Impressive talk by Dr. Dustin Baldridge tackling one of the biggest challenges in genomics: variants of uncertain significance. Deep mutational scanning is pushing us toward real answers — and real clinical impact. Powerful stuff. 🧬🔥 #PPI #VUS #Genetics @washumedicine.bsky.social

Big congratulations to Alex Li on passing his Qualifying Exam! 🎉 An impressive presentation spanning population genetics, Wolfram spectrum phenotypes, and future functional genomics approaches. Excited to see where this work goes next! @washumedicine.bsky.social #WolframSyndrome

Such an impressive talk by Dr. Michelle Gill! 🧬 From IL-4 as a central mediator in atopic asthma to the mysteries of IL-4Rα blockade and evolving trial designs — this session beautifully linked fundamental immunology with clinical impact. #PPI @washumedicine.bsky.social

Such an inspiring grand rounds presentation by Dr. Linda DiMeglio today 💙. We’ve come so far since the first purified insulin, and now teplizumab marks the first true disease-modifying therapy for diabetes. Universal screening, new trial designs, and big leaps ahead! @drdimeglio.bsky.social #EndoSky

Hormones out of whack? Don’t have a cow—we’ve got you. The Farmyard Endocrinology Crew was on duty today! 🐄🐷🐯 #EndoSky #PedsEndo

Pediatric Endocrinology Wrapped 2025 🎶 My year in hormones, growth charts, and CGM alarms I definitely slept through. See what really topped the charts this year. #PedsEndo #SpotifyWrapped #EndoLife #EndoSky

Amazing presentation by Dr. David Rosen! 🦠 Loved learning how Klebsiella uses RNA thermometers, virulence genes, and translational control to thrive in the environment and inside hosts. Brilliant science! #PPI #MedEd #Bacteriology #InfectiousDisease @washumedicine.bsky.social

Honored to recognize World Diabetes Day with The Stone Lab 💙. Grateful for our incredible team pushing research forward to better understand, treat, and prevent diabetes. Here’s to science that truly makes a difference. #WorldDiabetesDay @washumedicine.bsky.social

Amazing presentation by Dr. Andrew Janowski exploring astroviruses 🧬 — key players in gastroenteritis and encephalitis 🧠. Fascinating insights into the enigmatic S2M motif and its RNA “on/off” switch behavior! #PPI @washumedicine.bsky.social

Dr. Mary-Elizabeth Patti dives into the mystery of post-bariatric hypoglycemia — why only some patients are affected, and how bile acid–FGF19 pathways, serotonin, and enteroendocrine signaling may guide new treatments. #BariatricSurgery #Metabolism #Endocrinology @washumedicine.bsky.social

Dr. Bess Marshall’s Grand Rounds on GLP-1 physiology highlighted how gut-derived hormones talk to the brain to regulate insulin, appetite, and energy balance. 🧬 A perfect reminder that the gut is more than digestion—it’s an endocrine organ! @washumedicine.bsky.social

Viruses and autoimmunity collide. Dr. Tarin Bigley, MD PhD, reveals how HHV6 infection disrupts thymic development, increasing autoimmune risk—from murine models to thymus transplants in DiGeorge Syndrome. #PPI @washumedicine.bsky.social

Exciting progress in Wolfram syndrome! Dr. Fumihiko Urano outlines new therapies — from AMX0114 drug trials to gene-editing strategies aimed at restoring β-cell function and neuroprotection. Collaboration with patient groups is key. #WolframSyndrome #RareDisease @washumedicine.bsky.social

Maternal diet shapes the next generation. Dr. Mike Thompson shared how obesogenic diets in mothers profoundly alter the gut microbiome and bile acid metabolism of offspring. #PPI @washumedicine.bsky.social @hepatocrinologist.bsky.social

Dr. Colin G. Nichols shared how the KATP channel drives both neonatal diabetes & congenital hyperinsulinism. 🧬 Key insights: SUR1 mutations, shifts in calcium sensitivity, & why diazoxide works (when sulfonylureas may not). @washumedicine.bsky.social @colinnicholslab.bsky.social #EndoSky

Euglycemic DKA can develop in patients on SGLT2 inhibitors — even without diabetes. ⚠️ Important to counsel families on fasting and DKA symptoms as use of these meds grows in pediatric heart failure. @washumedicine.bsky.social #Endocrinology #DiabetesCare #HeartFailure #MedTwitter

Sketchnote from Dr. Carmen Halabi’s talk: 👉 Lox is essential for elastin in large vessels 👉 Knockout = aortic aneurysms 👉 Early mortality in mice 👉 Why is the ascending aorta most at risk? Big insights at the interface of genetics + vascular biology! #Research @washumedicine.bsky.social

🌟 Grand Rounds with Dr. Megan Cooper 🌟 One patient’s story can unlock diagnoses for dozens more. 🧬 From inborn errors of immunity to targeted therapies, genome sequencing is transforming care for #PrimaryImmuneDeficiency. #Genomics #PrecisionMedicine #Pediatrics #RareDisease

That’s a wrap on #ENDO2025! Thank you to the incredible speakers, attendees, and organizers who made this week unforgettable. Sketching my way through the science was a blast—what was your favorite? @endocrinesociety.bsky.social

Christoffer Clemmensen’s #ENDO2025 talk forecasted what’s coming next in obesity pharmacotherapy: 💉 Dual/triple/quad agonists (GLP-1, GIP, amylin, glucagon) 🧠 NMDA receptor targets = neuroplasticity 🔬 ghrelin → prevents regain 📉 GLP-1/GIP/meranzin combo↓ @endocrinesociety.bsky.social

Robert Semple at #ENDO2025 is pushing boundaries with deep mutational scanning of the #insulin receptor: 🔬 Testing all possible variants 🧩 Critical insights into cysteine-rich domains 🧠 Epitope mapping + therapeutic responsiveness @endocrinesociety.bsky.social

Vincent Harley at #ENDO2025 identified 2 novel genes in 46,XY DSD: 🧠 MAP3K7 kinase domain variants—Sertoli-specific, WNT-β-catenin disruption 🧬 DMRT3 variants—potential estrogen activation & gain-of-function @endocrinesociety.bsky.social #DSD #Genetics

Luca Persani on behalf of Federica Marelli presented cutting-edge models of thyroid hormone resistance at #ENDO2025: 🐟 Zebrafish = functional platform for VUS 📉 Easier to ID THRβ defects via TFT signature 📘 Guidelines -specific variant interpretation @endocrinesociety.bsky.social #ThyroidGenetics

Tracy Rankin’s #ENDO2025 session was full of practical grant-writing advice: ✅ Know when to contact your program vs. review officer ✅ Tailor your career dev plan for Ks ✅ Plan for conceptual + technical pitfalls ✅ Be aware of timelines—and stay resilient! @endocrinesociety.bsky.social #NIDDK

Jens Holst at #ENDO2025 called incretins “the silver bullet”—and for good reason: 💡 Modified GLP-1 has powerful central effects 🫀 Broad benefits: ↓ CV risk, ↓ inflammation, sleep apnea, MASH, Cancer? 🔑 Lifestyle change is key to keeping the weight off. @endocrinesociety.bsky.social

🚨 Poster alert! I’ll be presenting MON-573 at #ENDO2025 today from 12–1:30 PM. 🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes 📊 Proud to be part of the #RADIANT -study and this incredible research community. @endocrinesociety.bsky.social

At #ENDO2025, dinner with some of the most brilliant and kind-hearted Peds Endos I’ve ever met. These are the moments that make conferences meaningful—connection, mentorship, and shared purpose. @endocrinesociety.bsky.social #PedsEndo

#ENDO2025 “Meet the Professors” session featured Onno Holleboom & Eveline Bruinstroop with updates on MASLD: 🧬 FGF21 analogs + PPARδ = emerging therapies 📊 FIT-4 score + FibroScan = easy, non-invasive tools 🧠 GLP-1s may help too @endocrinesociety.bsky.social #MASLD

At #ENDO2025, Iza Machado shared key data linking puberty timing to adult cardiometabolic health: 📍 Early menarche = ↑ CV risk 📍 Late menarche = ↑ coronary artery disease 📊 Based on a large population cohort from Brazil @endocrinesociety.bsky.social #PubertyMatters #ENDO2025

Found my dose on the wall! 137 mcg Synthroid, powering me since 1994. Here’s to #ENDO2025, long-term hormone therapy, and stable thyroid vibes 🦋#LevothyroxineLife @endocrinesociety.bsky.social @abbvie.bsky.social

At #ENDO2025, Melanie Haines emphasized the need to monitor muscle and bone health in patients on GLP-1 therapy: 🏋️‍♀️ Muscle loss is an under-recognized concern 👵 Women + older adults face higher risk 🦴 Bone resorption via CTX? Whole-patient care matters. @endocrinesociety.bsky.social

Rossella Cannarella at #ENDO2025 highlighted how tirzepatide might address more than just weight: 🧬 Effective for metabolic hypogonadism 🍆 Boosts sexual function 👶 May hold promise for fertility 🔍 Could Sertoli-sperm cell signaling be key? Big questions, big potential. @endocrinesociety.bsky.social

Angela Rao at #ENDO2025 discussed GLP-1 use alongside bariatric surgery: 💊 Adjunctive therapy is not statistically significant yet—but may benefit Class IV obesity 🧩 Calls for individualized care plans 📝 Recommends pre- and post-op GLP-1 @endocrinesociety.bsky.social

At #ENDO2025, Christian Roth introduced KCN1—a novel antibody hitting GLP1, MCHR, and MC5R. 🔬 Rat studies show improved glucose tolerance, weight loss, and fewer GI side effects. 🤓 Also: Did you know rats can’t vomit? Precision obesity therapy may have a new contender. @endocrinesociety.bsky.social

Nancy Cox at #ENDO2025 dropped truths about the intersection of genomics + EHR data: 📊 Medical phenome analysis at Vanderbilt is transforming rare disease discovery 📢 “A diagnosis isn’t truth—it’s data” What does this mean for the future of precision endocrinology? @endocrinesociety.bsky.social

“Not just a library—a learning system.” Sir Mark Caulfield at #ENDO2025 highlighted the 100,000 Genomes Project is transforming diagnostics ✅ NHS-wide integration ✅ 25% rare disease Dx rate What if this was the future of newborn screening? @endocrinesociety.bsky.social @markcaulfield.bsky.social

Opening #ENDO2025 with urgency and hope. In his presidential address, John Newell-Price reminded us what matters most: 🧠 Science. 🌍 Inclusivity. 🗣️ Advocacy. Follow @endocrinesociety.bsky.social for updates and reflections throughout the meeting.

Thrilled to be attending my very first #ENDO2025! I’ll be sketching my way through the conference, translating the latest endocrine science into visual snapshots. Let’s make this one to remember. Follow along: @endocrinesociety.bsky.social ✍️🧬🧠

👉 What was your favorite sketch? Drop it in the comments! #ADASciSessions @amdiabetesassn.bsky.social #diabetesresearch #sketchnotes #precisionmedicine #endocrinology #medicalillustration

Smart solutions in pediatric diabetes at #ADASciSessions: 🧠 Atypical forms matter – Dr. Tosur 🏃‍♀️ Physical activity support – Dr. Zaharieva 📱 Shared med visits to boost tech, tailored by culture – Dr. Wong #PedsEndo #DiabetesTech

🎉 Celebrating #NIDDK’s 75th anniversary at #ADASciSessions! Legacy of DCCT/EDIC, TrialNet, innovative tissue networks, & the power of federal funding—all pushing diabetes research forward. Huge respect to the trailblazers in this space!

Dr. Eimear Kenny at #ADA2025: PRS + AI + genomics integration is here. Health systems must evolve—patients want results, clinicians need tools. @amdiabetesassn.bsky.social @eimearekenny.bsky.social #ADASciSessions #PRS #genomics #GIRA

At #ADA2025, Josep Mercader discussed how multi-ancestry PRS for T2DM offer better prediction—especially when overlaid with clinical risk factors. @amdiabetesassn.bsky.social @josepmercader.bsky.social #ADASciSessions #genomics #PRS #T2D #ancestryinresearch

At #ADA2025, Aaron Deutsch discussed how PRS can clarify T1D subtypes and support teplizumab decisions—if ancestry is matched correctly. @amdiabetesassn.bsky.social #ADASciSessions #T1D #PRS #genomics

Leslie Lange at #ADA2025: PRS must account for genetic ancestry to be valid across diverse populations. GWAS loci ≠ always functional. @amdiabetesassn.bsky.social #ADASciSessions #PRS #genetics #ancestryinresearch

Dr. Anna Gloyn at #ADA2025: Multiomic data reveals diabetes heterogeneity, linking polygenic scores, islet traits, and regulatory networks. @amdiabetesassn.bsky.social @annagloyn.bsky.social #ADASciSessions #T2D #genomics #multiomics

Dr. Steven Kahn, #ADA2025 Banting Medalist, delivered a powerful lecture on β-cell dysfunction, feedback loops, and the urgency of defending science. @amdiabetesassn.bsky.social #ADASciSessions #BantingMedal #scientificdiscovery

At #ADA2025, Dr. Rita Rastogi Kalyani reminded us that diabetes progress must be global—many still lack access to basic care. Let’s scale GLP-1s, SGLT2is, and training for all. @amdiabetesassn.bsky.social #ADASciSessions #diabetesleadership #healthaccess

Dr. Megan Oberle Bensignor at #ADA2025: In pediatric T2DM, treat obesity, protect β-cell function, and consider SGLT2i benefits/risks—always as a care partner. @amdiabetesassn.bsky.social #ADASciSessions #T2DM #pediatricdiabetes

Dr. Tamara Hannon at #ADA2025: Pediatric T2DM patients may benefit from GLP-1s, but we need longer-term data. Side effects still a concern. @amdiabetesassn.bsky.social #ADASciSessions #GLP1 #PediatricEndocrinology