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@biorxivpreprint.bsky.social Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social T Cell-Driven Mechanisms of Kidney Damage in Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis www.biorxiv.org/content/10.1...

IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions @cp-immunity.bsky.social www.cell.com/immunity/ful...

This Halloween I'm a vampire! 🧛‍♂️ hisss!!! Hisss! #HappyHalloween

A 37-color spectral flow cytometry panel to characterize phenotype and cytokine expression in human intestinal T cells https://www.biorxiv.org/content/10.1101/2025.10.29.685441v1

No one wants to do a postdoc anymore, they all want to rob the Louvre

This week has been full of wonderful scientific news ✨👩🏼‍🔬

Fat cat Friday (I’m allowed to post again)

It was wonderful to reconnect at the NYC Postdoc Night Science! Such a great and inspiring conversation about how to give better talks and tell science stories that matter

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

A human pan-disease blood atlas of the circulating proteome @science.org @buenoalvez.bsky.social www.science.org/doi/epdf/10....

😍😍

@biorxivpreprint.bsky.social TCR activation impairs CAR-T cytotoxicity against separate target cells www.biorxiv.org/content/10.1...

🚨New research highlight: study on managing immunotherapy side effects without weakening anti-tumor power! ECP reduces harmful immune activity via neutrophils/T cells & promotes M2 macrophages via adiponectin. Promising results from Zeiser et al. 🔬 🧪 🧫 Full summary: www.nature.com/articles/s41...

Treg cells rule!

Interested in learning how to be a good speaker and give effective talks? Season 2 of the NYC Postdoc Night Science Club begins October 15th. Join us NYC Postdocs for a 2hr workshop and maybe also a drink at a bar! Free registration (usually ~100 come): docs.google.com/forms/d/1dII...

Cis-elements required for Blimp1-mediated Tcf7 repression in control of memory CD8 T differentiation, where decoupling Tcf7 silencing from effector differentiation is permissive for effector gene expression @cp-immunity.bsky.social www.cell.com/immunity/ful...

S. aureus causes a basophil influx into skin-draining lymph nodes that heightens Th2 responses & increases serum IL-4, which enhances intestinal permeability, exaggerating oral anaphylaxis (dermatitis --> food allergy) @cp-immunity.bsky.social @harvardmed.bsky.social www.cell.com/immunity/ful...

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com www.nature.com/articles/s43...

NIH establishes nation's first dedicated organoid development center to reduce reliance on animal modeling | National Institutes of Health (NIH) share.google/odgU3dnlWbTv...

An optofluidic workflow for isolating antigen-specific functional CD8+ T cells with or without a prior knowledge of peptide-MHC specificities @cp-iscience.bsky.social www.cell.com/iscience/ful...

CD103 facilitates the interaction of naive CD8+ T cells with E-cadherin-expressing dendritic cells that in turn provide cytokine-mediated cues to promote their differentiation into memory-phenotype effector T cells @cp-immunity.bsky.social www.cell.com/immunity/ful...

IFN-induced senescent CD8+ T cells mediate immunotherapy nonresponsiveness in early TNBC, which can be reversed by nicotinamide mononucleotide www.science.org/doi/10.1126/...

Differentiation of naive into memory-phenotype CD8+ T cells does not promote the breakdown of peripheral tolerance in irradiated mice https://www.biorxiv.org/content/10.1101/2025.09.08.672311v1

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social academic.oup.com/jimmunol/adv...

TGFβ limits proximal CD8+ TCR signaling via PTPN22 following strong and moderate agonism @jimmunol.bsky.social academic.oup.com/jimmunol/adv...

The STUB1–CHIC2 complex is a regulator of cytokine receptor expression in CD8+ T cells and provide rationale for inhibiting this pathway to enhance CD8+ T cell-mediated anti-tumor immunity @natimmunol.nature.com @martinlafleur.bsky.social‬ www.nature.com/articles/s41...

Regulation of CD45 isoforms during human effector and memory CD8 T cell differentiation: Implications for T cell nomenclature www.pnas.org/doi/10.1073/...

As someone wrote on Twitter many years ago, "if someone tells you something is unclear, they are -by definition- correct"

A fascinating shift in how we think about PD‑1 from Anandasabapathy's Lab is now out: not only suppressive, but tissue-shaping! 🛑 PD‑1 isn’t just an immune brake. 🟢 It actively drives the formation and maintenance of CD8+ TRM cells in the skin. www.nature.com/articles/s41...

Surprise 😅

Focusing on the Dark Side of the Moon: Involvement of the Nonlesional Skin in Vitiligo doi.org/10.1016/j.ji...

Memory CD8+ T cells have differential cytotoxic capacities across human tissues @sciimmunology.bsky.social www.science.org/doi/10.1126/...

TGF-β and IL-12 conversely orchestrate formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine www.cell.com/iscience/ful...

IL-4 impairs the formation of skin-resident memory CD8+ T cells www.nature.com/articles/s41...

literally

This is still the picture Harry Potter uses for his lab website

Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanoma www.biorxiv.org/content/bior...

Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells www.nature.com/articles/s41...

The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells: Immunity www.cell.com/immunity/ful...

Tissue architecture dynamics underlying immune development and decline in the thymus https://www.biorxiv.org/content/10.1101/2025.06.28.662120v1

Insightful review on T-cell integrins and their role in autoimmune & inflammatory diseases, covering structure, function, and therapeutic targeting in IBD, MS, and psoriasis. A valuable reference for current and emerging treatments. 📖 https://bit.ly/3F1Dcd5 #Immunology

Different tumour-resident memory T-cell subsets regulate responses to anti-PD-1 and anti-CTLA-4 cancer immunotherapies www.nature.com/articles/s41...

Such an insightful review on the endotypes of atopic dermatitis! pubmed.ncbi.nlm.nih.gov/40054744/

Intratumoral Treg ablation is sufficient to mediate tumor control systemically without autoimmunity www.biorxiv.org/content/bior...

Elucidating Cell Intrinsic Regulators of CD8 T Cell Diferentiation: KLF2 Maintains E9ector CD8 Lineage Fidelity media.proquest.com/media/hms/PR...

Check out the Noster prize winning essays @science.org The vaccine we all wear: Skin microbiota can be engineered into topical vaccines | Science www.science.org/doi/10.1126/...

Cytokine and metabolite networks shape T cell residency and functionality at the term human maternal-fetal interface url: academic.oup.com/jimmunol/art...

HEB Restrains Effector Gene Expression during Early CD8+ Memory Precursor T Cell Differentiation www.tandfonline.com/doi/abs/10.1...