Lila S. Sanning, MD
@lilamd.bsky.social
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Neonatologist-Scientist at Wash U Medicine in St. Louis • Investigating host-microbe interactions
reposted by
Lila S. Sanning, MD
Science Magazine
16 days ago
Key human defenses against pathogens were forged billions of years ago in microbial battles with viruses. Learn more this week in Science:
https://scim.ag/3RTyCap
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Gastrointestinal tuft cells: Recent insights and next questions | Science Immunology
www.science.org/doi/10.1126/...
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Gastrointestinal tuft cells: Recent insights and next questions
This Review synthesizes our understanding of GI tuft cell activation mechanisms and downstream effector functions and identifies open questions.
https://www.science.org/doi/10.1126/sciimmunol.aea8740
15 days ago
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reposted by
Lila S. Sanning, MD
Nature Portfolio
15 days ago
Scientific figures can strongly influence how research findings are interpreted. This ‘How to’ Comment article in Nature Human Behaviour outlines a practical strategy for creating figures that communicate clearly across audiences and scientific contexts.
go.nature.com/3R00b1t
#Academicsky
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reposted by
Lila S. Sanning, MD
Stephen Stone, MD 🔬🧬🐁✏️
18 days ago
@lilamd.bsky.social
at PPI: Norovirus is a major cause of infant morbidity & mortality — not just a cruise ship nuisance! Interferon is a key mediator, but gaps in our understanding of the human norovirus receptor make culture models a real hurdle.
#Norovirus
#InfectiousDisease
#PedsResearch
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reposted by
Lila S. Sanning, MD
Nature Portfolio
about 1 month ago
The findngs of a study in Nature Communications show reveal previously unrecognised effects of coffee on the microbiota–gut–brain axis, suggesting that #microbiome profiles could potentially predict coffee consumption patterns.
go.nature.com/4mMKabb
#microbiome
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reposted by
Lila S. Sanning, MD
Waggoner Lab
2 months ago
@biorxivpreprint.bsky.social
T-bet Expressing B cells are Key Determinants of Protective Immunity Against Norovirus Infection
@scripps.edu
@thepenkpanther.bsky.social
www.biorxiv.org/content/10.6...
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reposted by
Lila S. Sanning, MD
Cell Host & Microbe
3 months ago
Virome regulates nutrient sensing Enteric virome, dominated by bacteriophages, can autonomously activate host immune signaling to modulate intestinal metabolic responses and regulate carbohydrate digestion & absorption
www.cell.com/cell-host-mi...
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Commensal enteric virome regulates intestinal carbohydrate digestion and absorption
Lin et al. show that the enteric virome, dominated by bacteriophages, can autonomously activate host immune signaling to modulate intestinal metabolic responses. Their findings identify the enteric vi...
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(26)00044-2
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reposted by
Lila S. Sanning, MD
Cell Host & Microbe
3 months ago
Influenza virus hitches a cellular ride to the heart Preview of
@cp-immunity.bsky.social
paper demonstrating that pro-DC3 cells ferry influenza virus to the heart, infecting cardiomyocytes and triggering damage via type I interferon signaling
www.cell.com/cell-host-mi...
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Influenza virus hitches a cellular ride to the heart
Influenza virus is associated with severe cardiac complications, yet mechanisms of disease, including how the virus traffics from lungs to the heart, have remained elusive. In a recent Immunity paper,...
https://www.cell.com/cell-host-microbe/abstract/S1931-3128(26)00080-6
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Very happy to share our latest work in
@bloodadvances.bsky.social
: Antibiotic treatment limits survival of peripheral and bone marrow B-cell populations
ashpublications.org/bloodadvance...
7 months ago
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reposted by
Lila S. Sanning, MD
Stephen Stone, MD 🔬🧬🐁✏️
about 1 year ago
Exciting energy from the next generation of physician-scientists at the 2025
@washumedicine.bsky.social
Pediatric Research Retreat! 🚀 Early career faculty are driving innovation across disciplines. The future of child health research is bright! 🌟#PedsResearch
#AcademicMedicine
#FutureLeaders
#WashU
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reposted by
Lila S. Sanning, MD
Nature Microbiology
about 1 year ago
Out now! Live bacteria can translocate to other tissues via Colonic goblet cell-associated passages which may be beneficial to the host!
#MicroSky
#MicrobiomeSky
🦠
www.nature.com/articles/s41...
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Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology
Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.
https://www.nature.com/articles/s41564-025-01965-1?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
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reposted by
Lila S. Sanning, MD
Mucosal Immunology
about 1 year ago
It’s
#MucosalMonday
and time for our monthly podcast. This episode features
@cjohansson-lab.bsky.social
, along with hosts
@marionbrunck.bsky.social
and
@ashu-mangalam.bsky.social
. Find it on your favorite platform, including spotify:
open.spotify.com/episode/4Ng1...
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Adding insult to injury during RSV infections
Mucosal Immunology Podcast · Episode
https://open.spotify.com/episode/4Ng1RHF7CwWAsRvqgLAENj?si=OsVQ44nFQIO9Ve92R4nK4A
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reposted by
Lila S. Sanning, MD
Eric Topol
over 1 year ago
In the US alone, each year, norovirus causes ~20 million acute gastroenteritis cases, 70,000 hospitalizations, up to 800 deaths, at a cost of ~$10.6 billion annually. An pill vaccine shows considerable promise in a clinical trial, establishing mucosal immunity
www.science.org/doi/10.1126/...
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An oral norovirus vaccine tablet was safe and elicited mucosal immunity in older adults in a phase 1b clinical trial
An oral norovirus vaccine tablet is safe and induces strong mucosal and systemic immune responses in adults aged 55 to 80 years.
https://www.science.org/doi/10.1126/scitranslmed.ads0556
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Just joined
@bsky.app
! Looking forward to connecting with neonatology & scientific communities on this platform.
over 1 year ago
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