Jason Derks
@jasonderks.bsky.social
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Increasing throughput of proteomics
@parallelsq.bsky
.social
reposted by
Jason Derks
Harrison Specht
4 months ago
A bit dense, but the important message is dead simple: We got to cite the E = mc² paper! Kidding :) The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed. Here's how:
www.biorxiv.org/content/10.1...
#TeamMassSpec
#Proteomics
🧪
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How to design 1000-plex mass tags using the differential mass defect
Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. These chemically-identical "mass tags" conjugate to peptides to encode sample...
https://www.biorxiv.org/content/10.1101/2025.10.22.679607v1
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reposted by
Jason Derks
🎶Jaaane says... 🎶 🇨🇦
9 months ago
The hits keep on coming from
@parallelsq.bsky.social
! Today we released an exciting use-case for plexDIA in single cell analysis of
#alzheimer's
disease, characterizing dysregulation of the 20S proteasome.
#TeamMassSpec
#Proteomics
www.biorxiv.org/content/10.1...
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Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
Alzheimer's disease (AD) is a relentlessly progressive, fatal neurodegenerative disorder associated with widespread aberrant proteomic changes. The full extent of protein dysfunctions in AD and their ...
https://www.biorxiv.org/content/10.1101/2025.05.29.656728v1
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Members of PTI have developed mass tags which improve spectral quality and enable 9-plexDIA in a project lead by
@harrisons.bsky.social
add a skeleton here at some point
9 months ago
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We are excited to introduce ‘time’ as a new domain for proteomics multiplexing! It enables: -Label-free multiplexing -Combinatorial multiplexing with plexDIA Using combined 9-plexDIA and 3-timePlex we demonstrate 27-plex DIA 🚀
9 months ago
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