Julia Rühle
@juruehle.bsky.social
📤 55
📥 102
📝 1
PhD Candidate
@CRG.eu
with
@larsplus.bsky.social
| Single Cell Tech Dev & Functional Genomics
pinned post!
🧬🔍How can enhancers achieve tissue-specific activity? We use MPRAs of synthetic enhancers to derive interpretable rules on TFBS arrangement 🚦 and discover that negative synergies drive specificity in hematopoiesis 🩸. Shoutout to @Robert Frömel &
@larsplus.bsky.social
for leading this work 🦹🦸.
add a skeleton here at some point
5 months ago
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11
2
reposted by
Julia Rühle
Deutsches Krebsforschungszentrum (DKFZ)
5 months ago
Researchers from the
@crg.eu
, the
@irbbarcelona.org
, and the DKFZ have discovered that the reservoir of blood stem cells shrinks with
#age
. It becomes increasingly dominated by stem cells that produce pro-inflammatory immune cells.
t1p.de/kjf02
👇
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How aging changes the blood system in humans and mice
The reservoir of blood stem cells shrinks with age. It becomes increasingly dominated by stem cells that produce immune cells associated with chronic inflammation. Almost all of the 60-year-olds studi...
https://t1p.de/kjf02
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reposted by
Julia Rühle
Lars Velten
5 months ago
Out
@nature.com
: Clonal tracing with somatic epimutations 🧬 Single cell methylome encodes cell state & clonal identity 🔨 EPI-Clone reads out both (+mutations, +RNA) at scale 🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
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Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
https://doi.org/10.1038/s41586-025-09041-8
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🧬🔍How can enhancers achieve tissue-specific activity? We use MPRAs of synthetic enhancers to derive interpretable rules on TFBS arrangement 🚦 and discover that negative synergies drive specificity in hematopoiesis 🩸. Shoutout to @Robert Frömel &
@larsplus.bsky.social
for leading this work 🦹🦸.
add a skeleton here at some point
5 months ago
0
11
2
reposted by
Julia Rühle
Michael Scherer
6 months ago
Honored to be able to speak among such an amazing line-up of speakers. Check out the Single Cell Genomics Day 2025 if you want to learn more about DNA methylation based lineage tracing:
satijalab.org/scgd25/
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Single Cell Genomics Day
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https://satijalab.org/scgd25/
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