Have you ever wondered if @lastweektonight.com gets overwhelmed by the sheer number of stories they could cover that happen during their break?

Shit of Damocles

A new article from @kashhill.bsky.social introduces an additional twist to the evolving relationships people are forming with LLMs (ie. AI boyfriends and girlfriends). However, I believe the underlying theme of this story is Ayrin’s apparent addiction to “new relationships energy”.

Following investigations into toxicity deaths, the Montana medical board has revoked Dr. Thomas Weiner's license. Findings confirm the oncologist treated patients with chemotherapy despite the absence of malignant disease. @propublica.org did some excellent reporting on Dr. Weiner below. #MedSky

Rare footage of St Paul’s Cathedral testing its giant flamethrower

I’ve already seen this movie before…

Sometimes we need to reflect on painful things and fully acknowledge what we’ve lost, not just to mourn, but to anchor ourselves in order to find our way back. This is a deeply humanizing read worth your time.

2025 LLM Year in Review by Andrej Karpathy karpathy.bearblog.dev/year-in-revi...

This is so sad, infuriating, and entirely predictable. Internal data reveals the Office for Civil Rights has not reached a single resolution in racial harassment cases involving Black students under the current administration, leaving over 1,000 investigations stalled or unmonitored.

I see a story like this and suspect an underlying thread that these actions are being taken on behalf of someone with limited to little time left on this mortal coil. Do I have any evidence? No, but I can’t help but wonder, aside from trying to avoid the courts, why the rush?

End of year reminder: the TRIPOD+AI reporting guideline is reporting standard for all clinical prediction model studies, including those using machine learning and AI. --> www.bmj.com/content/385/...

Recent data from arXiv and bioRxiv reveals that while LLMs significantly boost paper output, particularly for non-native English speakers, the correlation between complex writing and scientific merit has begun to invert. #AcademicSky

The Government Added a Comments Section to the Epstein Photo Dump www.404media.co/the-governme...

🧪 Adolescence is a pivotal stage for brain development. New data suggests that dog ownership helps teenagers navigate this period by fostering a gut microbiome that naturally lowers aggression and encourages social confidence. The cat couldn't be bothered to comment on the study. #MedSky #PedSky

@melanieatc.bsky.social turned in final grade yesterday (5 classes, 3 labs, and 233 students 😵‍💫) Now she is in baking mode. I had to do quality testing… they are delicious as always!

Cool work I missed using #LLMs for a scoping review on use of #SDOH in #mentalHealth research. mental.jmir.org/2025/1/e67192

Surprisingly rapid & high Ai adoption by doctors: 67% use it daily, 84% says it makes them better doctors, 42% says it makes them want to stay in medicine more (10% said less). A lot of the use cases appear to be administrative and research assistance. 2025-physicians-ai-report.offcall.com

U.S. AG Pam Bondi dismissed fraud charges against Dr. Kirk Moore for falsifying vaccine cards. The move signals a shift toward 'medical freedom' over public health laws, emboldening others to seek pardons for similar cases. #MedSky

Research in Nature Medicine shows AI models can detect liver cirrhosis from a standard ECG. This ubiquitous, low-cost tool doubled detection rates for advanced disease, providing a scalable path for early intervention. #MedSky #MLSky

Google’s vibe-coding tool Opal comes to Gemini techcrunch.com/2025/12/17/g...

Columbia and Harvard researchers find that apolitical creators are three times more persuasive than political pundits. Trust and parasocial bonds allow these influencers to shift policy preferences with unique efficacy.

We are getting a strong windstorm here in Missoula, but Washington is getting insane winds!

We’ve pushed out the Pareto frontier of efficiency vs. intelligence again. With Gemini 3 Flash ⚡️, we are seeing reasoning capabilities previously reserved for our largest models. This opens up entirely new categories of near real-time applications that require complex thought. More in thread ⬇️

Bluesky folks came up with a fundamentally new and privacy-protecting method of doing this unlike every other service. Almost every negative response is based on how people assume Bluesky is doing this based on how bad everyone else does it. Bad actors have so poisoned the entire market...

🚨NEW publication: "Beyond DeepSeek: China's Diverse Open-Weight AI Ecosystem and Its Policy Implications" How can we understand China's open LLM ecosystem one year after DeepSeek? Our Stanford team finds a rich and varied set of actors and policy implications. hai.stanford.edu/policy/beyon... 1/

Firms are leveraging debt to stockpile crypto, a strategy driven by regulatory easing. The line between corporate speculation and investment is vanishing. People are enticed by the crypto millionaires and billionaires, but fail to see the wreckage along the way.

Smartwatch bio-monitoring allowed parents to intervene in tantrums within four seconds. This preemptive approach reduced episode duration by over 50% (22 min -> 10 min), indicating a potential role for AI in managing pediatric behavioral crises. #MedSky #PedSky #MLSky

🧪 Year in Review for Computer Science: an undergraduate solved a 40-year hash table conjecture, and new proofs linked algorithmic time and space. Troublingly, training AI on sloppy code was found to trigger malevolent behavior. #MLSky

🧪 Reviewing a year in biology reveals memory in brainless cells and a 540 million year carbon cycle. New insights map the complex neurons behind touch and distinguish the molecular complexity of brains from AI.

The AI novelty is fading as grand promises clash with the reality of current tools. A necessary "hype correction" phase is underway. So, sad to report, that robot maid you saw online isn't going to be changing your car oil for you by this summer. #MLSky

🧪 Privacy laws complicate global health research. Synthetic data and federated networks solve this by mimicking real stats or keeping data local. These tools enable secure evidence generation across borders. #MedAI #MedSky #SyntheticData

Current economic studies fail to capture the rapid ripple effects of AI. Researchers must instead blend data with "social science fiction" and pilot programs. Proactive modeling is essential to guide policy effectively as society adapts. #MLSky

Fasting enhances breast cancer therapy in mice by triggering glucocorticoid signaling to suppress tumors. Targeted drugs might replicate this benefit, offering a way to improve treatment without strict dietary limits. #MedSky

🧪 Over half of researchers now use AI for peer review, often violating confidentiality protocols. As third-party tools risk data security, publishers are moving toward closed internal systems to safely integrate AI assistance. #AcademicSky #PeerReview

Dean @meganranney.bsky.social joined CNN the day after mass shootings at Brown University and Bondi Beach to discuss the long-term mental and physical health impact of these events. Dean Ranney is an emergency physician and firearm injury prevention researcher and spent 20 years at Brown.

🧪 @mariaa.bsky.social gets a nice spotlight in this video, where she briefly discusses #AIEthics, #Data, and where we should actually focus our trust versus where we might initially be inclined to place it. #MLSky

My top 10 books for 2025

🤝 AMIA is community. Hear from Susan Hull, MSN, RN, NI-BC, NEA-BC, FAMIA, on what AMIA membership means to her. Join or renew today: amia.org/its-amia-me-... #HealthInformatics #Community

A case report links a stroke and blood pressure of 254/150 mmHg to a regular habit of eight energy drinks per day. Cumulative toxicity from caffeine and guarana drove the crisis. Halting the habit of drinking so many energy drinks normalized pressure, yet neurological deficits remained. #MedSky 🛟

Workplace AI adoption has reached 45%, led by the tech and finance sectors. While weekly usage is climbing, daily integration remains low at 10%. Chatbots currently serve as the primary utility for the majority of these users. #MLSky

🧪 2025 biomedical highlights include customized CRISPR therapies, pig-to-human transplants, and data linking shingles vaccines to reduced dementia risk. Also notable is the value of treating male partners for bacterial vaginosis. #MedSky 🛟

🧪 Nature Medicine highlights eleven trials shaping 2026, including a potential century-first TB vaccine. Other key studies target pancreatic cancer via RAS inhibitors and rare diseases through stem cells. #MedSky 🛟

A new study finds removing race from breast cancer prediction models worsens calibration. The change underestimates risk for Black women and overestimates it for Asian women, potentially limiting access to supplemental screening. #MedSky #MLSky #Cancer

🧪 NIH plans to cap open-access fees have drawn 900+ comments. Critics warn the $2,000 to $6,000 limits may block access to top journals, creating equity issues for junior scientists unable to cover the difference. #AcademicSky

🧪 Seismic shifts hit US science in 2025 via mass firings and grant cuts. Officials argue this restores trust, but critics see an ideological purge. Former NIH director Elias Zerhouni warns of losing a generation of researchers. #AcademicSky

🧪 The best science images of 2025 — Nature’s picks www.nature.com/articles/d41...

Driving up to Kalispell this morning for a #LegoFirstLeauge scrimmage. Got to catch the sunrise over the lake.

My dog was so confused by tonight’s episode #pluribus

Holy cow, talk about a show! You’ll want to check out the set list.