Candice Fung
@candicefung.bsky.social
📤 101
📥 183
📝 4
Enteric Nervous System 🔬
https://cfunged.wixsite.com/website
pinned post!
Ecstatic to share our paper on nutrient signaling in the
#EntericNervousSystem
published in Nature! 🧪 We explored how neurons in the gut respond to basic nutrients that we typically ingest and tested whether they can distinguish between different nutrients 🔬 Check it out 👉
tinyurl.com/3vc756dv
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9 months ago
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Candice Fung
Rosa Uribe, PhD
about 2 months ago
A sneak peak of a complex and technically challenging experiment that my lab developed:
doi.org/10.1096/fj.2...
. Super proud of PhD candidate Hannah Johnson for showcasing our Whole-gut spatial genomic analysis in
#zebrafish
. This video illustrates one landmark in the protocol after multiple 1/3
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Candice Fung
Nature
2 months ago
Nature research paper: Intestinal macrophages modulate synucleinopathy along the gut–brain axis
go.nature.com/4rg6DOI
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Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature
Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understanding the accompanying mechanisms could pave the way for early-stage biomarkers.
https://go.nature.com/4rg6DOI
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Candice Fung
Neckel Lab
3 months ago
📢 Remember those sleepless nights when you were kept awake from not knowing how the HSPG expression was in
#ENS
ganglia in
#Hirschsprung
's disease?! 🤯 These days are over, as you can read all about it in our new paper
@ngmjournal.bsky.social
!
onlinelibrary.wiley.com/doi/10.1111/...
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Perlecan, CollagenXVIII, and Agrin Expression in Normo‐, Hypo‐, and Aganglionic Segments in Hirschsprung's Disease
The secretory heparan sulphate proteoglycans perlecan, agrin, collagen18A1 are expressed in the periganglionic sheath of enteric ganglia in resectates of Hirschsprung's disease patients and non-Hirsc...
https://onlinelibrary.wiley.com/doi/10.1111/nmo.70230?af=R
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Candice Fung
4 months ago
We're excited to announce that applications for the best early investigator meeting in the field are open now. Treat yourself in this festive period and apply. For details visit
lbbb2026.com
Please share with friends and colleagues.
@dgnm.bsky.social
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Candice Fung
sinan malik
4 months ago
Really enjoyed highlighting this work by
@vmsruetten.bsky.social
from
@mishaahrens.bsky.social
lab for preLights. WHOLISTIC! A whole-body functional atlas of cellular dynamics. Lots of cool things in the preprint.
@hhmijanelia.bsky.social
@prelights.bsky.social
add a skeleton here at some point
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Candice Fung
Waggoner Lab
4 months ago
Human gut M cells resemble dendritic cells and present gluten antigen
@nature.com
@hansclevers.bsky.social
www.nature.com/articles/s41...
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Candice Fung
Waggoner Lab
4 months ago
Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage controlling type 1 and 2 immune balance
@natimmunol.nature.com
@champalimaudf.bsky.social
@neuroimmune-rok.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
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Candice Fung
MargolisLab
4 months ago
Enteric Neurons Join the Dialogue on Pain! A recent study reveals that cholinergic circuits within the colon communicate through dorsal root ganglion (DRG) pathways, particularly following inflammation. 👉
www.cell.com/neuron/fullt...
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An enteric-DRG pathway for interoception and visceral pain in mice
Wang et al. reveal a neuroanatomical and functional crosstalk between cholinergic enteric neurons and sensory neurons of the dorsal root ganglia that mediates colonic interoception. While this…
https://www.cell.com/neuron/fulltext/S0896-6273(25)00748-2
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Candice Fung
Bench Side Story
6 months ago
STEM CELL THERAPIES FOR ENTERIC NEUROPATHIES, with Dr Lincon Stamp, Senior Research Fellow & Group Leader, Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne
@unimelb.bsky.social
, Victoria, Australia
@stamphaolab.bsky.social
youtu.be/4EdI2jJL1l8
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Candice Fung
Deutsche Gesellschaft für Neurogastroenterologie & Motilität
5 months ago
👉 We generated a starter pack for
#neurogastroenterology
and enteric
#neuroscience
! Let's connect and bring gut-brain research and clinical neurogastroenterology to the next level! 🌐
go.bsky.app/3Z82PbH
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Candice Fung
Mike Lacy
8 months ago
💡 Always a good time to be reminded: "if you fuse your protein of interest to GFP or EGFP to study the protein's behavior ... you are using a tag with a serious drawback." Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)
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When is a Monomer not a Monomer? The Top Three Ways Your Favorite Fluorescent Protein Oligomerizes in Cells
Many commonly used fluorescent proteins form dimers producing artifacts in a variety of experimental settings. Learn how to avoid these artifacts.
https://blog.addgene.org/when-is-a-monomer-not-a-monomer-the-top-three-ways-your-favorite-fluorescent-protein-oligomerizes-in-cells
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Candice Fung
Nature Reviews Gastroenterology & Hepatology
9 months ago
New online! Nutrient sensing and small intestinal enteric neurons
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Nutrient sensing and small intestinal enteric neurons
Nature Reviews Gastroenterology & Hepatology, Published online: 24 July 2025; doi:10.1038/s41575-025-01105-4Nutrient sensing and small intestinal enteric neurons
https://www.nature.com/articles/s41575-025-01105-4?utm_source=bluesky&utm_medium=social&utm_campaign=nrgastro
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reposted by
Candice Fung
Nature
9 months ago
Nature research paper: Nutrients activate distinct patterns of small-intestinal enteric neurons
go.nature.com/4lr616y
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Nutrients activate distinct patterns of small-intestinal enteric neurons - Nature
Calcium imaging of the mouse jejunum shows that specific nutrients in the intestinal lumen are detected by epithelial cells, which activate specific sets of enteric neurons through a serotonin-mediated signalling process.
https://go.nature.com/4lr616y
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Ecstatic to share our paper on nutrient signaling in the
#EntericNervousSystem
published in Nature! 🧪 We explored how neurons in the gut respond to basic nutrients that we typically ingest and tested whether they can distinguish between different nutrients 🔬 Check it out 👉
tinyurl.com/3vc756dv
loading . . .
9 months ago
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reposted by
Candice Fung
Boesmans Lab
9 months ago
The website for next year's symposium on 'ENS development, function and repair' is online! Please visit
ens-leuven2026.eu
and mark your 📆 Updates and more information will follow soon. We hope to see you next April in Leuven 🇧🇪 with your most exciting
#ENS
science!
@pietervandenberghe.bsky.social
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ens-leuven2026.eu
https://ens-leuven2026.eu/
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Candice Fung
UlrikaKMarklund
10 months ago
Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors!
#NatureNeuroscience
#EntericNervousSystem
rdcu.be/eoqXz
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The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine
Nature Neuroscience - The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of...
https://rdcu.be/eoqXz
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reposted by
Candice Fung
Conor McCann
12 months ago
New preprint from our group on bioRxiv, a little step towards a better understanding of how coordinated contractions develop in the human intestine. Please check it out and let us know your thoughts.
add a skeleton here at some point
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Candice Fung
Trends in Neurosciences
12 months ago
April 2025 issue of Trends in Neurosciences:
www.cell.com/issue/S0166-...
Free featured articles & more:
cell.com/trends/neuro...
Cover article: ‘MicroRNA regulation of enteric nervous system development and disease’ by Holland et al.,
@wboesmans.bsky.social
group
www.cell.com/trends/neuro...
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Candice Fung
MargolisLab
12 months ago
New study: Boosting serotonin in the gut (not the brain) eases anxiety + depression—without the side effects. A safer path for treatment, especially during pregnancy.
#GutBrainAxis
#MentalHealth
#SSRI
@karapedsgastrodoc.bsky.social
@nyupainresearch.bsky.social
www.nyu.edu/about/news-p...
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Scientists Find Promising New Target for Antidepressants—In the Gut
Increasing serotonin in the lining of the gut improves anxiety and depression in animal studies and may offer new therapeutic approach during pregnancy to avoid newfound risk of digestive issues in ch...
https://www.nyu.edu/about/news-publications/news/2024/december/gut-brain-antidepressants.html
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Candice Fung
LabSoap
about 1 year ago
Check this
#JS2025
#colloque
#GLICO
Glial communication 🧠 🎤
@wboesmans.bsky.social
@candicechaps.bsky.social
#IBrunet
#QRoux
@laisbfugio.bsky.social
#VMoulle
#CLeBerre
💻
#MDerkindren
#TDurand
@labsoap.bsky.social
🗓️ 27-05 Nantes 🚧 Free Registration limited seats
js.univ-nantes.fr/jassiste-aux...
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reposted by
Candice Fung
Cell Reports
about 1 year ago
Intestinal-region-specific functions of AHR in intrinsic enteric neurons during infections
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Intestinal-region-specific functions of AHR in intrinsic enteric neurons during infections
Intrinsic enteric neurons (iENs) emerge as crucial regulators of immune responses in the intestine, but the underlying molecular mechanisms remain unclear. Sun et al. show that AHR differentially regulates iEN activation in different intestinal segments and that AHR expression in neurons constrains ILC3 responses and antibacterial immunity in the ileum.
http://dlvr.it/TJvnGY
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Candice Fung
Cell - a Cell Press journal
about 1 year ago
Now online! Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force
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Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force
Expression and functional analysis define how Piezo1-dependent cholinergic responses by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation in mice.
http://dlvr.it/TJkNkb
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reposted by
Candice Fung
Irene Miguel-Aliaga
about 1 year ago
Epic effort led by Tomo Ameku in the lab, with contributions from the labs of Nick Bellono, Vassilis Pachnis,
@francoisleulier.bsky.social
,
@schwarzergnoto.bsky.social
,
@priscaliberali.bsky.social
, @coxlabkcl.bsky.social,
@priscaliberali.bsky.social
and Maria Rodriguez-Colman
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Candice Fung
The Journal of Physiology
about 1 year ago
📖 LATEST ISSUE NOW LIVE 📖 This issue commemorates the late Dr. Gary M. Mawe who was a highly respected and much-loved Reviewing Editor for The Journal of Physiology. His snowflake photography features as the issue cover art❄️📷 🔗https://buff.ly/8BaJ270
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Candice Fung
Neuron
about 1 year ago
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Enteric glutamatergic interneurons regulate intestinal motility
Hamnett, Bendrick, et al. identify two populations of glutamatergic enteric neurons—longitudinal descending interneurons and a previously unreported population of circumferential neurons. They observe that these VGLUT2+ neurons form synaptic contact with…
http://dlvr.it/TJ5Hp4
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Candice Fung
Carolyn Bertozzi
about 1 year ago
Excited to share this collaborative work led by Guosong Hong’s group
@stanfordneuro.bsky.social
. A new method to render animals optically transparent for deep tissue imaging across the visible spectrum 🌈
www.biorxiv.org/content/10.1...
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Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice
Light scattering in biological tissue presents a significant challenge for deep in vivo imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely...
https://www.biorxiv.org/content/10.1101/2025.02.20.639185v1
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Candice Fung
Nature
about 1 year ago
Nature research paper: Topological segregation of stress sensors along the gut crypt–villus axis
https://go.nature.com/4b4jcpC
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Topological segregation of stress sensors along the gut crypt–villus axis - Nature
Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of the gut.
https://go.nature.com/4b4jcpC
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Candice Fung
Nature
about 1 year ago
There is a disconnect between the current molecular, morphological and functional descriptions of cells in most nervous systems
https://go.nature.com/4jUeXRq
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Does a cell’s gene expression always reflect its function?
Transcriptionally similar neurons can be functionally diverse.
https://go.nature.com/4jUeXRq
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Candice Fung
The Francis Crick Institute
about 1 year ago
Does what's happening in your gut affect what's happening in your brain? Researchers at the Crick are continuously learning new things about this complex relationship. Read more about their work and the gut-brain connection. 👇
www.crick.ac.uk/news/2025-01...
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Understanding our complex gut brain
Researchers are uncovering the complex connection between your gut and brain.
https://www.crick.ac.uk/news/2025-01-24_understanding-our-complex-gut-brain
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Candice Fung
Liam Rooney
over 1 year ago
🚨 New pre-print out! 🚨 The world’s first fully 3D printed microscope! Is Santa bringing you a 3D printer for Christmas, or maybe you need a gift for your favourite microscopist - print the lenses, print the frame, and start imaging! ✨🔬 Check it out below and please repost!👇🏻🙏🏻 (1/N)
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Candice Fung
Meghan Azad, PhD
over 1 year ago
The gut 'remodels' itself during pregnancy and
#breastfeeding
- nearly doubling its surface area! 🧪
www.livescience.com/health/ferti...
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The gut 'remodels' itself during pregnancy, study finds
The inner lining of the small intestine nearly doubles in size during pregnancy and breastfeeding, according to new research in mice and human tissue.
https://www.livescience.com/health/fertility-pregnancy-birth/the-gut-remodels-itself-during-pregnancy-study-finds
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reposted by
Candice Fung
Masseck Lab
over 1 year ago
🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with: ✨exceptional, brightness ✨phototability ✨and optogenetic compatability. Check out our new preprint:
www.biorxiv.org/content/10.1...
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Candice Fung
Cedric Boeckx
over 1 year ago
Such a nice, comprehensive review by
@marcvoo.bsky.social
and
@erin-schuman.bsky.social
on the molecular diversity of synapses (h/t
@djabaudon.bsky.social
):
www.nature.com/articles/s41...
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Understanding the molecular diversity of synapses - Nature Reviews Neuroscience
The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular mechanisms that contribute to the d...
https://www.nature.com/articles/s41583-024-00888-w
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Candice Fung
Thiago Carvalho
over 1 year ago
The set up: "This extensive use of antibiotics is based on the assumption that, other than toxicity issues when used in large doses, antibiotics disrupt biological processes in microbes and not the host."
www.science.org/doi/10.1126/...
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Antibiotics damage the colonic mucus barrier in a microbiota-independent manner
Antibiotics inhibit production of the protective mucus in the colon, thus predisposing to gut inflammation.
https://www.science.org/doi/10.1126/sciadv.adp4119
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Candice Fung
bioRxiv Neuroscience
over 1 year ago
Gut bacteria-derived succinate induces enteric nervous system regeneration https://www.biorxiv.org/content/10.1101/2024.10.15.618589v1
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Gut bacteria-derived succinate induces enteric nervous system regeneration https://www.biorxiv.org/content/10.1101/2024.10.15.618589v1
Enteric neurons control gut physiology by regulating peristalsis, nutrient absorption, and secretion
https://www.biorxiv.org/content/10.1101/2024.10.15.618589v1
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