@lilamd.bsky.social at PPI: Norovirus is a major cause of infant morbidity & mortality — not just a cruise ship nuisance! Interferon is a key mediator, but gaps in our understanding of the human norovirus receptor make culture models a real hurdle. #Norovirus #InfectiousDisease #PedsResearch

🫁 Deepika Polineni, MD MPH at PPI: CF care has transformed — 90-95% of US patients now qualify for CFTR modulators! But there’s still much to learn, and new clinical trial endpoints are key to helping every patient with CF. Remarkable work! #CysticFibrosis #CFTRModulators #PedsResearch

MASLD in kids: more common than expected, linked to long-standing obesity, maternal metabolic health, gut microbiome shifts, bile acid changes & early risk factors like low birth weight + catch-up growth. 🎨 Dr. Mike Thompson, MD PhD #MASLD #PedsEndo #Obesity @hepatocrinologist.bsky.social

Infant seizes post-breastfeeding, BG 44 mg/dL. Critical sample: elevated insulin, positive glucagon test, elevated ammonia. Dx: HI/HA Syndrome, de novo GLUD1 variant. Responds to diazoxide + low protein diet! 🎨 Dr. Renad Al-Mefleh, MD #PedsEndo #Hypoglycemia #RareDiseases #GLUD1 #Hyperinsulinism

🔨 BZZZZZ! CLANK! Dr. Jennifer Wambach, MD gave a fantastic PPI talk on ABCA3 surfactant biology, 3D alveospheres, lipidomics, and lentiviral gene therapy — all while construction raged behind the wall. Unbothered. Inspiring. #LungDisease #GeneTherapy #PedsResearch

Sam Cortez, MD on Turner Syndrome at the #PCTI Seminar Series: single X chromosome, risks for ovarian failure and cardiovascular disease, and oral estrogen raises estrone while avoiding hepatic first-pass metabolism. What IS the best route? #TurnerSyndrome #PedsEndo #Endocrinology #PedsResearch

Honored to present our lab's research on Familial Partial Lipodystrophy at the 2026 WashU Pediatric Research Retreat! 🔬 iPSC-derived adipocytes + human adipose snRNA-Seq = new insights into a rare & complex disease. #Lipodystrophy #RareDisease #StoneLab #PedsResearch

Incredibly proud of post-bacc McKinlee Gobble presenting her poster on FGF21 signaling & insulin-mediated pseudoacromegaly at the 2026 WashU Pediatric Research Retreat! 🌟 Rare disease research, big impact. #FGF21 #RareDisease #PedsResearch #StoneLab

Stone Lab representing at the 2026 WashU Pediatric Research Retreat! 🧪💙 So proud of this team — the science, the energy, the people. This is what pediatric research looks like! #StoneLab #PedsResearch #Pediatrics #ResearchRetreat

Dr. Gary Silverman's final message as Chair of WashU Pediatrics at our Research Retreat hit differently. 💙 Take care of yourself. Take care of your family. Take care of your patients. A legacy of humanity and leadership. #Pediatrics #PhysicianWellness #Leadership #MedEd

Dean David Perlmutter, MD opened our Pediatric Research Retreat with a powerful keynote on Alpha-1 Antitrypsin Disease 🔬 Genetic modifiers + autophagy-targeting drugs = incredible promise for liver disease! #Alpha1 #Autophagy #PedsResearch #LiverDisease @washumedicine.bsky.social

Amino acids compensate for MPC metabolism in hepatocytes, BCAAs & pyruvate share similarities, & PPM1K phosphorylation ↑ in obese livers. Mouse CRISPR model insights! 🎨 Dr. Brian Finck, PhD at WashU #Metabolism #BCAA #LiverMetabolism #MetabolicResearch #MedEd @beineff.bsky.social

Immune checkpoint inhibitors → autoimmune diabetes risk, especially with pre-existing T2DM. Rapid C-peptide loss makes management tough. 🎨 Sketchnotes from Dr. Huda Al-Bahadili, MD's WashU lecture #ICI #Endocrinology #DiabetesAwareness #Oncology #T2DM

🦠 Drew Schwartz, MD PhD on the neonatal microbiome: prematurity impairs microbiome development, abnormal flora drives systemic infections, and IgA/IgG play fascinating roles in immunity. Critical work for our tiniest patients! #Microbiome #Neonatology #Immunology

Congenital #hyperinsulinism: common, high stakes, and historically limited treatment options.From neurologic risk of hypoglycemia to feeding challenges and emerging therapies, this CME webinar highlighted why innovation in HI is urgently needed. Exciting science ahead. #MedEd #PedsEndo

Amazing PPI presentation by Dr. Nicole Brossier on NF1, neurodevelopment, and tumor biology. Striking evidence that maternal obesogenic diet influences optic pathway glioma risk — with growth factor signaling driving the connection. Thought-provoking work. 🧠✨ #PPI @washumedicine.bsky.social

Amazing PPI presentation by Dr. Danielle Alfano exploring ADAM10 in sepsis biology. Loved the mechanistic insights into endothelial dysfunction, VE-cadherin shedding, and TAILS-based substrate discovery. Translational science at its best. 🧬🔥 #PPI @washumedicine.bsky.social

Fantastic talk by Dr. Aisha Ansar on monogenic diabetes. GCK-MODY causes mild, stable hyperglycemia with preserved C-peptide, negative antibodies, and low complication risk—critical to recognize when evaluating patients with atypical diabetes. #MonogenicDiabetes #MODY @washumedicine.bsky.social

Amazing presentation by Dr. Lori Holtz on the human virome. Loved learning how viral communities can shape health and disease, and the striking mother–child data showing high EBV levels and CMV links to maternal infection risk. Thought-provoking science! 🧬🚀 #PPI

Dr. Monika Bambouskova unpacks mevalonate kinase deficiency as both an inborn error of metabolism and immunity. From why statins are ineffective to IgD+ B-cell biology and isoprenoid supplementation—immune–metabolic insight in action. #RareDisease #Immunology #Metabolism @washumedicine.bsky.social

Isabelle South, PA breaks down how people with diabetes use social media: a double-edged sword that can spread misinformation, but also deliver practical insulin pump guidance, lifestyle tips, and humanity through humor. #DiabetesEducation #HealthCommunication @washumedicine.bsky.social

Amazing presentation by Dr. Nicole Gilbert on the vaginal microbiome and #UTI risk. Loved the deep dive into community state types, Gardnerella clades that can infect the bladder, and how shotgun metagenomics is changing what we see. 🧬🚀 #PPI @washumedicine.bsky.social

Impressive talk by Dr. Dustin Baldridge tackling one of the biggest challenges in genomics: variants of uncertain significance. Deep mutational scanning is pushing us toward real answers — and real clinical impact. Powerful stuff. 🧬🔥 #PPI #VUS #Genetics @washumedicine.bsky.social

Big congratulations to Alex Li on passing his Qualifying Exam! 🎉 An impressive presentation spanning population genetics, Wolfram spectrum phenotypes, and future functional genomics approaches. Excited to see where this work goes next! @washumedicine.bsky.social #WolframSyndrome

Such an impressive talk by Dr. Michelle Gill! 🧬 From IL-4 as a central mediator in atopic asthma to the mysteries of IL-4Rα blockade and evolving trial designs — this session beautifully linked fundamental immunology with clinical impact. #PPI @washumedicine.bsky.social

Such an inspiring grand rounds presentation by Dr. Linda DiMeglio today 💙. We’ve come so far since the first purified insulin, and now teplizumab marks the first true disease-modifying therapy for diabetes. Universal screening, new trial designs, and big leaps ahead! @drdimeglio.bsky.social #EndoSky

Hormones out of whack? Don’t have a cow—we’ve got you. The Farmyard Endocrinology Crew was on duty today! 🐄🐷🐯 #EndoSky #PedsEndo

Pediatric Endocrinology Wrapped 2025 🎶 My year in hormones, growth charts, and CGM alarms I definitely slept through. See what really topped the charts this year. #PedsEndo #SpotifyWrapped #EndoLife #EndoSky

Amazing presentation by Dr. David Rosen! 🦠 Loved learning how Klebsiella uses RNA thermometers, virulence genes, and translational control to thrive in the environment and inside hosts. Brilliant science! #PPI #MedEd #Bacteriology #InfectiousDisease @washumedicine.bsky.social

Honored to recognize World Diabetes Day with The Stone Lab 💙. Grateful for our incredible team pushing research forward to better understand, treat, and prevent diabetes. Here’s to science that truly makes a difference. #WorldDiabetesDay @washumedicine.bsky.social

Amazing presentation by Dr. Andrew Janowski exploring astroviruses 🧬 — key players in gastroenteritis and encephalitis 🧠. Fascinating insights into the enigmatic S2M motif and its RNA “on/off” switch behavior! #PPI @washumedicine.bsky.social

Dr. Mary-Elizabeth Patti dives into the mystery of post-bariatric hypoglycemia — why only some patients are affected, and how bile acid–FGF19 pathways, serotonin, and enteroendocrine signaling may guide new treatments. #BariatricSurgery #Metabolism #Endocrinology @washumedicine.bsky.social

Dr. Bess Marshall’s Grand Rounds on GLP-1 physiology highlighted how gut-derived hormones talk to the brain to regulate insulin, appetite, and energy balance. 🧬 A perfect reminder that the gut is more than digestion—it’s an endocrine organ! @washumedicine.bsky.social

Viruses and autoimmunity collide. Dr. Tarin Bigley, MD PhD, reveals how HHV6 infection disrupts thymic development, increasing autoimmune risk—from murine models to thymus transplants in DiGeorge Syndrome. #PPI @washumedicine.bsky.social

Exciting progress in Wolfram syndrome! Dr. Fumihiko Urano outlines new therapies — from AMX0114 drug trials to gene-editing strategies aimed at restoring β-cell function and neuroprotection. Collaboration with patient groups is key. #WolframSyndrome #RareDisease @washumedicine.bsky.social

Maternal diet shapes the next generation. Dr. Mike Thompson shared how obesogenic diets in mothers profoundly alter the gut microbiome and bile acid metabolism of offspring. #PPI @washumedicine.bsky.social @hepatocrinologist.bsky.social

Dr. Colin G. Nichols shared how the KATP channel drives both neonatal diabetes & congenital hyperinsulinism. 🧬 Key insights: SUR1 mutations, shifts in calcium sensitivity, & why diazoxide works (when sulfonylureas may not). @washumedicine.bsky.social @colinnicholslab.bsky.social #EndoSky

Euglycemic DKA can develop in patients on SGLT2 inhibitors — even without diabetes. ⚠️ Important to counsel families on fasting and DKA symptoms as use of these meds grows in pediatric heart failure. @washumedicine.bsky.social #Endocrinology #DiabetesCare #HeartFailure #MedTwitter

Sketchnote from Dr. Carmen Halabi’s talk: 👉 Lox is essential for elastin in large vessels 👉 Knockout = aortic aneurysms 👉 Early mortality in mice 👉 Why is the ascending aorta most at risk? Big insights at the interface of genetics + vascular biology! #Research @washumedicine.bsky.social

🌟 Grand Rounds with Dr. Megan Cooper 🌟 One patient’s story can unlock diagnoses for dozens more. 🧬 From inborn errors of immunity to targeted therapies, genome sequencing is transforming care for #PrimaryImmuneDeficiency. #Genomics #PrecisionMedicine #Pediatrics #RareDisease

That’s a wrap on #ENDO2025! Thank you to the incredible speakers, attendees, and organizers who made this week unforgettable. Sketching my way through the science was a blast—what was your favorite? @endocrinesociety.bsky.social

Christoffer Clemmensen’s #ENDO2025 talk forecasted what’s coming next in obesity pharmacotherapy: 💉 Dual/triple/quad agonists (GLP-1, GIP, amylin, glucagon) 🧠 NMDA receptor targets = neuroplasticity 🔬 ghrelin → prevents regain 📉 GLP-1/GIP/meranzin combo↓ @endocrinesociety.bsky.social

Robert Semple at #ENDO2025 is pushing boundaries with deep mutational scanning of the #insulin receptor: 🔬 Testing all possible variants 🧩 Critical insights into cysteine-rich domains 🧠 Epitope mapping + therapeutic responsiveness @endocrinesociety.bsky.social

Vincent Harley at #ENDO2025 identified 2 novel genes in 46,XY DSD: 🧠 MAP3K7 kinase domain variants—Sertoli-specific, WNT-β-catenin disruption 🧬 DMRT3 variants—potential estrogen activation & gain-of-function @endocrinesociety.bsky.social #DSD #Genetics

Luca Persani on behalf of Federica Marelli presented cutting-edge models of thyroid hormone resistance at #ENDO2025: 🐟 Zebrafish = functional platform for VUS 📉 Easier to ID THRβ defects via TFT signature 📘 Guidelines -specific variant interpretation @endocrinesociety.bsky.social #ThyroidGenetics

Tracy Rankin’s #ENDO2025 session was full of practical grant-writing advice: ✅ Know when to contact your program vs. review officer ✅ Tailor your career dev plan for Ks ✅ Plan for conceptual + technical pitfalls ✅ Be aware of timelines—and stay resilient! @endocrinesociety.bsky.social #NIDDK

Jens Holst at #ENDO2025 called incretins “the silver bullet”—and for good reason: 💡 Modified GLP-1 has powerful central effects 🫀 Broad benefits: ↓ CV risk, ↓ inflammation, sleep apnea, MASH, Cancer? 🔑 Lifestyle change is key to keeping the weight off. @endocrinesociety.bsky.social

🚨 Poster alert! I’ll be presenting MON-573 at #ENDO2025 today from 12–1:30 PM. 🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes 📊 Proud to be part of the #RADIANT -study and this incredible research community. @endocrinesociety.bsky.social

At #ENDO2025, dinner with some of the most brilliant and kind-hearted Peds Endos I’ve ever met. These are the moments that make conferences meaningful—connection, mentorship, and shared purpose. @endocrinesociety.bsky.social #PedsEndo

#ENDO2025 “Meet the Professors” session featured Onno Holleboom & Eveline Bruinstroop with updates on MASLD: 🧬 FGF21 analogs + PPARδ = emerging therapies 📊 FIT-4 score + FibroScan = easy, non-invasive tools 🧠 GLP-1s may help too @endocrinesociety.bsky.social #MASLD