In a new publication, Team Harper found that α-synuclein fibrils cause ESCRT-III loss through “collateral degradation,” weakening endolysosomes and promoting further aggregation🔬 🔗 Read the full #publication: bit.ly/4iPUayj

Grateful to @focalplane.bsky.social for inviting us to write about our last paper on lysosomal tubulation during the stress response (rupress.org/jcb/article/...)! focalplane.biologists.com/2025/12/11/d...

Autolamellasomes: An Autophagy-Dependent Parallel Pathway for Bulk ER Degradation and Lysosome Biogenesis https://www.biorxiv.org/content/10.1101/2025.11.16.688694v1

Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...

Lipid Landscape of human cells https://www.biorxiv.org/content/10.1101/2025.10.05.680593v1

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair https://www.biorxiv.org/content/10.1101/2025.10.23.684214v1

🚨 We’re hiring a postdoc! 🚨 Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab! Reach out directly: [email protected] Learn more: bonetponcelab.com Let’s chat!

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions. www.nature.com/articles/s41...

Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!

Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof

LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...

Nature research paper: Quantitative imaging of lipid transport in mammalian cells go.nature.com/4mmSygd

Interested in lysosome damage and repair pathways? Check out the latest updates.

Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio meetings.embo.org/event/26-org...

What a fantastic ESCRT meeting, the field is going strong and full of exciting science. Many thanks to @rouxlab.bsky.social @cellarchlab.com @jujumathieu.bsky.social @magromayor.bsky.social @majarad.bsky.social for organising such a a great event

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

A short reminder that registrations for the EMBO ESCRT meeting 2025 in Montreux June 23rd-June27th are still opened! Please register online at meetings.embo.org/event/25-escrt