"the benefits of NIH research in general are wide and diffuse. A very large number of advances—roughly one in two during the 21st century—are linked to NIH grants that are cut in our counterfactual scenario."

This paper does a great job with a "It's a Wonderful Life" scenario about NIH, supposing the consequences of the bottom 40% of the funding NIH grants never existed. www.science.org/doi/10.1126/... tl:dr The world would lose a lot, but directly and indirectly

Frequent user of epitope tags? Try ours! IPI epitope tag antibodies & plasmids are now available through our partner @addgene.bsky.social! buff.ly/YEuZDIp

preLights is a #preprint highlighting service—supported by @biologists.bsky.social—encouraging #ECRs to highlight and discuss preprints that spark interest or debate within the biological #community. #SciComm Interested in joining? Our 'call for preLighters' is open for another week! ⬇️👀

The expanded Promega Collection is here! 250+ new plasmids for cancer research, protein interactions, targeted degradation & more. ✔ Industry + academic access ✔ No MTA required ✔ Aliquots or stabs to fit your workflow Check it out: https://twp.ai/4iqKEV

My only regret is that we didn't go with the title "One buffer to rule them all, and in the darkness bind them", although "Squeaky clean staining" was a pretty good options too!

Do you know what happens when you touch a carnivorous sundew plant? If the touch is strong and large enough, a cytosolic calcium wave will spread from the site of touch throughout the whole plant, but if you only touch one tentacle (see post below), the calcium wave will be local and less intense.

New at Addgene! Three new yeast toolkits are now available for the community. Details in thread ⬇️ https://twp.ai/4iqKvQ

Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social More info below ⬇️

It's #FluorescenceFriday! Another movie from our preprint, showing exocytosis of VAMP2-pHluorin (live-cell TIRF, blue) correlated with 2-color STORM of spectrins (green) and clathrin-coated pits (magenta). www.biorxiv.org/content/10.1...

👀"robust treadmilling requires an optimal phase separation strength to maintain high local concentration while preserving condensate fluidity. A weakened phase separation fails to stabilize the bundles, whereas overly cohesive condensates impede filament dynamics." #actin #phaseseparation

Gene editing of single, targeted neurons in vivo is now feasible. We are proud to present our preprint for highly efficient single-cell electroporation using RNA. With @alex-fratzl.bsky.social, @munzlab.bsky.social, Botond Roska @iobswiss.bsky.social #neuroskyence www.biorxiv.org/content/10.1...

Baby KJ's metabolic disorder was treated through an intense six-month effort to create a personalized CRISPR base editor — made possible by the preceding nine years of base editing research. Our latest blog post lays out the timeline of the advances that went into this year's major milestone.

"Open access policymaking should ... focus less on freely accessible publications (which are no doubt important) and more on the processes and forms of governance that go into good publishing."

What is open science? 🤔 To celebrate #OpenScienceWeek, we're sharing why we give away our data, protocols, and resources to everyone. Featuring our #openscience friends at @chanzuckerberg.bsky.social, NASA, @addgene.bsky.social, and NIH.

New tools available! Plasmids deposited by the Mingshan Xue Lab expand the optogenetics toolkit with potent, blue-shifted channelrhodopsins. https://twp.ai/4iqCaZ

I am not a political pawn. I am a living, breathing human being who has dedicated her life to a scientific problem that I believe matters for human health. The article below tells our story; I hope you will read it and share it www.nytimes.com/2025/09/14/m...

In 2019, Anna Jost & @jencwaters.bsky.social reviewed best practices for validating quantitative #microscopy methods & discuss strategies to avoid unconscious bias in imaging experiments rupress.org/jcb/article/... 📕 In #Reproducibility & Best Practices in Cell Biology: rupress.org/jcb/collecti...

reposting with alt text - Top cited antibodies are not always the best option! (and link to the paper cited: doi.org/10.7554/eLif...) 🧪

forgot to include link to our looooooooong miRNA hairpin saga. pls share with your miRNA geek friends and let us know what you think! in the meantime, here's a picture of stretch armstrong i pulled from the interweb. www.cell.com/cell-reports...

New #miRNA paper from Lai lab!! 🧬🔥 some think this field, despite recent Nobel to Ambros and Ruvkun, doesn't have much surprises left. but, do we EVEN KNOW WHAT a miRNA precursor LOOKS LIKE? we found some conserved miRNA hairpins up to 10x longer than suspected. this is mir-12, just bonkers! 1/n

Thanks for sharing these new biosensor plasmids for phosphatidic acid! Find them all here www.addgene.org/browse/artic...

In selecting an antibody to use for your experiment, you should look in the literature and find the one that one is most cited. NOT!

From large national databases to bespoke sample collections, biobanks offer a wealth of avenues for scientific enquiry. New @nature.com, @smjyoti.bsky.social speaks with @ukbiobank.bsky.social & other biobanks and users to learn how best to make use of their services www.nature.com/articles/d41... 🧪

Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)

In 1999, the Centers for Disease Control and *Prevention* (at least until the fascists change the name) highlighted the 10 great public health achievements of the 20th century. Trump's people are undermining ~all~ ~of~ ~them~. www.cdc.gov/mmwr/preview...

"If someone else’s work is important to yours, there is no alternative to reading it and coming to your own conclusion about whether you think their data are reliable and their claims valid. There is not, has never been, and never will be, a system that can absolve you of the need to read papers..."

Why hasn't Preprint Peer Review caught on more? I discovered a small, but simple reason - authors are missing out on the JOY of getting feedback because they aren't notified when feedback occurs. more in thread below!

Fascinating to see this field develop! 🧪

🧵How to write and manage your first research budgets The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

Many transcriptome regions are translated but not known to encode proteins. They remain poorly annotated and thus under studied, partly due to the lack of terminology for these features. In @natmethods.nature.com we propose using "Translon" for any region decoded by the ribosome

Has anyone encountered DNA fragments that were hard to clone because “toxic” in E. coli? (Not because of expression). Any tools to detect that? #microsky

What are your "good hands" training tips? @baym.lol and others? - Slow down - Pay attention - Visualise doing the whole protocol. What do you need to have labelled when? Where are you standing? What are you doing during the incubation? Etc. - Start new methods with 2-3 small low-stakes experiments.

🚨 New call for preLighters!🚨 Help us highlight the most exciting biological #preprints. Share your insights, build your profile, and be part of a supportive community! 🌍 Interested? Apply today & help shape the future of science publishing! 📢 More info: prelights.biologists.com/news/join-th...

If you’ve previously checked out our Packaged on Request service, check again! We’ve expanded our offering to over 4,000 eligible plasmids, 7 serotypes, and 4 volume sizes. More targets. More flexibility. Same trusted QC. See what’s new: https://twp.ai/4iqcnQ

There's always space in the toolbox for a new tool... especially when that new tool is a bright, sensitive orange calcium indicator! Read about OCaMP in this guest blog post by @abhiaggarwal.bsky.social

It's summer time and things are heating up! Bright fluorescent proteins, plant genome editors, new viral tools, and more. That's right, it's our latest Hot Plasmids post! Read about these and other hot new tools on our blog.

The 2026 Chemistry Faculty Jobs List has 99 tenure-track positions and 11 teaching-only positions: docs.google.com/spreadsheets... #chemsky #chemjobs #facultychemjobs ⚗️🧪

ICYM ASAPbio seeks new board members to support our mission of driving positive change in science communication!🚀 🤝 Board members are involved in strategic planning, participate in decision-making, and engage the community to help connect ASAPbio to contacts who can help us achieve our mission.✍️ 🔬

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

A pleasant surprise from the Journal of Neuroscience RE the application of the updated NIH public access policy (authors deposit accepted manuscript in PMC, journal retains license to final copyedited version, no requirement to pay OA fee) www.jneurosci.org/content/righ...

Extremely excited to share the outcome of a fantastic collaboration with @erinduffyphd.bsky.social revealing how experiences reshape hippocamapl chromatin and gene expression. Check out our searchable gene database and look up your favorite gene 🧬 www.nature.com/articles/s41...

Double your photons with this one weird trick! 💡

The Condensate Community Comment is out! So honored to be a part of this incredible group of authors dedicated to moving this field in the right direction www.nature.com/articles/s41...

Looking for a calcium sensor to fill the gap between red and green spectra? Orange you glad we asked! Check out our latest blog post on OCaMP, by @abhiaggarwal.bsky.social!

(Yet another) shout-out to @joachimgoedhart.bsky.social and colleagues for their ongoing technical service to the cell biology community – in this case, the yeast cell biology community. Special kudos for making all the key plasmids available on @addgene.bsky.social. Stellar work all around!

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

These are the most challenging times for early-career scientists and engineers. My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers. We found 437 of them. Download it freely here: research.jhu.edu/rdt/funding-...

I am proud of my #NewPI activity this summer so I want to #humblebrag about a little. Many of my students had results, but weren't making graphs and writing like they needed to 📊. So, at the beginning of the summer, I issued a Publishable Pieces challenge: 10 PPs for lab 🍨 outing. They did it!

On Monday, the Harvard team in charge of keeping the Drosophila repository FlyBase alive learned it was being laid off, leaving the future of the database, which serves more than 4,000 labs worldwide, in limbo. By @claudia-lopez.bsky.social #neuroskyence www.thetransmitter.org/community/ha...