Physicians are good drivers of LLMs, but regular humans who don't know how to tell the "textbook story" can get dangerously divergent results. #medsky #MLsky www.evidencetriage.com/p/humans-llm...

8 more children died from influenza complications last week, according to CDC's FluView report, bringing the total to 60 pediatric deaths so far this season. The agency keeps tabs on childhood deaths caused by the flu, but doesn't recommend flu shots as a way to prevent infection👇

Vinay continuing to demonstrate his utter intellectual dishonesty and cowardice. #medsky www.nytimes.com/2026/02/10/h...

A lot of scope creep for thrombolysis in CRAO – but, no, the higher quality data emerging shows harms outweigh the benefit. #medsky www.evidencetriage.com/p/do-not-use...

Jay's passion for replication famously only applies to research he doesn't already agree with.

More "tissue not time" evidence – but these data are almost certainly weaker than they appear. Unfortunately, I expect they'll simply be piled upon the ever-expanding indications for stroke thrombolysis, along with corresponding indication creep. #medsky www.evidencetriage.com/p/the-option...

Amazing, thanks LLM helper.

Trial stopped early for futility. The opposite of the headline I would choose. www.thelancet.com/journals/lan...

The magic wand stethoscope doesn't reliably measure up – yet. Phonographic and single-lead ECG analysis by AI did not reliably improve diagnosis of atrial fibrillation, heart failure, or valvular heart disease. #medsky #MLsky www.evidencetriage.com/p/not-a-magi...

Fascinating thoughts and data here from Anthropic – analyses of conversations to determine the rate and extent to which AI may be providing harmful reinforcement or distortion. Spoiler – it's a lot, both in relative frequency and in absolute terms ... #medsky www.anthropic.com/research/dis...

Sci-Fi Author: In my book I invented the Torment Nexus as a cautionary tale Tech Company: At long last, we have created the Torment Nexus from classic sci-fi novel Don't Create The Torment Nexus

All I really want is … gulls. 🎶

More evidence of there not being much of an additive or synergistic effect between different types of analgesia for moderate acute pain – this example in pediatrics: #medsky www.evidencetriage.com/p/ibuprofen-...

Reason #2148 medical care in the U.S. is so expensive – zero tolerance for poor outcomes, avoidable or not, leading to over-testing, over-referral, and generally harmful practices focused narrowly on avoiding rare badness. #medsky www.expertinstitute.com/resources/in...

Yourself, but as a cartoon.

These sorts of retrospective analyses are always confounded by indication, but it is probably the case hyPERnatremia can be corrected as rapidly the salient clinical context requires. #medsky www.evidencetriage.com/p/does-it-ma...

Credit to Ed, toughing out the Christchurch "summer" in apparent good humour. Whilst you'd think it would be basic expectations for any professional to do their well-paid "job", not every touring artist displays the same level of resilience. thespinoff.co.nz/pop-culture/...

Remember – influenza antivirals have precarious, if any, evidence they save lives. Vaccination remains your best protection if high-risk. What little evidence (in pharma-sponsored trials) they have is minimal symptom duration reduction – usually less than a day in a weeklong illness.

Whatever publicity this NEJM article got, the recent advertorial in @theatlantic.com no doubt tops it. Right after opining that Xofluza could impact mortality (data?), the author concedes they mixed up Xofluza with a HIV medication. Strong work. www.theatlantic.com/health/2026/...

The new reality: if you have a information aggregation/interpretation problem that previously required a team of engineers and data scientists, there's an awfully good chance Claude Code or a tool like it can address it given functional requirements. #medsky medium.com/data-science...

Example #2914 of telling clinicians there's no bacteria to treat, but clinicians continuing the antibiotics. (in this case, the test is flawed, but I digress) #medsky www.evidencetriage.com/p/no-bacteri...

Emoji usage is slowly percolating into clinical documentation – and with some rather quirky choices, if I might say. #medsky www.evidencetriage.com/p/emojis-in-...

Amusingly, the cost-effectiveness manuscript produced by Roche assumed the floor for CENTERSTONE would be a reduction in transmission of 5% ... when in actuality, the reduction in symptomatic cases was less than 2%. pmc.ncbi.nlm.nih.gov/articles/PMC...

Most people don't need an antiviral to treat influenza, the least of which being Xofluza – unless you're bored with just causing antibiotic resistance and want to start working on some new influenza mutations. #medsky www.evidencetriage.com/p/another-ba...

Important Science — future IgNobel award? www.pbs.org/wgbh/nova/ar...

Sweet merciful Jessica, look at all those false-positive D-dimers. So, yes, please age-adjust your D-dimer for DVT, as well as PE. It doesn't make a big difference, but any improvement is welcome ... #medsky www.evidencetriage.com/p/adjust-again

FFS. Don't waste your time or money trying to chase this junk down .... www.bloomberg.com/news/article...

So when authorities say “she tried to run over an officer,” that is not a neutral description. It is a claim of intent that can be used to justify lethal force after the fact. When the state kills first and invents the threat afterward, it is not policing, it is death squad behavior. /end

"Entropy reduction" as a path to diagnostic certainty – a fun thought experiment trying to quantify which information in the emergency department contributes most towards clarifying diagnoses. #medsky #MLsky www.evidencetriage.com/p/what-reduc...

My ice cream scoop harbors the danger of artificial intelligence. #mlsky

AI agents are everywhere – but what are the "hidden" biases underlying their actions? Or, how could health system or patient-oriented values be in embedded in an agent? #medsky #MLsky www.evidencetriage.com/p/what-kind-...

New year, new you? Come revive your love of emergency medicine in New Zealand. Easiest search: type "FACEM" into Keywords, and you'll see all the consultant-level posts. Everything from surfing and sun in Gisborne to ... something different in Wellington! jobs.tewhatuora.govt.nz/jobtools/jnc...

No, "sepsis" is not any ED patient a fever – it's a complex, impaired host response to infection. Someday, that impaired response will be recognized as a heterogeneous tapestry of induced dysfunction, each with its own tailored treatment. #medsky www.evidencetriage.com/p/reversing-...

Almost no low-risk children will have SBI, and an even tinier fraction will be missed meningitis – but at what point is "minimal risk" acceptable versus "zero risk"? #medsky www.evidencetriage.com/p/can-we-yet...

Merry Christmas from my cats. 😐

It’s a bird! No, it’s a plane! No, it’s

RFK Jr. should have paid more attention to the comics in 1968.

Which physicians are the highest-earning cogs in the private equity machine? Unsurprisingly, gastroenterology, cardiology, and ophthalmology – especially those who own their own imaging, endoscopy, and surgical centers. This is all obviously good for patients. Ha! focusbankers.com/physician-pr...

More of the same biases towards blanket treatment with IVT of any stroke that smells like "disability" (definition of disability not available). #medsky www.evidencetriage.com/p/minor-upda...

The state of AI use in primary care in the UK: a lotta scribes and a lot of additional non-clinical needs. #medsky www.evidencetriage.com/p/how-are-gp...

What's your strategy for using LLMs to augment your clinical decision-making? (now, if we only had objective data regarding which was "best") #medsky #MLsky www.evidencetriage.com/p/are-you-a-...

I'm running the Chicago Marathon next year in support of Team ALS – – my choice of charity and my connection is personal, and I encourage everyone simply to give what they can to a charity meaningful to them. That said, donations are matched in Dec – secure.alsunitedchicago.org/site/TR/Endu...

“Within 48 hours of the Bondi shooting, federal and state leaders in Australia pledged to further tighten the country’s gun laws, already some of the most restrictive in the world … They noted that they were a lot more concrete than the ‘thoughts and prayers’ so often offered by American officials.”

Andexxa — Coagulation factor Xa (recombinant), inactivated-zhzo — is going off the market in the U.S. A victory for those who have been fighting this failed advance for years. #medsky

Andexxa — Coagulation factor Xa (recombinant), inactivated-zhzo — is going off the market in the U.S. A victory for those who have been fighting this failed advance for years. #medsky

Worried about etomidate and its suppression of cortisol in the critically ill? Worry no longer (in adults, anyway). #medsky www.evidencetriage.com/p/its-the-et...

AI models can predict patients' health insurance types from normal chest X-rays, revealing hidden socioeconomic biases in medical imaging. This research challenges the perceived neutrality of clinical data and calls for a reevaluation of AI fairness in healthcare. https://arxiv.org/abs/2511.11030

The Trump administration continuing to "Make America Healthy Again" by declaring war on preterm infants. 💪 www.reuters.com/business/hea...

i asked chat gpt to fact check an article for me