Cool new paper from the Munro lab!

Are you planning to attend the upcoming #Dros26 in Chicago? Closing date for early registration is January 15th (six days away), and the conference-rate hotel block registration deadline is February 3rd. Act soon!! genetics-gsa.org/drosophila-2... #Drosophila

Two classes of amine/glutamate multi-transmitter neurons innervate Drosophila internal male reproductive organs #Drosophila

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

Caffeine extends lifespan by enhancing lysosomal lipolysis in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.01.08.698302v1

This is a crucial study and moves us forward towards understanding fundamental biological questions about how cells integrate information related to how components within cells are regulated. These are Nobel worthy questions and the folks who answer them are moving us towards that understanding.

Sebinelli, Syska, Razmazma et al. @umontpellier.bsky.social show that the yeast protein Ist2, which localizes to ER–PM contact sites, possesses a #phospholipid scramblase activity in its ER-localized transmembrane domain that is important for several ER-related processes. rupress.org/jcb/article/...

🚨Last chance to submit your poster abstract for #Dros26! Get one-on-one feedback on your research from experts from all around the world. Submit your research by tomorrow, January 6, 7:59 p.m. EST. 🔗https://buff.ly/heeYoPC

Still up. Glad I posted here and not YouTube. This is what Bari Weiss and CBS tried to hide from us.

More news (not good) from NIH The renewal request from National Institute of Neurological Diseases and Stroke Director Walter Koroshetz has been denied. I guess the NIH_leadership™ needed another position to fill with their time-tested recruitment process.

ER generally a calcium source in dendrites and a calcium sink in axons during activity of Drosophila visual neurons....

Narbonne-Reveau, K., Erni, A., Eichner, N., Sankar, S., Kapoor, S., Meister, G., Cremer, H., Maurange, C., Beclin, C. (2025). In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors. PLoS Genet, 21(4):e1011680 journals.plos.org/plosgenetics...

Spotlight: Ivan Radin discusses new work from Ryken and colleagues (rupress.org/jcb/article/...) which shows how localization and function of autoinhibitory calcium ATPases maintains the strength of the tip-focus Ca2²⁺ gradient during polarized plant growth. rupress.org/jcb/article/... #PlantBiology

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins. buff.ly/hFHjKy9

Check out this work from @yuritakahashi.bsky.social that reveals reciprocal interactions between cell migration and fate specific to drive collective cell invasion. And follow Yuri at the same time

Rickle, A., Sudhakar, K., Booms, A., Stirtz, E., Lempradl, A. (2025). More than meets the eye: mutation of the white gene in Drosophila has broad phenotypic and transcriptomic effects. Genetics, 230(3) academic.oup.com/genetics/art...

@attychang.bsky.social, @nanigrotjahn.bsky.social et al. show that cytoplasmic #ribosomes on #mitochondria alter the local membrane environment for protein import. rupress.org/jcb/article/... 📕 From The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025

The Office of Science and Technology Policy (OSTP) is seeking input on Federal policy updates to accelerate the American scientific enterprise. This is your chance to give some feedback on how the past ~10 months have gone for science. www.federalregister.gov/documents/20... I plan to highlight:

Under Trump, the NIH is giving fewer grants to fewer scientists. The grants awarded are smaller and scientists have less time to spend them. Projects in cancer, diabetes, aging, neurological disorder, and more are going unfunded. “Make America Healthy Again.”

Yang, Kong, Liu et al. report that homocysteine, an intermediate in methionine-cysteine #metabolism and the cause of the life-threatening disease #homocystinuria, disrupts lysosomal functions by binding to and homocysteinylating V-ATPase. rupress.org/jcb/article/... #lysosomes

A new genetic screen published in #G3journal shows the effects of calypso, a deubiquitinating enzyme BAP1 ortholog in #Drosophila, knockdown in the eye and wing, producing chromatin dysregulation phenotypes. buff.ly/4mPnfdo

The FlyBoard is happy to announce the call for nominations for the Drosophila Community Service Award. Please submit your nomination by 01/16/2026 by email to: [email protected]. Please repost.

Our paper is now part of the newest Cellular Neurobiology collection @jcb.org, check it out if you haven't yet. 🔬📖

I served last year on this committee and have the privilege of chairing it this year. We have amazing students in our field from around the globe--nominate one of them! Make our job difficult 😆 #Drosophila RT

First-ever atlas of brain development shows how stem cells turn into neurons There are 6 excellent human brain development papers in Nature - www.nature.com/articles/d41... Check them out!

The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution — a Review by Jeffrey J. Colgren & Pawel Burkhardt @jeffcolgren.bsky.social @pawelburkhardt.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...

I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n unc.peopleadmin.com/postings/307...

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Our latest published paper on developmental consequences of a human DVL1 variant in a Drosophila model of Robinow Syndrome.

How is developmental speed regulated ? 🪰 Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye. www.biorxiv.org/content/10.1... A big thanks to everyone involved!

We have an uncorrected proof published for Bhagaban Mallik's study on Mitochondrial Complex I and how it regulates synapse function. You can find it in @plosbiology.org. I am so proud! H/T collaborators: Drs. Sajad Bhat and Xinnan Wang @xinnanwanglab.bsky.social journals.plos.org/plosbiology/...

🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

We only had a very minor contribution to this story with Alexis, but definitly worth a reading for those interested by patterning, precision and refinment. Nice combining of quantitative live imaging, modeling and optogenetics to dissect vein patterning dynamics www.cell.com/developmenta...

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

www.thecrimson.com/article/2025... Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research

My MCDB dept is accepting applications for a faculty position at the Assistant Professor level! Applications Due by October 15, 2025 We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels. lsa.umich.edu/mcdb/news-ev...

The University of Notre Dame is hiring 5 tenure or tenure-track professors in Neuroscience, including Computational Neuroscience, across 4 departments. Come join me at ND! Feel free to reach out with any questions. And please share! apply.interfolio.com/173031

Come be my colleague! We are hiring for two tenure-track positions. www.reed.edu/dean_of_facu...

Please please please, if you are able, consider supporting Flybase fiscally. They need our help! I donated this evening. They are in danger of closing and any amount will help. We cannot allow this critical pillar of science to collapse!

Embryonic induction of fate is a core concept in developmental biology. But, cells can also modify the physical state of surrounding tissues a process we call 'actuation'. I reviewed with @mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.

Fly folk: The Amazing and essential @flybase.bsky.social is in existential need due to Trump termination of the grant that supports this vital resource. Please donate to help keep Flybase alive. I just did. Info here on how to make a tax deductible donation: wiki.flybase.org/wiki/FlyBase...

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

What happens to the mitotic apparatus during the prolonged spindle assembly checkpoint–induced mitotic arrest? Read the latest #GENETICS study that uses mutational analysis of #Drosophila CMG helicase to answer this question. buff.ly/OoriIaC

Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium

I doubt that there is a single family in America that hasn’t benefitted directly from the NIH.

No better time to call or email your members of Congress. Next year’s NIH budget is being debated in the Senate. A new nonpartisan campaign is making it easy to defend science and protect America’s innovation. Just follow this link to contact your representatives: www.protectscienceandinnovation.org

How do RGCs in the neocortex 'know' it is time ⌚ to start making oligodendrocyte precursors cells? Check out this great work by my colleagues @luulitran.bsky.social & @thefrancolab.bsky.social to find out!! Congratulations! 🧠