Amazing to have our work finally out!!! 😍🤩😍

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

🚀 We’re hiring a Postdoc! Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome! 📅 Deadline: Nov 1, 2025 🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf

Disney/ABC have a responsibility to refuse to participate in corruption. Kimmel must be reinstated. If Disney/ABC agree to this extortion then perhaps creatives + workers should consider collective action to push back. Same w/buying park + cruise tickets if they bow. People have power. Ask Target

Nature Review: Cis-regulatory elements at cellular resolution www.nature.com/articles/s4...

Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome: The E2G Portal! e2g.stanford.edu This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues. Uses cases 👇 1/

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene by the @basvansteensellab.bsky.social www.science.org/doi/10.1126/...

I'm voting for free speech with my wallet, and cancelling my Disney+ subscription.

New preprint from our lab! What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells? Find out here: www.biorxiv.org/content/10.1... 👇 1/

After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.

Great #EMBOdnatopology meeting in Szklarska Poręba: exciting science, inspiring discussions, and pleased to share our #DNAreplication work! Thanks to Dagmara Jakimowicz, Marcin Szafran & organizers! @embo.org

Many great talks at the #E2BRN & #ESDR2025 meeting! Glad to share recent work form my lab on keratinocyte epigenetics and catch up with old friends! Big thanks to Danuta Gutowska-Owsiak & Ryan O'Shaughnessy for organising #E2BRN! #epigenetics @esdrorg.bsky.social

It's been great pleasure to host Takeshi Matsui in Poznan @uam-ibmib.bsky.social - amazing talk, meeting with PhD students & postdocs, inspiring science discussions! Many thanks to #ID_UB for funding! #epigenetics #epidermalBarier #corneoptosis #E2BRN

Join us on Monday for @UAM_IBMiB seminar of Takeshi Matsui from the Tokyo University of Technology to learn about keratinocyte-specific cell-death in formation of epidermal barrier! PhD students/postdocs are welcome for the cereer advice meeting! #cellDeath #corneoptosis #ID_UB

🚀🧬 Exciting space science! Yeast engineered with tardigrade genes have been launched to the International Space Station for pioneering experiments by Hanna Kmita's group @uam-ibmib.bsky.social ! Check out the movie for more details! #ISS #tardigrades #space #radiation

Prof. Krzysztof Sobczak , the director of the IBMiB UAM, has been elected to the prestigious group of corresponding members of the Polish Academy of Sciences - congratulations !

Join us this Friday morning @uam-ibmib.bsky.social for the seminar: Prof. Kashmir Singh from the Panjab University, India will give a talk on the role of long Non-Coding RNAs in fungal infections in grapevine! #lncRNA

The teams of @piotraz.bsky.social Ziółkowski from @uam-ibmib.bsky.social and Mikhail Mikhailov discovered that a natural DNA trick triples #recombination in maize! Congratulations to the authors !!! Check out the paper: lnkd.in/dh3QEFSy

Congratulations to Jan Brezovsky form the @uam-ibmib.bsky.social & @iimcb.bsky.social on being recently awarded the @ncn.gov.pl OPUS-LAP research grant! His work on rational design of substrate transporters in bacteria to enhance metabolism promises exciting insights! hashtag#NCNtoTlen

Money Talks! At least it does for the success of many core facilties. A webinar with Emma Hesketh an me discussing all things around facilities. www.thermofisher.com/uk/en/home/e... @thermofishersci.bsky.social #UKTSN @ctlslifescience.bsky.social @rmsearlycareer.bsky.social @abrf.bsky.social

Spread the news! We are excited to expand our research team, working on cellular senescence, at the Cancer Research UK Cambridge Institute, University of Cambridge. jobs.cam.ac.uk/job/52026/ jobs.cam.ac.uk/job/52027/

The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice www.nature.com/articles/s4...

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

2nd Polish #RNA Biology Meeting in #Poznan co-organized by @uam-ibmib.bsky.social‬ has started yeaterday evening with talks of Ramesh Pillai & Sebastian Glatt @sebastianglatt.bsky.social‬ - many more great talks, posters & discussions ahead! #PolishRNABiologyMeeting

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

Asia Kwiatkowska & Ewa Stein from Kinga Kamieniarz-Gdula Lab @stoplab.bsky.social‬ shared their expierience with insect cells culturing for protein production! Check out the paper at scientific reports: www.nature.com/articles/s41... look also at the twittorial: x.com/kwiatkowska_...

Congratulations to Magda Kopczyńska @mgkopczynska.bsky.social from @uam-ibmib.bsky.social‬ for best PhD publication in 2024 Award given by @polskaakademianauk.bsky.social !!!

Join us this Friday morning for seminar: Mateusz Bajczyk from @uam-ibmib.bsky.social‬ will give a talk on the roles of DEAD-box Helicases in Plants! #DEADbox

How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function? In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9 doi.org/10.1186/s130...

Join us this Friday morning for seminar: Franz Boideau from @uam-ibmib.bsky.social #Geneome Biology Lab @piotraz.bsky.social‬ will give a talk on the mechanisms controlling meiotic crossovers! #meiosis

Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social‬: www.biorxiv.org/content/10.1... 🧵 below

Great news for @uam-ibmib.bsky.social‬ research groups: OPUS @ncn.gov.pl‬ grant was awarded to Artur Jarmołowski to study U1 snRNP & Sonata to Halina Petrykowska to investigate Male-specific microRNAs - big congratulations!!! #NCNtoTlen #3ProcentNaNaukę

Join us this Friday morning for the seminar: Lidia Vasilieva from Oxford University @ox.ac.uk will give a talk on regulation of #RNA biogenesis! @BiochemOxford #RNAbiogenesis

The @economist.com celebrating the economic and political success of Poland...hope it's not premature

Katarzyna Tutak with Anna Baud & Krzysztof Sobczak @uam-ibmib.bsky.social‬ identified novel modifiers of #fragileX linked Repeat Associated Non-AUG #RAN translation associated with RPS25, RPS26 & chaperone TSR2. Just published in @elife.bsky.social‬, congratulations! elifesciences.org/articles/98631

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...

www.nature.com/articles/d41... Coverage of our collaboration with the Liu group.. ' “This is crazy directed evolution!” - Makoto Saito'

Andrzej Zieleziński @uam-ibmib.bsky.social with Adam Gudyś & @sdeorowicz.bsky.social dvelopped Vclust: fast and accurate tool for calculating intergenomic similarities (like ANI) and clustering virus/#phage genomes. Just published @naturemethods - congratulations! www.nature.com/articles/s41...

@akispapantonis.bsky.social seminar, moderated by @stefanschoenfelder.bsky.social : Senescent cells repurpose proteins to cluster CTCF, rewiring genome architecture. Recording: www.youtube.com/watch?v=6NtH... Next "3D Regulatory Genome" speaker coming soon! #CellularSenescence #GenomeRegulation

Join us this Friday morning for the @uam-ibmib.bsky.social seminar: Nick Proudfoot from @ox.ac.uk will give a talk on noncoding transcriptome in human! @DunnSchool.bsky.social #lncRNA

Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social. www.nature.com/articles/s41... This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu

Join us tomorrow for the @uam-ibmib.bsky.social seminar: Stefan Heckmann from the Leibniz Institute of Plant Genetics and Crop Plant Research @leibnizipk.bsky.social in Gatersleben will share with us his insights in #meiosis!

📢 Register! us02web.zoom.us/webinar/regi... @akispapantonis.bsky.social presents "Senescent cells co-opt CTCF on nuclear speckles to sustain their splicing program" on May 8, 4PM UK, moderated by @stefanschoenfelder.bsky.social #GenomeArchitecture #Senescence

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

🚨 Preprint alert 🚨 Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇 doi.org/10.1101/2025...

It's been great to have Mike Robson @drmrobson.bsky.social @uam-ibmib.bsky.social - amazing talk, meeting with PhD students & postdocs, hopefully another stop towards tightening of collaboartions between Poznan & Berlin @mdc-berlin.bsky.social! Thanks to #ID-UB for funding! #epiegenetics #LADs

Collab. work of Krzysztof Sobczak, Kasia Taylor @uam-ibmib.bsky.social & Łukasz Sznajder,University of Nevada showed: tandem repeat expansions in the myotonic dystrophy are linked with the disruption of alt. splicing of #autism-risk genes! Check out the paper @NatureNeuro: nature.com/articles/s4159

#PancreaticCancer patient-derived organoids capture therapy response and tumor evolution 🧪 www.biorxiv.org/content/10.1...

Gene Therapy Lab @uam-ibmib.bsky.social led by Prof. Krzysztof Sobczak is looking for enthusiastic PhD student for the EU MSCA Doctoral Network project on therapeutical potential of antisense oligonucleotides in myotonic dystrophy, check out link for details! #ASO euraxess.ec.europa.eu/jobs/324410

All Eurpean RNA Researchers: join us at the 2nd Polish RNA Biology Meeting @uam-ibmib.bsky.social,June 24-27 Poznan! Keynote speakers include Elena Conti, Andrzej Dziembowski @sebastianglatt.bsky.social, Reinhard Lührmann, Kai Papenfort, Ramesh Pillai & Bertrand Séraphin! #RNA 2ndrna.web.amu.edu.pl