EMBL scientists found metabolism controls embryonic development tempo through signalling in a way separate from its established metabolic function. More research related to this signalling could illuminate how it guides cell fate, developmental timing -- even disease. www.embl.org/news/science...

Optimized signaling pathway-based culture conditions stabilizes canine iPSCs & improves differentiation potential, including differentiation into cardiomyocytes. Valuable resource for future #diseasemodeling cell.com/stem-cell-re... @isscr.org @ucdavisvetmed.bsky.social

💸 Stem cell culture that’s ~95% cheaper and weekend-free: a win-win for PIs and trainees! Our revised manuscript is online at ORE: open-research-europe.ec.europa.eu/articles/4-1... Benchmarked across cell lines & differentiation protocols, including scRNA-seq — with lessons for #cultivatedmeat too!

Studies of prohormone convertase knockouts in mouse islets reveal plasticity in proglucagon processing to support intra-islet α cell-to-β cell communication, normally dominated by glucagon secretion www.science.org/doi/10.1126/...

record 17,058 Marie Curie proposals in 2025 vs. 10,360 in 2024!!! the reason is pretty obvious, but wow that is a huge jump marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...

Announcing our new PA biosensor, PILS-Nir1 – seen here in HeLa cells during PLC activation #lipidtime #phospholipids Read the OA paper in JCB

Come and work with us 5-year position available for a University Researcher in Bioimaging 1.11.2025-31.12.2030 abo.rekrytointi.com/paikat/index...

A multi-omics overview of perturbations in the #T1D pancreas at the single cell level #islets www.science.org/doi/10.1126/...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Early embryos develop... and eliminate threats @estebanhoijman.bsky.social & co recently discovered that early embryos can eliminate bacterial infections before immune cells are formed. Take a look at the dynamics of their first encounter with microbes. thenode.biologists.com/early-embryo...

Integrated transcriptomic analysis reveals a metabolically quiescent state and gene expression networks related to intermediate and mature human 8-cell stage embryo resembling cells in vitro https://www.biorxiv.org/content/10.1101/2025.09.03.673953v1

Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...

Pekka Katajisto @katajistolab.bsky.social introducing Nobel laureate Shinya Yamanaka who will talk about 2 of my favorite topics: sciences and marathons

On the jump forward of CRISPR genome editing beta islet cells, preempting the need for immunosuppression, for a one-shot treatment of autoimmune (Type 1) diabetes www.nejm.org/doi/full/10.... www.nature.com/articles/d41...

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...

Anna Gloyn (@annagloyn.bsky.social), Jie Liu, Noel Burtt, and Marcela Brissova from the PanKbase team gave a webinar for the HIRN webinar series. If you missed it and want to know how PanKbase might help compliment your type I diabetes research, watch it here: youtu.be/3qLiBdIOJhY?...

Excited to share a new study from the lab published in Diabetes. This was amazing work performed by Sandra Blom! "Proinflammatory Cytokines Mediate Pancreatic β-Cell–Specific Alterations to Golgi Integrity via iNOS-Dependent Mitochondrial Inhibition" doi.org/10.2337/db25...

Beautiful work from Nan Xu and the @studerl.bsky.social lab in @natcellbio.nature.com combining directed differentiation of hPSCs and genome-wide CRISPR screens to identify the epigenetic factors Menin and SUZ12 as regulators of developmental pace across germ layers. www.nature.com/articles/s41...

No solo es una cuestión climática, hemos evitado más de 59.000 millones de € de importar combustibles fósiles. @revenergetica.bsky.social

Bluesky busca su sitio tras surfear el 'efecto huida' de Elon Musk: “El éxodo ha terminado” La red social, que ofrece una alternativa descentralizada a X, encara ahora el reto de consolidar su comunidad www.eldiario.es/tecnologia/b...

Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):

I am excited to announce our paper “Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis” is out in Cell Reports! @eaphelps.bsky.social www.cell.com/cell-reports...

In Brief: A new center in San Francisco will offer tailor-made CRISPR therapies to cure children with rare diseases www.nature.com/articles/s41...

NEW: The first evidence of a solar take-off in Africa☀️✈️ x33 rise in Algeria solar panel imports in the 12 mths to June 2025, compared to previous 12 mths. x8 in Zambia x7 in Botswana x6 in Sudan x3 in each of Liberia, DRC, Benin, Angola, Ethiopia 🧵

🎉 Excited to share that our latest research has been accepted for publication in Anesthesiology! Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms. pubmed.ncbi.nlm.nih.gov/40802988/

Multitudinaria concentración en León para exigir la emergencia nacional por los incendios y la dimisión de responsables de la Junta ileon.eldiario.es/actualidad/m...

🔴⚠️🌡️Hell is ongoing in #Spain where #wildfires are burning many thousands of hectares pushed by dry weather and strong winds. This #Sentinel2 📸shows the situation at the border of Galicia and Castilla y León,the most affected regions. with visible pyrocumulonimbus #climateemergency

Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes - @zhangf.bsky.social go.nature.com/46OFcoj

1/n Fun journey continues: Our new @cp-cellstemcell.bsky.social paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells". www.cell.com/cell-stem-ce...

New @nature.com The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses nature.com/articles/s41...

Lovely news for the summer! My latest artwork was just published on the cover of @cp-cellmetabolism.bsky.social. Incredible science from @daveyboyhod.bsky.social lab! They discovered how pancreatic alpha cells regulate beta cell function via enriched GLP-1 receptor nanodomains.

Online now: HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

California y España generan cada vez más energía solar para su demanda eléctrica Pero los estadounidenses se ayudan de baterías que aprovechan esa energía acumulada durante la noche: así podríamos cubrir hasta un 28% de la demanda nocturna ¿Ves la diferencia? www.eldiario.es/economia/cam...

One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system erictopol.substack.com/p/our-braini...

A 6-year long study from the Lab is finally out @genomeresearch.bsky.social Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social Why is our work Important? Discover it in the quick Bluetorial 👇 genome.cshlp.org/content/earl...

We wrote this introductory review on how concepts from dynamical systems can help us understand developmental biology, hope it’s useful to somebody! It was a lot of fun to put together, and great to collaborate with brilliant colleagues across theory and experiments

Very proud to share the first review from the lab with contributions of all lab members. Writing this gave our new lab opportunity to read and discuss many papers and grow as a team. www.frontiersin.org/journals/imm...

Now out @genomeresearch.bsky.social this fantastic work in collaboration with Claudio Cantù's lab. About how #Wnt signalling activation induces #CTCF binding and formation of new #chromatin #loops at #CREs of target genes. genome.cshlp.org/content/earl...

A compost heap in Finland has yielded the country’s first giant virus. Bigger than some bacteria and packed with hundreds of mysterious genes, it might hold clues to early life and new biotech tools. Gabriel Almeida explains in the eLife Podcast.

Out today in @jclinical-invest.bsky.social! We discovered a novel regulator of adaptive beta cell proliferation, the protein deacetylase SIRT2, that acts through a metabolic mechanism. Bluetorial below (1/5). tinyurl.com/ydvv9u2s

Helsinki hasn't had a traffic fatality in a year: "Helsinki's current traffic safety strategy, covering 2022–2026, is nearing completion. It has focused on improving safety for children, youth, pedestrians and cyclists with safer crosswalks and smarter intersection design."

Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉 🧫 New galactose #CRISPR screen 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂 Mito defects in #Menieres www.cell.com/cell-reports...

Big news, friends! I just joined the team at Kurzgesagt – In a Nutshell @kurzgesagt.org as a Researcher & Fact-Checker 🐦💻🔍 Basically I get to nerd out over science with wildly creative people every day. Dream job 💚 Go watch their stuff if you haven’t already! www.youtube.com/@kurzgesagt

Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...

✨New issue!✨ 🧪 Check out the latest in #metabolism research from across all disciplines. Read about #Triglycerides in the #Brain, #CagriSema, #Exercise, #LipidMetabolism, the #Microbiome - and many more topics! www.nature.com/natmetab/vol...

Pre-print alert 🚨: We have developed 2D and 3D stable iPSC endothelial-differentiation models through dox inducible ETS expression. We demonstrate endothelial identity and used these models for studying malaria pathogenesis research. www.biorxiv.org/content/10.1...

I hear the July issue of @natmetabolism.nature.com is a real page turner, check it out. bit.ly/3GIeTFM

Excited to share our latest work with @jamesbriscoe.bsky.social . A global #cis-regulatory temporal program guides how spatial cues are interpreted in neural progenitors. We show how #space and #time can be integrated to generate cell type diversity in the #spinalcord. Congrats to all authors.

In our new preprint, we show that protein O-GlcNAc is decrerased in mice with mitochondrial disease. We found that O-GlcNAc is strictly dependent on temperature in fruit flies, zebrafish, cultured mammalian cells and in the hypothermic mice. @folkhalsanresearch.bsky.social @stemmprogram.bsky.social

Inflammation, unfolded protein response, and secretory hormone processing create #T1D epitopes in human cytokine-treated #islets www.cell.com/cell-reports...