🧠✨ Genetic Tools Atlas 3.0 is here! The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets. 🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas #neuroskyence

First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience Our latest in @natrevneuro.nature.com Link: rdcu.be/eMX3E @jeffcolgren.bsky.social @msarscentre.bsky.social

Check this out from our colleagues! Congratulations!

Fully‐Functionalized Natural Product Probes to Expand the Chemical Tractability of the Human Proteome onlinelibrary.wiley.... --- #proteomics #prot-paper

Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)

Please repost! We are looking for a new research specialist for our lab. See korblab.com for more about what we do and apply at wd1.myworkdaysite.com/en-US/recrui...

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

Designed protein pockets recognize intrinsically disordered protein regions @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... www.statnews.com/2025/07/17/n...

Apply to this program and share with students in your networks! We will work 1:1 with you on your applications, CVs, interviews, etc bsky.app/profile/stan...

Here's Memoli "reviewing" in 6 minutes 6 grants flagged by a DOGE member to cut. Must be a quick reader! And then Judge Young roasts Memoli for saying research on gender identity is "often scientific" without any proof. "Ironically, these kinds of phrases would never survive peer review," he writes

For full details, see @evgenykvon.bsky.social's excellent 🧵 bsky.app/profile/evge...

"The money the government sends to Harvard is, in effect, not a subsidy to advance the university’s mission. It’s a payment for the role Harvard plays in advancing the research mission of the United States." www.nytimes.com/interactive/...

Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling: Cell www.cell.com/cell/fulltex...

Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.

Given the challenging last few months, this is a bright spot - the approval of lenacapavir twice yearly to prevent HIV. Unlike past PrEP meds, it was found t be 100% protective in cisgender women. But it will only work if gets to people, especially those communities that need it most.

Remembering Dave’s goodness gives me hope every day.

📢BREAKING: Just left the courthouse for our NIH grant termination case Judge ruled terminations are “VOID & ILLEGAL” As a plaintiff, I felt a wave of relief & hope; he acknowledged the discrimination & harm Closed by asking, ‘Have we fallen so low? Have we no shame?’

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & expanding my inpatient neuropsychiatry in the service of basic discovery bsky.app/profile/deis...

Despite research linking sleep duration with health, people from cultures with short average sleep durations—such as Japan and Taiwan—are not less healthy than people with long average sleep durations--such as the Netherlands and France. In PNAS: www.pnas.org/cgi/doi/10.1...

We've launched the Armamentarium, a new toolkit for targeted gene delivery to the brain and spinal cord. This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators. 🧠📈 www.nih.gov/news-events/...

🧪 #neurology #neuroskyence tinyurl.com/bp5d8386 Another beautiful example of NIH-SPONSORED bedside to bench and back to bedside work from an outstanding clinician scientist. This work is producing some of the most compelling responses to treatment in what is arguably the worst pediatric brain tumor.

New online! Functional synonymous mutations and their evolutionary consequences

Astrocytes have long been conceived as passive support player cells in the brain. But today @science.org (via 3 reports) they got a big upgrade for their active role in neuromodulation and control of brain function www.science.org/doi/10.1126/...

Curious about current topics in chromatin and epigenetics research? This upcoming @embl.org symposium will cover topics in heterochromatin research, developmental epigenetics, nuclear architecture, and more. Virtual Registration closes May 6. Learn more: plos.io/4j9slQK #EMBLChromatin

Our featured article: DNA methylation in mammalian development and disease go.nature.com/3X14Ali #Review by Zachary D. Smith @yaleschoolofmed.bsky.social, Sara Hetzel & Alexander Meissner @molgen.mpg.de Free to read here: rdcu.be/dQEND

BREAKING: @aclu.org says Trump deported a child (U.S. citizen) with metastatic cancer without medication or consultation with physicians. This is the second child with cancer he's deported. www.rollingstone.com/politics/pol... @rollingstone.com

The Genetics research community has a problem. Most recent articles do not consider #splicing/isoforms. Here, we analyze how important this opportunity gap is - and spoiler warning - we find it is essential for both analysis of common and rare variants More info👇 www.medrxiv.org/content/10.1...

The termination of the NIH MOSAIC program is a critical loss. As one of the 5 societies supporting MOSAIC scholars, ASCB remains dedicated to supporting early-career scientists & broadening the biomedical workforce. We'll continue our mentorship & development efforts through the end of the grant.

It's a sad day for me and the MOSAIC Scholars.

I'm excited to share that the last chapter of my PhD thesis is now published in Nature! 🍾 What drives serotonin neurons? We think it's the expectation of future reward and --- critically --- how fast this expectation is increasing. 📈 doi.org/10.1038/s415... 1/6

Check out our new review on induced proximity modalities (#TPD and a lot more!) aimed cell surface targets @naturebiotech.bsky.social, spearheaded by postdocs Nick Till and "Rahm" Ramanathan www.nature.com/articles/s41...

Such a GREAT thread of tips for efficient writing

#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler. www.nature.com/articles/s41...

When you don't have new results to show in your lab meeting

Compassion, self-compassion and fears of compassion influence well-being and clinical symptoms and syndromes. A Review in Nature Reviews Psychology elaborates on these links to elucidate the role for compassion in the treatment of mental disorders. https://go.nature.com/3FBxSAS 🔒

My alma mater, the University of British Columbia, Dept of Medical Genetics, is hiring for a tenure track junior faculty position specializing in chromatin regulation / gene regulatory mechanisms. Beautiful city and vibrant epigenetics research. Please share! medgen.med.ubc.ca/assistant-pr...

Please share: @delauro.house.gov is cochair of the US House Congressional Rapid Response Task Force and Litigation Working Group. They are looking for instances where the impoundment and restriction of NIH/NSF funds is having a negative impact. Submit examples here delauro.house.gov/constituent-...

Also check out his lab's recent paper from days ago: www.science.org/doi/epdf/10....

What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX

Federal restrictions & funding freezes threaten vital research and halts scientific progress that benefits all Americans. Join fellow #NeuroAdvocates in urging Congress to protect congressionally approved funding & ensure uninterrupted support for the scientific workforce. 👇 #NeuroSky

“...to care is an act not of weakness, but of strength.” The Lancet response: bit.ly/4jRb5Av

That’s my mom!

Seeing ribosomes in action? Thanks to researchers from the @marvintanenbaum.bsky.social lab this is now possible. They created a technology to track individual ribosomes during mRNA translation. The team found that ribosomes ‘help’ each other in difficult situations www.hubrecht.eu/ribosomes-te...

“whether C. cyclolites possess opsins…remains uncertain... However, C. cyclolites’ mode of locomotion, bell-shaped body plan, and ability to differentiate light bandwidths suggests the involvement of complex optical mechanisms and potentially more intricate neural systems akin to jellyfish.” Cool.

Our story on the mechanism of co-transcriptional histone mark deposition is now officially out: www.science.org/doi/10.1126/...

Our collaboration with the Muir lab revealed that N-terminal histone modifications can 'detoxify' K27M inhibition by altering PRC2-substrate interactions. Acetylation showed the greatest impact, supported by xenograft data from the Monje group. pubs.acs.org/doi/epdf/10....

Thrilled to have our collaboration with Dr Laramie Duncan out in @natureneuro.bsky.social! We leveraged two landmark datasets (GWAS + snRNA-seq from 105 regions of human brain) to infer the cell types involved in the etiology of psychiatric phenotypes (SCZ, AUD, Sleep) www.nature.com/articles/s41...

Our February 2025 issue is now live: go.nature.com/3PHvYjI Topics include: histone variants and their role in gene regulation, DNA replication and repair; toxicogenomics; human metabologenomics; and a roadmap to increasing research and clinical genomic data sharing

Uncovering the whole genome silencers of human cells via Ss-STARR-seq www.nature.com/articles/s41...