A sneak peak of a complex and technically challenging experiment that my lab developed: doi.org/10.1096/fj.2.... Super proud of PhD candidate Hannah Johnson for showcasing our Whole-gut spatial genomic analysis in #zebrafish. This video illustrates one landmark in the protocol after multiple 1/3

Nature research paper: Intestinal macrophages modulate synucleinopathy along the gut–brain axis go.nature.com/4rg6DOI

📢 Remember those sleepless nights when you were kept awake from not knowing how the HSPG expression was in #ENS ganglia in #Hirschsprung 's disease?! 🤯 These days are over, as you can read all about it in our new paper @ngmjournal.bsky.social ! onlinelibrary.wiley.com/doi/10.1111/...

We're excited to announce that applications for the best early investigator meeting in the field are open now. Treat yourself in this festive period and apply. For details visit lbbb2026.com Please share with friends and colleagues. @dgnm.bsky.social

Really enjoyed highlighting this work by @vmsruetten.bsky.social from @mishaahrens.bsky.social lab for preLights. WHOLISTIC! A whole-body functional atlas of cellular dynamics. Lots of cool things in the preprint. @hhmijanelia.bsky.social @prelights.bsky.social

Human gut M cells resemble dendritic cells and present gluten antigen @nature.com @hansclevers.bsky.social www.nature.com/articles/s41...

Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage controlling type 1 and 2 immune balance @natimmunol.nature.com @champalimaudf.bsky.social @neuroimmune-rok.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...

Enteric Neurons Join the Dialogue on Pain! A recent study reveals that cholinergic circuits within the colon communicate through dorsal root ganglion (DRG) pathways, particularly following inflammation. 👉 www.cell.com/neuron/fullt...

STEM CELL THERAPIES FOR ENTERIC NEUROPATHIES, with Dr Lincon Stamp, Senior Research Fellow & Group Leader, Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne @unimelb.bsky.social , Victoria, Australia @stamphaolab.bsky.social youtu.be/4EdI2jJL1l8

👉 We generated a starter pack for #neurogastroenterology and enteric #neuroscience! Let's connect and bring gut-brain research and clinical neurogastroenterology to the next level! 🌐 go.bsky.app/3Z82PbH

💡 Always a good time to be reminded: "if you fuse your protein of interest to GFP or EGFP to study the protein's behavior ... you are using a tag with a serious drawback." Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)

New online! Nutrient sensing and small intestinal enteric neurons

Nature research paper: Nutrients activate distinct patterns of small-intestinal enteric neurons go.nature.com/4lr616y

Ecstatic to share our paper on nutrient signaling in the #EntericNervousSystem published in Nature! 🧪 We explored how neurons in the gut respond to basic nutrients that we typically ingest and tested whether they can distinguish between different nutrients 🔬 Check it out 👉 tinyurl.com/3vc756dv

The website for next year's symposium on 'ENS development, function and repair' is online! Please visit ens-leuven2026.eu and mark your 📆 Updates and more information will follow soon. We hope to see you next April in Leuven 🇧🇪 with your most exciting #ENS science! @pietervandenberghe.bsky.social

Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz

New preprint from our group on bioRxiv, a little step towards a better understanding of how coordinated contractions develop in the human intestine. Please check it out and let us know your thoughts.

April 2025 issue of Trends in Neurosciences: www.cell.com/issue/S0166-... Free featured articles & more: cell.com/trends/neuro... Cover article: ‘MicroRNA regulation of enteric nervous system development and disease’ by Holland et al., @wboesmans.bsky.social group www.cell.com/trends/neuro...

New study: Boosting serotonin in the gut (not the brain) eases anxiety + depression—without the side effects. A safer path for treatment, especially during pregnancy. #GutBrainAxis #MentalHealth #SSRI @karapedsgastrodoc.bsky.social @nyupainresearch.bsky.social www.nyu.edu/about/news-p...

Check this #JS2025 #colloque #GLICO Glial communication 🧠 🎤 @wboesmans.bsky.social @candicechaps.bsky.social #IBrunet #QRoux @laisbfugio.bsky.social #VMoulle #CLeBerre 💻 #MDerkindren #TDurand @labsoap.bsky.social 🗓️ 27-05 Nantes 🚧 Free Registration limited seats js.univ-nantes.fr/jassiste-aux...

Intestinal-region-specific functions of AHR in intrinsic enteric neurons during infections

Now online! Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force

Epic effort led by Tomo Ameku in the lab, with contributions from the labs of Nick Bellono, Vassilis Pachnis, @francoisleulier.bsky.social, @schwarzergnoto.bsky.social, @priscaliberali.bsky.social, ‪@coxlabkcl.bsky.social,‬ @priscaliberali.bsky.social and Maria Rodriguez-Colman

📖 LATEST ISSUE NOW LIVE 📖 This issue commemorates the late Dr. Gary M. Mawe who was a highly respected and much-loved Reviewing Editor for The Journal of Physiology. His snowflake photography features as the issue cover art❄️📷 🔗https://buff.ly/8BaJ270

Excited to share this collaborative work led by Guosong Hong’s group @stanfordneuro.bsky.social. A new method to render animals optically transparent for deep tissue imaging across the visible spectrum 🌈 www.biorxiv.org/content/10.1...

Nature research paper: Topological segregation of stress sensors along the gut crypt–villus axis https://go.nature.com/4b4jcpC

There is a disconnect between the current molecular, morphological and functional descriptions of cells in most nervous systems https://go.nature.com/4jUeXRq

Does what's happening in your gut affect what's happening in your brain? Researchers at the Crick are continuously learning new things about this complex relationship. Read more about their work and the gut-brain connection. 👇 www.crick.ac.uk/news/2025-01...

🚨 New pre-print out! 🚨 The world’s first fully 3D printed microscope! Is Santa bringing you a 3D printer for Christmas, or maybe you need a gift for your favourite microscopist - print the lenses, print the frame, and start imaging! ✨🔬 Check it out below and please repost!👇🏻🙏🏻 (1/N)

The gut 'remodels' itself during pregnancy and #breastfeeding - nearly doubling its surface area! 🧪 www.livescience.com/health/ferti...

🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with: ✨exceptional, brightness ✨phototability ✨and optogenetic compatability. Check out our new preprint: www.biorxiv.org/content/10.1...

Such a nice, comprehensive review by @marcvoo.bsky.social and @erin-schuman.bsky.social on the molecular diversity of synapses (h/t @djabaudon.bsky.social): www.nature.com/articles/s41...

The set up: "This extensive use of antibiotics is based on the assumption that, other than toxicity issues when used in large doses, antibiotics disrupt biological processes in microbes and not the host." www.science.org/doi/10.1126/...

Gut bacteria-derived succinate induces enteric nervous system regeneration https://www.biorxiv.org/content/10.1101/2024.10.15.618589v1