Poorly performing antibodies have plagued biomedical sciences for decades. This article explores alternatives, hoping for specific protein binders: The antibodies don’t work! The race to rid labs of molecules that ruin experiments www.nature.com/articles/d41...

Benchmarking Software for DDA-PASEF Immunopeptidomics www.sciencedirect.co... --- #proteomics #prot-paper

Holy fuck, am I reading this correctly? Are they going to do a single-blind RCT (i.e., some babies will get placebo instead of HepB vax and their parents won't know)??? This seems insanely unethical, like Tuskegee levels of unethical public-inspection.federalregister.gov/2025-23245.pdf

🚨 What if evolution is the ”law”… and networks are the machines that do the work? In this paper (just published) I try to formalize how living systems are non-equilibrium, information-processing, adaptive matter. With a great biological flavor! 🧪🌐🌍🧬🦠 👉 iopscience.iop.org/article/10.1... 🧵 1/

This week is World #AntimicrobialResistance Awareness week This article collection spans the breadth of #AMR across pathogens (bacteria, viruses, fungi, parasites), covers epidemiological monitoring, diagnostics, treatment, etc

Affinity has been my favorite design software for awhile now. Now that its free is even better!

New paper from the @klingmuelab.bsky.social & Timmer labs out in @cp-cellsystems.bsky.social: #Diclofenac & #acetaminophen unexpectedly shape #IL-6 and #hepcidin signaling in #liver cells. 🔗 doi.org/10.1016/j.ce... 👇 Thread with key findings

msBayesImpute: A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data www.biorxiv.org/cont... --- #proteomics #prot-preprint

My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology: www.ebi.ac.uk/training/onl... Including both molecular and epidemiological examples

1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by ‪@walterwchen.bsky.social‬ and a dream team of collaborators, as explained below. www.nature.com/articles/s41...

SynchroSep-MS: Parallel LC Separations for Multiplexed Proteomics pubs.acs.org/doi/10.... --- #proteomics #prot-paper

Our work on new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr) is out in @natcellbio.nature.com! Equal collab w/Tony Rodrigues (Jorge Azevedo lab), @dwendscheck.bsky.social (Bettina Warscheid lab) www.nature.com/articles/s41...

🥳🥳🥳 Congratulations to everyone involved and in particular to @dwendscheck.bsky.social! I am soooo happy to see that this story is online now and that I could contribute to it ❤️

📈 Last week I had the chance to present my project on the influence of #interferon on antigen processing by the proteasome at the 2nd #Heidelberg Interferon Symposium! 🦠🧬🧫 1/3

PXD051501 🚨 Pex39 facilitates peroxisomal import of PTS2 proteins – ScPex18 AP-MS data 🚨 New dataset alert! 🚨

Great first day at the #IFNSymposiumHD, with BBQ dinner, drinks and especially: great people and discussions 😊 Now looking forward to the second day, which will be kicked off by @meganstanifer.bsky.social shortly!

Let's leave behind simplistic & naive notions. .

📣Attention please! 🦠🧫🧬Interferon researcher in and around Heidelberg are kindly welcome to register for the 2nd Interferon at DKFZ symposium in July! 📜Submit your abstract until tomorrow here: indico.dkfz.de/event/1320/

A unified pan-cancer proteome atlas www.cell.com/cancer-... --- #proteomics #prot-paper

@miquai.bsky.social and Robert Hazen explore a bold new law of nature: complexity steadily rises - not just in biology, but in everything from rocks to life. A fascinating weekend read. Thoughts welcome. #Science #Biology #Evolution #LawsOfNature #FunctionalInformation #ResearchSky #WeekendReads

Start your day right with 1,184,046 error messages 😂

More evidence for the role of protein degradation in significantly shaping the proteome of brain tissue!

There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation.

Love today’s #xkcd comic on #MassSpec 🤣

The antiviral cytokine interferon is thought to act through the induction of hundreds of genes. In this #PLOSBiology Perspective, @jschoggins.bsky.social highlights recent findings that instead suggest distinct viruses are targeted by small subsets of the induced gene repertoire. 🧪 plos.io/4m7hOYi

Second Heidelberg Interferons Symposium coming up!! If you are based in HD or Mannheim (@dkfz.bsky.social, @uniheidelberg.bsky.social, @hlsalliance.bsky.social, @embl.org,...) and interested in any facet of these incredible #cytokines, join us on 🗓️ July 10/11 🏫 Marsilius Kolleg ✍🏻 bit.ly/IFN2025

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

💫 Great Symposium ahead! If you are interested in Interferons, come and join 🥳

Applications with short and medium term payoff are fruitful and needed. They are easier to understand, especially by non experts. The benefits of basic research are harder to understand. Understanding & appreciation require more expertise and longer term perspective.

ibaqpy: A scalable #Python package for baseline quantification in proteomics leveraging #SDRF metadata www.sciencedirect.com/science/arti.... We continue our effort to provide tools and algorithms that leverage SDRF metadata to perform quantitative proteomics analysis.

DDM (n-dodecyl β-D-maltoside). This seems too good to be true?! It's giving us a huge boost in hydrophobic peptide signal.

For establishing a new collaboration and to explore the role of #interferon on the #immunopeptidome in #hepatoma Julian Beyrle (Tenzer Lab, HI-TRON in Mainz) and I received a collaborative research grant from @dkfz.bsky.social! Many thanks to selection committee for believing in this project 💙

To all of my #teamMassSpec folks, The „proteomics“ wikipedia article reads like a relict. Maybe a few of us should put some effort to update it 🤔 en.m.wikipedia.org/wiki/Proteom...

Looking for a handy list of #OpenAccess journals and publishers in the biological/biomedical and computational biology space? Want to follow journals sharing scientific content without restrictions or paywalls? Well look no further go.bsky.app/5WRrHpw

🧵 STATEMENT: WHO expresses deep concern on the implications of the immediate funding pause for #HIV programmes in low- and middle-income countries. These programmes provide access to life-saving HIV therapy to more than 30 million people worldwide. Read more bit.ly/42yxxIz 1/5

I hate it when polls are represented as a fixed number without any information about the spread of the error! Not about the actual poll results (although they are shocking enough), but can we take a second to appreciate that „Spiegel online“ finally started to show individual polls as datapoints!

More and more DKFZ scientists are joining Bluesky! Here is a starter pack with the intention to connect us 💙

Look who's here @pnas.org ✔️ @science.org ✔️ @naturecellbiology.bsky.social ✔️ @natrevgenet.bsky.social ✔️ @naturebiotech.bsky.social ✔️ @naturemicrobiol.bsky.social ✔️ @naturechemistry.bsky.social ✔️ @genesdev.bsky.social ✔️ @cellchembiol.bsky.social ✔️ @genomeresearch.bsky.social ✔️ @jcellbiol.bsky.social ✔️

Hello DKFZ people! I hope this list will grow and help all new bluesky members from our institute to find each other here ☺️ go.bsky.app/V64sJYM

Hello DKFZ people! I hope this list will grow and help all new bluesky members from our institute to find each other here ☺️ go.bsky.app/V64sJYM

Hope I'm the first to post this all time classic on this platform

📣To all the people from @dkfz.bsky.social (DKFZ Heidelberg): I could only find a few of us here on bluesky 🦋 but I would to make a starter pack. Can you help me find the rest of us? @mphartmann.bsky.social @milsommick.bsky.social @thebinderlab.bsky.social @dblipka.bsky.social

Few quick notes for new followers 🦋 Please add some bio ✍️ before starting to follow. I still have time to go through new followers and skip those without bio just as a precaution. If you add it later, I (and others) may not return to follow back and I would hate to miss out on great scientists👩‍🔬🧑‍🔬!

⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...

Any #proteasome or #immunoproteasome people here already? A side project developed towards proteasomal degradation and I could use some review/paper recommendations as well as names of labs that are leading the field 🙏🤗

When are all the journals migrating to 🦋? I was using twitter a lot to find new publications and it would be great if I could also do it here

📣 Intro post: I am a PhD working on type-I interferons and hepatitis B virus infections at DKFZ Heidelberg. The Klingmüller lab, I am part of, is developing hypothesis driven mathematical models for several cytokines and and I am working on how to integrate proteomics data for this purpose.

@alejandrobrenes.bsky.social your Starter Pack really got some people here 😁 Thats amazing 😻

#teamMassSpec here is a starting pack in case you just moved over, or in case you've been absent for a while. This is #proteomics or #massspec related. The pack is not comprehensive but it's a start. go.bsky.app/HH7kqEh