Several diabetes experts were escorted out of an influential medical conference by the police on Friday after they handed out copies of an editorial criticizing the Trump administration’s attacks on scientific research.

(🧵1/10) Here are publications that came out last month from CIRTN labs! Works are from the labs of Drs: Ferron, Rutter, Hill, Hull-Meichle, Johnson, P. MacDonald, Levings, Rabasa-Lhoret, Riddell, Screaton and Sefton.

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

New study from Taija Mäkinen's lab @taijamakinenlab.bsky.social at the #WRIHelsinki discovering an essential role for the major angiogenic receptor VEGFR2 in lymphangiogenesis 👇 tinyurl.com/47bns9pp

The interaction between environmental factors during development with genetic predisposition can give rise to congenital heart disease. Read about the new study from @emmihelle.bsky.social’s lab www.helsinki.fi/en/researchg... @helsinki.fi

La sonificación matemática transforma ecuaciones abstractas en sonidos y gráficos dinámicos en tiempo real. Esta traducción intuitiva permite al cerebro captar patrones y anomalías de forma natural, convirtiendo fórmulas complejas en experiencias vivas, accesibles y adictivas para el público.

Excited to see our review out in @cp-trendsendomet.bsky.social! Great team effort and lots of fun to dive into how #islets form and how we can use this knowledge for #diabetes therapy. @mireiamoli.bsky.social @ckarampelias.bsky.social @heikolickert.bsky.social www.sciencedirect.com/science/arti...

We are looking for a new colleague to join us in Galway. The position is in Biochemistry and if research focus lines up we hope the successful person will join us in the Centre for Chromosome biology (chromosome.ie). Reach out if you are interested in applying! tinyurl.com/2jy4rj3r

Happy to share that our latest work on VEGFR2 in lymphatic endothelium is published @natcomms.nature.com “VEGFR2 is required for VEGF-C–VEGFR3–PI3Kα-mediated sprouting lymphangiogenesis” tinyurl.com/47bns9pp This project has been a long journey for the lab @taijamakinenlab.bsky.social , A thread.

Is distal gene activation by enhancers inherently different from promoter-proximal activation? We propose not. But both cohesin and cooperativity are important aspects of how transcription is affected. Happy to share our recent preprint (thread below) 1/ www.biorxiv.org/content/10.6...

Our amazing gene therapy study now out in @moltherapy.bsky.social A step towards treatment for babies with neonatal mitochondrial disease, currently incurable inherited diseases. @mito-news.bsky.social @mitoworld.bsky.social @folkhalsanresearch.bsky.social @helsinki.fi

FYI: New online! Tools and tactics for studying alternative splicing

A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵

The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI

Fue un lujo poder explicar al cineasta Oliver Laxe la magia que rodea a La Térmica Cultural del @miteco.gob.es . Una antigua central ahora colonizada por árboles y plantas. Esta simbiosis entre industria y naturaleza nos recuerda que sin vegetación no es posible la vida humana en la Tierra.

One month until early-bird deadline for @dev-journal.bsky.social & @wellcometrust.bsky.social-funded consortium HDBI's 2026 Meeting on Human Development: Stem Cells, Models, Embryos. Check out the programme biologists.com/meetings/dev... and register by 8 May www.biologists.com/meetings/dev...

I posted on LinkedIn about my reflections on the genome, 25 years on. www.linkedin.com/posts/ewan-b...

📣 New Perspective out in @natcellbio.nature.com! With an interdisciplinary team of scientists, ethicists & lawyer we propose embedded ethics as a framework for navigating the complex ethics of human stem cell–based embryo models. www.nature.com/articles/s41... Free full text link: rdcu.be/fckmY 🧵

"Here we present the Human Development Multiomic Atlas, a single-cell atlas of chromatin accessibility and gene expression from 817,740 fetal cells across 12 organs, spanning 203 cell types and more than 1 million candidate cis-regulatory elements" www.nature.com/articles/s41...

Following several years (!) of discussion and rumination, our team of excellent colleagues - Martin Pera, @nicolasrivron.bsky.social, @amartinezarias.bsky.social, Karen Sermon and Nienke de Graeff - have published a new ethical perspective on SCBEM #embryomodels rdcu.be/fcklG [1/5]

"Hay que mejorar la sanidad pública, la ciencia es la única que puede salvarnos" El alegato de la activista Noah Higón sobre la importancia de cuidar nuestro sistema sanitario

Out now in @science.org Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...

The #Artemis II astronauts said they needed more superlatives to describe their view of the eclipse, when the Sun was behind the Moon and its near surface was faintly illuminated by Earthshine

#Artemis II lunar flyby images are showing up! 😍 A crescent Earth setting behind the Moon.

Mitochondria use a shape-shifting process called "pearling" to evenly distribute their DNA, supporting cellular health and offering new insight into mitochondrial genome organization.

Here are a couple of examples. Lung cancer survival rates for EGFR+ mutated Lung cancer.

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

The @vbcscitraining.bsky.social is looking a PhD Program Manager! Needless to say this is an incredible important position. So please apply if you want to help us find, recruit and train the next generation of scientists! RT appreciated!

The Frenster Lab is here! 🍾 I am so excited to start my #EmmyNoether funded group at @uni-freiburg.de this summer. Our group studies #CellCompetition dynamics during embryonic development using #gastruloids from multiple species. Thanks to the @dfg.de for creating this opportunity! FrensterLab.com

Believe it or not: "Primate-specific ZNF808 is essential for pancreatic development in humans". Amazing story. www.nature.com/articles/s41...

📣 paper alert We are happy to share our latest work on how HNF1A's involvement in GLI3 processing affects #pancreatic & intestinal #development 5 years of work is 🆕 ONLINE ahead of print 🆕 in @genesdev.bsky.social I must say I'm really proud of my team! 👏 genesdev.cshlp.org/content/earl...

🧬 New from Johnson et al! 📄Bi-allelic variants in the non-protein-coding minor spliceosome components RNU6ATAC and RNU4ATAC cause syndromic monogenic autoimmune diabetes

Hot off the press! This paper provides protocols for directed differentiation of hPSCs to different pancreatic islet-like endocrine cells as well as to enterochromaffin cells. Congratulations to the whole team! www.nature.com/articles/s41...

RESEARCH | @ozvanbocher.bsky.social E Zeggini (U Brest, Helmholtz Munich) et al. The causal links of gene expression and protein abundance on type 2 diabetes risk in 4 ancestries 🧪

MetaScale will create a new community for cutting edge Metabolism research spanning from basic biology to human disease. #Metabolism #research #science #centreofexcellence #centerofexcellence #CoE

We are funded by Research Council of Finland and located at two campuses of Univeristy of Helsinki @helsinki.fi, Faculty of Biological and Environmental Sciences and Faculty of Medicine

We will explore how metabolism is spatially organized across biological scales and how controlled exchange of metabolites links organelles, cells and organs into functionally integrated networks. #metabolism #research

Excited to Kick-off our 8-year Centre of Excellence focusing on Metabolic Integration. MetaScale brings together the groups of @pekka-katajisto.bsky.social @awartiovaara.bsky.social Elina Ikonen, Ville Hietakangas @emmihelle.bsky.social @rafabolism.bsky.social and @diegobalboa.bsky.social

Hyperinsulinema, adiposity weight gain and #obesity Associations vs. causality #insulin www.nature.com/articles/s41...

🚨 Job Alert - Please share! 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! We’re recruiting: ✅ PhD students ✅ Postdocs 💻🧪 Experimental or computational backgrounds welcome 👇 Details below

New paper out in Nature Communications: www.nature.com/articles/s41... We found >250 metabolic enzymes on chromatin. Only ~20 had been reported before. This means hundreds of metabolic enzymes may have unexplored nuclear roles.

An advisory panel to Japan’s health ministry has recommended limited marketing approval for therapies using induced pluripotent stem cells for heart failure and Parkinson’s disease. https://scim.ag/4bj5iBw

Two decades of iPS cell research. By my friend and colleague @gladstoneinst.bsky.social Shinya Yamanaka, in @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

Sheep and pig #gastruloids, @IftachN: www.biorxiv.org/content/10.6... The accumulating knowledge of the relationship between #SCBEMs and #Embryos, allow us to learn about species similarities and differences in gastrulation and body plan elaboration.

Find our latest Perspective article in Nature Genetics on "The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements" at www.nature.com/articles/s41..., with implications for the future of research on the cause of human disease.

Reminder:

New from @dev-journal.bsky.social: we're launching a new initiative and hiring Preprint Editors to help navigate the growing world of preprints in developmental & stem cell biology Join our community & shape the future of research journals.biologists.com/dev/article/...

Luo Ting Huang, Yaser Tahamtani, @nictitate.bsky.social & co explored the possibility of magnetic selection of insulin-expressing stem cell‑derived β‑cells using a CRISPR/Cas9 technology and transmembrane glycoprotein CD19 as a marker. @bcchresearch.bsky.social Read: doi.org/10.1242/dmm....

SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) is a regulator of PC2 biology and an essential mechanism for maintaining α cell function and glucagon biosynthesis www.nature.com/articles/s41...