Dr. Mundi @mmundi.bsky.social presenting about GLP-1 at the annual KYSPEN meeting.

Orforglipron, small molecule GLP-1ra in type 2 #diabetes. ➡️mean HbA1c at baseline was 8.0%. At week 40, it dropped −1.24% with 3-mg, −1.47 % with 12-mg, −1.48 % with 36-mg dose, and −0.41 % with placebo. www.nejm.org/doi/full/10.... #ADA2025

A consequence of climate change being worsening sleep apnea is something I never even considered. 🍎🧪

Our toolbox for management of #obesity continues to grow with phase 3 data being released today for the combination of cagrilinitide and semaglutide. Average weight loss for the combined drugs was over 20% and side-effect profile was similar to semaglutide. #Medsky 🧪🍎 www.nejm.org/doi/full/10....

Outstanding review of neuroinflammation and dysfunction in #LongCovid onlinelibrary.wiley.com/doi/full/10.... @virusesimmunity.bsky.social @jannamoen.bsky.social

If you're trying to build muscle, getting enough protein is a must. But does it matter if that protein comes from meat or plants? A new study overturns assumptions.

Analysis of Epic Cosmos data shows use of semaglutide and tirzepatide continues to increase for management of #Obesity now at 2.3% of eligible adults. Discrepancies in prescribing remain based on race and where you live. #Medsky jamanetwork.com/journals/jam...

This is such a tremendous loss for nutrition and obesity research. Truly hope you are able to continue your work elsewhere especially in Ultra-processed foods.

Sedentary Behavior and Light-Intensity Physical Activity During Pregnancy and Cardiovascular Health: A Science Advisory From the American Heart Association. www.ahajournals.org/doi/epub/10.... @ahajournals.bsky.social @ahascience.bsky.social #CardioSky #MedSky #Circulation

(1/n) Why is it so hard to stop eating when something tastes amazing? Our new @ science.org paper reveals that dopamine helps sustain our drive for tasty treats—and may explain how anti-obesity Ozempic tames those urges. doi.org/10.1126/science.adt0773

Do artificial sweeteners increase our appetite? This study using fMRI seems to show that artificial sweeteners activate key regions of the hypothalamus that regulate appetite. #Medsky #Obesity 🧪🍎 www.nature.com/articles/s42...

This is such an amazing study. Researchers tracked people over 300,000 births looking at how biomarkers change & recover postpartum. ~60% stabilise close to pre-conception levels after 3 months, but some (eg for bone & liver health) take a year. Others never recover! 🧪 www.nature.com/articles/d41...

Are tirzepatide and semaglutide cost effective? Although they would reduce 20,854 & 19,211 cases of DM2 and 10,655 and 8263 cases of CVD per 100K respectively, their prices would require a 30.5% and 81.9% reduction from current price to be “cost-effective" #Medsky 🧪 jamanetwork.com/journals/jam...

adiposetissue.org: A knowledge portal integrating clinical and experim... www.sciencedirect.com/science/arti... Thanks to the authors for providing a great online tool for the community

edhub.ama-assn.org/jn-learning/... #obesity #oncsky #medsky #cancer

We do see similar rapid weight loss with bariatric surgery. So medication selection, ie the correct medication based on BMI and medical co-morbidities will be key. 🧪 #obesity #Medsky

Great review on cardiovascular fitness. Imagine if VO2 max was a vital sign measured annually. #Nutsky 🧪🍎

Looking forward to ASPEN 2025. See you in Columbus.

Our review on Short chain fatty acids was just published. SCFA were once thought to just influence the gut mucosa locally, but now appear to have systemic effects: immune-modulation, anti-inflammatory, appetite suppression, mitochondrial function, etc. #MedSky 🍎🧪 journals.lww.com/co-clinicaln...

Are GLP-1 receptor agonists associated with higher risk of thyroid cancer. It looks like there is only an increase in the first year most likely due to increased vigilance. Overall no increase compared to other diabetes medications. #Medsky #Obesity 🧪 jamanetwork.com/journals/jam...

Hope to see ongoing research about the impact of microplastics.

Thanks for raising this issue. Really important to set social media curfew before bedtime especially in current political climate. #Medsky 🧪

Sugar-sweetened beverages are associated with an increased risk of Type 2 diabetes. Now we may know why. Changes in the gut microbiome and its metabolites www.cell.com/cell-metabol...

Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity www.cell.com/iscience/ful...

📣 Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-clinical trial @naturemedicine.bsky.social 👩‍🔬🥼🧪👨‍🔬 #Semaglutide #KidneyDisease #Obesity #kidney #NephroSky #CardioSky #NephSky 👇👇👇 pubmed.ncbi.nlm.nih.gov/39455729/

More real world data regarding benefits and side effects of GLP-1 agonists. Used VA database to compare patients w/ DM who used GLP-1 versus other meds. In addition to cardiometabolic benefits, also reduced substance abuse, psychotic disorders. #obesity #Medsky 🧪 www.nature.com/articles/s41...

#IDSky: Infectious diseases & malnutrition exist within a vicious cycle. The lowered immunity brought about by malnutrition makes people more vulnerable to disease, while the higher energy requirements and reduced appetite associated with many infectious diseases increase the risk of malnutrition.

Just incredible.

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X https://go.nature.com/42tH8Ai

Preparing for major surgery by exercising and improving diet (“prehabilitation”) is associated with fewer complications, less time in hospital, and improved recovery and quality of life in adults, suggests an analysis of clinical trials www.bmj.com/content/388/...

As our understanding of microplastics expands, the implications become increasingly concerning. The challenge will be in removing them from the environment. #medsky 🧪

Cancer statistics, 2025 PDF Download acsjournals.onlinelibrary.wiley.com/doi/epdf/10....

The cardiovascular benefit of these drugs was definitely surprising especially the degree of reduction MACE events.

A narrated video piece by Doug Mills, on photographing the Biden era. Doug is not only one of the great White House photogaphers. He is also a super nice person and colleague. www.nytimes.com/video/us/pol...

Some good news to start the new year. The prevalence of #obesity is plateauing and declined a bit in 2023 to 45.6%. Could this be the impact of GLP-1 agonists? #Medsky #NutSky 🧪 jamanetwork.com/journals/jam...

Exciting to see more options being developed for management of #obesity. #medsky 🧪

Our newest preprint about a new GLP-1R/GIPR dual agonist: www.biorxiv.org/content/10.1...

With everything so seemingly terrible these days & no sign of anything remotely hopeful in the near future, I thought you might need this photo of a baby giraffe.

A new study pits 2.5 servings/day of plant-based meats against animal meat. It finds ... basically nothing. The reason to eat plant-based meats *isn't* human health. It's environmental impact & animal welfare. www.sciencedirect.com/science/arti...

🧠🍽️ Thrilled to share my first review: Here we explore the role of sex in the therapeutic effects of GLP-1 analogs. Spoiler: there is still more research to be done :) 🧪 #neuroskyence #GLP1 #SexDifferences #ObesityResearch

My latest cartoon for @newscientist.bsky.social

As a heart-doc I’m a bit challenged when I have to deal with kidney physiology, but this graphical abstract is really beautiful to explain where and how our diuretics are actually acting!

Pretty sobering report on impact of climate change.

Physiological Principles of Exercise. Amazing!!!! evidence.nejm.org/doi/full/10.... @nejm.org #CardioSky #MedSky #PhysioSky

Most smokers realise that smoking could shorten their life but not the impact of each cigarette they smoke. The price of a cigarette: 20 minutes of life: 17 for men and 22 for women. onlinelibrary.wiley.com/doi/10.1111/...

Research suggests that resistance bands are often as effective as weights at building strength, endurance and muscle mass.

Millions are being treated by doctors using #AI to take notes and draft emails to patients. But we still don’t know when these tools are accurate or biased -- or if they even save doctors time, by @geoffreyfowler.bsky.social www.washingtonpost.com/technology/2... via @washingtonpost.com

This is important evidence to share with any patient or clinician concerned about cholesterol levels that might be “too low!” #MedSky #CardioSky evidence.nejm.org/doi/full/10....