“You are here to learn to ride a bicycle, not to invent a bicycle.” 🚲🧪 Read my story in Science Magazine on how I dealt with my "Mid-PhD Crisis". www.science.org/content/arti... @science.org @sciencecareers.bsky.social #ScienceWorkingLife #AcademicChatter #AcademicTwitter #ScienceTwitter

Neurons and β-cells share many similarities, including the expression of very specific transcription factors. This prompted a long-standing search for connections between diabetes and mental disorders. This amazing discovery finally reveals a mechanistic link! www.nature.com/articles/s41...

Can amylin-based drugs upstage GLP-1 agonists? They could avoid muscle loss and gastrointestinal side effects of current obesity therapies. My latest for @natbiotech.nature.com rdcu.be/ezwbM

Hoy sábado a medianoche sale nuestra entrevista en el programa "Desde el Conocimiento" por #C5N ¡Gracias a la producción del canal por la invitación para difundir nuestro trabajo en el #IFIBYNE! Transmisión online: www.c5n.com/vivo

Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @natcomms.nature.com www.nature.com/articles/s41...

💥 A single infusion into the portal vein of embryonic stem cell-derived pancreatic islet result in 12/12 patients free of severe hypoglycemic and 83% with insulin independence at one year. However, one death due to the immunosuppressive treatment. buff.ly/ZI14m2i

¡Gracias a la Agencia de Difusión de la Universidad Nacional de San Martin por ayudarnos con la difusión de nuestro trabajo en el #IFIBYNE, y de la difícil situación por la que está atravesando el sistema científico-tecnológico de Argentina! www.agenciatss.com.ar/una-hormona-...

Missed our @eisg2025.bsky.social post? If you study beta cell function using rat islets or INS-1 cells, check out Ri-lnc1! Strongly linked to mature beta cells but missing from current rat genome annotations. Overlooked? Happy to collaborate—just contact us!

Stem cell islets for those living with T1D! www.nejm.org/doi/full/10....

Already on my way back to Argentina! Every trip must come to an end, but this one has truly been an amazing experience that will leave a lasting mark. Looking forward to consolidating the exciting new collaborations that will drive future work!

Amazing talks by @diegobalboa.bsky.social, @labspagnoli.bsky.social, Simona Chera and many other colleagues yesterday at @eisg2025.bsky.social ! I'm also really glad for the opportunity to share our recently published work. Looking forward to more exciting talks today!

Great opening yesterday @eisg2025.bsky.social meeting! Glad to see many interesting talks using INS-1 rat cells to study β-cell function—I couldn’t help but wonder how these treatments might affect Ri-lnc1 expression, our recently reported novel rat long non-coding RNA enriched in mature β-cells 👇

Did you know that the glucocorticoid receptor fine-tunes physiological pancreas development from the earliest progenitor stages? Below, an image worth a thousand words. Want to know more? Visit us at Poster #135 @eisg2025.bsky.social today, Wednesday, at 16:55!

#TCTeAC brought more stickers for day2, find the girl with the lipstick 💄 to get yours! 😉

Thank you, Philip Allan Seymour, for the great meeting today in Copenhagen and for contributing key experiments to our follow-up work on the role of glucocorticoids in pancreas development. Looking forward to getting this continuation story out soon!

Finally! All the pieces are in place for the last stage of an amazing trip. Excited to share our results @eisg2025.bsky.social, showing that endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in pancreatic progenitors of mice and humans!

It was an honor to present our most recent results on the characterization of Procr-like cells in #pancreas #development at the Shanghai Institute of Biochemistry and Cell Biology. Thank you, Dr. Yi Zeng and team, for the warm reception and the engaging perspectives!

Everything is ready for the second stage of my trip. Shanghai awaits—looking forward to interesting discussions on the characterization and role of Procr-like cells in #pancreas #development! @ifibyne @ubaglobal #DiabetesResearch

It was a pleasure discussing our latest results with Prof. Cheng-Ran Xu today at Peking University and learning more about his breakthrough advances in endocrine cell specification in mice and humans. Looking forward to a productive follow-up! #StemCells #DiabetesResearch

You can say it louder, but not clearer. "Scienticide" = the systematic eradication of any possible trace of scientific work in Argentina. www.nature.com/articles/d41...

¡Gracias @CONICETDialoga y Bruno Geller por esta excelente nota difundiendo los principales resultados de nuestro trabajo @ifibyne publicado recientemente en Development! www.conicet.gov.ar/diabetes-tip... -- Thank you @CONICETDialoga for this excellent note!

Thank you, Jorge! Your support, along with Miguel Angel's expertise with the immunos, was instrumental during the initial steps of this project. Looking forward to exploring potential follow-ups together!

It was great to present the work of our lab at #IFIBYNE, for the Endocrinology Department at #PekingUniversity . Thank you, Wei Rui and team, for the warm welcome and very interesting feedback! Thank you #UBAInternacional for supporting this #InternationalResearch between #Argentina & #China.

Ten years ago we reported TEAD/YAP as pancreas development gatekeepers in mouse and human. Now we propose adding Glucocorticoid Receptor (GR) to this selective club - with one key difference! It plays the opposite role: GR activation (→ nuclear localization) promotes progenitor differentiation.

Balanced work & relaxation today—excited to present the work of our lab @ifibyne tomorrow at Peking University Third Hospital’s Endocrinology Department! #BetaCell #DiabetesResearch #StemCells

Everything is ready for my first-day visit to the lab of Prof. WEI Rui at Peking University!

Embarking on my most epic trip yet—looking forward to exploring new collaborations for our lab @ifibyne in Beijing and Shanghai, and to presenting our latest lab results @eisg2025.bsky.social on my way back!

Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal! Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵 🔗 doi.org/10.1242/dev....

Perone et al. explored the role of IL-1β-mediated hormesis in defending β-cells against dysfunction and death induced by pro-inflammatory cytokines. 🧪 #PancSky www.researchsquare.com/article/rs-6...

Lab gathering today to celebrate a big milestone—our paper on the glucocorticoid receptor’s role in early pancreas development is now accepted in Development! 🎉🔬 More details coming soon! #Science #DevelopmentalBiology

Excelente nota reflejando el colapso de la ciencia en Argentina, y llamando a sostener con dignidad lo que quede. Para que "cuando la Argentina decida reencontrarse con su futuro, la ciencia siga estando ahí" www.eldestapeweb.com/opinion/cris...

Farewell to Rachel following a successful research visit funded by @royalsociety. More exciting projects ahead—thank you for the collaboration!

Great talk by Rachel Jennings from Manchester University today @ifibyne in Buenos Aires, Argentina. Thank you for your visit, Rachel!

This issue of The Endocrinologist is dedicated to diabetes research (our SC-islets on the cover!) www.endocrinology.org/endocrinolog...

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation | Science Advances www.science.org/doi/10.1126/...

Transcriptomics in the era of long-read sequencing go.nature.com/421ZTJm #Review by @carolinamonzo.bsky.social, Tianyuan Liu & @anaconesa.bsky.social @conesalab.bsky.social @i2sysbio.bsky.social

Looking forward to hosting our invited speaker, Dr. Rachel Jennings, next Tuesday at 1pm at IFIBYNE! 🔬 University of Manchester 🏥 Manchester University NHS Foundation Trust Talk title: "Does the risk of Type 2 Diabetes begin during development?" #DiabetesResearch #IFIBYNE

Can a subset of mesothelial-like cells act as pancreatic progenitors during organ development? Or do pancreatic progenitors in mice and humans express a broader, unexpected range of EMT markers, including Procr? Our study sparks the debate on these intriguing questions.

🧬🔍 Thrilled to share our new research on Procr+ progenitor cells! Previous studies found them in adult mouse islets. Here, we uncover Procr-like mesothelial cells in the embryonic pancreas! 🐭👶🔬 Learn more: www.frontiersin.org/journals/end... #PancreasResearch #DevelopmentalBiology 👇🧵

From a completely different funding starting point, we've seen this same movie last year in Argentina. I just can't believe that the USA, a reference for high quality research and wealth of funding, is repeating the same steps. It's the decadence of society as we know it.

Still time to apply! Applications from US welcome – four years can feel longer or shorter depending on where you are 😉

MIT method enables ultrafast protein labeling of tens of millions of densely packed cells in organ-scale tissues #NBTintheNews picower.mit.edu/news/mit-met...

Registration to the EMBO Workshop on Liver and pancreas in metabolic disease: from pathways to therapies April 2-–4, 2025 is open. Great speakers, nice venue and numerous speakers will be selected from submitted abstracts. meetings.embo.org/event/25-liv...

Excited to see Moscot (moscot-tools.org) published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at www.nature.com/articles/s41...

Sana Biotechnology's first-in-human study of hypoimmune-engineered deceased donor islets shows insulin production & immune evasion without immunosuppression #Diabetes #T1D #CellTherapy ir.sana.com/news-release...

Towards single-cell ChIP-seq? Great step forward for ChIP-seekers, looking forward to testing this new tool! www.biorxiv.org/content/10.1...

Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update: www.cell.com/cell-stem-ce.... 116 clinical trials with regulatory approval, testing 83 hPSC products!

A must read for parents, educators, politicians, and everyone in between. Highly recommended!

Great opportunity. Apply! 👇

Join us in a beautiful location for this multidisciplinary experience. Top speakers linking topics such as organoid modeling, synthetic biology, gene regulation or genetics with disease mechanisms & new therapies for T1D, T2D, and MASLD meetings.embo.org/event/25-liver-pancreas