Playing around with how to represent volume in #Snouty light sheet data. Here is a dividing hiPSC with endogenously tagged histone in all three orthogonal projections. Bluer is further away. If anything, it distracts from politics.

🍀🔬 MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap @natcomms.nature.com from Toyota lab. www.nature.com/articles/s41...

Giotto Suite provides a comprehensive, flexible and scalable platform for technology-agnostic spatial omics analysis using R. @rndries.bsky.social www.nature.com/articles/s41...

SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N

My group at Science has been running a big campaign to engineer new channelrhodopsins. Excited to share the first results from it today: a suite of highly sensitive new opsins. We call them "WAChRs". Everyday indoor office lighting is enough to activate them pretty strongly.

A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2

Ant reproduction is getting weirder and weirder. Here’s the latest: queens of a Mediterranean harvester ant mate with males from a different species and then lay eggs that clonally inherit those males’ genome. I.e., they lay eggs that develop into a different species. 🤯

I’ve already highlighted this landmark #lipidtime paper by @nadlerlab.bsky.social & colleagues, but ICYMI, do read André’s thread — this study is a huge leap forward in understanding the logic of intracellular lipid flux & is a phenomenal example of #chembio probes 🤝 quantitative imaging 🤝 modeling!

Nice! A song about one of my favorite fluorescent proteins! mStayGold!

It's reassuring to know that letting your beverages dry out in your workplace coffee mugs and turning them into disgusting gobs of sticky goo is an ancient and time-honored practice. www.smithsonianmag.com/smart-news/s...

Beyond Static Screens: A High-Throughput Pooled Imaging CRISPR Platform for Dynamic Phenotype Discovery by Kees Jalink and team: www.biorxiv.org/content/10.1...

Biggest real problem Europe has is that after a certain career age, it’s Advanced or bust for many people. And there’s VERY few ERC advanced grants (way lower number than R01s). This creates a huge problem for recruitment, especially from outside, which is supposedly what they’re trying to improve.

Cool idea that stems from integrating learnings from animal behaviorists with leading edge vaccine technology 👏

Production has started for a new #Snoutscope objective, AMS-AGY v3. It has significantly larger FOV and some other tweaks from v1 and v2. Currently accepting pre-orders. The price will need to increase modestly after deliveries start late October.

Attempts by law enforcement & governments to subvert end-to-end encryption are ongoing. The European Commission will spend a year thinking about their new "Roadmap for law enforcement access to data" & they are (genuinely) asking for people to join an expert group to help: berthub.eu/articles/pos...

Speak up to prevent a major loss for the field. CASP, which helped shaping structural biology including AlphaFold is on the verge of shutting down. NIH funding has lapsed, UC Davis support ends and the core team is being let go. Painfully shortsighted.

Anyone know of service providers who can do shallow shotgun sequencing for 1000s of samples at a low cost per sample? We want to use shotgun sequencing to screen 1000s of samples so we want the cost per sample to be as low as possible and do not need that much data per sample (~100 Mb or so).

Episode 8 - CellProfiler does a lot, but could it do EVEN MORE? Hop on in to let @erinweisbart.bsky.social tell you all about CellProfiler plugins - where to find them, how to use them, and how they can add the Power Of Deep Learning to your local copy of CellProfiler!

FlyBase needs our help.

Definitely worth the 5 minutes to watch. Succinct summation of what is being thrown away

Quantitative comparison of fluorescent proteins using protein nanocages in live cells, from @microtubule.bsky.social pubmed.ncbi.nlm.nih.gov/40326462/

🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸‍♀️. Try it now on 🤗 huggingface.co/spaces/mouse... paper: www.biorxiv.org/content/10.1... w/ @computingnature.bsky.social 1/n

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Non-model Bioeng Custom Lab Hardware Turn Key Genetic Design Please repost for reach 💚

We get data *from* the WHO. Without this, we're flying blind with data regarding evolution of infectious agents globally, putting us behind if we need to develop vaccines & treatments, just for one aspect. This puts the whole country at risk.

Learn about the periodic ER organization along neurites in insects and vertebrates and its potential role in long-range Ca2+ signal integration www.sciencedirect.com/science/arti... by the fabulous @lorenabenedetti.bsky.social and friends.

Highlighting our recent paper on how we think doublecortin (green) contributes to growth cone biomechanics in developing neurons for #FluorescenceFriday www.cell.com/current-biol...

BREAKING NEWS: A powerful 7.0 earthquake has struck off the northern California coast. A tsunami warning has been issued. The tsunami warning stretches hundreds of miles from the Bay Area of California north into central Oregon.

High-resolution template matching of the human ribosome in situ by Lippincott-Schwartz Lab @hhmijanelia.bsky.social @hhmi.bsky.social. >40 conformations within together reveal molecular dynamics of the elongation cycle with previously unknown bending and “spring-like” motion.

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

A video we made at @mbarinews.bsky.social explaining some functions of #fluorescence in the ocean, and how #bioluminescence is different… but related. 🦑🧪🌊 m.youtube.com/watch?v=whbe...

WHO TO FOLLOW Find folks you like and follow who "they" follow, but Bluesky also has Starter packs to help people you invite avoid feeling like they arrived too early to a party. You can search over 6k starter pack from the link, but make your own later to help invite your friends later! #AMIA2024

#ExM has transformed how we perceive the microbial diversity all around us. Some gorgeous critters from the @EMBLHeidelberg pond - DNA red, centrin yellow, tubulin gray, images by @fmikus.bsky.social Bonus points if you identify at least 4! Want more? www.biorxiv.org/content/10.1... #PlanExM

My turn to create a starter pack for scientists using live imaging in their research! Of course, I’ve likely missed many—please let me know who else I should include. Thanks! go.bsky.app/KYYr7xc #liveimaging #livevellimaging #microscopy

Here's a starter pack that focuses on engineers/builders/makers/enablers of optical tools for (cell) biology. I'm pretty sure that the pack is incomplete - if you want to join the list, please reply with your favorite probe (that you made or used) and I'll add you 🤓 go.bsky.app/2YVvYER

Starter Pack: Collective #CellMigration /Dynamics is growing. Looking at related emergent phenomena eg. #intercallation, dorsal closure or branching #morphogenesis? Reach out! Also modelers, soft-matter physicists & YOUNG scientists etc etc! go.bsky.app/DLUDYX3 #cellbio #SoftMatterPhysics #science

Is basic science undervalued? David Glanzman (UCLA) talks about the decline of 'middle class' labs and that "there is no empirical evidence that the translational approach accomplishes this [cures] any better than the traditional one. Claims to the contrary at this point are mere propaganda."

Introducing the Goga Lab @ctbatucsf.bsky.social @ucsfcancer.bsky.social We study aggressive breast and liver cancers and mechanisms of oncogene signaling that lead to metastasis. Our works spans various areas including metabolism, cell cycle and spatial organization of tumors. oncogenes.net

Ottman Tertuliano and I are looking for a postdoc to work on optogenetics & mechanobiology! Email me at [email protected] if you or someone you know is interested! https://www.med.upenn.edu/orl/boerckellab/