Several BreakthroughT1D funding opportunities available 1) Advancing GRS, especially in non-European backgrounds 2) Early detection in adult-onset T1D 3) Tech for scaling manufactured islets Feel free to reach out with questions. Open to industry and academia #funding #grants #T1D

Are you interested in developing a research programme in cell biology of diabetes? Do you work in pancreatic islets and/or other metabolically relevant cells? We have a Lectureship post opening in our Section @imperialcollegeldn.bsky.social Apply by 25th March: www.imperial.ac.uk/jobs/search-...

Listening to my academic friends tell me all about their plans to write and be productive during their sabbaticals knowing full well that if I was ever given one I’d used it to binge watch all 47 seasons of survivor chronologically

Cool advancements! The biggest obstacle for use is still how long it takes to image these things, even using an Operetta it would take me more than a full day to image 96 well plates before with how many stacks were needed for sufficient resolution.

How cool, the Clevers lab able to generate fetal pancreatic organoids with all 3 lineages including insulin+ endocrine cells. Will be a really powerful tool for understanding and modeling pancreatic development and dysfunction.

Really encouraging results! T1D patients on tirzepatide lost an average of 10% of their bw without an increase in DKA or severe hypoglycemic events … looking forward to future studies with readouts on its effect on CVD www.sciencedirect.com/science/arti...

Really interesting read! To me, vascularization of grafts is the least developed aspect of islet transplantation and studies like this are helpful for understanding what exactly is it we're trying to build

Stem cell-derived islets engineered to express EGFRt were targeted by CAR-Treg cells to suppress innate and adaptive immune responses, which may prevent immune rejection for #T1D cell therapy. Congrats to the Ferreira and Russ teams! www.cell.com/cell-reports... #regenerativemedicine

Really interesting ... maybe it will help with the shaming (often from medical professionals) of women who struggle to produce enough if there is an additional alternative to formula

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s422... A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social

Check out this fantastic work by our lab alumnus Kai Wang: Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery. Now out in Cell Stem Cell www.cell.com/cell-stem-ce...

Great to see this update by Kidney Research UK on all things #Diabetic #Kidneydisease in 2024. Special thanks for highlighting the work of our #PhD student Paige on targetting cell senescence in diabetic nephropathy 👩‍🔬🥼🧪..Full details 👇👇 #NephSky #diabetes www.kidneyresearchuk.org/2024/10/24/d...

Wow not sure if it was just the gays behind us yas-ing every 15 seconds but the Wicked movie was kind of … incredible? Also no one sang along!!! I’m sorry I doubted you Times Square AMC, it just felt like you’d be likely to attract people who wouldn’t be able to contain themselves

Actually maybe the sign of mainstreaming is when Greys Anatomy does a CAR T centric episode

Cell therapy manufacturing hubs like the one being built on Long Island are going to be huge for access (and economically) as CAR-T and other treatments expand beyond oncology and become more mainstream, especially as the hypoimmune CAR-T efforts seem to be struggling

Our new work! We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination). Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors www.biorxiv.org/content/10.1...

⭐💸 Funding Opps 💸⭐ Two new calls from BreakthroughT1D The first is for advancing technologies that support engraftment of transplants The second looks at common mechanisms for autoimmune disease Feel free to reach out with questions #funding #t1d #grants www.breakthrought1d.org/explore-rese...

Glucagon-like Peptide-1 Receptor Agonists: New Evidence of Kidney and Cardiovascular Protection From the FLOW and SELECT Trials 👇👇👨‍🔬🧪🥼 #cardiacsky #nephsky #medsky #cardiovascular #kidneydisease #Type2diabetes #semaglutide www.ajkd.org/article/S027...

One of my favorite things about these early BlueSky days is getting recommended posts like this and discovering entire fields of science I didn’t even know existed/had a name

I set up a calendar reminder to buy I’m Still Here tickets weeks ago but then was too distracted by talks at AHA and forgot to buy them and now they’re sold out 😭😭😭😭

Another exciting trial result for GLP-1s (tirzepatide), this time for HFpEF Add that to the growing list of secondary benefits it could have for T1D patients as an adjuvant to insulin www.nejm.org/doi/full/10....

Looking forward to reconnecting with the science community (and the nice sections of the film community :p ) on this app I'm also here at #AHA2024 exploring therapies for the T1D community if anyone has insights they'd like to share!