Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...

A modular lentiviral system for multiplexed gene perturbation and functional analysis reveals interdependence of hormone receptors in breast cancer growth in vivo https://www.biorxiv.org/content/10.64898/2025.12.07.692832v1

Researchers have performed a large-scale genetic screen to uncover the hidden roles of #microproteins. One of the discovered microproteins, named PIPPI, was found to protect cells from stress in the endoplasmic reticulum. Published in @narjournal.bsky.social 🧪 #proteomics news.ki.se/new-micropro...

Happy to share a new preprint on NUDT5's role in regulating nucleoside analog (NA) drug efficacy. 🔗 👇 🧵: We show that perturbing NUDT5 abundance by RNAi or a PROTAC (DDD2), but not inhibition with TH5427, desensitizes cells to thiopurines and most NA drugs in a titratable manner. 1/n

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky

DNAi: an open-source AI tool for unbiased DNA fiber analysis https://www.biorxiv.org/content/10.1101/2025.09.30.679603v1

🚨 Happy to finally share our first @biorxivpreprint.bsky.social on PROTACs and TPD with Mikael Altun and DDDP @scilifelab.se. 🚨 We develop a suite of cell-based methods to assess degrader functionality and show this with new PROTACs toward NUDT5 as PoC. 👇 www.biorxiv.org/content/10.1... 🧵 1/4

This phenomenon describes how those with an early advantage or success tend to accumulate over time https://go.nature.com/45AJ1Ni

NAD+ Sensing by PARP7 Regulates the C/EBPβ-Dependent Transcription Program in Adipose Tissue In Vivo https://www.biorxiv.org/content/10.1101/2025.04.07.647692v1

Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq https://www.biorxiv.org/content/10.1101/2025.03.19.644003v1

THREAD This Is The Story Of The The Pernicious Rise of AI-Generated Papers and their Online Impact An Incomplete History Told In The Voice of Documentarian Adam Curtis 1/31

Great perspective on the importance of conventional chemotherapy. Despite many many decades of successful use, do we understand how these drugs work? www.nature.com/articles/s41...

Thrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead! www.biorxiv.org/content/10.1...

Very happy to have been able to contribute to this amazing story! Check out the paper at Nature Communications and the 🧵 by @nckvalerie.bsky.social below 👇. We believe #CeTeam will be an invaluable tool for #drugdiscovery and #targetvalidation in #cells 🔗: www.nature.com/articles/s41...

Good timing for a first Bluesky post! 🦋 I'm thrilled to share that our BioRxiv preprint on #CeTEAM has now been published in Nature Communications! 🔗: www.nature.com/articles/s41... A short 🧵 1/x 👇

Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust electron transport chain abundance, with many implications for the role of ROS in development and disease. www.cell.com/molecular-ce...

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Awesome paper, I think the authors are not on Bluesky yet

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. www.biorxiv.org/content/10.1...

Excited to launch a new Gordon Research Conference on synthetic lethality in oncology. Great cutting edge program, superb speakers and lots of networking opportunities. Applications open. www.grc.org/synthetic-le...

@thornsesholdlab.bsky.social set up a feed, that will show all posts with #ChemBio. If you are interested in the feed, click this link, click "Pin to Home" and it will be added as feed to your home screen: bsky.app/profile/did...#ChemBio.I will use this hashtag in all relevant posts.

Intriguing new paper by @mflangelier.bsky.social in the Pascal lab showing that PARP1 can generate free poly-ADP-ribose (PAR) (not attached to proteins) in vitro and in cells. In some cases PAR is attached to NAD+! #PARP #ADP-ribosylation #NAD+ www.cell.com/molecular-ce...

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

🧬 I'm happy to announce that our latest study, "ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapping," is now available on bioRxiv! 🧬 Check it out here: biorxiv.org/content/10.1... @buissonlab.bsky.social