Life Metabolism
@lifemetabolism.bsky.social
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Science journal concerning all aspects of metabolism
Research Highlight: SLC25A35 carrier endows mitochondrial PEP with glyceroneogenesis
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4 days ago
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Three-dimensional mapping and functional analysis of sympathetic innervation in aortic perivascular adipose tissue
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Three-dimensional mapping and functional analysis of sympathetic innervation in aortic perivascular adipose tissue
Abstract. Perivascular adipose tissue (PVAT) is a critical regulator of vascular homeostasis, and sympathetic nerves play a fundamental role in vascular fu
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag015/8704503
4 days ago
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Structure-guided design of a PCSK9 epitope vaccine with efficacy against hyperlipidemia and atherosclerosis
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4 days ago
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Exercise preserves Ī²-cell function in type 2 diabetes by reshaping intra-islet macrophage-Ī²-cell crosstalk
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4 days ago
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CLPTM1L remodels lipid rafts to promote glioblastoma growth | EurekAlert!
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CLPTM1L remodels lipid rafts to promote glioblastoma growth
The plasma membrane is more than a passive boundary. It is organized into dynamic lipid-rich microdomains, often referred to as lipid rafts, that concentrate receptors and signaling molecules. In glio...
https://www.eurekalert.org/news-releases/1130155
12 days ago
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CLPTM1L modulates membrane lipid rafts to promote tumor EGFR signaling
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CLPTM1L modulates membrane lipid rafts to promote tumor EGFR signaling
Abstract. The plasma membrane dynamically organizes into specialized lipid domains to sustain cell proliferative signaling, yet the regulatory mechanisms d
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag012/8688177
25 days ago
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Sphingolipid homeostasis and dysregulation in liver function and disease
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about 1 month ago
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New issue online in Life Metabolism: Vol. 5 Issue 2 brings together new work on mitophagy, gut circadian rhythms, MASLD, calorie restriction, Ī²-cell function, fasting-induced hepatic lipid metabolism, and precision nutrition. Explore the full issue:
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Volume 5 Issue 2 | Life Metabolism | Oxford Academic
Life Metabolism aims to provide an open access platform for the publication of works of high significance and broad interest in all areas of metabolism
https://academic.oup.com/lifemeta/issue/5/2
about 1 month ago
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New issue online | Life Metabolism Vol. 5 Issue 1 features Research Highlights and Original Articles spanning circadian metabolism, macrophage sensing, gut urate metabolism, the gutāliver axis, lean MAFLD, and hepatic autophagy. Read the issue:
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about 2 months ago
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Comprehensive metabolic characterization of pediatric ependymomas
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Comprehensive metabolic characterization of pediatric ependymomas
Tong Li, Ying Jin, Sikang Ren, Yifan Liu, Dan Cheng, Zhanying Bi, Yanong Li, Xiaoli Chen, Xiaoqin Zhu, Zheng Chen, Weiwei He, Yangyang Li, Yuwei Liu, Guomi
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag010/8659413
about 2 months ago
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Fasting turns brain lysosomes into reservoirs for TCA cycle metabolites | EurekAlert!
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https://www.eurekalert.org/news-releases/1119558
2 months ago
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Age-specific effects of HbA1c, blood pressure, and cholesterol (ABC) levels on incident cardiovascular diseases among adults with diabetes in China: a 10-year prospective cohort study url:
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Age-specific effects of HbA1c, blood pressure, and cholesterol (ABC) levels on incident cardiovascular diseases among adults with diabetes in China: a 10-year prospective cohort study
Abstract. Optimal control of hemoglobin A1c (HbA1c), blood pressure, and cholesterol (ABC risk factors) is essential for reducing cardiovascular disease (C
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag008/8586749
2 months ago
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Circadian biology and exercise: the time to move url:
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Circadian biology and exercise: the time to move
Abstract. Exercise performance in endurance- and power-based events is time-of-day dependent in both humans and rodents. Accordingly, there has been growin
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag009/8554094
2 months ago
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Reducing the strain on calorie restriction
@johnspeakman4.bsky.social
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Reducing the strain on calorie restriction
Abstract. Calorie restriction (CR) is a nutritional intervention known to delay aging and extend lifespan across a wide range of species, raising the possi
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag006/8527875
3 months ago
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Original Article: Lysosomes contribute to the synthesis of TCA-related metabolites in the hippocampus url:
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4 months ago
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functionally integrated cross-tissue alternative splicing program during short-term calorie restriction url:
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A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Abstract. Alternative splicing (AS) involves production of several different RNA molecules from a single pre-mRNA. Calorie restriction (CR) is a sustained
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf046/8475404
4 months ago
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Special Issue: Inter-organ crosstalk url:https://academic.oup.com/lifemeta/pages/special-issue-inter-organ-crosstalk
4 months ago
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Featured Articles Collection of 2025 url:https://academic.oup.com/lifemeta/pages/featured-articles-collection-of-2025
4 months ago
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Latest issue now online.
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Volume 4 Issue 6 | Life Metabolism | Oxford Academic
Life Metabolism aims to provide an open access platform for the publication of works of high significance and broad interest in all areas of metabolism
https://academic.oup.com/lifemeta/issue/4/6
4 months ago
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Cytosolic acetyl-CoA: a metabolic regulator of mitophagy url:
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Cytosolic acetyl-CoA: a metabolic regulator of mitophagy
Jianhua Xiong; Cytosolic acetyl-CoA: a metabolic regulator of mitophagy, Life Metabolism, , loag002, https://doi.org/10.1093/lifemeta/loag002
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag002/8441219
4 months ago
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Timekeepers of the gut: host circadian rhythms and microbial modulators url:
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Timekeepers of the gut: host circadian rhythms and microbial modulators
Abstract. The intestine is more than a digestive organ. It is a system under circadian control, where cellular renewal, barrier integrity, absorption, immu
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag003/8445289
4 months ago
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Gestational progesterone restores menstrual cycle in PCOS patients via enhancing ovary estrogen production url:
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Gestational progesterone restores menstrual cycle in PCOS patients via enhancing ovary estrogen production
Abstract. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, typically characterized by irregular mens
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag004/8455742
4 months ago
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Predictive value of 1-hour postprandial SPARC levels on metabolic outcomes from mediterranean diet adherence: results from a randomized controlled feeding study url:
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7 months ago
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Urate metabolism, in the gut url:
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7 months ago
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P5CS-coupled proline metabolism manipulates metabolic dysfunction-associated steatotic liver disease url:
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https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf040/8328310
7 months ago
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miR-378 as a metabolic-state-dependent switch controling liver autophagy and fat accumulation | EurekAlert!
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miR-378 as a metabolic-state-dependent switch controling liver autophagy and fat accumulation
Emerging evidence reveals that dysregulated autophagy, particularly the selective degradation of lipid droplets (lipophagy), is crucial to maintaining hepatic lipid balance, yet how its activity is re...
https://www.eurekalert.org/news-releases/1106459
7 months ago
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Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gutāliver axis url:
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Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gutāliver axis
Abstract. The gut commensal bacterium Akkermansia muciniphila (AKK) has emerged as a candidate for treating liver disorders, yet its therapeutic potential
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf036/8277574
7 months ago
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Loss of liver GH signaling causes lean fatty liver | EurekAlert!
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Loss of liver GH signaling causes lean fatty liver
A recent study published in Life Metabolism by Wu et al. from Dalian Medical University addresses this knowledge gap. The researchers developed a liver-specific Ghr knockout (...
https://www.eurekalert.org/news-releases/1103820
7 months ago
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Aberrant miR-378 expression promotes hepatic lipid accumulation via hijacking the bile acid-regulated autophagy url:
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Aberrant miR-378 expression promotes hepatic lipid accumulation via hijacking the bile acid-regulated autophagy
Abstract. Dysregulated autophagy contributes to liver steatosis, yet its regulation under distinct metabolic contexts remains poorly defined. Here, we iden
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf038/8320033
7 months ago
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Deletion of hepatic growth hormone receptor contributes to the pathogenesis of lean MAFLD by elevating CD36 url:
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Deletion of hepatic growth hormone receptor contributes to the pathogenesis of lean MAFLD by elevating CD36
Abstract. Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most prevalent chronic liver disease worldwide, affecting both obese
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf037/8304743
8 months ago
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A newly identified reductive uric acid pathway offers hope for gout | EurekAlert!
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A newly identified reductive uric acid pathway offers hope for gout
A new study published in Life Metabolism reports an alternative “reductive pathway” that functions without oxygen. In this route, uric acid is first reduced to a newly identified meta...
https://www.eurekalert.org/news-releases/1097422
9 months ago
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Well Met: RIPK1 senses S-adenosyl methionine to ensure cell survival url:
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10 months ago
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Review article by Dr. Lauren Palluth, Prof. Joseph S Takahashi and Prof. Carla B Green: Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time url:
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10 months ago
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The 13th Xiamen Winter Symposium on Lipid Metabolism and Physiology January 15-18, 2026 Learn more:
xws.xmu.edu.cn
10 months ago
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A reductive uric acid degradation pathway in anaerobic bacteria
Abstract. Uric acid (UA) is a key intermediate in purine degradation across diverse organisms, while its accumulation in humans leads to inflammation and g
https://academic.oup.com/lifemeta/advance-article/doi/10.1093/lifemeta/loaf031/8219984
11 months ago
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Weight loss benefits of Tirzepatide persist after stopping treatment in Chinese adults | EurekAlert!
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Weight loss benefits of Tirzepatide persist after stopping treatment in Chinese adults
In a recent study published in Life Metabolism, researchers at Fudan University report that even after stopping the anti-obesity drug tirzepatide, Chinese obese individuals can maintain significant we...
https://www.eurekalert.org/news-releases/1092128
11 months ago
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11 months ago
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Energy stress-induced PKCĪ¶ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation url:
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Energy stress-induced PKCĪ¶ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation
Abstract. Energy stress triggers the activation of AMP-activated protein kinase (AMPK) via phosphorylation mediated by liver kinase B1 (LKB1). A pivotal st
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf027/8203150
11 months ago
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brown fat-enriched exosomal miR-206-3p attenuates hepatic lipogenesis by decreasing pentose phosphate pathway url:
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The brown fat-enriched exosomal miR-206-3p attenuates hepatic lipogenesis by decreasing pentose phosphate pathway
Abstract. Brown adipose tissue (BAT) orchestrates interorgan crosstalk through secreted mediators, including proteins, lipids, and exosomal microRNAs (miRN
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf028/8197807
11 months ago
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Weight loss maintenance after tirzepatide cessation in people with overweight/obesity: a real-world follow-up of the phase 3 SURMOUNT-CN trial url:
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Weight loss maintenance after tirzepatide cessation in people with overweight/obesity: a real-world follow-up of the phase 3 SURMOUNT-CN trial
Abstract. Tirzepatide, a dual GIP/GLP-1 receptor agonist, has shown unprecedented efficacy in weight loss and improving metabolic parameters in clinical tr
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf024/8160888
12 months ago
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RME-1-associated recycling endosomes participate in vitellogenin secretion in Caenorhabditis elegans url:
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RME-1-associated recycling endosomes participate in vitellogenin secretion in Caenorhabditis elegans
Abstract. Vitellogenins (VITs), the lipoprotein precursors of yolk proteins in Caenorhabditis elegans, are expressed in the intestine, secreted into the ps
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf026/8177094
12 months ago
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12 months ago
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12 months ago
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Research Highlight: MDVs bridge metabolite signals to mitochondrial fitness url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf022/8158082
about 1 year ago
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Building the adipose atlas: consensus guidelines and a standardized analytical workflow url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf020/8158406
about 1 year ago
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Combination of time-restricted feeding with resistance exercise ameliorates MAFLD and improves glycemic homeostasis in obese mice url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf023/8159207
about 1 year ago
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about 1 year ago
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Spatially segregated multiomics decodes metformin-mediated functional-specific metabolic characteristics in diabetic kidney disease url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf019/8153028
about 1 year ago
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Circadian metabolism in myeloid cells url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf018/8152711
about 1 year ago
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Cryo-EM structure of the human MON1A-CCZ1-RAB7A complex provides insights into nucleotide exchange mechanism url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf017/8149154
about 1 year ago
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