Among critically ill adults with metabolic acidosis receiving vasopressors in the ICU, sodium bicarbonate did not lead to a lower risk of major adverse kidney events within 30 days than placebo. Full SODa-BIC trial results: https://nej.md/4ofXcyq #CCR26 | @criticalcarereviews.com#CCR26

I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

Diabetes org apologizes for ejecting scientists over criticism of Trump arstechnica.com/health/2026/...

Two days later. @altmetric.com score nearly doubled. Upper bound reach around 5 mil BlueSky accounts and 1 mil Twitter accounts. Again if you’d like to read the editorial is is available here: diabetesjournals.org/care/article...

I'll have A LOT of retatrutide thoughts. Alot. But these cardiometabolic improvements are stunning. 40% drop in triglycerides, 20% drop in LDL. 63% drop in hsCRP, 12 point reduction in BP. It's not a stretch to imagine this drug massively reducing death from CVD and CKD all on its own.

17 days until retatrutide phase 3 data and here's some published and unpublished data on decreases in glucose, insulin resistance and fasting insulin levels in diabetics and non-diabetics. This just in obese patients and the decrease in fasting insulin is *enormous* over 50% and still dropping!

Low-dose digoxin in patients with heart failure with reduced or mildly reduced ejection fraction: a randomized controlled trial. Sometimes, "old" therapies are still valuable today. www.nature.com/articles/s41... @natmed.nature.com @escardio.bsky.social #CardioSky #HeartFailure2026

This is a crime. www.nytimes.com/2026/05/05/u...

Generic Farxiga/Metformin combo pills are now starting to be dirt cheap locally with GoodRx!! By year's end I expect my new diabetic starter meds to mostly be these two. Especially if they have hypertension or high cholesterol or even slightly diminished renal or cardiac function. Yay for generics!

Cardiac resynchronization therapy restores ventricular synchrony in #HeartFailure patients with reduced ejection fraction and left bundle-branch block, improving function and lowering mortality. 🧵 ja.ma/4tTXfSR

Extremely sad to hear of the passing of Icahn School of Medicine at Mount Sinai #cardiology alumnus Dr. Eugene Braunwald. His impact on medicine is immeasurable. He was a friend, mentor, and so much more. #cardiovascular #cardiosky @harvard.edu @harvardmed.bsky.social @mgbresearch.bsky.social

📢 We've reached *3000* documented authoritarian-like actions of Trump's second term since Jan 2025... the two most recent are classic suppression of the press & using the justice system to attack political enemies www.trumpactiontracker.info

"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."

This image of home just came down from the Artemis II crew. Taken after their translunar injection burn, there are aurorae at top right and lower left, and zodiacal light at lower right. Credit: NASA/Reid Wiseman

GLP-1 Receptor Agonists. www.nejm.org/doi/full/10.... @nejm.org #CardioSky #MedSky #Cardiology #EndoSky #GLP1RA

Discontinuation of Beta-Blocker Therapy after Myocardial Infarction. www.nejm.org/doi/full/10.... @nejm.org @accintouch.bsky.social @jaccjournals.bsky.social #ACC26 #CardioSky

GLP-1 Receptor Agonists. www.nejm.org/doi/full/10.... @nejm.org #CardioSky #MedSky #Cardiology #EndoSky #GLP1RA

Discontinuation of Beta-Blocker Therapy after Myocardial Infarction. www.nejm.org/doi/full/10.... @nejm.org @accintouch.bsky.social @jaccjournals.bsky.social #ACC26 #CardioSky

Clopidogrel vs aspirin after PCI: 10-year HOST-EXAM follow-up shows lower ischemic and bleeding events with clopidogrel—but no difference in mortality. Read more: spkl.io/63327A0hCP #ACC26

Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per deciliter. Full Ez-PAVE trial results: nej.md/4rSQvT4 #ACC26

This is an incredible documentation of the systematic, intentional collapse of American health science, by Elizabeth Ginexi. open.substack.com/pub/elizabet...

After nearly 3.5 years of deliberations, researchers concluded their independent assessment of the origin of the coronavirus SARS-CoV-2 go.nature.com/4qUxijx

New—Diabetes and mental health thelancet.com/journals/lan... #T1D #T2D #GDM #MentalHealth fear of #hypoglycaemia #diabetes #distress #depression #disordered #eating #sleep disorders #MedSky #EndoSky #PsychSky

Secondary Prevention after Ischemic Stroke. www.nejm.org/doi/full/10.... @nejm.org #CardioSky #Stroke

Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials. www.thelancet.com/journals/lan... @thelancet.com #CardioSky #Statin

Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials. www.thelancet.com/journals/lan... @thelancet.com #CardioSky #Statin

A series of graphics reveals how the Trump administration has sought historic cuts to science and the research workforce. #NIH #NSF www.nature.com/immersive/d4...

Glucagon-like receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits. www.thelancet.com/journals/lan... @thelancet.com #CardioSky #GLP1

Standardization of Baseline and Provocative Invasive Hemodynamic Protocols for the Evaluation of Heart Failure and Pulmonary Hypertension: A Scientific Statement From the American Heart Association. www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @ahascience.bsky.social #CardioSky

How to best model glucotoxicity preclinically to study #diabetes www.nature.com/articles/s41...

The expanding landscape of GLP-1 medicines. www.nature.com/articles/s41... @natmed.nature.com #CardioSky #EndoSky #GLP1

Beyond a singular focus on GLP-1: why we need a new nomenclature now www.thelancet.com/journals/lan... #GLP-1 receptor agonists #incretins #obesity type 2 #diabetes #T2D #MedSky #EndoSky

President Trump is taking 325 mg of aspirin a day to prevent heart disease. His doctors advise him to take 81 mg. Both are wrong. Here’s why. New edition of Ground Truths, open-access erictopol.substack.com/p/the-lowdow...

Cardiogenic Shock. www.nejm.org/doi/full/10.... @nejm.org #CardioSky #CardiogenicShock

Cardiogenic Shock. www.nejm.org/doi/full/10.... @nejm.org #CardioSky #CardiogenicShock

Single-Pill Combination Therapy for the Management of Hypertension: A Scientific Statement From the American Heart Association. www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social #CardioSky

Do clinical trials expire? New heart attack studies show that evidence from 1980s may not apply to patients in 2025. Beta blockers are a case study in how medicine evolves, and how slowly our evidence base often keeps up. My latest Substack: neverdelegateunderstanding.substack.com/p/do-clinica...

Wellcome #NejmClinician ! NEJM Clinician — Finding the Medicine That Matters in an Age of Infinite Evidence www.nejm.org/doi/full/10.... @nejm.org #CardioSky #nejm

The American Diabetes Association Releases “Standards of Care in Diabetes—2026” - goo.gl/alerts/FJBpRx #GoogleAlerts

The top 10 people of 2025 @nature.com who shaped science. Recognizes Dr. Susan Monarez, the CDC Director who was "fired for holding the line on scientific integrity" www.nature.com/immersive/d4...

Safety, Utility, and Outcomes of Procainamide Challenge for the Diagnosis and Exclusion of Brugada Syndrome. www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social #CardioSky #Circulation

The ACIP decision to discontinue the recommendation for a universal hepatitis B birth dose vaccine will cause harm. As the federal government continues to fail children's health, families can rely on our nation's physicians to continue to put children's health first.

The decision by the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention to downgrade its recommendations to protect infants from hepatitis B is a dangerous move that will harm children. Click here to read AAP's full statement: bit.ly/3Y9ZQJT

Launching soon: NEJM Clinician NEJM Clinician gives you trusted, clinically relevant knowledge that brings confidence, peace of mind, and better care to your practice. Learn more: nej.md/48djv0c #MedSky

Safety, Utility, and Outcomes of Procainamide Challenge for the Diagnosis and Exclusion of Brugada Syndrome. www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social #CardioSky #Circulation

Here is a summary of our grocery trial from the AHA. medicaldigest.org/scientific-c...

Contemporary, non-invasive imaging diagnosis of chronic coronary artery disease. www.thelancet.com/journals/lan... @thelancet.com #CardioSky

Heart failure with reduced ejection fraction. www.thelancet.com/journals/lan... @thelancet.com #CardioSky #HFrEF #HeartFailure

Heart failure with reduced ejection fraction. www.thelancet.com/journals/lan... @thelancet.com #CardioSky #HFrEF #HeartFailure

New insights into the management of fulminant myocarditis academic.oup.com/eurheartj/ad.... @escardio.bsky.social #CardioSky #EHJ