New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development. www.science.org/doi/10.1126/... @unmc.bsky.social @uwbiochem.bsky.social

my friend and wonderful colleague Stan is hiring at Genentech in South San Francisco! 🧬 🌉 Biochemist/structural biologist looking for your first position in industry? I can’t recommend working with Stan enough ☺️ please repost for visibility www.linkedin.com/posts/stanis...

5 raisons de suivre la formation « HIV Sciences » www.fun-mooc.fr/fr/actualite... @pasteuredu.bsky.social

Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.

about PAE #alphafold PAE viewer pae-viewer.uni-goettingen.de PAE Figure editor thecodingbiologist.com/tools/pae.html

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

Visualizing influenza A virus assembly by in situ cryo-electron tomography www.nature.com/articles/s41...

Scientists have designed an interleukin-21 mimic with increased stability and capacity to induce more potent antitumor activity than the native protein, which could inform improved #immunotherapies. Learn more in #ScienceImmunology: https://scim.ag/47jQLSW

Current mood

🚨 new paper alert 🚨 Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: bit.ly/47s7btG.

Wow! we didn’t expect this kind of response! 🚀 Huge amount of papers were uploaded in the past two hours, and our servers are feeling it, so we’ve temporarily reinstated a waitlist. We’ll gradually let everyone in, don’t worry. Thank you for the incredible enthusiasm and support!

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

New findings from @salehlabparis.bsky.social

Thank you, Carl. This is badly needed.

AMAZING and wonderful news. I can think of few scientists more deserving of this honor. Congratulations to Jason and all the colleagues who have helped with his incredibly impactful work!

I don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:

A Chemistry Nobel that many had anticipated: metal-organic frameworks! Writeup coming on the blog later this morning:

#nobelprize #womeniSTEM #womeninscience 😊

A new Nature Medicine study analyzing health records from >100 million people in the US offers compelling evidence that reactivation of varicella-zoster virus (VZV) ,the same virus that causes chickenpox and shingles may contribute to dementia risk. www.nature.com/articles/s41...

Again, this shows the importance of vaccination to protect against, in this case, an old infection that can reawaken. bsky.app/profile/mar... 6/6

We discovered an endogenous retrovirus that's still spreading in natural D. melanogaster populations! It was horizontally transferred from D. erecta in Central Africa, so we named it "Kuruka", which means "jump" in Swahili. Read its cool story here: www.biorxiv.org/content/10.1...

Elaborate machinery for inserting proteins into the outer membrane of bacteria www.nature.com/articles/d41...

We can't wait to welcome you at the #IBSBC2026 in Brussels next year! Make your mark now by submitting your nomination for the Bertini Award - with €15,000 prize money and presentation at the conference, recognise an outstanding achievement in structural biology - instruct-eric.org/submit-call/...

🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry. Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, [email protected], PPU-EID @upcite.bsky.social & more 🧬 Register now ✍️ www.pasteur.fr/en/education...

Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...

for more lulz www.tylervigen.com/spurious-cor...

Have to repost with an Extended materials figure, that will make all cryo-EM folks dream :)

Ben Vollmer and Kay Grunewald & team @cssbhamburg.bsky.social and the beautiful structure along important insights for herpesvirus entry and membrane fusion.

Ben Vollmer and Kay Grunewald & team @cssbhamburg.bsky.social and the beautiful structure along important insights for herpesvirus entry and membrane fusion.

Talk about 'species'. This is fascinating!

As we already know from social media, mis- and disinformation comes from a very small group of people that i just picked up and amplified through halfknowledge. Vaccines are no different, yet more important as a topic. www.nytimes.com/interactive/...

Toxorynchites (elephant 🦟) are cool, but not the most…scalable intervention for little container habitat breeders (like Aedes, which transmit chik). (Similarly, predatory fish are way better at targeting species that develop in large bodies of water.) A tox larvae on the hunt from my porch last year

Please RT! Call for Fellows! If you’re a structural biologist and wanting to start your lab by applying for an external Fellowship then we at Imperial may be excited to host you. Synthetic biologists too.. Please submit expression of interest with details below 🙏 www.imperial.ac.uk/media/imperi...

New preprint: In situ Architecture of #Plasmodesmata. Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores. 🔗 doi.org/10.1101/2025... 🧪🧵1/n #teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM

Happy birthday Rosalind Franklin (1920 –1958), #chemist & x-ray crystallographer whose x-ray diffraction images were instrumental to discovering double-helix structure of DNA, made important contributions to carbon & virus research, was 1 of the great scientists of the 20th century.⁠ 🧪🐡👩🏼‍🔬 #histsci 🧵

HOW COOL IS THIS? Researchers have developed a DENTAL FLOSS that can DELIVER vaccines THROUGH the gums, a method that could one day offer a NEEDLE-FREE alternative for vaccination. This approach effectively stimulated immunity AND provided FULL protection against a lethal strain of influenza. 🧪🧵⬇️

Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction Scientists have just designed a nanobody that breaks the blood-brain barrier, reaches the brain receptors and activates a glutamate receptor to correct schizophrenia cognitive deficits. www.nature.com/articles/s41...

That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv! biorxiv.org/content/10.110

We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org. pubs.acs.org/doi/10.1021/... @xdh.bsky.social @hangryhobbit.bsky.social

“I think it’s very different in their minds, who is getting the D.E.I. stuff,” Mr. Dillard said. “People on the right, they don’t realize they’re limiting the opportunity of their own kids by supporting this.” www.nytimes.com/2025/07/10/u...

See? There's money! What would be great, instead, is to increase the budget for the existing schemes, though 🧪

Made an attempt at generating a video of protein unfolding with #veo3 😹

Molecular cat tweezers? 😺

How metamorphic proteins change conformation. 😸

Alright, last one, now I need to get back to real work... 😸

Finally out! Mass spec analysis of #trypanosome flagellar tubulins reveals some surprises including a new #glutamylation site on beta-tubulin! Many thanks to the teams of Julia Chamot-Rooke and Mariette Matondo! pubs.acs.org/doi/10.1021/...

In situ insights into antibody-mediated neutralization of a pre-fusion Junin virus glycoprotein complex: Cell Reports www.cell.com/cell-reports...