Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction. www.biorxiv.org/content/10.6...

Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes. www.nature.com/articles/s42...

Taming Autoimmunity: Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Promote Regulatory T Cell Crosstalk to Reverse Diabetes: Molecular Therapy www.cell.com/molecular-th...

Glycemia shifts pancreatic islet rhythmicity by influencing interactions between δ cells and α cells: Cell Systems www.cell.com/cell-systems...

A metabolic atlas of mouse aging: Cell Metabolism www.cell.com/cell-metabol...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging. www.science.org/doi/10.1126/...

Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes. www.nature.com/articles/s41...

Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene. www.nature.com/articles/s41...

JCI - Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes www.jci.org/articles/vie...

A vascular-associated fibroblastic cell controls pancreatic islet immunity. www.cell.com/cell-reports...

Improving cellular fitness of human stem cell-derived islets under hypoxia. www.nature.com/articles/s41...

Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity. www.science.org/doi/10.1126/...

Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation. www.nature.com/articles/s41...

Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms. www.cell.com/cell-genomic...

Distinct adipose progenitor cells emerging with age drive active adipogenesis | Science www.science.org/doi/10.1126/...

#SkeletalMuscle #Mitophagy #ERPhagy ACTA1-Cre::BNIP3L KO🐭muscle 👉Accumulated Mitochondria 👉⏬glycolytic myofiber ⏬oxidative fiber 👉⏫ #ERPhagy (ER-mCherry/GFP-LC3; ER-Emerald/LysoTracker) ⏬ER Ca2+ 👉Centronuclear myopathy @josephwgordon.bsky.social #Autophagy 2025 www.tandfonline.com/doi/full/10....

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...

Excited to share our work in @naturecomms.bsky.social We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41... #DiabetesResearch #BetaCells

Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes. www.nature.com/articles/s41...

Characterization of islet cells from people with type 1 #diabetes underscores the complex interplay between immune signaling, metabolic stress, and cellular identity in shaping islet cell phenotypes in #T1D @bcellorg.bsky.social www.biorxiv.org/content/10.1... @albertadiabetes.bsky.social

Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants. www.cell.com/cell-genomic...

High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4+ T cells reduces the risk of #diabetic #kidney disease by inhibiting the Th1 response tinyurl.com/nhhj48sx 🔓

Dear Friends, Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...

β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome | Science Translational Medicine www.science.org/doi/10.1126/...

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues | Science www.science.org/doi/10.1126/...

🚨 Excited to share new results! We find that beta cells activate innate immune signaling to adapt to obesity or metabolic stress by promoting both Parkin dependent and independent mitophagy. Mitophagy FTW! We'd be honored if you gave it a read. 😀 www.biorxiv.org/content/10.1...

#RNaseIII #snoRNA #Spombe www.biorxiv.org/content/10.1...

MDA5 variants trade antiviral activity for protection from autoimmune disease. www.medrxiv.org/content/10.1....

Mechanistic insights and approaches for beta cell regeneration. www.nature.com/articles/s41...

The Center for Epigenomics at UC San Diego is pleased to announce Spatial Epigenomics Virtual Day, which will take place on Jan. 29, 2025, on Zoom. This event will feature multiple talks about Spatial Epigenomics from leading experts in the field. Registration is now open: bit.ly/41PJ3Pc

ANDROGENS PROTECT ILC2S FROM FUNCTIONAL SUPPRESSION DURING INFLUENZA VIRUS INFECTION. www.biorxiv.org/content/10.1...

Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats. www.sciencedirect.com/science/arti...

Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis. www.science.org/doi/10.1126/...

Antigen-specific immunotherapies for autoimmune disease. www.nature.com/articles/s41...

Sex-specific cytokine, chemokine, and growth factor signatures in T1D patients and progressors. faseb.onlinelibrary.wiley.com/doi/full/10....

Apology for the non-working link to this intriguing Spatial Skin paper. Spatiotemporal single-cell roadmap of human skin wound healing Here is the correct link www.cell.com/cell-stem-ce...

A famsin-glucagon axis mediates glucose homeostasis. www.cell.com/cell-metabol...

The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes. www.medrxiv.org/content/10.1...

We did a thing! Our first human islet isolation at Michigan by @cortig.bsky.social in partnership with our wonderful friends in the Alberta IsletCore @bcellorg.bsky.social. Excited for this to be the first of many to support diabetes research! 🤩

Our paper is out in Science! Congrats to Nish and the team for making the cover 🎉

Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages. www.cell.com/cell/fulltex...

New, from Amanda Schukarucha Gomes in our group: “Molecular Correlates of Glycine Receptor Activity in Human β Cells” https://www.biorxiv.org/content/10.1101/2024.12.02.626463v1