Daraxonrasib is the first drug to substantially extend survival in pancreatic cancer trials. Median survival reached 13+ months compared to <7 months for chemo. It finally shuts down the "undruggable" KRAS protein, once called a greasy ball, using a novel molecular glue. #MedSky

Mannosylated nanoparticle immunogens enhance the circumsporozoite protein-specific B cell response and improve protection against sporozoite challenge https://www.biorxiv.org/content/10.64898/2026.05.04.722690v1

May is #maintainermonth! Meet the humans behind your favorite #rstats packages All month, we will spotlight the maintainers behind rOpenSci's software ecosystem. Stay tuned to meet them!

We built an AI that will tell you what will get your grant rejected. It’s a tough critique, but it’s better to know when you can still do something about it 👇 @qedscience.bsky.social

PDBe-SIFTS: an open-source tool for Structure Integration with Function, Taxonomy, and Sequences, featuring improved alignment, scoring scheme, and accelerated search https://www.biorxiv.org/content/10.64898/2026.04.30.721839v1

Excited to share that my 2025 collection of science-inspired drawings is now live on the Protein Data Bank (PDB) website. Thank you @rcsbpdb.bsky.social! It is free to explore and download. I’d love to hear what you think! pdb101.rcsb.org/sci-art/bezs...

#PostDoc opportunity in medicinal chemistry at Liverpool School of Tropical Medicine (Liverpool UK) ref: APR20260383 | duration: 3 years | closing: 31-May-2026 #MedChem #SynChem #ChemPostDoc #PostDocJobs #chemsky 🧪 app.vacancy-filler.co.uk/salescrm/Car...

#Medsky🧪 ##IDsky Emerging evidence suggests that implant-derived titanium particles (i-TiPs) serve as nonmicrobial, abiotic cofactors in the progression of implant disease Peri-implantitis (PI) is a prevalent & destructive complication of dental implant therapy

#AcademicSky #Stats Sometimes, statistical/methods concepts are best captured in an image. 👇

WHO is aware of and supporting a public health event involving a cruise vessel sailing in the Atlantic Ocean.

Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice We have now seen a few (2-3?) of these papers. This is building up momentum towards mechanism in PAIS. link.springer.com/ar... 1/7

☕Paquola et al. present a technique named lipid-trap mass spectrometry (LTMS) to study lipid–protein interactions directly captured from mammalian cells. bit.ly/4tEPW10

Our lab is proud to present our latest work harnessing Bridge Recombinase for genome-scale editing in diverse bacteria, microbiome editing, and programmable horizontal gene transfer.

Out Now! Prioritizing prenatal screening to prevent Chagas disease #MicroSky

I've written a short blog post introducing "The Art of Visualization with ggplot2"! This book is all about the end-to-end process of creating charts with #ggplot2 📊 including data wrangling, sketching, and styling your plots! nrennie.rbind.io/blog/art-of-... #RStats #DataViz #TidyTuesday

Our webinar series on programmatic access to structural data with PDBe starts next week. The first webinar will be delivered by Cristian Escobar Bravo, introducing PDBe programmatic access. Registration is free but essential www.ebi.ac.uk/training/eve... #Bioinformatics #StructuralData #APIs #PDBe

Dolichol biosynthesis in yeast traces the expanded reaction pathway of higher eukaryotes https://www.biorxiv.org/content/10.64898/2026.04.22.720056v1

What's new in the era of genomics, big data, and AI?🧬 Share your insights at our Target Validation conference. 🗓️ 21–23 September | 📍 Wellcome Genome Campus, UK Abstract deadline: 13 July 📩 Bursary support available! 👉 bit.ly/4aBLEiy #TargetValidation #AIInDrugDiscovery #PrecisionMedicine

How I went from Oracle to Postgres (with a big NoSQL detour) with Gwen Shapira (E38) #TalkingPostgres talkingpostgres.com/episodes/how...

Now out in @acs.org JACS Au, the manuscript by #BarbaraTerlouw et al. describing PARAS, a high-accuracy machine-learning algorithm to predict substrate specificities of nonribosomal peptide synthetase (NRPS) adenylation domains, key for estimating natural product structures from BGC sequence. 1/n

New preprint @cxqiu.bsky.social @jshendure.bsky.social ! Can we learn regulatory grammars of human cell types — by training on mouse development and transferring across 241 mammalian genomes? Introducing STEAM & a whole-organism scATAC-seq atlas from E10 to birth. www.biorxiv.org/content/10.6...

How can we see where genes are active in tissues? The Spatial Transcriptomics Portal combines imaging and molecular data to map gene activity in spatial context. Explore how cells interact and develop. www.ebi.ac.uk/about/news/u... @bioimagearchive.bsky.social @expressionatlas.bsky.social

Feel free to ask me about society publishing, publish-and-read deals, pitch a paper for MGen, maybe even for our Microbial Eukaryote genome collection... maybe for a taster, take a look at all the cool stuff already in there! 2/2 www.microbiologyresearch.org/content/micr...

☕Chica et al. combined genetic network mapping, time-resolved imaging and deep learning to generate a dataset called AutoDRY that describes multilayered control of #autophagy and uncovers new regulatory pathways. bit.ly/4sfZa2g

If you're wondering about the phases, here's our phased transition strategy enabling you to move over your MkDocs projects to Zensical: zensical.org/compatibilit...

Release News: V96 of #Reactome is live! 🎉 We have new and updated topics and pathways in Developmental biology, Disease, Immune system, Metabolism, Muscle Contraction, and more. 💡 Read more about V96 here :https://reactome.org/about/news/291-v96-released

A new paper reports a cytosine hypermodification pathway in phage HY126 that confers nuclease resistance www.nature.com/articles/s41...

Glad to share our new work: RitS (Right into the Saddle): a generative model for direct transition state (TS) prediction. 📄 Paper: chemrxiv.org/doi/full/10.26… 🤠 Code: github.com/isayevlab/RitS • Flow-matching model with explicit stereochemistry control • Direct TS generation from SMILE#compchemem

Worth sharing. Powerful. Please share. #AIForHumanity developer.nvidia.com/blog/designi...

Coupling between sterol and sphingolipid structure in ordered membrane domains https://www.biorxiv.org/content/10.64898/2026.04.01.715929v1

There are over 200 HPV strains 40 are sexually transmitted and infect the genitalia and oral cavity. 12 are considered high-risk for cancer Of these, HPV 16 and HPV 18 are responsible for most cancers Don’t believe me, believe this massive study, not the ACIP. Make sure your children are vaccinated!

Continuous abundant viral antigen drives expansion and clonal deletion (attrition) of high-affinity antiviral B cells, while low-affinity B cells are sustained. Attrition is B cell-intrinsic but is mitigated by exogenous antibody @pnas.org @unibas.ch www.pnas.org/doi/10.1073/...

Reminder that you can get up-to-date curated data, including gene names, #GO annotations, #phenotypes, #PTMs, #disease, #interactions, biochemical #pathways, #regulation, #complexes, etc. from SGD Downloads. Updated weekly. Get your data and get to work: sgd-archive.yeastgenome.org/curation/lit...

Chemists use atomic radius as a measure of the size of an atom, typically defined as half the distance between the nuclei of two adjacent atoms. However, in reality atoms don’t have fixed boundaries, @philipcball.bsky.social reports. www.chemistryworld.com/news/the-que...

This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.

This is fantastic!! www.science.org/content/arti...

Lab Leakers: "SARS-CoV-2 can't infect bats, so it must have been made in a lab". Science: "Let's do the experiment". SARS-CoV-2 behaves exactly like one would expect in a reservoir species - low-level infection, no overt disease, etc. Elegant study from Sato Lab: www.biorxiv.org/content/10.6...

We did a new major #RDKit release yesterday. v2026.03.1 is out and the conda-forge builds are available. As always, especially with major releases, be sure to read the "Backwards incompatible changes" section of the release notes! github.com/rdkit/rdkit/...

Review @cp-cellreports.bsky.social The maternal-fetal interface as an immunological barrier: Structure, regulation, and breakdown www.cell.com/cell-reports...

🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬 👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk

Happy to see our work on SLCO2A1 with @smlea.bsky.social, Nakanishi and Newstead labs out now. Important insight into how prostaglandin and many drugs are transported. Hats off to @weitse-hsu.bsky.social for computational work! @oxfordbiochemistry.bsky.social www.nature.com/articles/s41...

"One of the biggest drivers...unsustainable harvest for their blood to be used in pharmaceuticals. Now, two major pharmaceutical companies, Amgen Inc. and Abbott Laboratories, have publicly announced they will shift toward synthetic blood instead." news.mongabay.com/short-articl...

𝗣𝗗𝗕𝗲 𝗺𝗺𝗖𝗜𝗙 𝗩𝗮𝗹𝗶𝗱𝗮𝘁𝗼𝗿: validate your mmCIF files against PDBx/mmCIF dictionary ✅ Real-time check ✅ Metadata completeness indicator pip install pdbe-mmcif-validator install VS code extension: marketplace.visualstudio.com/items?itemNa... GitHub - PDBeurope/mmcif-validator: github.com/PDBeurope/mm...

🆕 | Sii's Dr Mariana Ferreira Silva has been awarded a Young Investigator Grant from FAPESP to establish a research group at the University of São Paulo. The group will investigate how the ubiquitination system contributes to the Toxoplasma gondii life cycle. 🔗 More: www.gla.ac.uk/schools/infe...

Check out our pre-print, where we train a protein and small molecule force field from scratch with a graph neural network. We show comparable performance to existing, manually-tuned force fields on a range of tasks including binding free energy prediction. (1/4) arxiv.org/abs/2603.16770

What goes on in a collection of assays in purified proteins can be very different from what happens in a living well. Case in point:

It's out! Happy to present ITEC, a semi supervised algorithm with an extremely low error rate that can track cells in files of any size (think Terabytes!). We used it in many organisms, including zebrafish, to study how organs form and linked it to gene expression www.biorxiv.org/content/10.6... +🧪

AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk

"Socrates feared that writing would give us the appearance of wisdom without the discipline of truly knowing. In our age of large language models, that no longer sounds like an ancient complaint. It sounds like a warning." www.psychologytoday.com/us/blog/the-...