OFERTA DE EMPLEO (por favor difundir): Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas 👇

Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....

Delighted to start my next scientific adventure with Cecilia, Kari and Taija looking at lymphatic immune interfaces. Many thanks to the research council of Finland to fund our Center of Excellence www.abo.fi/en/news/the-...

Suomen Akatemia on valinnut 11 uutta tutkimuksen huippuyksikköä ohjelmakaudelle 2026–2033. Niistä viittä johdetaan Helsingin yliopistosta. Yhteensä yliopiston tutkijat ovat mukana kahdeksassa uudessa huippuyksikössä. www.helsinki.fi/fi/uutiset/y...

Pleased to share our latest paper characterizing a beta cell specific GABA knockout by first-author and fantastic postdoc Sandra Ferreira www.sciencedirect.com/science/arti...

🚨Excited to kick off our online seminar series on Metabolism in Development and Physiology! Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ... #Metabolism #Development #StemCells Please RT! 🙏

My lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩‍🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...

7) Thanks to all the coauthors who helped me with this final piece of my PhD. Currently looking for a suitable publication channel!🤓

5) We then investigated a long-acting analogue of ghrelin, relamorelin in combination with octreotide, the current first line treatment for these CHI patients. We demonstrate that the combination of these drugs act synergistically to increase blood glucose more than the sum of the individual drugs

4) In these mice, we tested ghrelin, which reversed the hypoglycaemia and reduced the human SC-islet specific insulin secretion

3) we then implanted immunocompromised mice with KCNJ11 wildtype and knockout SC-islets, demonstrating rapid development of hyperinsulinaemic hypoglycaemia in the mice implanted with the knockout SC-islets

2) We then tested insulin secretion affecting compounds in vitro for their ability to suppress the insulin hypersecretion from the KCNJ11 knockout SC-islets. We identified the expected reduction from the clinically used octreotide and exendin 9-39 with reduction with 3 novel compounds

1) We created KCNJ11 knockout stem cells, differentiated them to stem cell derived islets (SC-islets) and demonstrated over 3-fold increased insulin secretion in sub-stimulatory glucose, recapitulating the cardinal defect of congenital hyperinsulinism in vitro

Reporting on successful use of SC-islets in drug development for #congenitalhyperinsulinism! We identified ghrelin analogues as novel candidate drugs, demonstrating reversal of hypoglycaemia in mice, which was caused by the hyperinsulinaemic human SC-islets #PancSky www.biorxiv.org/content/10.1...

13 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a #NobelPrize for in 2020. On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN

At MONCYTE Health we are looking for a laboratory technician. Are you ready to join a vibrant and exciting team, pushing boundaries in precision medicine? Please apply! More information can be found here: moncytehealth.com/open-positio... The closing date for applications is: 30.11.2025

How do endodermal cells behave during gastrulation? In this paper, the authors found that a gradient of BMP regulates mesoderm and endoderm convergent extension. Endoderm cells also use the mesoderm and Cxcr4a signalling to guide their movement. The imaging is beautiful! doi.org/10.1016/j.cd...

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Our latest work seeks to answer a longstanding question: why is discovering new protein binders seemingly unpredictable – and can we better quantify and understand the de novo binder discover process? 1/12 www.biorxiv.org/content/10.1...

🦖 Something HUGE just hatched. Plasmidsaurus now offers RNA sequencing for gene expression analysis: • As fast as 3 day turnaround • $50/sample for academia, $80 for industry • Up to ~10M unique transcript 3’ end reads per sample • Interactive results Explore Plasmidsaurus RNA-Seq today.

Great work from my friend @lithoviusv.bsky.social with very nice combination of disease modeling and a drug gable solution to pair it with! @PancSky www.biorxiv.org/content/10.1...

Model organisms as platforms for training scientific minds www.nature.com/articles/s41...

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

The ISSCR is proud to announce the release of Best Practices for the Development of PSC-Derived Cellular Therapies, a comprehensive new resource designed to accelerate the translation of human PSC-derived therapies into clinical trials and commercial use. https://ow.ly/gsuE50X9fvK

The Crick is looking for new junior group leaders! Any postdocs or early career researchers wanting to be our colleagues should apply 👍

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔 In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n www.science.org/doi/10.1126/...

We lost another Gem of a scientist: www.cam.ac.uk/research/new... His work inspired so many of us, such a brilliant mind and a kind human Apart from rewriting our fundamental understanding of cell identity, his love for science is equally legendary

Discovery and protein language model-guided design of hyperactive transposases - @marcguellc.bsky.social @upf.edu @icreacommunity.bsky.social @crg.eu go.nature.com/4gXLGEw

So sad to hear the news - John truly was an inspiration to so many, and one of a kind. www.cam.ac.uk/research/new...

Very sad news, John Gurdon has died. A developmental biologist's developmental biologist, Nobel prize winner His work is the foundation of much of today's dev & stem cell bio. An inspiration to many, including me. Always asking questions & wanting the answers www.magd.cam.ac.uk/news/profess...

⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work. 🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab

We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...

Latent plasticity of the human pancreas across development, health, and disease. https://www.biorxiv.org/content/10.1101/2025.10.01.679230v1

Latent plasticity of the human pancreas across development, health, and disease. https://www.biorxiv.org/content/10.1101/2025.10.01.679230v1

Latent plasticity of the human pancreas across development, health, and disease. #SingleCell 🧪🧬🖥️ https://www.biorxiv.org/content/10.1101/2025.10.01.679230v1

Ghrelin and relamorelin alleviate hypoglycaemia in humanised mice with congenital hyperinsulinism https://www.biorxiv.org/content/10.1101/2025.10.02.680116v1

Ghrelin and relamorelin alleviate hypoglycaemia in humanised mice with congenital hyperinsulinism https://www.biorxiv.org/content/10.1101/2025.10.02.680116v1

Finally .. incredible much awaited wok on deriving avian naive ESCs “Derivation of embryonic stem cells across avian species” www.nature.com/articles/s41...

Another record month for bioRxiv - and further evidence the pandemic spike+dip was just that and growth continues. Thanks to all involved and that includes 🫵

We published a detailed protocol for our Plate-CUT&Tag method on @protocolsio.bsky.social to accompany our recent preprint (www.biorxiv.org/content/10.1...) give it a try! Feedback welcome! dx.doi.org/10.17504/protocols.io.n2bvjed5wgk5/v1

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Collectively, we report species-specific differences in protein production and degradation rates and provide *in vivo evidence* that degradative machineries are less active in human embryos than in mice. Finally, we establish a causal role for protein degradation on dev. tempo. 👇👇

We've updated our first #preprint from the lab! A collaboration with @jamesbriscoe.bsky.social 🔥 now including in vivo 🐭&👤 embryo data www.biorxiv.org/content/10.1...

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

Our paper is finally out in Molecular Cell! 🚀 We uncover why PAM-relaxed Cas9 variants like SpRY are inefficient — they get kinetically trapped during target engagement. Mechanistic insights like this are key to engineering smarter, faster genome editors. Huge thanks to the team! #CRISPR #editing🔬🧬

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...

Comprehensive biologic characterization of a 117-year old supercentenarian, the world's oldest living person www.cell.com/cell-reports...

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

EMBL scientists found metabolism controls embryonic development tempo through signalling in a way separate from its established metabolic function. More research related to this signalling could illuminate how it guides cell fate, developmental timing -- even disease. www.embl.org/news/science...