In mice. "Portal vein-enriched metabolites as intermediate regulators of the gut microbiome in insulin resistance" www.sciencedirect.com/science/arti...

Fab collaboration with @HashemiLab! where we optimized their voltammetry technique to measure realtime secretion of #serotonin from human #gut #organoids. Led by 2 awesome ECRs @yuxian_lei and Bettina Bohl. @kingscollegelondon.bsky.social @kingshealth.bsky.social pubs.acs.org/doi/10.1021/...

A privilege to attend the launch of the @thelancet.bsky.social commission on clinical obesity with @kingshealth.bsky.social Great discussions on how a new definition of clinical obesity impacts policy, prevalence calcs, management, treatment, stigma and research in the field.

Gcg+ cNTS neurons monitor intestinal nutrients, cumulative ingested calories and have long-term effects on satiation. Th+ cNTS neurons encode esophageal distension and gulp size via vagal afferent inputs, providing quick feedback regulation of ingestion speed. www.nature.com/articles/s41...

@lifemetabolism.bsky.social is now indexed on PMC. Come on down and check out our great content. Please share and repost.

Latest from our group in collaboration with Lotte Bjerre Knudsen and other Novo scientists. They developed a GLP-1/Leptin co-agonist that we put through its paces in a number of mouse models to prove that both parts of the molecule matter. More options on the table! www.science.org/doi/10.1126/...

The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice 🧪 www.cell.com/cell-metabol...

Prepint has been out for a bit, but now you can read the skeetorial as well. See how you can map the impact of disease across the whole body.

LepR positive for Glp1r neurons represent targets for a GLP-1R/LepR dual agonist that potently reduces food intake and body weight. www.science.org/doi/10.1126/...

Sure, but how are those with greatest need going to be identified. Difficult choices to be made. #obesity #GLP-1 www.statnews.com/2024/12/04/o...

Regenerative drugs may be targeting cycling alpha cells in human islets. www.cell.com/cell-reports...

Fantastic McDowell lecture by the awesome Andy Pepper @PepperLab_UofA for @KclPhysiology. Great to chat about all things science, fishing and life in general! @AlbertaDiabetes. #diabetes #islets #T1D

This paper is important. It provides a really strong case for working as hard as possible to include samples from those centres that serve the traditionally underrepresented patient groups in research. If we want treatments to work on everyone, we need to ensure research includes everyone.

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

XF-DISC is highly promising for the development of regenerative ISC therapy for human intestinal diseases. #organoid www.nature.com/articles/s41...

Human fetal pancreatic organoids generate functional acinar and endocrine cell lineages upon differentiation LGR5 marks tripotent stem cells, precursors to all exocrine and endocrine lineages www.cell.com/cell/fulltex...

Gcg+ cNTS neurons monitor intestinal nutrients and cumulative ingested calories and have long-term effects on food satiation and preference. www.nature.com/articles/s41...

New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5

Must-read for 🧠 #organoid researchers: In a new preprint, the @knoblich-lab.bsky.social presents 4 organoid protocols that recreate the vast majority of cell types in the developing human brain. The data is freely available as a new #neuroscience reference. www.biorxiv.org/content/10.1...

We know everything about IL-33 already, right? No! In fact we know very little about IL-33 in the colonic epithelium Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵 www.mucosalimmunology.org/article/S193...

New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥 shorturl.at/EImjA

PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance | Science www.science.org/doi/10.1126/...

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

Microfluidic Organoids-on-a-chip: The future of human models A very nice update on Done (& To-Do) Brain Heart GI tract Liver Pancreas Tumor Explicit technical details Flavio Rizzolio lab Semin Cell Dev Biol 2023 www.sciencedirect.com/science/arti...

Current Biology Interoception and gut–brain communication www.cell.com/current-biol...

Science takes time - a lot of time. Time that is more and more difficult to make available because of increased workloads. Time that exceeds the temporary contracts of postdocs and PhDs. I'll illustrate this using our paper published in Nature yesterday. 🧵 (1/x) www.nature.com/articles/s41...

Over 800 million adults are now living with #diabetes worldwide with more than half not receiving treatment, global analysis suggests. Explore the findings ▶️ bit.ly/3Be89wl

Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets https://www.biorxiv.org/content/10.1101/2024.11.17.624030v1

Check out our review led by the amazing @rlhull-meichle.bsky.social on the role of pancreatic microvascualture in health and disease and beta cell replacement therapies: journals.sagepub.com/doi/full/10....

Really interesting read! To me, vascularization of grafts is the least developed aspect of islet transplantation and studies like this are helpful for understanding what exactly is it we're trying to build

Specific loss of GIPR signaling in GABAergic neurons enhances GLP-1R agonist-induced body weight loss Dual GLP-1R/GIPR agonism requires GIPR signaling in GABAergic neurons for its weight loss superiority over GLP-1R agonism www.sciencedirect.com/science/arti...

TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis www.sciencedirect.com/science/arti...

Progress in the mechanism of functional dyspepsia: roles of mitochondrial autophagy in duodenal abnormalities www.frontiersin.org/journals/med...

New work reveals the impact of anxiety & depression on PhD students. "Anxiety and depression can have a substantially detrimental impact on graduate students’ experiences [..] and likely also contribute to increased time to degree and student attrition." nature.com/articles/s41...

The Natural Products Atlas 3.0: extending the database of microbially derived natural products - thanks to the Linington lab for letting the Duncan lab be part of the curation efforts academic.oup.com/nar/advance-... #NaturalProducts #SpecializedMetabolites #microsky #microbialchemistry

Plasma concentration of gastrointestinal hormones and subjective appetite ratings after diet or bariatric surgery: 1-year results from the DISGAP study www.nature.com/articles/s41...

Gut microbiota regulates stress responsivity via the circadian system - our latest paper just out - well done Gabriel Tofani & all www.cell.com/cell-metabol...

Amgens GLP-1 agonist and GiPR antagonist MariTide: Achieved 20% weight loss over 52 weeks in phase 2, in people with #obesity or overweight without T2 #diabetes. Those with T2 diabetes achieved up to 17% weight loss. Shares slid as analysts expected 25% weight loss! Sky high expectations.

TRISCO A solid step closer to 3D #SpatialTranscriptomics 😎 Optimized probe-based 3D RNA imaging in whole organs isHCR Tris 500 mM 4'C Validated probe list in Table S1 Brain Heart Lung Kidney @peruhlen.bsky.social @science.org 2024 www.science.org/doi/10.1126/...

For those who don’t know us yet, a quick intro.👋 preLights is a community-driven preprint highlighting service—supported by @biologists.bsky.social—encouraging #ECRs to highlight & discuss #preprints that spark interest/debate in the biological #community. Interested in joining? DM (& follow) us!

Do you wonder if #regeneration and #tumorigenesis are always linked, or can they be unlinked to maintain tissue homeostasis? 🤔 Excited to share our latest work published in @Nature, where we explore this fundamental question in the #gut! Link: www.nature.com/articles/s41... 🧵👇

Stem cell-derived islets engineered to express EGFRt were targeted by CAR-Treg cells to suppress innate and adaptive immune responses, which may prevent immune rejection for #T1D cell therapy. Congrats to the Ferreira and Russ teams! www.cell.com/cell-reports... #regenerativemedicine

Welcome to our new EISG 2025 Bluesky account! 🧪 We'll soon start sharing exciting news about our upcoming conference in Malmö! So stay tuned for the latest info, and occasional diabetes-related puns. #IsletYouKnow #BetaCellDrama #BetaLateThanNever

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s422... A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social

Discontinuation of GLP-1 agonists is something we all need to start discussing. High cost, side-effects, etc. leading to many stopping within 12 months. What happens when patients stop using? Weight regain and possible worsening of medical issues. #MedSky #Obesity jamanetwork.com/journals/jam...

"Metabolic heterogeneity in stage 2 diabetes, differences between rapid- and slow-progressors, and heterogeneous impacts of immunotherapy, suggesting the need to account for these differences when designing and interpreting clinical trials" link.springer.com/article/10.1...

A vertical takeoff of life science with #AI LLLMs. Publication of 10 new foundation models of Proteins, DNA, RNA, methylation, cells, and interactions, evolution, and design in the past couple of weeks! Unprecedented progress, reviewed in the new Ground Truths erictopol.substack.com/p/learning-t...

Sharing again as I have added a at least 20 newbies and people how I just found out were here. Just need to get that Giles Yeo over here now go.bsky.app/NRoqMvp