In a recent Nature paper, @djcalebc.bsky.social et al. explore how PIKfyve regulates lysosomal lipid recycling in PDAC. This opens up a therapeutic window: co-inhibition of PIKfyve and the KRAS–MAPK pathway leads to synthetic lethality & tumor regression. View it here >>> nature.com/articles/s41...

more from last week www.nature.com/articles/s41...

My team and I are at #AACR25 and have posters to discuss parts of the project (and some future directions) tomorrow! Rüya Pakkan will present on Tuesday AM Abstract #4158 Sec 13 board 8. I will present on Tuesday PM #5384 Sec 12 board 12. Come visit!

Thanks @bryantkl.bsky.social for the shoutout!! Look forward to seeing your future work including target PIKfyve as well as RAS in PDAC 💪

Thanks for this writeup and for highlighting our work!!

🔥Smoking hot new paper and tweetorial from @djcalebc.bsky.social (collab with Chinnaiyan Lab)! 🔥 We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼

Excited to be part of this #AACR25 (@theaacr.bsky.social @rickbuck.bsky.social) Social Media Ambassadorship!! Look out for updates on the #Tumor-microenvironment ( #TME )-relevant events and highlights. I’ll be posting from Sunday afternoon to midday Wednesday 😎

Thank you for the highlight!!

Thanks for the highlight!!!

Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!

Congrats to @djcalebc.bsky.social and @lyssiotislab.bsky.social for this awesome work🤩 www.nature.com/articles/s41...

Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell! We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals! www.sciencedirect.com/science/arti...

Excited for this!

An incredible tour de force in biochemistry and cell biology by superstar @robzonculab.bsky.social lab postdoc @aakritijain.bsky.social LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells. www.science.org/doi/10.1126/...

Short but very fun visit to UNC Chapel Hill! Definitely one of the most beautiful college campuses.

Yesterday, the House passed an FY25 budget bill that slashes funding to the Pancreatic Cancer Research Program by 57%. Research for pancreatic cancer is already woefully underfunded, and now the only program exclusively funding pancreatic cancer research is one step closer to devastating cuts.

A beautiful thesis defense from Narges Pourmandi for CMB, Michigan Medicine. Back to the hospital next week to complete her medical training ❤️🙌🏼🩺 We are so proud of her many accomplishments! @YatrikShahLab