Now online in Cancer Discovery @aacrjournals.bsky.social: Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling - by Hsi-wen Yeh, Nicole Del Gaudio, Kivanç Birsoy, and colleagues doi.org/10.1158/2159... @rockefelleruniv.bsky.social

Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...

UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...

New Science story about multi-year funding and it potential catastrophic consequences www.science.org/content/arti... 1/n

President Donald Trump’s cuts to research funding are putting the US at risk of losing the technological race against other countries including China, said former US Commerce Secretary Penny Pritzker

In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.

PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.

“Simply put, there is never a good time to pull out of an investment that continually pays such strong dividends and directly benefits the citizens of our state.” Cuts to research funding risk the collapse of U.S. science and technology | Guest Column | wyomingnews.com

Funding scientific research is the only way we will cure cancer penncapital-star.com/commentary/f...

Pan-cancer human brain metastases atlas at single-cell resolution: Cancer Cell www.cell.com/cancer-cell/...

🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding. Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24. See 7:15 below. Full Senate appropriations committee meets tomorrow about it. 🧵 1/3

Patients with advanced melanoma who received nivolumab + relatlimab before and after surgery had lasting results four years later. Biomarkers may help predict who benefits most. http://spr.ly/633224xKCO #EndCancer

After years of searching, we now describe elusive roles of Dishevelled, a potent regulator of development, co-opted in #cancer. Dalia, a talented postdoc, along w/ our amazing team describe new dimensions of DVL1 function. Please check it out soon @natcomms.nature.com ❤️ @dalimartinez.bsky.social 🧪

Important research on IBC that can also benefit understanding other types of aggressive #breastcancer

Exciting new ideas about how LMD happens! @debeblab.bsky.social #cansky

Huge thanks to our collaborators and funders - @DoD, @METAvivor, @ACS, @NIH/NCI … And big congrats to Xiaoding Hu for leading this impactful work!👏👏👏 @mdanderson.bsky.social

Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2 👉 biorxiv.org/content/10.110…

Vanderbilt University Medical Center, one of the largest academic research and hospital care systems in the southeast, expects to lay off 650 employees as a result of grant and other funding cuts made by the Trump Administration, it said in a statement. From @anitawadhwani.bsky.social.

The massive funding cuts Trump and DOGE have made to scientific research should concern everyone; they will stifle American innovation and reduce economic growth. Researchers found that "a 50 percent reduction in funding would lower [GDP] nearly 7.6 percent" and cause permanent economic damage:

The Spencer Foundation is offering rapid response bridge funding for those who lost NSF research grants. www.spencer.org/grant_types/...

FYI “Spencer Foundation, Alfred P. Sloan Foundation, William T. Grant Foundation and Kapor Foundation are providing quick turnaround grants of up to $25k for education scholars impacted by the abrupt NSF grant cancellations.” www.spencer.org/news/meeting...

Academia isn’t perfect, but it offers a rare space to pursue knowledge for its own sake. If research were fully privatized, only profit-driven questions would get asked. Yet many of the most transformative discoveries began as curiosity-driven inquiries whose value wasn’t clear for years.

Congratulations Drs Woodward and Lynce on developing a new #IBC scoring system to improve IBC diagnosis. #IBCdiagnosis

Thrilled to share work from our @mdanderson.bsky.social IBC team & the IBC team at @dfcibreastonc.bsky.social led by Dr. Filipa Lynce Komen and @ibcresearch1.bsky.social support to validate a new IBC scoring system to improve IBC diagnosis! #medsky #ibcsky #cansky academic.oup.com/jnci/advance...

A huge loss at FDA. Peter Marks originated rhe Operation Warp Speed Covid vaccine idea and has overseen so many essential biotech programs such as genome editing cures www.wsj.com/politics/top...

How does exercise and fitness promote healthy brain aging? An outstanding, comprehensive review @thelancet.bsky.social reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more www.thelancet.com/journals/lan...

“Medical research is a gift-a legacy that we leave for the next generation. The beauty of our National Cancer Program is that we have all lived to see its gifts—the even million Americans whose lives have been saved.” Mary Lasker (1900 - 1994)

Congrats @drrebeccahowell.bsky.social on this well-deserved achievement!! 🎉🎉🙌@mdanderson.bsky.social

This is just horrible. The FY25 CR obliterates the already small funding allocations for the development of new treatments for patients with pancreatic cancer, lung cancer and glioblastoma.... for what purpose? These are three of the deadliest types of cancer.

They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...

The new Defense department budget erases $20 MILLION DOLLARS for pancreatic cancer research. $20,000,000 gone, for a disease with a 5-year survival rate of 13%.

Betty Kim & Wen Jiang and colleagues report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models. @bettykimmdphd.bsky.social @wenjiang-nano.bsky.social @mdanderson.bsky.social ⬇️ www.nature.com/articles/s43...

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University & academic career... 1/🧵

Our university’s NIH CTSA (Clinical and Translational Science Award) was just cancelled for having some keywords that just mean it will serve ALL people in Utah. This funds research that moves discovery science into clinical therapies. This is literally the mandate of the NIH! 😰 🧪

The NCI grant supporting the Columbia comprehensive cancer center was terminated. Tell me how terminating support for cancer research helps the economy. taggs.hhs.gov/Content/Data...

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

NIH is the best investment there is. www.forbes.com/sites/michae...

Thrilled to kick off this exciting project with an incredible team! Grateful for the support from the UT-MDACC Accelerator Grant as we push forward innovative drug development for IBC and other aggressive breast cancers. #IBC #breastcancer #bcsm #TRIUMPH-IBC @mdanderson.bsky.social

So thrilled to be working with Drs. Woodward and Debeb at MDACC to make strides in aggressive BC therapy! It’s incredible to team up with such fantastic experts. We’re also joined by Drs. Adam Klivans, Everett Stone, Brant Gracia, Danny Diaz, and Axel Brilot at UT Austin - dream team!

Our @mdanderson.bsky.social inflammatory breast cancer team led by @debeblab.bsky.social joined protein gurus Dr. Jen Maynard, Dr @annalee-nguyen.bsky.social & others @utaustin.bsky.social & won a $4M accelerator grant for our TRIUMPH-IBC drug development program!! So excited! #bcsm #cansky

THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️

Unbelievable news. Pancreatic is one of the deadliest cancers. New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care. www.nature.com/articles/s41...

The Atlantic story on the situation at NIH is sobering. We are so screwed. www.theatlantic.com/health/archi...

Friends, I am at a loss of words for how devastating it would be to lose the entire intramural #NIH program. Some of the biggest medical and scientific breakthroughs have come from scientists in the NIH Intramural program. #SaveTheNIH 🧬🧪 🖥️ 🧠 www.science.org/content/arti...

As federal research grants continue to be frozen, and NIH staff is being gutted, please note this study was funded by federal research grants, including from NIH. If they continue with staff cuts, and continue to freeze new awards, this is just one example of what we lose.

THIS IS HUGE! A cancer vaccine developed by Yale University and DFCI shows MAJOR promise. Results of an early-phase trial reveal ALL patients with ADVANCED stage kidney cancer had successful anti-cancer immune responses AND have remained CANCER-FREE approximately THREE years after treatment. 🧪🧵⬇️

New article up in The Scientist the-scientist.com/federal-empl...

Freezing out the NIH's funding means freezing out American innovation. Research into curing cancer, Alzheimer's, and Parkinson's all delayed. And ultimately it won't just cost us advancements in life-saving research, it will cost us lives.

Guardian story about Federal Register issue is up. www.theguardian.com/us-news/2025...