Check out our selection for our latest #ReactomeResearchSpotlight! 💡 In their March 2026 Society of Toxicology paper, “A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets”. 🖥️🧬

Release News: V96 of #Reactome is live! 🎉 We have new and updated topics and pathways in Developmental biology, Disease, Immune system, Metabolism, Muscle Contraction, and more. 💡 Read more about V96 here :https://reactome.org/about/news/291-v96-released

Check out our selection for our latest #ReactomeResearchSpotlight! 💡 🔗 reactome.org/content/reac... 🧠 We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us ([email protected]) to submit your work for our monthly spotlight! 🖥️🧬

Preprint alert! 🚨 We’ve released two new Reactome preprints. Together, these studies show how AI can scale curation and improve accessibility without compromising accuracy or biological rigor. Learn more here: reactome.org/about/news/2... 🖥️🧬

Check out our selection for our first 2026 #ReactomeResearchSpotlight! 💡 🔗 reactome.org/content/reac... 🧠 We love to learn about how #Reactome empowers your research. If you have one to share, please reach out to us ([email protected]) to submit your work for our monthly spotlight! 🖥️🧬

Release News: V95 of #Reactome is live! 🎉 We have new and updated topics and pathways, including Disease pathways such as Dengue virus infection, Gene Expression, Immune System, Metabolism, and Vesicle-mediated transport.

New Reactome paper in NAR 2026 Databases Issue: doi.org/10.1093/nar/... Redesigned Angular interface ReacFoam & entity-level visualizations Multi-omics analysis tools React-to-Me chatbot FAIR-compliant, CoreTrustSeal certified, and ELIXIR-recognized 🖥️🧬

Advances like this underline how much early detection and mechanistic clarity matter in rare metabolic disease. For those examining the underlying biology of Hunter syndrome, Reactome’s pathway (reactome.org/content/deta...) provides a clear view of the disrupted iduronate-2-sulfatase process.

This week marks World Antimicrobial Resistance (AMR) Awareness Week. In 2024, Reactome expanded its coverage of AMR biology with new pathway annotations. Explore our current AMR pathway set here: reactome.org/PathwayBrows...

Check out our selection for October's #ReactomeResearchSpotlight! Ringquist et al's September 2025 @natureportfolio.nature.com Biomedical Engineering paper, "An immune-competent lung-on-a-chip for modelling the human severe influenza infection response" Read more: 🔗 reactome.org/content/reac... 🖥️🧬

See you all next week!

🚨 New Beta Release: Reactome Pathway Browser Explore biology with a modernized interface: 🔗 reactome.org/beta/Pathway... Feedback welcome → forms.gle/TPBxaWnnVLLZ... 🖥️🧬

🎉 We just launched the Reactome Figma Library! You can now drop our professionally illustrated pathway icons straight into your Figma designs — great for teaching, presentations, or science communication. All under CC BY 4.0. www.figma.com/community/fi... Demo video: youtu.be/xl2LfczKhGY 🖥️🧬

Release News: V94 of #Reactome is live! 🎉 We have new and updated topics and pathways, including Cell Cycle, Developmental Biology, Disease, Immune System, Metabolism of proteins, and Transport of small molecules 🖥️🧬

Reactome audits all curated refs against Retraction Watch. Of 40,000+ papers, just 70 were retracted — and all annotations reviewed or removed. A small number, but we take every one seriously. #FAIRdata #OpenScience #Reactome 🖥️🧬 Read more about it here: reactome.org/content/reac...

Exciting news! Reactome is hosting an interactive workshop at #ASHG25 on Tuesday, October 14th. Advanced ticket purchase is required, so don't forget to sign up for our session "Pathway Analysis for All" when you register for the conference.

Starting the new academic year with a Reactome Research Spotlight🖥️🧬 In the February2025 issue of Nature Communications, Carli et al. reported the development of a predictive model of cell line drug sensitivity from RNA-seq data using machine learning approaches pmc.ncbi.nlm.nih.gov/articles/PMC...

Exciting news! Reactome is hosting an interactive workshop at #ASHG25 on Tuesday, October 14th. Advanced ticket purchase is required, so don't forget to sign up for our session "Pathway Analysis for All" when you register for the conference.

Release News: V93 of #Reactome is live! 🎉 We have new and updated topics and pathways. 💡 Read more about V93 here: reactome.org/about/news/2...

Reactome audits all curated refs against Retraction Watch. Of 40,000+ papers, just 70 were retracted — and all annotations reviewed or removed. A small number, but we take every one seriously. #FAIRdata #OpenScience #Reactome 🖥️🧬 Read more about it here: reactome.org/content/reac...

Reactome is now CoreTrustSeal certified, meaning that our pathway data meets global standards for transparency, accessibility & long-term stability. Learn more at reactome.org/about/news/2... A big win for #FAIRdata, open science, and everyone who relies on Reactome for biological knowledge. 🖥️🧬

Check out this recap, where our #Reactome Outreach Coordinator summarizes some of the team discussions we had at #ReactomeSAB 2025! 🖥️🧬

Check out our new Youtube video about contributing to Reactome! Learn more by watching our youtube video, created by Cristoffer Sevilla! www.youtube.com/watch?v=P5Gi... Like and subscribe to our Youtube channel for more updates! 🖥️🧬

Reactome Release News: V92 of #Reactome is live! 🎉 We have exciting new and updated topics and pathways in this release. This release, we added 81 new reactions to Reactome, which you can read about at this link: reactome.org/about/news/2... 🖥️🧬

Discover Pathways with Ease! Explore biological pathways like never before with the React-to-Me AI Chatbot. We’d love your feedback to improve it! Try it now and share your experience through our short questionnaire. Link: reactome.org/chat/ 🧬🖥️ 🧪

Discover Pathways with Ease! Explore biological pathways like never before with the React-to-Me AI Chatbot. We’d love your feedback to improve it! Try it now and share your experience through our short questionnaire. Link: reactome.org/chat/ 🧬🖥️ 🧪

Check out the Reactome Research Spotlight 💡 for February 2025. The paper "BPP: Biochemical Pathway Prediction framework" by Yi et al is summarized here: reactome.org/content/reac... If you have a publication that leverages Reactome, please submit them to [email protected]!

The #ReactomeResearchSpotlight for January is a paper by Tindle et al. that identified two Crohn’s disease (CD) molecular subtypes - immune-deficient infectious CD and stress and senescence-induced fibrostenotic CD - through multi-omics and functional analyses of patient-derived organoids 🖥️🧬

🔓Juan Antonio Vizcaino on open data practices in proteomics, highlighting data reuse activities in the context of big data approaches 💻Eliot Ragueneau demonstrating @reactome.org GSA for multi-omics data analysis #FoG2025

Release News: V91 of #Reactome is live! 🥂 🎉 We have exciting new and updated topics and pathways in this release, which you can read about at this link: reactome.org/about/news/2...

Please consider spending a few moments of your day supporting our resource by providing your feedback to our team! The things we learn from the user survey is essential for our continued success! 🖥️🧬

Let's play 20 questions! If Reactome has touched your work or helped you save valuable time, please consider giving us 5 minutes of your time through our user survey, reachable at our home page, or at the following link: docs.google.com/forms/d/e/1F... 🧪🖥️🧬

Do you know about ALL the ways you can download #Reactome? Check out our latest youtube video created by Cristoffer Sevilla describing our downloadable materials! Don't forget to share and like our video: youtu.be/UJfPfWpq9lA 🖥️🧬

Come speak to @reactome.bsky.social representatives at the @medicinebydesign.bsky.social symposium in Toronto on Dec 9th! We will be giving away some goodies and giving a sneak peak of our new AI features!

Reposting a great starter pack:

Please consider spending a few moments of your day supporting our resource by providing your feedback to our team! The things we learn from the user survey is essential for our continued success! 🖥️🧬

Let's play 20 questions! If Reactome has touched your work or helped you save valuable time, please consider giving us 5 minutes of your time through our user survey, reachable at our home page, or at the following link: docs.google.com/forms/d/e/1F... 🧪🖥️🧬

An exciting #ReactomeResearchSpotlight! In the feature article of the October 2024 issue of Drug Discovery Today titled "Chemical coverage of human biological pathways" by Kwak et al. describe the #Target2035 initiative! Read more: reactome.org/content/reac...

Release News: V90 of #Reactome is live! 🥂 🎉 We have new and updated topics and pathways in this release, including Cellular response to stimuli, Disease, Gene Expression, Metabolism, and Metabolism of Proteins, which you can read about at this link: reactome.org/about/news/2... 🖥️🧬

We were thrilled to collaborate with Biobox Analytics on an article exploring Reactome’s curation practices and our innovative graph database! Check it out! 🖥️🧬 blog.biobox.io/p/the-reacto...

Time for #ReactomeResearchSpotlight! Bracha et al. use #Reactome expression analysis to confirm that they successfully delivered multiple large therapeutic proteins across the blood-brain barrier into target neurons in mice using engineered Toxoplasma gondii secretion systems. 🧬🖥️

Going to #ASHG2024🏔? Reactome is coming to Denver, CO! Come talk to Nancy T Li in the #OmicsTechnology session about the #Reactome knowledgebase, and how you can use our data and analysis tools in your research! Please reach out if you'd like to chat! 🧪🖥️🧬

Need a ~3 minute intro to #Reactome's analysis tools? Check out our latest youtube video created by Cristoffer Sevilla describing our qualitative and quantitative data analysis methods! Don't forget to share and like our video: youtu.be/rxEpA-lJguE?... 🧪 🖥️🧬

Have you seen our latest #ReactomeResearchSpotlight? This month's focused on the recent work by Chen et al. reactome.org/content/reac... Chen et al used data simulated based on Reactome pathways to validate their Functional Representation of Gene Signatures (FRoGS) algorithm. 🧬🖥️

Release News: V89 of hashtag#Reactome is live! 🥂 🎉 We have numerous new and updated topics and pathways in this release, including an exciting update to the "epigenetic regulation of gene expression" pathway. which you can read about at this link: reactome.org/about/news/2... 🖥️🧬🧪

🚨 New paper alert! "ReactomeGSA: new features to simplify public data reuse" discusses enhancements to ReactomeGSA, a tool used for multi-omics pathway analysis. You can now fetch GREIN resources directly for analysis, try it out! doi.org/10.1093/bioi... 🖥️🧬

How to cite Reactome? A common question with an easy answer: If you need an individual pathway or diagram, you can use our "Cite us" sidebar functionality! You can also find more information at: reactome.org/cite 🧪🧬🖥️ youtu.be/91eQ6iLeguk

Note that links to KEGG/Reactome metabolic pathways are specifically displayed in the Metabolic Pathways subsection of Pathways, alongside similar links to FlyCyc, as well as in the External Data subsection. @reactome.bsky.social

Check out our new animated video introducing "Reactome's Main Search", now available on Youtube! Learn to quickly find your favourite genes, proteins, reactions, and pathways in the @reactome.bsky.social database. Created by the talented Cristoffer Sevilla, our graphic designer. 🧬🖥️

Have you seen our latest #ReactomeResearchSpotlight? Zhang et al published a study in Toxicology and Applied Pharmacology (12/23) that uses the ReactomePA R package to identify enriched pathways responding to nickel-induced transcriptional memory in response to nicotine!