Jon Daniels
@jsdaniel02.bsky.social
📤 445
📥 535
📝 45
Scientific instrument developer, focused on
#lightsheet
and other
#microscopy
🔬 at ASI
If you are at
#CellBio2025
stop by and say hello at booth 1101
about 12 hours ago
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Great to see the ASI single-objective light sheet used for long-term imaging of tumor cells to study the transition between single-cell and multi-cellular spheroids:
www.biorxiv.org/content/10.1...
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Cells dynamically adapt their nuclear volumes and proliferation rates during single to multicellular transitions
Tumour development and progression are associated with biophysical alterations that manifest across multiple spatial scales, from the subcellular to multicellular tissue scale. While cells can dynamic...
https://www.biorxiv.org/content/10.1101/2025.10.04.679984v1
about 1 month ago
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Production has started for a new
#Snoutscope
objective, AMS-AGY v3. It has significantly larger FOV and some other tweaks from v1 and v2. Currently accepting pre-orders. The price will need to increase modestly after deliveries start late October.
5 months ago
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I'm excited to be able to be in Zurich for the mesoSPIM symposium. This is a really fantastic project.
add a skeleton here at some point
7 months ago
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Most high-NA air objective lenses are coverslip-corrected but sometimes you want to image in air, e.g. high-NA SOLS. We have glued coverslips onto objectives for this. To make sure it gets glued properly we take image stack of diffraction-limited beads supported on a coverslip. 🧵
9 months ago
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Interested in getting imaging data like this? ASI is commercializing single-objective light sheet microscopes and might make one like DaXi if there are people who would buy it. DaXi originally developed by
@loicaroyer.bsky.social
and Bin Yang.
vimeo.com/801341925
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Zebrafish embryo development acquired on the DaXi light-sheet microscope
Volumetric imaging of zebrafish embryo development acquired on the DaXi light-sheet microscope. Imaging volume is 1200 μm * 800 μm * 300 μm acquired every…
https://vimeo.com/801341925
about 1 year ago
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