, Noel Burtt, and Marcela Brissova from the PanKbase team gave a webinar for the HIRN webinar series. If you missed it and want to know how PanKbase might help compliment your type I diabetes research, watch it here: youtu.be/3qLiBdIOJhY?...

It's a big day at the Academy as we welcome our 2025 Fellows 🎉 We’re celebrating 54 remarkable scientists joining our esteemed Fellowship of 1,450 leading researchers. 📣 Meet our new Fellows: ow.ly/VtGs50WmPqc 🌟 And our Honorary Fellows: ow.ly/4syL50WmPyi And stay tuned for highlights!

🎉 Our New Fellows Admissions Day is in full swing! We're welcoming an inspiring group of leaders advancing research and shaping the future of medicine! 💡

Really proud of this Exeter–Stanford collaboration identifying bi-allelic variants in PAX4 as a novel cause of transient neonatal diabetes—the first new genetic cause of this subtype described in over a decade. This work expands our understanding of beta cell development. 🔗 doi.org/10.1016/j.mo...

Our DEG explorer enables interactive visualizations of differential gene expression within human pancreatic islets. Data was generated from the integrated single-cell RNA sequencing from 140 human donors sourced from HPAP, IIDP, and Prodo. Check out the tutorial here: youtu.be/jL8SgEMF_sg?...

Please check out our new paper on bioRxiv evaluating genetic background influences on heterogenous responses to S64F MAFA!: www.biorxiv.org/content/10.1...

Thrilled and honored to be a part of this amazing session on rare genetics and GWAS in diabetes with @Romina39356029‪ @annagloyn.bsky.social and @miriam_udler ! #ADA2025

Dr. Anna Gloyn at #ADA2025: Multiomic data reveals diabetes heterogeneity, linking polygenic scores, islet traits, and regulatory networks. @amdiabetesassn.bsky.social @annagloyn.bsky.social #ADASciSessions #T2D #genomics #multiomics

PanKbase #ADA spotlight: PanKbase PI, Dr. Jie Liu, Associate Professor of Computational Medicine and Bioinformatics Michigan Medical School will be presenting during the session "Decoding Diabetes—AI-Driven Advances in Genetic Research". June 23rd 3:15 PM - 4:15 PM. Look forward to seeing you there!

Edit to the time, Julie will now be presenting at 5:30pm.

PanKbase #ADA poster alert!!! Dr. Ha Vu (@hahvu.bsky.social) will be presenting her work on our PanKbase platform: "PanKbase Integrated Single-Cell Map—A Comprehensive Atlas of Human Pancreatic Islets Unlocking Insights into Type 1 and Type 2 Diabetes" Sunday, June 22 at 12:30p CT (Poster 2121-LB).

Planning your #ADA2025 visit? Don’t miss the NIDDK #DataScience Corner hosted by #dkNET! 📍 Between ADA Member Lounge & Product Theater 1 🗓 Visit during the reception or exhibit hours 🎉 Celebrate 75 years of #NIDDK! 🔗 dknet.org/data-science... #ADASciSessions

Welcome to Chicago! If you're at the 85th Scientific Sessions of the #ADA, stop by the PanKbase booth 1047 in the exhibit hall to learn about the our updated single cell browser, ask questions, or give us feedback. youtu.be/sNEGvSIjh3M?...

Romina Bevacqua and PanKbase PI Anna Gloyn (@annagloyn.bsky.social) preview the presentations of #ADA session Genetic Regulation of Beta-Cell Mass and Function in Humans—Lessons from GWAS and Rare Genetics happening June 22, at 1:30 p.m. CT in Room W194 AB www.adameetingnews.org/genetic-regu...

Check out the platform at pankbase.org. Come see us at the 85th Scientific Sessions of the American Diabetes Association #ADA2025 #DataScience Booth 1047!!! We'd love to discuss more what we're doing and hear your feedback.

What is PanKbase? Watch our introduction video to find out: youtu.be/glGHni2tXGg?....

We're less than two weeks away from #ADA2025. PanKbase, booth 1047 will be located in the NIDDK #DataScience corner. Come see us to learn more about the platform and meet the PanKbase team.

PanKbase #ADA2025 spotlight: PI @annagloyn.bsky.social presents Sun. the 22nd at 2pm CDT. Session: Genetic Regulation of Beta-Cell Mass and Function in Humans: Lessons from GWAS and Rare Genetics. Her talk: "Integrating Multiomic Data to Understand Complex Gene Regulatory Networks in Islets"

Progress in Polygenic Risk Scores (PRS), which take multiple disease-modifying variants into account, are increasingly powerful tools to identify, predict and classify #diabetes mellitus @natrevendo.nature.com www.nature.com/articles/s41...

📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41... Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.

Wishing I were Ferris! 🤯 40 years ago!

New content online: Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation

Out today from #HectorOrtega & #SethASharp A state of the art review on polygenic risk scores (#PRS) in diabetes. This is your #101 on what we currently know about them and their application to understanding disease heterogeneity & clinical translation. Read for free here - rdcu.be/eprel

Honoured to have been elected to the fellowship and excited to contribute to the academy’s mission. This recognition reflects the amazing scientific community I am part of and the incredible trainees and collaborators I’m privileged to work with. Thankful 🙏

Our new paper updating GRS2 with a new tool to easily generate standardised T1DGRS 🧬 Thanks to Seth Sharp, @annagloyn.bsky.social, Richard Oram and @mnweedon.bsky.social for a great collaboration! tinyurl.com/4bsaz9hx

OMG - this might just be the BEST ever lab gift from an alumni!! Huge thanks to Evelyn Ibarra (visiting grad student from @bennyscience.bsky.social Lab) for 3D printing us a shimmering pink multi-tube rack ... practical and perfect with our lab color scheme 💜💗🧪

Such a pleasure to visit colleagues at the Penn Institute of Diabetes Obesity and Metabolism yesterday for their annual Hammond Lecture. My time there in the Matschinsky Lab in 2002 opened so many doors for me as a scientist. Wonderful to return and see familiar faces and collaborators

Every year we celebrate our departmental lab communities, bringing people together from different lab neighbourhoods for lunch and fun! Because we are stronger together!

These are a very rare and exceptional set. Limited edition, in high demand. Will go quickly off the shelves.... #teamscience #procrastinating #shouldbeworking

There are fewer than 10 documented genetic causes of Transient Neonatal Diabetes (TNDM) and now PAX4 is one of them! Really proud of this collaborative work done between the Neonatal Diabetes Research Team at Exeter and the Translational Genomics of Diabetes Lab in Stanford.

When two alumni from your lab are invited speakers at an EMBO Meeting on Liver & Pancreas Disease and meet for the first time in person. My heart is bursting with pride and joy for these two amazing women <3. @nkrentz.bsky.social & Aimee Bastidas-Ponce meetings.embo.org/event/25-liv...

Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans https://www.medrxiv.org/content/10.1101/2025.04.01.25324926v1

More genetic evidence of the importance of PAX4 in diabetes.

Lessons from Mother Nature: Complete loss of the transcription factor PAX4 causes transient neonatal diabetes. Different to the effects seen in mice & expands the allelic series for diabetes risk.... www.medrxiv.org/content/10.1...

Let's go! World's experts @annagloyn.bsky.social (Stanford) and Rob Sladek (McGill) are on deck for today's 🇨🇦 National Islet and Diabetes course @uoft.bsky.social to discuss of the impact of genetics on #T2D risk @cirtn.bsky.social

" I believe there are many who forget all the tragedy women face in Afghanistan, that is why I use my paintings as a mean to remind the people" - Shamsia Hassani Afghan Artist #InternationalWomensDay

On #internationalwomensday2025 I am grateful for all the amazing women scientists I am honoured to work with. We strive to make the lives better for all people living with diabetes.

Hundreds of people gathered at a Stand Up for Science rally outside San Francisco City Hall on Friday, protesting in the face of widespread cuts and layoffs from the Trump administration.

Amazing speech from Carolyn Bertozzi at the SF Stand Up for Science Rally today! @standupforscience.bsky.social @carolynbertozzi.bskyverified.social

Thanks to @nature.com for featuring Stand Up for Science! ☀️🧬🧪 www.nature.com/articles/d41...

🚨 Calling all Bay Area scientists 🚨 #StandUpForScience rallies are being organized in Palo Alto and San Francisco this Friday, March 7. Because federal funding for research saves lives and yields economic benefits! PA: Lytton Plaza, 12-2p SF: Civic Center Plaza, 1-3p

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction. https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1

Inter individual variability in the child and adolescent proteome is influenced by genetic variants, age, sex and body mass index @naturegenet.bsky.social #proteomics #genetics www.nature.com/articles/s41...

It was a pleasure for our team to be able to contribute to this manuscript on Vimentin+ alpha cells in CF 👇🏻 joe.bioscientifica.com/view/journal...

Super proud of Eliel Akinbami and the amazing work he is pioneering to understand how enzyme sequence encodes enzyme function!

This morning we stepped out of our normal routines to learn about our personality types and how they influence our leadership style. Check out with this amazing group of early career faculty! Thanks to Stevie Eberle from Stanford Bioscience Careers for an informative interactive session!