Life Metabolism
@lifemetabolism.bsky.social
📤 149
📥 73
📝 115
Science journal concerning all aspects of metabolism
Original Article: Lysosomes contribute to the synthesis of TCA-related metabolites in the hippocampus url:
academic.oup.com/lifemeta/art...
9 days ago
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functionally integrated cross-tissue alternative splicing program during short-term calorie restriction url:
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A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Abstract. Alternative splicing (AS) involves production of several different RNA molecules from a single pre-mRNA. Calorie restriction (CR) is a sustained
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf046/8475404
23 days ago
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Special Issue: Inter-organ crosstalk url:https://academic.oup.com/lifemeta/pages/special-issue-inter-organ-crosstalk
26 days ago
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Featured Articles Collection of 2025 url:https://academic.oup.com/lifemeta/pages/featured-articles-collection-of-2025
26 days ago
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Latest issue now online.
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Volume 4 Issue 6 | Life Metabolism | Oxford Academic
Life Metabolism aims to provide an open access platform for the publication of works of high significance and broad interest in all areas of metabolism
https://academic.oup.com/lifemeta/issue/4/6
26 days ago
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Cytosolic acetyl-CoA: a metabolic regulator of mitophagy url:
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Cytosolic acetyl-CoA: a metabolic regulator of mitophagy
Jianhua Xiong; Cytosolic acetyl-CoA: a metabolic regulator of mitophagy, Life Metabolism, , loag002, https://doi.org/10.1093/lifemeta/loag002
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag002/8441219
about 1 month ago
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Timekeepers of the gut: host circadian rhythms and microbial modulators url:
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Timekeepers of the gut: host circadian rhythms and microbial modulators
Abstract. The intestine is more than a digestive organ. It is a system under circadian control, where cellular renewal, barrier integrity, absorption, immu
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag003/8445289
about 1 month ago
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Gestational progesterone restores menstrual cycle in PCOS patients via enhancing ovary estrogen production url:
academic.oup.com/lifemeta/art...
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Gestational progesterone restores menstrual cycle in PCOS patients via enhancing ovary estrogen production
Abstract. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, typically characterized by irregular mens
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loag004/8455742
about 1 month ago
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Predictive value of 1-hour postprandial SPARC levels on metabolic outcomes from mediterranean diet adherence: results from a randomized controlled feeding study url:
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3 months ago
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Urate metabolism, in the gut url:
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3 months ago
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P5CS-coupled proline metabolism manipulates metabolic dysfunction-associated steatotic liver disease url:
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https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf040/8328310
3 months ago
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miR-378 as a metabolic-state-dependent switch controling liver autophagy and fat accumulation | EurekAlert!
www.eurekalert.org/news-release...
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miR-378 as a metabolic-state-dependent switch controling liver autophagy and fat accumulation
Emerging evidence reveals that dysregulated autophagy, particularly the selective degradation of lipid droplets (lipophagy), is crucial to maintaining hepatic lipid balance, yet how its activity is re...
https://www.eurekalert.org/news-releases/1106459
4 months ago
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Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gut−liver axis url:
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Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gut−liver axis
Abstract. The gut commensal bacterium Akkermansia muciniphila (AKK) has emerged as a candidate for treating liver disorders, yet its therapeutic potential
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf036/8277574
4 months ago
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Loss of liver GH signaling causes lean fatty liver | EurekAlert!
www.eurekalert.org/news-release...
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Loss of liver GH signaling causes lean fatty liver
A recent study published in Life Metabolism by Wu et al. from Dalian Medical University addresses this knowledge gap. The researchers developed a liver-specific Ghr knockout (...
https://www.eurekalert.org/news-releases/1103820
4 months ago
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Aberrant miR-378 expression promotes hepatic lipid accumulation via hijacking the bile acid-regulated autophagy url:
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Aberrant miR-378 expression promotes hepatic lipid accumulation via hijacking the bile acid-regulated autophagy
Abstract. Dysregulated autophagy contributes to liver steatosis, yet its regulation under distinct metabolic contexts remains poorly defined. Here, we iden
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf038/8320033
4 months ago
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Deletion of hepatic growth hormone receptor contributes to the pathogenesis of lean MAFLD by elevating CD36 url:
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Deletion of hepatic growth hormone receptor contributes to the pathogenesis of lean MAFLD by elevating CD36
Abstract. Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most prevalent chronic liver disease worldwide, affecting both obese
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf037/8304743
4 months ago
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A newly identified reductive uric acid pathway offers hope for gout | EurekAlert!
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A newly identified reductive uric acid pathway offers hope for gout
A new study published in Life Metabolism reports an alternative “reductive pathway” that functions without oxygen. In this route, uric acid is first reduced to a newly identified meta...
https://www.eurekalert.org/news-releases/1097422
6 months ago
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Well Met: RIPK1 senses S-adenosyl methionine to ensure cell survival url:
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6 months ago
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Review article by Dr. Lauren Palluth, Prof. Joseph S Takahashi and Prof. Carla B Green: Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time url:
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6 months ago
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The 13th Xiamen Winter Symposium on Lipid Metabolism and Physiology January 15-18, 2026 Learn more:
xws.xmu.edu.cn
6 months ago
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academic.oup.com/lifemeta/adv...
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A reductive uric acid degradation pathway in anaerobic bacteria
Abstract. Uric acid (UA) is a key intermediate in purine degradation across diverse organisms, while its accumulation in humans leads to inflammation and g
https://academic.oup.com/lifemeta/advance-article/doi/10.1093/lifemeta/loaf031/8219984
7 months ago
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Weight loss benefits of Tirzepatide persist after stopping treatment in Chinese adults | EurekAlert!
www.eurekalert.org/news-release...
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Weight loss benefits of Tirzepatide persist after stopping treatment in Chinese adults
In a recent study published in Life Metabolism, researchers at Fudan University report that even after stopping the anti-obesity drug tirzepatide, Chinese obese individuals can maintain significant we...
https://www.eurekalert.org/news-releases/1092128
8 months ago
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8 months ago
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Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation url:
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Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation
Abstract. Energy stress triggers the activation of AMP-activated protein kinase (AMPK) via phosphorylation mediated by liver kinase B1 (LKB1). A pivotal st
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf027/8203150
8 months ago
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brown fat-enriched exosomal miR-206-3p attenuates hepatic lipogenesis by decreasing pentose phosphate pathway url:
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The brown fat-enriched exosomal miR-206-3p attenuates hepatic lipogenesis by decreasing pentose phosphate pathway
Abstract. Brown adipose tissue (BAT) orchestrates interorgan crosstalk through secreted mediators, including proteins, lipids, and exosomal microRNAs (miRN
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf028/8197807
8 months ago
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Weight loss maintenance after tirzepatide cessation in people with overweight/obesity: a real-world follow-up of the phase 3 SURMOUNT-CN trial url:
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Weight loss maintenance after tirzepatide cessation in people with overweight/obesity: a real-world follow-up of the phase 3 SURMOUNT-CN trial
Abstract. Tirzepatide, a dual GIP/GLP-1 receptor agonist, has shown unprecedented efficacy in weight loss and improving metabolic parameters in clinical tr
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf024/8160888
8 months ago
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RME-1-associated recycling endosomes participate in vitellogenin secretion in Caenorhabditis elegans url:
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RME-1-associated recycling endosomes participate in vitellogenin secretion in Caenorhabditis elegans
Abstract. Vitellogenins (VITs), the lipoprotein precursors of yolk proteins in Caenorhabditis elegans, are expressed in the intestine, secreted into the ps
https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf026/8177094
8 months ago
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8 months ago
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9 months ago
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Research Highlight: MDVs bridge metabolite signals to mitochondrial fitness url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf022/8158082
9 months ago
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Building the adipose atlas: consensus guidelines and a standardized analytical workflow url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf020/8158406
9 months ago
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Combination of time-restricted feeding with resistance exercise ameliorates MAFLD and improves glycemic homeostasis in obese mice url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf023/8159207
9 months ago
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9 months ago
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Spatially segregated multiomics decodes metformin-mediated functional-specific metabolic characteristics in diabetic kidney disease url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf019/8153028
9 months ago
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Circadian metabolism in myeloid cells url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf018/8152711
9 months ago
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Cryo-EM structure of the human MON1A-CCZ1-RAB7A complex provides insights into nucleotide exchange mechanism url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf017/8149154
9 months ago
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9 months ago
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Cryo-EM structure of the human MON1A-CCZ1-RAB7A complex provides insights into nucleotide exchange mechanism url:https://academic.oup.com/lifemeta/article/doi/10.1093/lifemeta/loaf017/8149154
9 months ago
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10 months ago
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10 months ago
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Explore the latest discoveries in metabolic biology with Life Metabolism Volume 4, Issue 1. Learn more:
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Volume 4 Issue 1 | Life Metabolism | Oxford Academic
Life Metabolism aims to provide an open access platform for the publication of works of high significance and broad interest in all areas of metabolism
https://academic.oup.com/lifemeta/issue/4/1
10 months ago
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Now Online: Life Metabolism Vol. 4, Issue 2. Explore all articles:
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Volume 4 Issue 2 | Life Metabolism | Oxford Academic
Life Metabolism aims to provide an open access platform for the publication of works of high significance and broad interest in all areas of metabolism
https://academic.oup.com/lifemeta/issue/4/2
10 months ago
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10 months ago
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New in Life Metabolism: Hyaluronidase-1 mediates postprandial suppression of hepatic gluconeogenesis from Prof Yi Zhu lab @bcmhouston. Read more:
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Hyaluronidase-1 mediates postprandial suppression of hepatic gluconeogenesis
Abstract. Hepatic gluconeogenesis is a critical process that generates glucose from non-carbohydrate precursors during fasting to support vital organs like
https://academic.oup.com/lifemeta/advance-article/doi/10.1093/lifemeta/loaf016/8129667
10 months ago
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An original article from Prof. Martin Picard's lab: Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific regulatory mechanisms
academic.oup.com/lifemeta/adv...
10 months ago
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DHHC5 regulates intestinal lipid absorption and lymphatic function | EurekAlert!
www.eurekalert.org/news-release...
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DHHC5 regulates intestinal lipid absorption and lymphatic function
The study reveals that DHHC5 is essential for the proper function of lacteals. DHHC5 mediates the palmitoylation of CRYBG1, an actin-binding protein, thereby regulating the localization of VEGFR2 in l...
https://www.eurekalert.org/news-releases/1082292#
10 months ago
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10 months ago
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11 months ago
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reposted by
Life Metabolism
Daniel Drucker
11 months ago
A novel cyclopeptide that targets FXR-coactivator interaction, reduces ceramides, increases GLP-1, thus paving the way for a new approach to treating MASH with FXR antagonists.
@lifemetabolism.bsky.social
academic.oup.com/lifemeta/art...
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Development of cyclopeptide inhibitors specifically disrupting FXR–coactivator interaction in the intestine as a novel therapeutic strategy for MASH
Abstract. Intestinal farnesoid X receptor (FXR) antagonists have been proven to be efficacious in ameliorating metabolic diseases, particularly for the tre
https://academic.oup.com/lifemeta/article/4/2/loaf004/8005845?login=false
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11 months ago
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