When that mass spectrometry data gives Patrick vibes ... (so sorry in advance, couldn't resist)

@jasonderks.bsky.social is presenting at iSCMS! Come by this Saturday afternoon around 2pm to hear his talk: "Increasing proteomics throughput by multiplexing in the mass and time domains". singlecellms.org?page_id=442

don't release preprints without a Methods section don't release preprints with a Supplementary Materials section don't release preprints without data don't release preprints without code use preprint servers to share your science, not advertisements

Lazy Sunday (or manic Monday depending on when you look) question to proteomics skywalkers: does/can fragpipe make mzID files for a full PRIDE dataset? Surely, right, but all I see are pep.xml.

Join us for the guest lecture of Prof. Olga Vitek olgavitek.bsky.social, leading computational mass spec expert, for cutting-edge Stats & AI insights on Sep 24, 10am, in person or zoom. Registration: ucdavis.zoom.us/meeting/regi... #Metabolomics #AI #Massspectrometry @mikelangelipid.bsky.social

I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level: Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging elifesciences.org/articles/96892

😎 I love seeing these new, creative approaches to metalloproteomics! A new frontier. 🧪

Really cool talk by @nmriley.bsky.social on glyco mass spec just now at the @cecamevents.bsky.social meeting on glycans in Cagliari. Check out his group’s cool work here: www.riley-research.com/research

There’s a route that our drug molecules can take after dosing that we haven’t been paying enough attention to. Many might not even realize it exists;

New paper in @ScienceMagazine with Schoof & Porse labs: We chart early human hematopoiesis using single-cell proteomics, and amongst others developed a dynamic model linking RNA to protein levels, explaining more proteomic variation. 📄 www.science.org/doi/10.1126/...

Probabilistic scoring of DIA matches without spectral deconvolution? Not only is it possible, we're working on implementing it in Mascot DIA. www.matrixscience.com/blog/probabi... #proteomics #massspec

Our recent ADP-ribosylation study is now online. many #HDL proteins circulate in ribosylated forms, accumulating in plaques. This work opens a new field in dyslipidemia research! #TeamMassSpec @ahajournals.bsky.social www.ahajournals.org/doi/10.1161/...

Do you or your lab use the Skyline software for #MassSpectrometry #proteomics? I'm looking for instructors to help with this year's Skyline Online, a virtual workshop/crash-course for all things Skyline! I'm especially looking for early career researchers for this opportunity. Please DM!

What determines the human gut fungal community? @emilyvansyoc.bsky.social @erdavenport.bsky.social @symbionticism.bsky.social &co present the first #GWAS of human genetic loci that influence the abundance of gut #fungi, linking these to disease risk #mycobiome @plosbiology.org 🧪 plos.io/42bCKou

Celebrating Al Burlingame's 41 years of the @asbmb.bsky.social Molecular and Cellular Proteomics meeting which he started before "proteomics" was a term. Congrats Al!

In praise of the strangeness of scientific research, which these days I think could use a few good words said for it:

🧪 Very nice feature!

Big day for @neuroproteome.bsky.social All proteomic data released at neuroproteome.org and publications in print. Lots to read on AD, PD, FTD and ALS.

Moving forward to a new era: just loaded our first single cell samples from a demo on the CellenONE using Arabidopsis protoplasts. Very curious to see the results! #proteomics #singlecellproteomics #plantscience #corefacility

📣 We're excited to share the new lean-lang.org! Relaunching our website was a key deliverable in our Year 2 roadmap to provide "improved navigation and access to valuable content, resources, and tools." We hope you like it! #LeanLang #LeanProver

We are excited to share that our Director of Proteomics Research, Dr. Sasha Singh, will be speaking at #FOGBoston at the end of this month! Registration is free for over 90% of attendees, so don't miss out! Reserve your spot at hubs.la/Q03cHRdb0. #genomics #biodata

E11 Bio is launching Volara: an open-source Python library for block-wise processing of large volumetric microscopy datasets! 🧪🔬 Volara features block-wise task abstractions, making scalable image processing more accessible, robust, and repeatable. Read more: e11.bio/blog/volara

The hits keep on coming from @parallelsq.bsky.social! Today we released an exciting use-case for plexDIA in single cell analysis of #alzheimer's disease, characterizing dysregulation of the 20S proteasome. #TeamMassSpec #Proteomics www.biorxiv.org/content/10.1...

🧪 Transforming biomedical discovery needs proteomics that is specific and accurate, but also faster and cheaper @parallelsq.bsky.social is proud to introduce 9-plex PSMtags: a new mass tag that improves sequencing and increases throughput in sensitive proteomics 👇 www.biorxiv.org/content/10.1...

Booking for the @ukbspr.bsky.social post-conference single-cell proteomics workshop is now open! Numbers are capped at 20 participants, so please register early to avoid disappointment. payments.liv.ac.uk/conferences-... If the system tells you it is at capacity, please drop me an email.

Is anyone aware of an exhaustive list of all human histone PTMs identified? Something like CST’s, except (1) continuously updated and (2) describing the actual modification (e.g. ‘symmetric dimethylation’, instead of ‘methylation’)… #epigenetics #biochemisty 🧬🧪

🧪💙📚 my bad on the emjois for books and science

Want to speak out on behalf of science and rational thought. Here's a great "cheat sheet" and "how to" to share with your community, friends, colleagues. Local is powerful. Speaking out is important. sciencehomecoming.com

Single cell proteomics at UofL Proteomics Technology Center. Another tool for dissecting proteomes in disease and biolgy.

🤔 Ever wondered how proteomics thrives in (bio)pharma🚀? How you could provide impact in industry with proteomics background earned in academia? Please join me and @drawheatcraft.bsky.social for Sunday morning US HUPO 2025 short course 👇

I’m finding a lot of proteins in my blood proteomics work that have no known secretion pathway. Proteins like histone subunits, parts of the nuclear pore complex, and proteosome subunits. Does anyone know how these get into the blood stream? It has to be cell turnover, right?

A problem articulate by one of my favorite science writers, Derek Lowe. I think #proteomics scientists may contribute a great solution, too: www.science.org/content/blog...

Had to finish this for @jakeyeston.bsky.social #ChemSky

This was a ton of fun to write with @ypriverol.bsky.social and all of the other authors 👏 Our goal was to share a vision of #OSS #proteomics for us to build toward, and propose some ways to get there 🚀 I’m blown away by how many folks contributed and how much it evolved beyond just my voice 🙌

A new, exciting lab for #proteomics!

On BlueSky, I've been exposed to a much broader range of scientists. Enjoying the people and the platform so far! 🧪

Individual grants of up to $1m from AI for Math Fund by Renaissance Philanthropy. Very cool 🧪 renaissancephilanthropy.org/initiatives/...

An enjoyable read for anyone working with isotopes #ChemSky #Proteomics #TeamMassSpec www.nature.com/articles/nch...

Volunteering for the ASMS Mock Interviews always reassures me that the #TeamMassSpec future is bright!

Towards a future where brain circuits are understood. Get excited! 🧪 🧠

Sci-sky help: do non-sessile animals w radial symmetry swim in helical paths ie do their bodies always rotate as they swim?

Astrophysics has Dark Matter, Proteomics has the Dark Proteome ... and it is a little more recognized now! 🧪 www.science.org/content/arti...

Chromatography is such a fun and tangible science topic! 🧪

I took biochem in 2001, and for nearly 20 years read amino acid sequences daily… and I never knew Dayhoff named them or even the logic behind things like Q until last Friday (h/t Mike Janech). Also, this is another big Dayhoff moment for me. She was incredible! #proteomics #bioinformatics

🔎 Want to see how fast a molecule can make a biological system break down specific proteins? 🧪 #proteomics Colleagues at the Krijgsveld Lab do: www.cell.com/cell-chemica...

‘I am afraid that there will be little tangible left in a later age to remind our heirs that we were men, rather than cogs in a machine.’ - John Pierce, Bell Labs researcher A poignant thought for those trying to create the next Bell Labs. 🧪

Helen Shen profiled Elisabeth Bik, the scientific image sleuth 🧪 www.nature.com/articles/d41...

This scientific question by Ben Neely received a lot of engagement! Glad to see the #proteomics community on this platform. 🧪

Quantifying proteins from archived tissue continues to improve. #proteomics www.biorxiv.org/content/10.1...

Levity and understanding in acapellascience's music video 🧪 www.youtube.com/watch?v=f8FA...