sinan malik
@sinanmalik.bsky.social
📤 557
📥 671
📝 33
RA
@juliesemmelhack.bsky.social
Lab| systems neuroscience | writes @preLights
pinned post!
Really enjoyed highlighting this work by
@vmsruetten.bsky.social
from
@mishaahrens.bsky.social
lab for preLights. WHOLISTIC! A whole-body functional atlas of cellular dynamics. Lots of cool things in the preprint.
@hhmijanelia.bsky.social
@prelights.bsky.social
add a skeleton here at some point
5 months ago
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sinan malik
Wataru Koyama
1 day ago
My PhD paper is out in Science Advances! We found that the adult zebrafish cerebellum encodes both positive and negative valence during GO/NOGO task learning, and teaching signals sent to Purkinje cell update internal models of task rules.
www.science.org/doi/10.1126/...
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The cerebellum implements structured representation of valence to support adaptive behavior control
Cerebellar circuits identify danger and safety to guide flexible, adaptive behavior.
https://www.science.org/doi/10.1126/sciadv.aeb5860
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sinan malik
Roxana Zeraati
about 2 months ago
Many thanks to
@klaus-tschira-stiftung.de
and
@gso-forresearchers.bsky.social
for this wonderful opportunity to study the mechanisms underlying naturalistic decision processes in the context of foraging behavior! We’ll also soon have openings for PhD students, stay tuned!
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sinan malik
Kenneth Harris
12 days ago
New method for identifying the fine transcriptomic types of thousands of neurons recorded in vivo!
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sinan malik
Martin Haesemeyer
18 days ago
New preprint from the lab, led by Bradley Cutler. With the
@james-gagnon.bsky.social
lab we use zebrafish to show that fever is not a reduction in the perception of warmth. Immune signals instead increase the valence of warming stimuli while cooling turns aversive.
www.biorxiv.org/content/10.6...
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sinan malik
Rory Cooper
19 days ago
Having a lovely time using the incredible imaging facilities at
@clf-stfc.bsky.social
🦈🔬
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sinan malik
James Gagnon
about 1 month ago
Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes!
www.biorxiv.org/content/10.6...
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Nature
about 1 month ago
Nature research paper: Astrocytes connect specific brain regions through plastic networks
go.nature.com/4eBe8fV
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Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
https://go.nature.com/4eBe8fV
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sinan malik
Fumi Kubo
about 1 month ago
Happy to share our new paper published in Nature Communications!
www.nature.com/articles/s41...
We developed CaMPARI-seq to link neural activity with molecular profiles and revealed how the brain distinguishes optic flow to guide behavior. Congratulations to our postdoc Koji Matsuda!
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Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors
Nature Communications - In this study, the authors develop CaMPARI-seq to link neural activity with molecular profiles in larval zebrafish. They identify inhibitory pretectal neurons required for...
https://rdcu.be/fdW1q
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sinan malik
Dayu Lin
about 2 months ago
What has changed in mama bear brain (well, actually mice) to make her risk her life to attack a potential threat and protect her young? Oxytocin is the key! Happy to share our new study led by two awesome postdocs: Takashi Yamaguchi and Rongzhen Yan.
www.nature.com/articles/s41...
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The neural mechanisms supporting the rise and fall of maternal aggression - Nature
In mice, female aggression is governed by an amygdala–to–medial hypothalamus circuit that is strengthened during pregnancy and is dynamically amplified by oxytocin during lactation.
https://www.nature.com/articles/s41586-026-10354-5
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sinan malik
Yale Kavli Institute for Neuroscience
about 2 months ago
In a new study,
@yale.edu
researchers led by
@yaleschoolofmed.bsky.social
's
@ehoffmanlab.bsky.social
, MD, PhD 🥼 identified a promising candidate to rescue disrupted brain activity in zebrafish carrying mutations in autism risk genes 🦓🐠
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Zebrafish reveal new insights into the biology of autism
In a new study, Yale researchers identified drug candidates that reverse disrupted behaviors in zebrafish carrying mutations in autism risk genes.
https://news.yale.edu/2026/04/02/zebrafish-reveal-new-insights-biology-autism
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sinan malik
Constantinople lab
2 months ago
Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning.
www.nature.com/articles/s41...
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Acetylcholine demixes heterogeneous dopamine signals for learning and moving
Nature Neuroscience - Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and...
https://www.nature.com/articles/s41593-026-02227-x.epdf?sharing_token=A381CAlAnIRJBODuL-yPRNRgN0jAjWel9jnR3ZoTv0OC3rXlFW58DrJ2kzezlHt7_VZRr1kz9ZpB6He68KpSxccZoqYSN8FPevDB6Zt6K7RBgpaFnYCXtvKTxYkOPpoosjt6i1Kknh2OfwTbaXSxX_A9OVNz3DlK0ig7gMRr9rI%3D
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Natalie Schaworonkow
2 months ago
a while ago, I made this feed for neuroscience/cognitive science summer schools. after some tuning, it generally manages to find cool events. 🙂
bsky.app/profile/did:...
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sinan malik
Emily Troyer
2 months ago
Out now in Science: The Truman Show, but with killifishes! "Continuous recording of a vertebrate’s adult life from adolescence until death would provide a complete view into the behavioral architecture of aging."
www.science.org/doi/10.1126/...
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Lifelong behavioral screen reveals an architecture of vertebrate aging
Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behaviora...
https://www.science.org/doi/10.1126/science.aea9795
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sinan malik
Benjamin Judkewitz
3 months ago
How do fish localize sound without interaural cues?
@johve.bsky.social
et al. found a behavioral algorithm for directional hearing that predicts behavior from a pressure/motion phase comparison and accounts for how this relationship varies with distance.
www.cell.com/current-biol...
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An algorithm underlying directional hearing in fish
Veith et al. show how a fish—Danionella cerebrum—can reliably startle away from sound. It uses the relative phase between particle motion and pressure to infer the direction of sound. This sensorimoto...
https://www.cell.com/current-biology/fulltext/S0960-9822(26)00170-3
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sinan malik
Benjamin Judkewitz
3 months ago
First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by
@joerghenninger.bsky.social
,
@mh123.bsky.social
sky.social
and team.
www.biorxiv.org/content/10.6...
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sinan malik
The Transmitter
3 months ago
“Astrocytes in the lateral septum may explain, or be at the basis of, the sex differences we observe in terms of social fear.” –Alexandre Charlet. By Holly Barker
www.thetransmitter.org/spectrum/ast...
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Astrocytes orchestrate oxytocin’s social effects in mice
The cells amplify oxytocin—and may be responsible for sex differences in social behavior, two preprints find.
https://www.thetransmitter.org/spectrum/astrocytes-orchestrate-oxytocins-social-effects-in-mice/?utm_source=bluesky&utm_medium=org-social&utm_campaign=20260304-news-astrocytes-orchestrate-oxytocin-social-effects-mice
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sinan malik
Ahmed El Hady
3 months ago
An exciting study with Roberto Garza and Armin Bahl
biorxiv.org/content/10.6...
We combine high-throughput behavioral assays in larval zebrafish with drift-diffusion modeling studying integration dynamics across development and a variety of mutants . Give it a read :D
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sinan malik
Florian Engert
3 months ago
Check this out! Latest collaborative work from my and Mark Fishman's labs - led by Roy Harpaz, with help from Pedro Piquet and Yasuko Isoe (
@yasukoisoe.bsky.social
)
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sinan malik
Portugues Lab
4 months ago
Have you ever wondered how the brain should represent the sensory world in order to generate behavior? Read our new preprint: work by Shuhong Huang
shuhonghuang.bsky.social
with our long-standing collaborator James Fitzgerald at Northwestern.
add a skeleton here at some point
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sinan malik
Oded Rechavi
4 months ago
“ok so this is embarrassing but just for the record and just so we have it, your C.V says "Nature Scientific Reports"? sorry to have to even ask”
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sinan malik
Peter Rupprecht
4 months ago
Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with
@sianduss.bsky.social
@bohaceklab.bsky.social
, and many others:
www.biorxiv.org/content/10.6...
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sinan malik
Oded Rechavi
about 1 year ago
Supplementary figure 16
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sinan malik
Simon Schultz
5 months ago
Lu, Schultz, Kozlov, Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli Now published in J Neurophys
journals.physiology.org/doi/abs/10.1...
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Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli | Journal of Neurophysiology | American Physiological Society
Astrocytes are increasingly recognized as active participants in sensory processing, but whether they show selective responses to stimulus features, analogous to neuronal receptive fields, is not yet ...
https://journals.physiology.org/doi/abs/10.1152/jn.00505.2025
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sinan malik
5 months ago
In
@elife.bsky.social
: Pallium-encoded valence-specific chemosensory amplification of eye-body coordination in larval zebrafish
doi.org/10.7554/eLif...
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Pallium-encoded valence-specific chemosensory amplification of eye-body coordination in larval zebrafish
https://doi.org/10.7554/eLife.109494
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sinan malik
Portugues Lab
5 months ago
1/6: New publication from the lab: “Plastic landmark anchoring in zebrafish compass neurons” by Ryosuke Tanaka (
@ryosuketanaka.bsky.social
) and Ruben is available here:
rdcu.be/eX1L4
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Plastic landmark anchoring in zebrafish compass neurons
Nature - Using two-photon microscopy with a panoramic virtual reality setup, how head direction cells in larval zebrafish integrate visual landmarks and optic flow to track orientation is revealed.
https://rdcu.be/eX1L4
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sinan malik
Artologica aka Michele Banks
5 months ago
Okay, well, I painted some new neurons in burnt sienna and black
#sciart
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sinan malik
Portugues Lab
5 months ago
1/n: A new collaborative preprint from the lab to start the year: "A multi-ring shifter network computes head direction in zebrafish" together with Siyuan Mei, Martin Stemmler and Andreas Herz from the LMU, Munich.
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sinan malik
BWJones
5 months ago
Surprise mother$#@%er! Q: What does this mean for neural systems to understand them? A: We absolutely need the wiring diagram. All synapses, chemical and electrical.
#Connectomics
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sinan malik
Mackenzie Weygandt Mathis
5 months ago
Interested in the latest advances in neuroscience (neural dynamics and internal models) and how they can be leveraged to build smarter, adaptive AI? ➡️ My first real solo piece 🖤🫶
@natneuro.nature.com
rdcu.be/eWVmA
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Leveraging insights from neuroscience to build adaptive artificial intelligence
Nature Neuroscience - Adaptive intelligence envisions AI that, like animals, learns online, generalizes and adapts quickly. This Perspective reviews biological foundations, progress in AI and...
https://rdcu.be/eWVmA
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sinan malik
Ann Kennedy
5 months ago
"My New Year's Resolution is to find a principled way to think about all those cell types in the brain" Why friend, you are in luck, because
@rgast.bsky.social
has just the perspective for you:
www.sciencedirect.com/science/arti...
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How heterogeneity shapes dynamics and computation in the brain
Much effort has been spent clustering neurons into transcriptomic or functional cell types and characterizing the differences between them. Beyond sub…
https://www.sciencedirect.com/science/article/pii/S0896627325008967
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sinan malik
allen institute
5 months ago
Glutamate is the primary molecule that neurons use to communicate with each other. Previously, scientists have mostly recorded when neurons fire output signals, but now with a new glutamate indicator, they can record the many inputs that causes cells to fire. 🧵
#neuroskyence
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sinan malik
Joey Tidei
5 months ago
I don't always get pretty, isolated, AND transfected primary neurons in culture, but when I do I take advantage.... Rat hippocampal neuron overexpressing ThymosinB4-mScarlet and imaged for 16hr on a
@zeiss-microscopy.bsky.social
LSM880 with Airyscan.
#FluorescenceFriday
#Microscopy
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sinan malik
Jonas Wietek
5 months ago
Merry Christmas, Hanukkah, et al.
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Really enjoyed highlighting this work by
@vmsruetten.bsky.social
from
@mishaahrens.bsky.social
lab for preLights. WHOLISTIC! A whole-body functional atlas of cellular dynamics. Lots of cool things in the preprint.
@hhmijanelia.bsky.social
@prelights.bsky.social
add a skeleton here at some point
5 months ago
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10
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sinan malik
Current Biology
7 months ago
Check out our newest issue where we interview
@juliesemmelhack.bsky.social
, who studies the neural circuits of visual behavior at the Hong Kong University of Science and Technology.
www.cell.com/current-biol...
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Q & A
Interview with Julie Semmelhack, who studies the neural circuits of visual behavior at the Hong Kong University of Science and Technology.
https://www.cell.com/current-biology/fulltext/S0960-9822(25)01258-8
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sinan malik
Adrian Jacobo
6 months ago
It's finally out! Our paper on optogenetic interrogation of the lateral line:
www.cell.com/iscience/ful...
This one involved a lot of sweat and tears, and it was a real tour de force. It was also the last paper we got to write with Jim, so it's a special one (and hence, the tears).
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Optogenetic interrogation of the zebrafish lateral line reveals brain-wide neural circuits involved in pattern separation
Zoology; Neuroscience; Sensory neuroscience
https://www.cell.com/iscience/fulltext/S2589-0042(25)02453-8
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sinan malik
Oded Rechavi
6 months ago
The fun leaving your body the moment you're done with the science and it's time to get it published
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sinan malik
Leibniz-Institut für Neurobiologie
6 months ago
We are very excited:
@hannazwaka.bsky.social
has been awarded a Leibniz Best Minds grant as a Junior Research Group Leader! Five years of independent research, tenure track and part of the Best Minds network – a real boost for her career.
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You're not you when you're hungry... and neither is a zebrafish! Our new paper shows that hunger completely overrides the instinct to flee, making zebrafish approach potential threats instead. "Hunger shapes predator avoidance in zebrafish."
@zebrafishrock.bsky.social
🐟
doi.org/10.1080/0394...
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Hunger shapes predator avoidance behaviour in zebrafish
All organisms, including humans, engage in behavioral choices and complex decision-making processes, which are crucial for survival. The mechanisms underlying behavioral choices require the acquisi...
https://doi.org/10.1080/03949370.2025.2563566
6 months ago
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sinan malik
Abe Goldfarb
6 months ago
when someone tells me not to use em dashes because AI uses em dashes
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sinan malik
Portugues Lab
6 months ago
(1/n) We are excited to share our new paper in Nature Communications, by Hagar Lavian (
@hlavian.bsky.social
) and team, revealing how the zebrafish brain integrates visual navigation signals!
www.nature.com/articles/s41...
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Visual motion and landmark position align with heading direction in the zebrafish interpeduncular nucleus - Nature Communications
How are various visual signals integrated in the vertebrate brain for navigation? Here authors show that different spatial signals are topographically organized and align to one another in the zebrafi...
https://www.nature.com/articles/s41467-025-66084-1
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sinan malik
David Schoppik
6 months ago
Like most animals, fish move less at night. Underwater, stable posture requires movement. Find out how fish don't fall down at night in: Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish from
@yunluzhu.bsky.social
doi.org/10.1101/2025...
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Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish
Most fish are inherently unstable and must swim to stabilize posture. How diurnal fish reduce activity at night while maintaining postural control remains unclear. We defined distinct locomotor strate...
https://doi.org/10.1101/2025.11.18.689084
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sinan malik
Matthew Logie
7 months ago
The changes we experience may be the source of our subjective experience of time.
www.nature.com/articles/s41...
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Time, space, memory and brain–body rhythms - Nature Reviews Neuroscience
Understanding how the brain represents experienced time and how representations of space and time are integrated to form episodic memories has been a goal of much neuroscientific research. In this Per...
https://www.nature.com/articles/s41583-025-00987-2
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sinan malik
Oded Rechavi
7 months ago
Going to the lab during the weekend to do cell culture work and trying to do everything at double speed
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sinan malik
Oded Rechavi
7 months ago
Writing the “Alternative Plans” part of the grant
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Caroline Wee
7 months ago
Now published in Molecular Metabolism, improved by the helpful reviewers! We hope to continue to leverage the
#zebrafish
to understand the neurometabolic and hormonal regulation of appetite and beyond! Read the full article here:
www.sciencedirect.com/science/arti...
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sinan malik
7 months ago
✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡
www.biorxiv.org/content/10.1...
1/13 🧵
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Large-scale cellular-resolution read/write of activity enables discovery of cell types defined by complex circuit properties
The complexity of the mammalian brain’s vast population of interconnected neurons poses a formidable challenge to elucidate its underlying mechanisms of coordination and computation. A key step forwar...
https://www.biorxiv.org/content/10.1101/2025.10.21.683734v1
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sinan malik
MPI for Biological Intelligence
7 months ago
How does a fish know when to blend in? Scientists identified a key circuit controlling camouflage in zebrafish – from cells in the retina sensing light to nerve cells in the brain controlling the release of a hormone that pales the skin to match bright backgrounds.
www.bi.mpg.de/news/2025-11...
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