Andrew
@andrewfong.bsky.social
📤 10
📥 14
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reposted by
Andrew
Edelblum Lab
2 months ago
📚NEW
#gdTcell
PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in
@mucosalimmunol.bsky.social
!
#gastrosky
#GIsky
#IBDsky
Join us for a Bluetorial 🧵...
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Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…
https://www.sciencedirect.com/science/article/pii/S1933021925000765?via%3Dihub
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reposted by
Andrew
Edelblum Lab
5 months ago
Congrats to
@ananya-p.bsky.social
on her outstanding Master’s defense on
#gdTcell
migration! 🍾🎉 We’re looking forward to another couple of years with Ananya as she takes on the new role of senior grad student
@sinaiimmuno.bsky.social
😁
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reposted by
Andrew
Edelblum Lab
7 months ago
#Bluetorial
: In our latest paper on
#gdTcells
and
#IBD
in
#ScienceImmunology
we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n
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reposted by
Andrew
Edelblum Lab
7 months ago
If you read our
#ScienceImmunology
paper and want to know how the
#microbiota
induces
#CD39
to promote a
#gdTcell
#immunoregulatory
phenotype, check out our new
#preprint
!
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Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...
https://www.biorxiv.org/content/10.1101/2025.03.22.644616v1
0
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4
reposted by
Andrew
Edelblum Lab
7 months ago
📣 New preprint drop! In
#ScienceImmunology
, we found that regulatory
#CD39
γδ IELs are reduced in
#IBD
, now
@saraalonsomera.bsky.social
shows that gut
#microbiota
promote enhanced CD39 expression in γδ IELs through
#TCR
and IL-15 activation.
#gdTcells
#GIresearch
#Gastrosky
@sinaiimmuno.bsky.social
add a skeleton here at some point
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reposted by
Andrew
Edelblum Lab
7 months ago
Congrats to co-first authors
@weilix27.bsky.social
and
@nbgolovchenko.bsky.social
on their fantastic achievement and hard work getting this project off the ground! Thanks to Irving for all the help in the revision process and the many labmates
@andrewfong.bsky.social
that contributed. 9/n
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1
reposted by
Andrew
Edelblum Lab
7 months ago
@sinaiimmuno.bsky.social
just gained a rockstar
#PhD
student with the acceptance of
@ananya-p.bsky.social
! Come see why we’re so lucky that Ananya will be joining us for a few more years at the APS Summit. She’ll be presenting two flashtalks (#GIL Trainee Symposium & Forte) on
#gdTcell
#migration
😍
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reposted by
Andrew
Edelblum Lab
7 months ago
📚NEW
#gdTcell
PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology Bluetorial coming soon!!!
#gastrosky
#GIsky
#IBDsky
@nbgolovchenko.bsky.social
@squeakyanimal.bsky.social
@andrewfong.bsky.social
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Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis
Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.
https://www.science.org/doi/10.1126/sciimmunol.adk7429
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reposted by
Andrew
Edelblum Lab
7 months ago
Congratulations to Dr. Sara Alonso on a spectacular defense! 👏 🍾 Sara is a powerhouse of
#gdTcell
#immunometabolism
data in the lab. We can’t wait to share the
#preprint
of her thesis work on
#gdTcells
and
#microbiota
with you later this week.
@sinaiimmuno.bsky.social
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Reminder to floss on
#FluorescenceFriday
just like this gamma delta IEL (pink)!
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7 months ago
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