Excited to share one of the first papers to link #lncRNA #structure to its function in #cancer! We mapped the structure of a tumor-suppressive DRAIC lncRNA and identified a 36-nucleotide hairpin as necessary and sufficient for its #anti-oncogenic function. www.sciencedirect.com/science/arti...

It’s interesting how an offside project can bring so much value. Working on ORCs gave me new experiences, deeper insights into #DNAreplication, and some of the most fun I have had giving talks. #Orc #LOTR Read more in @elife.bsky.social Version of Record: elifesciences.org/articles/102...

Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically connecting ‘cell surface RNA biology’ to cancer biology @natbiotech.nature.com www.nature.com/articles/s41...

🎉 Incredibly proud to share my first-author paper in @nature.com! Heartfelt thanks to my mentor @andrzejdziembowski.bsky.social and the brilliant team at DziembowskiLab at @iimcb.bsky.social. More details in the 🧵below ⬇️

🌐Our @nature.com paper is out! Researchers from IIMCB and other Polish institutions show how TENT5A boosts mRNA vaccine efficacy by stabilizing therapeutic mRNAs and enhancing antigen production. A step toward better therapies for cancer and beyond! 🧬 👉Read the story: bit.ly/3XYvQkI #Nature #mRNA

Urgently reposting! University leadership need to actively check the SEVIS database every day (studyinthestates.dhs.gov/sevis-help-hub). Ask your chair to commit to it. Yesterday, UW discovered 9 visa cancellations & only found out b/c they ran a status check. www.seattletimes.com/seattle-news...

A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA. Enables ‘watching’ of RNP assemblies inside living cells Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com www.nature.com/articles/s41...

Congratulations to all authors, especially Natalia! Great work! #ninetails #nanopore #polyA #mRNA #vaccines

This is crazy shit. Here is early work on a very promising mRNA vaccine against pancreatic cancer. Is cancer treatment anti-American now? 🧪 www.nature.com/articles/s41...

Have you wondered what the @elife.bsky.social peer-review process looks like? Feel free to see our responses to the reviewer comments on our manuscript "DNA replication in primary hepatocytes without the six-subunit #ORC". I enjoyed the process and highly recommend it!

One of the many, many “pauses” and cancellations devastating our next generation of researchers. “The NIH Intramural Program has paused the recruitment of IRTAs, CRTAs, and Visiting Fellows in all training programs pending guidance from Health and Human Services. Check back daily for updates.”

This is an exciting piece of research that brings us closer to an informed choice of therapy for individual patients. I am grateful to my PI and all collaborators for letting me learn how to start a translational project and how far it can reach. Thanks to UVA Engineering for highlighting our work!

#Rstats trick: use case_when(). I use it almost every week. No more nested if else gist.github.com/crazyhottom...

New university housing for graduate students #snowday #snowweek #work-life-integration

Happy to close 2024 with my last first-author publication from PhD thesis: "DNA replication in primary hepatocytes without the six-subunit #ORC" in @elife.bsky.social. This study challenges existing paradigms in #DNAreplication. 🧵(1/4) elifesciences.org/reviewed-pre...

Thrilled to share my first-author postdoc paper, "Patient-derived response estimates from zero-passage organoids of luminal breast cancer," just published in Breast Cancer Research! This project brings us closer to personalized treatments for #BreastCancer patients. 🧵(1/5)

Feeling so hopeful for 2025 after an amazing close to 2024! Grateful for a wonderful family vacation to recharge and thrilled to have two first-author papers published as a late birthday surprise on the very last day of the year. Wishing everyone a happy and fulfilling new year!

Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs. bioart.niaid.nih.gov

Another beautiful example of #lncRNA #structure-function study from Dutta lab at UAB. Grateful to add a small puzzle piece to this work. Congratulations Xiaoxiao and all involved!

A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-kB and tumor cell phenotypes https://www.biorxiv.org/content/10.1101/2024.12.23.629241v1

Many academics point to bioRxiv as “the one thing improving science publishing”. If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2

Our recent preprint about using a custom chromatin capture assay, to identify potential target genes for cancer risk variants. For several variants, the target gene for cis regulation was ~ +/- 1Mb away, and we experimentally confirmed this for multiple targets. www.medrxiv.org/content/10.1...

We often hear that nutrition needs are dynamic over your life, that some things are more important as kids (calcium), that there are super foods. If you are like me, these concepts can seem a bit vague. This new @pnas.org paper is a great resource. 🧵 🧪 #PEDSky #MEDSky www.pnas.org/doi/full/10....

"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles" www.biorxiv.org/content/10.1...

Following @daylab.bsky.social’s nice paper on eRNA regulating Fos, and then our paper showing eRNA mediated regulation of NR4A2, here’s yet another eRNA controlling NPAS4. LncRNAs for the win in the brain! www.science.org/doi/10.1126/...

Hello Bluesky 🤠 Our very first post is about our recent paper in Nucleic Acids Research: so-called PUN motifs are repetitive elements enabling proteins to catalyze #RNA folding and RNA-dependent #condensate formation ( #LLPS). 15% of human proteins contain 3 or more PUN motifs. See bit.ly/4fZ3f54.

Are you a senior PhD student or postdoc? Do you have a cool science story to tell? Do you want to visit Buffalo when the weather is perfect? Then apply for the Emerging Leaders Seminar Series at Roswell Park! DM or email me with questions. (RT please!) www.roswellpark.org/education/pr...

If you ever wondered why #SystemsBiology, this movie is for you! Prepared by Sarah Groves from Janes lab at UVA BME and SASCO Center. youtu.be/rmuj1cyIn44?... WHAT is systems biology? WHY do we need systems approaches in cancer? HOW do systems approaches get used in the clinic today?

Cool new work from Jenn Prescher and coworkers @ucirvine.bsky.social, “RNA lantern” technology for bioluminescence imaging of RNA transcripts www.nature.com/articles/s41...

An update on our Dept faculty search. We had 165 applications and after reviewing, we discussed the top 30. 12 were selected for Zoom interviews, and then we discussed and selected 5 for in person interviews which start soon. For those still interviewing, Zoom questions are attached. Good luck!

MirGeneDB 3.0 is published. Great teamwork and substantial improvement of database, Taxon sampling and we took over nomenclature of novel genes and families, too academic.oup.com/nar/advance-...

🧬 Excited to share our new preprint! DMS chemical mapping, a key technique for studying RNA structure. Everyone assumes low DMS reactivity = Watson-Crick , high = non-WC. However, analyzing 7,500 RNA structures containing known 3D structures reveals it's not that simple. doi.org/10.1101/2024...

Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025

sunburn is from ribosomes stalled by UV damage to RNA? super cool www.sciencedirect.com/science/arti...

Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis https://www.biorxiv.org/content/10.1101/2024.11.26.625435v1

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation! www.science.org/doi/10.1126/...

How to write a grant? 1. The application is for the reviewer, not you, the applicant. 2. Communicate in stories. 3. Make your story cohesive—leave no puzzling gaps. 4. Make your story resonate to keep the reviewer reading. 5. Accept chance and noise in peer-review. www.pnas.org/doi/epub/10....

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

Take a look at this amazing work of @camthevirusguy.bsky.social from Janes lab at UVA BME. This is what I call the scientific advance! Congratulations 🎉👏 www.science.org/doi/10.1126/...

Hi! 👋 I'm new here 👋 I recently defended my PhD and I'm loved in #RNA structures in vivo 🫶 Very excited to share my two articles at NAR (results of my PhD)! 1📎 academic.oup.com/nar/article/... 2📎 academic.oup.com/nar/article/... The first #RNAstructure of Ty1 and Ty3 LTR #retrotransposon genomes!

All packed and ready for the Cold Spring Harbor Laboratory Scientific #Writing Retreat! Excited to dive into grants and beyond starting tomorrow. It's my first time visiting @cshlaboratory.bsky.social and @cshlbanbury.bsky.social—any recommendations for must-see spots or hidden gems?

⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...

Let's make a thread of RNA-related conferences in 2025 🧵 (add missing!)

Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...

We have a very basic starter pack!! If you work on 3D biology and organoids broadly defined and want to be included, leave a comment below go.bsky.app/QeDg2YD

🔬🧫 🧬 Are you looking for an opportunity to set up your own laboratory focused on RNA or cell biology in an inspiring environment surrounded by like-minded researchers? The IIMCB in Warsaw is offering an excellent opportunity www.rnasociety.org/junior-group... www.iimcb.gov.pl/en/ #CellBiology #RNA

Small RNA Biology starter pack, with a heavy bias towards our worm community! Just getting this started, and we'd like it to max out, so please message me if I've missed you (and apologies!)! go.bsky.app/HgPCPen

🇵🇱 Today, we celebrate Poland's Independence Day! In honor of this special occasion, let's recognize the incredible contributions of Polish scientists. While Marie Curie-Skłodowska is a shining star, there are many more to admire! 🧵 #PolishIndependenceDay #Science #Poland