Applications for our training course, 'Bioinformatics for immunologists' are open until 15 March 2026: www.ebi.ac.uk/training/eve... Travel grants and fee waivers are available for this essential bioinformatics training course. 🧬🖥️📊🎗️

I’ve recorded ~8h explaining the architectures of AlphaFold, AF2 & AF3, as well as the context needed to understand their development, applications and limitations :) youtu.be/_jDRr5BcTaY Slides drive.google.com/file/d/1i4QE... English is available only via auto-translated subtitles

How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...

Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎 Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕 Please share widely- love to hear your feedback!

📢 #BSCSeminar: “Guiding directed evolution of enzymes”. 🗣️ Rocio Espada, University of Buenos Aires 📆 04 February ➡️ bsc.es/4JB #EquityinBSC #WomeninBSC @sommalliance.bsky.social

🚀 InterPro 108.0 is live! ✨ Updated to Pfam 38.1 and NCBIFam 18.0 ✨ 1,911 InterPro entries Explore the latest annotations and discover new protein insights. Explore it now: www.ebi.ac.uk/interpro/

On World NTD Day, we are highlighting innovative approaches to fighting NTDs. A recent paper from Swiss TPH shows the potential repurposing of tuberculosis drug candidates to fight Buruli ulcer, a chronic skin disease caused by M. ulcerans. 👉Read more: bit.ly/47WdrXA

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...

⚕️Tomorrow is #WorldNTDDay🌐2026, and Chagas Coalition will be supporting it through a webinar with our colleagues from PAHO & @dndi.org. It's about data management related to these 21 neglected diseases ✍️ paho-org.zoom.us/webinar/regi... On January 30, let's #BeatNTDs & call for #UniteActEliminate

PhD position in my team at @pasteur.fr ! The selected canddiate will work on the development of new methods combining biophysicial and machine learning modelling for single-cell multi-omics spatiotemporal data. emploi.cnrs.fr/Offres/Docto...

Should an iconic #bacterial #chassis be renamed without community consensus? Our @mbio.bsky.social #article vindicates the established identity of #Pseudomonas putida KT2440 & argues for continuity, community practice & common sense in naming · @vdlorenzo.bsky.social journals.asm.org/doi/10.1128/...

Thousands of scientists inflate their CVs with self-published studies that cost millions of dollars of public money 1 in 8 'special issues' is filled with articles written by the editor, particularly at the publisher MDPI @manuelansede.bsky.social english.elpais.com/science-tech...

Excited to share a new story that transformed how we think about membrane domains in the ER! rdcu.be/eR7Cn ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export Wondering what’s so new and exciting? Skytorial below! 1/9

The secreted staphylococcal biofilm protein Sbp forms biomolecular condensates in the presence of DNA @cincyresearch.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

A new study in Nature Communications has challenged 50-year-old dogma by revealing that vaccinia virus mRNAs with 5'-poly(A) leaders lack the 5' m7G caps. This unexpected finding reshapes our understanding of poxvirus RNA polymerase function and viral gene expression. More: rdcu.be/eXksT

This is really cool. Who said IgG can't protect the mucosae? #immunosky www.thelancet.com/journals/lan...

#Virology Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process

Got an Orbitrap-based mass spec that couldn’t do STORI/direct mass technology before (any aside from the UHMR and Tribrid Ascend)? This is a cool open-source implementation that even works on an Orbitrap Elite! #teammassspec

This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition, The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance Iconic imo

New Year, New Paper from the lab! An enhanced fluorogenic phenotyping assay for screening of new drugs against Trypanosoma cruzi, the causative agent of #Chagas disease. And two new antifungals with activity against T. cruzi! @unsamoficial @CONICETDialoga @ebynunsam 🧵 1

I despise the coining of new acronyms. Except this one: when is a paper in a special issue PISS (Published In Support of Self)? The answer, of course, is way too often.

The Issue with Special Issues: when Guest Editors Publish in Support of Self. arxiv.org/abs/2601.07563 Thanks @hansonmark.bsky.social for putting the effort in documenting this plague. We need to stop it. #PISS is damaging academia.

Ever wonder why some projects just work and others slowly eat your soul? In this paper by @urialonlab.bsky.social discuss the importance of choosing both interesting and actually doable ideas. Impact matters as well as feasibility!

When you think you met the right phd advisor but then he stops answering emails

Find out how to answer scientific questions about #ligands in the #PDB directly from your web browser. Watch the latest talk by Ibrahim Roshan at the CCP4 Study Weekend 2026. 🎥 Watch the talk: ukri.zoom.us/rec/play/U_J... #PDBeKB #CCP4 #StructuralBiology

Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵

🚀 #OpenProject 17.0 is here! We're excited about features such as: 📝 Real-time collaboration in Documents 🗂️ Programs + portfolios (Enterprise add-on) 🗓 Improved Meetings 🔎 Smarter global search 🛡️ Stronger privacy 🔗Please read: www.openproject.org/docs/release... #Release #OpenSource #FOSS

We've got ISSUES. Literally. We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do? arxiv.org/abs/2601.07563 A 🧵 1/n

🚨Bug bounty opportunity for ethical hackers: #OpenProject has launched a public bug bounty program via #YesWeHack, supported by the European Commission. Learn how to participate and help secure open source: www.openproject.org/blog/bug-bou... #OpenSource #BugBounty #DigitalSovereignty

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines. www.biorxiv.org/content/10.6...

The single most undervalued fact of linear algebra: matrices are graphs, and graphs are matrices. Encoding matrices as graphs is a cheat code, making complex behavior simple to study. Let me show you how!

2025 was the year we stopped debating whether paying peer reviewers might work and started showing that it does.

All I want for Christmas is your feedback in our preprint! Happy to share work from Daniil Lepikhov, Laura Sandner and me, where we show that including information from the enzyme-substrate interaction interface in deep learning models can improve the prediction of Michaelis constants. #compchem

Doing a PhD is - at heart - one long discussion with your mentor. The discussion changes over time - with unexpected turns and ups & downs - but through it all is a pair of people discussing a topic endlessly to make sense of it. PhD students: choose someone you like to talk to!

Realy cooooooooooooooooool

We also stopped mass lead poisoning, stopped burning holes in the ozone layer, and massively reduced acid rain. So much is actually possible. Even in the broken world we live in, absolutely gargantuan goals against "necessary" realities were accomplished.

I highly recommend this book. For those whose picture of Darwin is a white-bearded old man sitting in his British study, this will blow your mind. Watch him ride across the pampas with the gauchos in the midst of a revolution and you'll learn his life was a radical as his ideas 🧪

this is the greatest feeling, when the cord box proves its utility to a family member

December news! 🗞️ #rstats 📼 rOpenSci at LatinR 📼 rOpenSci at uRos 📆 Coworking 📈 New package {mantis} 👋 Call for contributions & new maintainers 🗒️ 3 tech notes! 🧰 Package Development Corner https://ropensci.org/blog/2025/12/18/news-december-2025/

🚀 OpenProject 17.0.0 is coming on Jan 14 A major release focused on better collaboration — from real-time documents to portfolios, smarter search, stronger privacy, and improved accessibility. Stay tuned. #OpenProject #OpenSource #Collaboration #Documents #PortfolioManagement

New preprint🚨 Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design? What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be? Why to be wary🧵👇

"The only kind of thinking that matters in science is structured thinking. The only way to give structure and substance to your thoughts is to write them down. Writing. Is. Thinking." Thinking about this in the context of AI tools....

i know this is hardly a new take but isn’t it WILD that wikimedia has to ask for donations to keep itself afloat when every LLM in the world has been trained on wikipedia data?

🦠 Grad students & postdocs in parasitology: Apply now for the Biology of Parasitism (BoP): Modern Approaches course at @MBLScience. Hands-on labs, expert lectures, and cutting-edge tools. 📅 Summer 2026 | ⏰ Deadline Feb 5 🔗 mbl.edu/courses

We are pleased to release today GraTools, an user firendly tools to manipulate the #pangenome variation #graph in GFA format. @ird-fr.bsky.social @cirad.bsky.social @inrae-france.bsky.social

There are better options. Biology Open (nonprofit, @biologists.bsky.social) pays reviewers (£220/manuscript), delivers decisions with reviews in 7 working days & charges $2,500 APC vs $4,150 at Science of the Total Environment. Rigorous. Faster. More ethical. Why wouldn’t you submit there? 8/8

We're drowning in “digital content of low quality that is produced usually in quantity by means of artificial intelligence". And it's getting worse

Made a site comparing the sizes of living things :) The great Julius Csotonyi spent 5 months painting over 60 illustrations for the site, no ai used > neal.fun/size-of-life/

This is absolutely amazing. #Science 🧪 The proteasome, cleaving proteins into antimicrobial peptides. Biology is a amazing “There’s something that we thought is so familiar and so well understood, and then boom — something totally unexpected and exciting comes out of it.” — Medzhitov