If you havent seen this, make sure you read.

Pretty obvious.

As I point out regularly, because FL is one of the most primitive, regressed states in America, you cannot be elected or appointed to any office there unless you’re a thoroughly despicable and corrupt criminal.

Sam Altman: ‘If I Don’t End The World, Someone Far More Dangerous Will’

"Iran has been at war with us for 40-some years" is only one step removed from "we have always been at war with Eastasia"

ChromSMF preprint is out!🚀 tinyurl.com/ChromSMF We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting! In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬 What does this unlock? ⬇️

So US/Proxy Forces are currently bombing or threatening to bomb: Iran Palestine Lebanon Iraq Yemen Afghanistan Russia Colombia Cuba Venezuela And I’m just wondering how long it took people to realize they were in a world war 80 years ago.

🧵 What does single-cell transcriptomics reveal about individual patients with acute (AKI) and chronic (CKD) kidney 🫘 disease? Can we use it to find new biomarkers? In our new preprint 👇, we asked this using biopsies from 150+ participants from the Kidney Precision Medicine Project.

“We are a defensive alliance, which means that we don’t do military attacks.” - Finland President, Alexander Stubbs I’ll translate that for you Donald, it means that NATO countries aren’t your bitches.

Simple information about what the SAVE Act would actually do to American voters. Tens of millions would lose their right to vote unless they spend lots of $$$ and jump through bureaucratic hoops before November.

We warn fellow members of the Muslim community that at some point the GOP would return to demonizing Muslims. The GOP simply rotates their hate depending on need. Their hatred towards Latinos is costing them votes so now it's Muslims. Soon they will be back to LGBTQ, Blacks, women and repeat.

How do immune disease-relevant variants rewire gene regulation in CD4+ T cells? In a collaboration led by Daniel Schraivogel and Lars Steinmetz at @embl.org, we combined two large-scale CRISPRi screens (4.1M cells) to map the downstream cascades of thousands of SNPs.

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Pediatrics & Child Health has been publishing fictional case studies for 25 years and is now "correcting" them to acknowledge they are fictional. I have never seen anything like this. retractionwatch.com/2026/03/03/c...

Out now on bioRxiv! 🧬🖥️ Dewi Moonen, @anniquec.bsky.social and a team led by Lars Steinmetz and Daniel Schraivogel at EMBL have mapped the downstream regulatory networks of thousands of immune disease-relevant variants in CD4+ T cells www.biorxiv.org/content/10.6...

🧵 See 👇 our new preprint on shared and organ-specific gene expression programs of fibrotic diseases 🧬 📄 Paper: doi.org/10.64898/202... 📊 Explore the data: organfibrosis.saezlab.org

We have a winner alignmentalignment.ai

The brain drain continues – the U.S. has lost arguably its most important scientific awards ceremony: arstechnica.com/science/2026...

When a US missile killed 160 children, president shits-a-lot claimed Iran stole the missile and fired at the school. When asked why he was the only one making this claim, he said "because I just don't know enough about it". Go ahead. See if you can make this make sense. (Source: RB Hubbell)

Trump’s War On Iran: Myth Vs. Fact https://theonion.com/trumps-war-on-iran-myth-vs-fact/

In Deutschland denken Frauen heute darüber nach, ihre Babys abzutreiben, weil die Wohnung zu klein ist. Keine bezahlbare Wohnung, keine Kinder. Und die CDU will die Partei von Familie und Heimat sein? In den 60er Jahren schuf die CDU "das Wohnungswunder"! Für Adenauer war…

We are are searching a scientific manager for the ZMBH. This position requires a life sciences PhD & excellent German skills, therefore the advertisement is formulated in German. Very good English skills are needed as well. You are welcome to share the ad: www.academics.de/jobs/wissens...

Is the linear map of cell signaling a myth? New research suggests the reality of cellular networks is more complex. @savitski-lab.bsky.social & @saezlab.bsky.social combined experimental and computational expertise to test how we map kinase–substrate interactions. www.nature.com/articles/s41...

The religious right has infiltrated far into our military with disturbing consequences.

The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩... 🔗 doi.org/10.64898/202...

Now, synthetic enhancers with single cells - great work by @juruehle.bsky.social : www.biorxiv.org/content/10.6...

Hannah Ritchie has built a fun little tool where you can compare energy usage of various products and activities. This is super helpful imho, because it's so hard to develop intuitions even just about the scales involved here. hannahritchie.substack.com/p/does-that-...

Chance and Consensus in Peer Review (1981) www.science.org/doi/10.1126/... tltle: it's a lottery system)

Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here: rdcu.be/e5EgU #EvoBio #EvoDevo 🐟🦎🐢🦇🐊🦜

Democrats Wear White Flag Pins To SOTU To Indicate Surrender

THERE’S POWER IN BOYCOTTING!

Thunderstorms can generate weak electrical discharges on the plants underneath, but until now, they had never been observed in nature

Press the Red Button, Dave. A small study at LANL has real-world #biosecurity relevance: evaluating whether AI can transfer tacit laboratory skill to novices. doi.org/10.59350/6e0...

THIS 👇is pure EVIL.

📖 Our new pseudotime alignment tool ptalign identifies Wnt antagonist SFRP1 as central for glioblastoma cell activation, opening new avenues for patient stratification and therapeutic avenues. 🔗 lnkd.in/ees8bhNY by @Leo Carl Foerster, Oguzhan Kaya et al. #glioblastoma #pseudotime #neurobiology

ggannotate: interactively add annotations to your {ggplot2} plots by pointing and clicking github.com/MattCowgill/... #Rstats

Absolutely savage, I love it.

With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.

8/ 🤘 For those about to rock (around the Christmas tree), we salute you 🎸🎄: Isabelle Seufert & our team from @dkfz.bsky.social & BioQuant & @akispapantonis.bsky.social, Philipp Mallm, @s-anders.bsky.social & Petros Kolovos labs with support from @spp2202.bsky.social & @mspacealliance.bsky.social.

1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.

It is utterly catastrophic that RFK Jr. plans to end CDC recommendations for most childhood vaccines. It’s a betrayal of science, ethics, compassion, and the people of the United States. And it was also a specific goal of Project 2025 (page 254).

This is the most alarming story I’ve read today. Giving up the fight before it’s started

ISCO (Innovations in Single-Cell OMICS) will be back in beautiful Barcelona! 🗓️ 28th/29th of May 2026 📍Barcelona Biomedical Research Park @prbb.org (beachfront!) Keynotes: @bartdeplancke.bsky.social and @bocklab.bsky.social Submit your abstract and present your research! www.isco-conference.eu

One step in the right direction from @cnrs.fr . Here’s hoping others will follow and we can get some more space for actual science. 🧪 www.cnrs.fr/en/update/cn...

Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...

Our Ensembl 2026 paper is out! Learn about 1,900+ new genomes, expanded pangenome support, new regulation interfaces, and what’s coming in our 2026 releases. doi.org/10.1093/nar/gkaf1239

#Postdoc alert! We are looking for motivated individual with experience in computational systems biology to join our NetworkCommons initiative to benchmark and democratise network contextualisation methods across multiple applications. Deadline Dec 17th link here: tinyurl.com/yrrzxa94

Fifteen Years xkcd.com/3172/

Frikkin amazing stuff.