Act fast, the end of the rainbow is at the East Somerville T stop.

Happy lazy #Caturday from Cassie and Minnie Pearl on the rainy lounge....

May I add "A mass of Spectrometrists"?

Ditto

My summer cat crop is coming along nicely! #CatsofBluesky

Building a diverse and collaborative community Making proteomics more accessible, scalable and powerful youtu.be/VTF6m5RviPE?...

We're doing #ToeBeanTues now?! Minnie Pearl is all in! @darthbluesky.bsky.social

America - With all due respect, we’ll pass on becoming your 51st state. #cdnpoli

Another rainy #caturday?!? Just let me sleep.....

It's hurricane season. Own a real flashlight.

🟦 Label-free single-cell proteomics (blue bars). 🟧 Multiplexed single-cell proteomics affords higher throughput (orange bars). ⬛️ Proteome depth & quantitative accuracy are comparable. We aim to make the 🟧 bars taller. www.parallelsq.org/psmtags www.biorxiv.org/content/10.1...

The hits keep on coming from @parallelsq.bsky.social! Today we released an exciting use-case for plexDIA in single cell analysis of #alzheimer's disease, characterizing dysregulation of the 20S proteasome. #TeamMassSpec #Proteomics www.biorxiv.org/content/10.1...

🧪 Transforming biomedical discovery needs proteomics that is specific and accurate, but also faster and cheaper @parallelsq.bsky.social is proud to introduce 9-plex PSMtags: a new mass tag that improves sequencing and increases throughput in sensitive proteomics 👇 www.biorxiv.org/content/10.1...

We are excited to introduce ‘time’ as a new domain for proteomics multiplexing! It enables: -Label-free multiplexing -Combinatorial multiplexing with plexDIA Using combined 9-plexDIA and 3-timePlex we demonstrate 27-plex DIA 🚀

We're up to some amazing things here at @parallelsq.bsky.social! Read our latest, get in touch! Let's do some science! #TeamMassSpec #Proteomics

Amazing amount of progress made advancing high throughput proteomics in such a short time from the team at @parallelsq.bsky.social 🚀

Increasing throughput in mass spec proteomics requires new ways to model the increased complexity of the spectra. We are delighted to share JMod, our new open source software developed at @parallelsq.bsky.social , which enables new multiplexing approaches. 1/7 www.biorxiv.org/content/10.1...

Almost intentionally, looks like all of the new Thermo instrument pages are up (Astral Zoom, Excedion Pro, Optispray). Overall vibes? Excedion is the bigger upgrade, almost 2x faster and can now do ETD. Astral Zoom improvements are more incremental. No change to instrument sensitivity specs.

....and the data analysis program to sift through all these data! www.biorxiv.org/content/10.1...

We've also been working on multiplexing with time offsets www.biorxiv.org/content/10.1...

So excited to share our novel mass tags for multiplexing DIAa s DDA data acquisition in BioRxiv www.biorxiv.org/content/10.1...

Happy #Caturday from my favorite calico kitty Minnie Pearl

As we get ready for the British Society for Proteome Research annual meeting in Liverpool (July 7-9th), we will start highlighting our amazing speakers. First is @slavov-n.bsky.social who will talk to us about Biological and technological frontiers for single-cell proteomics.

We are looking forward to our symposium next Tuesday.

Protein samples can be multiplexed to increase throughput. In 2023, PTI set out to make tags (barcodes) that not only increase throughput but also enhance peptide sequence identifications: pubs.acs.org/doi/10.1021/... We will share results soon: www.parallelsq.org/workshops-an...

Happy #Caturday from the princess herself, Miss Cassie #CatsOfBluesky #RescueCats

So I walked past a car with a bumper sticker that said "I hope something good happens to you today" and then minutes later I walk into Porter Sq station and am greeted by the great #KeytarBear! #MBTA #Camberville

So excited to share the really cool work we're doing at PTI and celebrate our 2nd birthday at the same time! Come join us!!!

Good morning Bluesky, happy #Caturday from Minnie Pearl and Cassie! #FurBabies #CatsIfBlueSky

Check out the latest substack from our non-profit parent research umbrella! After 25yrs in biotech, working for an FRO has been an amazing experience in a challenging problem solving environment! #MassSpec #Proteomics

Beware the Ides of March and blue eyed monsters having their 6th birthday today! #CatsOfBluesky #Caturday

Ok, this is a crazy ass new halftime act! #celtics #NBAsky ☘️🏀☘️🏀☘️☘️

FuckinA JB!!☘️☘️☘️🏀

....and THIS is why I love #Somerville! 😜😅 From the police blotter: "Monday, March 3 11:51 a.m. — Police responded to a report of a past breaking and entering on Warrick Street. A party reported that a man broke the lock off a door of a home under construction and began caulking."

Woooo! Goooooal

WHO ATE MY YOGURT!? IT HAD MY NAME ON IT YOU SAVAGES!

@zefrenchkornet.bsky.social ohmagod! Luke got the "words before the game" ❤️🏀☘️🏀❤️

@numb.comfortab.ly Merry Catsmas from Miss Cassie and Minnie Pearl!

Minnie Pearl is making a rare social media appearance to wish Merry Catsmas too!

Cassie wishes everyone a Merry Catsmas and hopes you find joy today

Happy #caturday! Cassie is still a bit confused on how to wrap presents but I'm sure she'll get the hang of it soon ....

One proteome to rule them all? We have published a tool to create custom protein databases from large panels of genotypes in @naturemethods.bsky.social. Check the post below to see why it matters, why you should use it, and how it will make your life both easier and more difficult.

Ja WHAAAT?!?!

Picked up the tree last night! Not sure which is the higher danger: fire or feline...

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

Prioritized mass spec data acquisition increases proteomic data completeness & coverage depth. The increase is largest for the most challenging proteins. When using TMTpro, data completeness reaches 93% for all proteins across multiple sets. nature.com/articles/s41...

Payton fucking Pritchard!!

Santa Jaaaane (Jaaanta?) has a lot of work ahead of her....