Join me & keynote speaker Dr. Florian Rieder at #CCCongress26, Jan. 22-24 in Vegas. @ibd-flomd.bsky.social does an outstanding job bridging #IBD basic science and clinical research, so this is sure to be a great talk Register by 10/21 & SAVE: 🔗 bit.ly/4m85s1N #IBDsky #GIsky #Gastrosky

#Bcells are emerging as key players in #IBD, far beyond a T-cell story. From IgA protection to pro-inflammatory subsets, we highlight how understanding B cell diversity can unlock precise #Immunotherapy in #IBD. Check Fran and Bianca's review 👇 doi.org/10.1016/j.im...

📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...

Giggling her way into 3 months old

🔊 Paper alert 1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬 rdcu.be/exou9

Immune cell stratification in the inflamed intestinal epithelium #immunofluorescence #microscopy #ibd

Review the contributions of mucus-associated microbes who are “Living on the Edge” in the colon: www.mucosalimmunology.org/article/S193...

Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy

We’re excited to share our recently published story “A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing” in @mucosalimmunol.bsky.social Fantastic work led by @ramoralescastro.bsky.social ! www.mucosalimmunology.org/article/S193...

Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social

The colonic mucus barrier & sentinel goblet cells protect the distal gut from microbial challenges. Johansson, @gobletcellguy.bsky.social et al show that microbial colonization drives sequential development of both of these barrier mechanisms in the pre-weaning intestine. rupress.org/jem/article/...

Household mischief level about to double, welcome home baby two 🙃

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

Bluetorial: The path to a new pain medication with little potential for addiction Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. https://go.nature.com/41a7Zzj

1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.” I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports... Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?

New online! Understanding the therapeutic toolkit for inflammatory bowel disease

New: Lee et al. @harvardmed.bsky.social provide a compendium of early transcriptional responses to major inflammatory #cytokines across all major immunocyte lineages of the mouse, highlighting unappreciated relationships btwn these cytokines and with other cytokine families https://buff.ly/4gn71Fg

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

A little confocal time in the empty lab is the New Year's start that I needed!

Immune phenotyping of the colon in IBD #immunofluorescence #microscopy

NEW Year-in-Review in #NatureReviewsGastroHep highlighting the key papers in #IBD in 2024 Biologic agents for IBD come of age as host–microbe interactions emerge By Leolin Katsidzira & Benjamin Misselwitz www.nature.com/articles/s41... #IBDsky #GastroSky #Microsky 🧪

Z-stacking thru a goblet cell stained enteroid #immunofluorescence #microscopy

We know everything about IL-33 already, right? No! In fact we know very little about IL-33 in the colonic epithelium Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵 www.mucosalimmunology.org/article/S193...

Time-lapsing some organoid mini-colons #microscopy Grow, collapse, grow

Beautiful paper in intestinal epithelial biology! IMO the organoid experiments clarify some long-standing questions RE: what lineages can function as facultative stem cells after injury. A must read for the ISC field and reemphasizes the importance of cell plasticity in adult regeneration!

A mucus-enriched colonic organoid

You asked for it...

Excited to dive into #SciSky! Celebrating with a celestial field of intestinal organoids 🎉 #microscopy