Joshua Tran (@joshuatran.bsky.social)

Molecular basis for the regulation of membrane proteins through preferential lipid solvation - Nature Chemical Biology Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force. https://www.nature.com/articles/s41589-025-02032-w?utm_source=bluesky&utm_medium=social&utm_campaign=nchembio