The link to our paper: dlvr.it/TP5gK5

Also thanks to Zachary Sebo and Navdeep Chandel for writing a preview to our work as well as a complementary study from Thomas MacVicar's lab www.cell.com/molecular-ce...

The cover depicts a GWAS Manhattan plot as a city skyline reflected onto a New York City-style subway metabolic map: organelles as boroughs, metabolites as stations, transporters as trains.

Happy to see our recent work on SLC25A45 featured on the cover of @cp-cellmetabolism.bsky.social . Huge thanks to @yuyangliu.bsky.social for the design! @KivancBirsoy @rockefeller.edu

Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...

Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!

Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell! We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals! www.sciencedirect.com/science/arti...

Worst week for science EVER. Sunday: ASM scrubs DEI mentions from website. Tue: NASA scrubs DEI from website; ICE arrests a student on campus; NSF plans to cut staff; USAID halted. Wed: HHMI kills diversity program; NIH trashes applications for diversity F grants. Fri: NIH cuts indirects.

This will kill science in the US. This is how China wins. Why is this not on the news? Why are people not more upset about this? grants.nih.gov/grants/guide...

A Primer on Indirect Cost Rates

We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎 Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...

Registration and abstract submissions are open for the Third Annual SoCal Metabolism Symposium at USC. Go to gero.usc.edu/event/third-... The abstract and early bird price deadlines are Feb 28th

Fresh new paper alert 🚨 by @marcellharhai.bsky.social @jourdainlab.bsky.social et al. expanding the inventory of potential #mitodisease genes and a herculean deep-dive into FAM136A across models and human disease! 🧪🧫🐭👂 Really happy to see it out and to have played a small part 🔬 #mito #sciencesky

Really enjoyed writing this spotlight highlighting recent works from @keunwooryu.bsky.social at al in the Thompson lab along with @lyssiotislab.bsky.social and Yatrik Shah! Mitochondria heterogeneity FTW! --- Link below to the spotlight and the original @nature.com articles in the reference👇

ONLINE NOW! Subcellular mitochondrial heterogeneity enables opposing metabolic demands, by @brandontwchen.bsky.social, Yatrik Shah and @lyssiotislab.bsky.social, discussing the recent work by @keunwooryu.bsky.social et al. Read it for free until March 19th at: authors.elsevier.com/a/1kWLq3jDgW...

I got home from lab and immediately called and wrote to my representative and senators. I urge you to do the same.

I decided to be more efficient in my doomscrolling & made my first starter-pack!😅 These are folks that IMO have been great sources of reliable info during the federal communication ban. Please 1) tell me if you want to be taken off, and 2) give suggestions for others to add go.bsky.app/KZnq7Qe

I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.

All NIH/NSF awards may be paused as of today. Money is disbursed annually, so if you have your money, you're OK for a while. My next R35 grant year starts Apr 1. I hope Trump doesn't read my X/bsky feeds that say he's a racist, a rapist, a cheat, & a traitor. www.washingtonpost.com/business/202...

From a source inside the National Cancer Institute: “Everyone is scrambling to figure out how we’re supposed to work to serve the public when we can’t engage at all.”

Academic workers across the country are organizing to call on our congressional representatives on Thursday, 1/30, at 3pm ET / 12pm PT to demand these restrictions be lifted immediately. There will be a training over zoom at the beginning of the event. Join us! form.jotform.com/250226137228...

Reiterating my call to fellow federally-funded scientists: Call your reps, tell them how this hurts science and everything good that comes from science (Also non-scientists, and scientists without federal funding! But the more of us who can directly speak to the impacts of these freezes the better)

I'm one of these 11,965, and with funding from the NIH and NSF, I've been able to recruit several more full-time employees to MI (many coming from other states!) since 2023. @repdingell.bsky.social, please advocate for us in science, health, and research to continue supporting the michigan economy

Crazy that I defended on Friday! Really appreciate everything I learned from Yatrik and @lyssiotislab.bsky.social over the years! Can't ask for better mentors, labs, colleagues, friends, and support over the years! Next step, postdoc with Kivanc Birsoy at Rockefeller University !🧿🗽

The end of an era. @brandontwchen.bsky.social brought us kicking & screaming into cell biology, and what an exciting journey it’s been. We are so very proud of everything he’s accomplished! Join us 1/17 for his defense. Thereafter… watch out NYC, here he comes!!

hahahahahahaha

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

Come with me as I troubleshoot this very high GC PCR toward clonable homology arms in an actinobacteria. Testing DMSO, Betaine 1M, and Propylene Glycol to see if we get amplification. Arms are 1000bp. Full length with arms and gene is 2800bp. Let's go! 🧵 1/n

Excited for some cool science at #CellBio2024 this year! Come by my poster (Sun. Dec 15, 1.30-3pm Board B136) and stay for my talk (Sun. Dec 15, 4 pm Rm 33B) where I'll tell you about our work on a lysosomal mechanism for membrane protein degradation!

If you are attending #ASCB2024, check out this suite of Shah/Lyssiotis Lab presentations! @brandontwchen.bsky.social

Are you going to #ASCB2024 @ascbiology.bsky.social? Excited to be co-chairing a session on Organelle Biogenesis, Turnover, & Quality Control with @labfriedman.bsky.social on Monday, 12/16. We have a fantastic line up of speakers - see you there!

Looking forward to returning to #CellBio2024 and present our updated work on metabolic regulation of ER-mito contact sites! Excited to meet new fiends and re-connect with my fav colleagues! link to preprint: www.biorxiv.org/content/10.1...

Amazing course for someone who really wants to dive into the fascinating world of quantitative light imaging 🤩

We are so excited that @janfunkey.bsky.social has agreed to give the keynote seminar for @qiatcshl.bsky.social 2025 @cshlnews.bsky.social! 🔬🖥️ 🛤️ Applications due 1/31/2025. t.co/x87ngy34UC

Is BluSky ready for this much Mo? This group of Dudes is serious about Mo’s and about raising awareness for men’s mental health and cancer research 👨🏻💪🏼 #Movember @ja-nietocarrion.bsky.social

Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!

You can now watch the I2K video tutorial on #micro-sam by @anwaiarchit.bsky.social on YouTube: www.youtube.com/watch?v=dxjU... Check it out for an in-depth explanation for how to use our tool to segment your microscopy images.

Are you going to #CellBio2024? Be sure to check out my session Sunday morning about the future of metabolism, featuring talks from trainees (grad & postdoc) and early career faculty!

🧪Dear Grad student, Are you overdue for a thesis committee meeting but feel like you have nothing to show since your last meeting? I'm begging you to schedule that meeting now! 1/🧵

A tragically failed staining for #FluorescenceFriday, but a fun opportunity to play with @kwolbachia.bsky.social awesome LUTs! Can anyone recognize the structures in this bouquet? 💐 #SciSky #AcademicSky #FluorescentFriday 🔬 🧪 🐡 🦑

🚨For the lucky colleagues attending #CellBio2024 in San Diego, check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! A fantastic lineup covering the latest across the field. See you there! **Please RT** 🥳 t.co/6eq3cyGlVZ

The amount of concurrent science writing (grants, articles, reviews, dissertation) I'm doing right now at the end of grad school is kind of insane, but I'm kinda loving it. WEIRDDD

I’m excited to share new work out of the lab in Nature Metabolism today on the impact of tumor-relevant glucose concentrations on the response to pyrimidine synthesis inhibitors. t.co/9hOGW4x97T. PDF: rdcu.be/d1vkV

Getting some pretty IF images done with @mruckert.bsky.social on the @leicamicrosystems.bsky.social Stellaris before Thanksgiving break 🤩🍂

Hello, BlueSky Universe! I'm Sonya Neal, an Associate professor at UC San Diego and HHMI Freeman Hrabowski Scholar. Proudly First-Gen, Black in STEM and passionate about paying it forward. In my people-first lab, we are driven to explore the most understudied membrane proteins

How to write a grant? 1. The application is for the reviewer, not you, the applicant. 2. Communicate in stories. 3. Make your story cohesive—leave no puzzling gaps. 4. Make your story resonate to keep the reviewer reading. 5. Accept chance and noise in peer-review. www.pnas.org/doi/epub/10....

Hello Bluesky community! Since I’m new here, I wanted to introduce myself! I am a neonatologist and scientist studying mitochondria, peroxisomes, and metabolism (currently a postdoc in @rjdlab.bsky.social). A short thread of some work I have done:

Building out an eclectic mix of #nutrition, food and #metabolism folks here ⬇️ bsky.app/profile/did:...