Science is not truth. Science is finding the truth. When science changes its opinion, it didn't lie to you. It learned more.

Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

No, DeepMind has not solved the protein folding problem. #Alphafold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination.

Integrated structural biology at its best with fantastic talks in cryo-EM, NMR, and X-ray techniques Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'

Jane Richardson was born #OTD in 1941 + Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures) + MacArthur Fellow, 1985 + Elected, Nat'l Academy of Sciences, 1991 + President, Biophysical Society, 2012 #WomenInSTEM

Biochemist/molecular biologist Joan Steitz was born #OTD in 1941. She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM

Have no fear if you weren't in the packed audience this week for @martinpacesa.bsky.social's awesome seminar, because you can check out the recording 👇 youtu.be/qQihl6If9vU

Huge congratulations @nboyd.bsky.social with Mosaic that absolutely killed in the competition! 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕2 did also pretty well with the second highest hit rate in the competition! proteinbase.com/collections/...

Excellent overview of the (mind-blowing) effects of the Shingles vaccine against dementia by @erictopol.bsky.social Ground Truth 🧪 "Two new studies add to a remarkable body of evidence for benefit" ⬇️ open.substack.com/pub/erictopo...

"If Covid was a fire alarm, our response, incredibly, has been to rip out the wiring. Instead of correcting the underbuilt public health systems that allowed thousands to die in the dark, we are choosing to institutionalize blindness." 👇 www.statnews.com/2026/01/18/t... via @statnews.com

Published in Cell, a new study shows that the immune system’s reaction to the common Epstein-Barr virus can ultimately damage the brain and contribute to multiple sclerosis, from a team @ki.se www.cell.com/cell/fulltex...

3 papers on EBV and MS Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis Anoctamin-2 (ANO2) is targeted by T cells in approximately 57% of persons with MS www.cell.com/cell/fu... 1/6

'But what if IAVs could use a different receptor? Our previous work revealed that the IAV subtypes H17N10 and H18N11, which have so far been detected exclusively in bats, use MHC-II molecules as entry receptors instead of the conventional sialic acid receptors'

Open #postdoc fellowship in my group. Virus replication and cryo-ET. Projects can be tailored to ambitious candidates with diverse backgrounds, so don't hold back from applying! DM for more info. Deadline 8 Feb. Apply here: umustipendie.varbi.com/en/what:job/... #virus #virology #teamtomo #cryoEM

Wanting to do some paleovirology of your own? We recently published HI-FEVER, enabling users to run their own fast searches for endogenous viral elements. Huge thanks to @humanceae.bsky.social, @emma-harding.bsky.social, José Gabriel and Cormac. @biology.ox.ac.uk academic.oup.com/bioinformati...

Here's a summary of all the data that supports adding more red meat to your diet

Given everything happening right now, I updated this article with options for weather apps, web forms, and translation services — along with some tweaks to existing categories. I hope it helps your transition off US tech!

New @science.org today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging) @bloodgenes.bsky.social @kharaslab.bsky.social science.org/doi/10.1126/...

The EMDB wishes you a very Merry Christmas, a Happy New Year and we are delighted to share our jointly designed EMDB/PDBe Christmas card with you. It has been a busy year, we look forward to seeing you in the New Year here! Card: A mixture of #cryoEM and X-ray diffraction structures.

Seven feel-good science stories to restore your faith in 2025 www.nature.com/articles/d41...

Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD? Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool! 👉 www.molgen.mpg.de/5094682/Fuey...

The decision by the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention to downgrade its recommendations to protect infants from hepatitis B is a dangerous move that will harm children. Click here to read AAP's full statement: bit.ly/3Y9ZQJT

Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...

Special kudos to @thomasbourgeron.bsky.social and authors for writing up the ⭐ FAQ section ⭐ accessible to general audience 👏 👏 For those interested, the FAQs are in the Supplement to their article, section 8 (page 59), downloadable via the link already posted. An example of a question addressed 👇

#4/5 This work has been made possible thanks to the participants and to the help of the Autism Representative (A Reps) from @AIMS 2 Trials 🙏. A FAQ 📋 has been added to explain the main results of the paper. Follow us on @aims2trials.bsky.social and @r2d2mh.bsky.social MH for more information 🗣️!

#5/5 Find out more here: www.medrxiv.org/content/10.1... Declan Murphy, Eva Loth, @tonycharman.bsky.social, @vw1 @mathisfleury.bsky.social @zmougin.bsky.social @pasteur.fr @upcite.bsky.social @gisautismetnd.bsky.social

#1/5 Our new study is out in medRxiv. It is a major collaborative effort that brought together researchers and experts by experience from across Europe, including psychologists 🧠, psychiatrists 👩‍⚕️, geneticists 🧬, neuroscientists 🔬, and, importantly, autistic people 🌈, relatives 👪 and caregivers 🤝.

Interesting! I have been teaching the multiple origins of viruses since 1983, I will point out...😁 www.the-scientist.com/where-do-vir...

In fact, I even have a useful illustration, from The Good Book.

Each such discovery is a game changer for our understanding of eukaryote evolution, and this paper is no exception. Meet Solarion, which displays yet again novel types of subcellular structures. Congrats to all authors on a fascinating story. #protistsonsky www.nature.com/articles/s41...

Frikkin amazing stuff.

Incubation times. This is the time between getting infected and developing symptoms of an infectious disease. Typically this is measured in days, sometimes weeks. It seems something technical. Why would understanding this matter to you? 1/9

Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine. If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again. #sciencematters

"If you are eligible for vaccination, please don’t wait." www.ecdc.europa.eu/en/news-even...

🧪For anyone interested in EBV in autoimmunity, I strongly urge you to read this incredible study by @shady-myounis.bsky.social, Bill Robinson, and @tobiaslanz.bsky.social. It is not only a scientific tour de force, it has a deeply provocative discussion that everyone in the field should consider 1/

נגיף הEBV (מחלת הנשיקה) נקשר לאחרונה להתפתחות טרשת נפוצה ועכשיו גם לזאבת👇🏼 מתי יהיה חיסון?

Remind us @nytimes.com, who is it that is ruining the workplace? www.thecrimson.com/article/2025...

And here we have our Fourier transform nr. 58! As far as I'm concerned, perhaps the most enigmatic and unexpected spectrum so far... anyway, quite a spectacle! #BraggYourPattern #Fouriertransform #crystallography As always, more on behance.net/specialdefects and instagram.com/specialdefects

New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development. www.science.org/doi/10.1126/... @unmc.bsky.social @uwbiochem.bsky.social

my friend and wonderful colleague Stan is hiring at Genentech in South San Francisco! 🧬 🌉 Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility www.linkedin.com/posts/stanis...

5 raisons de suivre la formation « HIV Sciences » www.fun-mooc.fr/fr/actualite... @pasteuredu.bsky.social

Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.

about PAE #alphafold PAE viewer pae-viewer.uni-goettingen.de PAE Figure editor thecodingbiologist.com/tools/pae.html

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

Visualizing influenza A virus assembly by in situ cryo-electron tomography www.nature.com/articles/s41...

Scientists have designed an interleukin-21 mimic with increased stability and capacity to induce more potent antitumor activity than the native protein, which could inform improved #immunotherapies. Learn more in #ScienceImmunology: https://scim.ag/47jQLSW

Current mood

🚨 new paper alert 🚨 Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: bit.ly/47s7btG.

Wow! we didn’t expect this kind of response! 🚀 Huge amount of papers were uploaded in the past two hours, and our servers are feeling it, so we’ve temporarily reinstated a waitlist. We’ll gradually let everyone in, don’t worry. Thank you for the incredible enthusiasm and support!