Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Our latest published paper on developmental consequences of a human DVL1 variant in a Drosophila model of Robinow Syndrome.

How is developmental speed regulated ? 🪰 Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye. www.biorxiv.org/content/10.1... A big thanks to everyone involved!

We have an uncorrected proof published for Bhagaban Mallik's study on Mitochondrial Complex I and how it regulates synapse function. You can find it in @plosbiology.org. I am so proud! H/T collaborators: Drs. Sajad Bhat and Xinnan Wang @xinnanwanglab.bsky.social journals.plos.org/plosbiology/...

🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

We only had a very minor contribution to this story with Alexis, but definitly worth a reading for those interested by patterning, precision and refinment. Nice combining of quantitative live imaging, modeling and optogenetics to dissect vein patterning dynamics www.cell.com/developmenta...

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

www.thecrimson.com/article/2025... Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research

My MCDB dept is accepting applications for a faculty position at the Assistant Professor level! Applications Due by October 15, 2025 We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels. lsa.umich.edu/mcdb/news-ev...

The University of Notre Dame is hiring 5 tenure or tenure-track professors in Neuroscience, including Computational Neuroscience, across 4 departments. Come join me at ND! Feel free to reach out with any questions. And please share! apply.interfolio.com/173031

Come be my colleague! We are hiring for two tenure-track positions. www.reed.edu/dean_of_facu...

Please please please, if you are able, consider supporting Flybase fiscally. They need our help! I donated this evening. They are in danger of closing and any amount will help. We cannot allow this critical pillar of science to collapse!

Embryonic induction of fate is a core concept in developmental biology. But, cells can also modify the physical state of surrounding tissues a process we call 'actuation'. I reviewed with @mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.

Fly folk: The Amazing and essential @flybase.bsky.social is in existential need due to Trump termination of the grant that supports this vital resource. Please donate to help keep Flybase alive. I just did. Info here on how to make a tax deductible donation: wiki.flybase.org/wiki/FlyBase...

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

What happens to the mitotic apparatus during the prolonged spindle assembly checkpoint–induced mitotic arrest? Read the latest #GENETICS study that uses mutational analysis of #Drosophila CMG helicase to answer this question. buff.ly/OoriIaC

Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium

I doubt that there is a single family in America that hasn’t benefitted directly from the NIH.

No better time to call or email your members of Congress. Next year’s NIH budget is being debated in the Senate. A new nonpartisan campaign is making it easy to defend science and protect America’s innovation. Just follow this link to contact your representatives: www.protectscienceandinnovation.org

How do RGCs in the neocortex 'know' it is time ⌚ to start making oligodendrocyte precursors cells? Check out this great work by my colleagues @luulitran.bsky.social & @thefrancolab.bsky.social to find out!! Congratulations! 🧠

🧪Have a terminated NSF grant? Or been impacted by such a termination? Call your Senators, esp if they're Repub!! An amendment to restore killed NSF grants will later be debated on the *full Senate* floor, after it narrowly failed in committee today. 🧵 Brief thread 1/4

Future of NIH in the hands of five senators. Write to them if you are in PA -McCormick WV - Moore Capito ME - Collins AL - Britt LA - Cassidy

Bassem Hassan @bassemh.bsky.social, Corey Harwell & yours truly are co-chairs for 2026 Neural Development #GRC August 2-7, 2026 in Newport, RI 🇺🇸 - if you are interested in updates on the conference & to hear about our 🤩 line-up of speakers...follow @neuraldevgrc.bsky.social! 🧠🪰🐭🐙🐸🦎🧒🏻🧫🧪🧠

For all the #DevNeuro postdocs & graduate students...Neural Development GRS will be held right before - Aug 1-2, 2026 and is co-chaired by @deepthavasu.bsky.social & Aleksandra Recupero - we will post about this as well! Check out the website www.grc.org/neural-devel...

We will be updating the GRS website and announcing our exciting keynote speaker in the coming weeks!

I’m thrilled to share a @biorxivpreprint for my postdoc work in the @PerrimonLab🎉. Together with our collaborators, we built a tissue-specific atlas of circulating secreted proteins in Drosophila 🧬🪰🧪🗺️. Thread below🧵 1/8 www.biorxiv.org/content/10.1...

IMPORTANT IMPORTANT IMPORTANT IMPORTANT Please watch the workshop video and COMMENT by 5:00 Monday 7/14 This is the source of the "no more model organism only grants in NIH-funded research" decree.

Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows. Gift link: nyti.ms/44KFFFv

Summary Table of the massive defunding of biomedical research in the United States www.nytimes.com/interactive/...

I had the best time visiting CSH to give the cell neural biology lecture at the fly course. Thank you so much to Robert, Tania and @rister.bsky.social for the opportunity!

🔬👨‍💻📰 #SReD is out! Automated structural detection for #ImageJ & #FIJI, from nano to macro ✨🐘. No training data, no bias - texture analysis with GPU acceleration!⚡️ Brainchild of @afonsomendes92.bsky.social and adventure w @christlet.bsky.social lab + friends. Check: www.nature.com/articles/s41...

Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in. mcgill.wd3.myworkdayjobs.com/en-US/McGill...

A little more than a year that @carmeloferrai.bsky.social and I published our review "Mechanotransduction in stem cells"🤯! I'm happy that it was received well 😃! Stay tuned, more to come in this direction in a not too far future😎.

APHA is gathering grants by TOMORROW NOON for Phase 2 of their lawsuit vs. NIH which regards NIH **applications** that were unfairly pulled from review, mishandled, or delayed from being awarded due to DEI issues. To add your grant to this lawsuit, become an APHA member & submit this survey:

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!

Another day testing the limits of resilience. The Alexandria NSF building was designed for the NSF merit review process (gold standard), complete with a floor devoted to panels. Now we aren’t allowed to have in person panels. The loss of US science leadership will haunt this country for decades.

MassLive.com recently interviewed several Harvard FlyBase people and wrote this news article about the importance of FlyBase: tinyurl.com/4chpts9f

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

NEW: NSF will be kicked out of their building. Announcement will be made tomorrow by HUD Sec. and Governor of VA. HUD will take over the NSF building over the next two years. NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."

In #GENETICS, @perrimonlab.bsky.social ‬presents a new, comprehensive #Drosophila resource using in vitro & in vivo datasets linking transcription factors to their target genes along with protein-protein interaction, tissue-specific transcriptomic, & chromatin accessibility data: buff.ly/Ou5wyYW

New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix and lysosomes—and the resulting implications for research and therapeutics for neurodegenerative disorders. Learn more in this #ScienceSignaling Review: scim.ag/4kG61io

"OnlyFlies"

BREAKING: A federal judge in Massachusetts (the Reagan-appointed William Young) has declared the Trump administration's cuts to NIH grants — ostensibly over Trump's EOs on gender ideology and DEI — are "illegal" and "void." He's ordering many grants restored.

Love this. Who needs sheets!?

This one is close to my scientific heart 💜: An excellent read shining the light on an aspect of RNA biology that is way too often overlooked. #RNAsky #RNAlocalization

Very happy to share our latest lab publication! The hard work of @bboumard.bsky.social, Gwenn Le Meur and collaborators! Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila: Developmental Cell authors.elsevier.com/a/1lDFi_Yv6z...