@biorxivpreprint.bsky.social T cells use TNF and IFNγ for paracrine killing with target discrimination programmed by pathogen-derived factors www.biorxiv.org/content/10.6... @mayocliniccancer.bsky.social

Immunological liver-skin axis: a systemic Vγ4+ γδT17 cell responselinks psoriasis-like inflammation and MASLD https://www.biorxiv.org/content/10.64898/2025.12.22.695890v1

Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis @natcomms.nature.com @umich.edu www.nature.com/articles/s41...

I love academia, half your coworkers left yesterday evening and won't be back until Jan 6, the other half will frantically try to contact you at 8am on New Year's Day

Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment www.nature.com/articles/s41... @nanaborsa.bsky.social @wellcometrust.bsky.social @oxfordunipress.bsky.social

Restoring youth to old immune cells: mRNA therapy turns back the clock Testing in mice suggests that rejuvenating T cells could make vaccines and some cancer therapies more effective. www.nature.com/artic... 1/3

Opinion @cp-trendsimmuno.bsky.social @ngllab.bsky.social @washumedicine.bsky.social Immune cellular homeostasis and its breakdown at the maternal–fetal interface www.cell.com/trends/immun...

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood @jem.org @scripps.edu @mikerobe.bsky.social rupress.org/jem/article-...

📢🚨

#WeAreWhatWeEat! Jones &co show @natmetabolism.nature.com that dietary restriction empowers CD8+ T cells within the #tumor microenvironment by potentiating #mitochondrial metabolism via ketone body utilization, limiting T cell exhaustion, & synergizing with anti-PD1 immunotherapy!

@natrevimmunol.nature.com Guidelines for T cell nomenclature www.nature.com/articles/s41...

AI and flow cytometry @jimmunol.bsky.social academic.oup.com/jimmunol/adv...

@natimmunol.nature.com News & Views Quiet custodians of CD8+ T cell fate www.nature.com/articles/s41... on www.nature.com/articles/s41... www.nature.com/articles/s41...

🫨🫨

@biorxivpreprint.bsky.social Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social T Cell-Driven Mechanisms of Kidney Damage in Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis www.biorxiv.org/content/10.1...

IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions @cp-immunity.bsky.social www.cell.com/immunity/ful...

This Halloween I'm a vampire! 🧛‍♂️ hisss!!! Hisss! #HappyHalloween

A 37-color spectral flow cytometry panel to characterize phenotype and cytokine expression in human intestinal T cells https://www.biorxiv.org/content/10.1101/2025.10.29.685441v1

No one wants to do a postdoc anymore, they all want to rob the Louvre

This week has been full of wonderful scientific news ✨👩🏼‍🔬

Fat cat Friday (I’m allowed to post again)

It was wonderful to reconnect at the NYC Postdoc Night Science! Such a great and inspiring conversation about how to give better talks and tell science stories that matter

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

A human pan-disease blood atlas of the circulating proteome @science.org @buenoalvez.bsky.social www.science.org/doi/epdf/10....

😍😍

@biorxivpreprint.bsky.social TCR activation impairs CAR-T cytotoxicity against separate target cells www.biorxiv.org/content/10.1...

🚨New research highlight: study on managing immunotherapy side effects without weakening anti-tumor power! ECP reduces harmful immune activity via neutrophils/T cells & promotes M2 macrophages via adiponectin. Promising results from Zeiser et al. 🔬 🧪 🧫 Full summary: www.nature.com/articles/s41...

Treg cells rule!

Interested in learning how to be a good speaker and give effective talks? Season 2 of the NYC Postdoc Night Science Club begins October 15th. Join us NYC Postdocs for a 2hr workshop and maybe also a drink at a bar! Free registration (usually ~100 come): docs.google.com/forms/d/1dII...

Cis-elements required for Blimp1-mediated Tcf7 repression in control of memory CD8 T differentiation, where decoupling Tcf7 silencing from effector differentiation is permissive for effector gene expression @cp-immunity.bsky.social www.cell.com/immunity/ful...

S. aureus causes a basophil influx into skin-draining lymph nodes that heightens Th2 responses & increases serum IL-4, which enhances intestinal permeability, exaggerating oral anaphylaxis (dermatitis --> food allergy) @cp-immunity.bsky.social @harvardmed.bsky.social www.cell.com/immunity/ful...

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com www.nature.com/articles/s43...

NIH establishes nation's first dedicated organoid development center to reduce reliance on animal modeling | National Institutes of Health (NIH) share.google/odgU3dnlWbTv...

An optofluidic workflow for isolating antigen-specific functional CD8+ T cells with or without a prior knowledge of peptide-MHC specificities @cp-iscience.bsky.social www.cell.com/iscience/ful...

CD103 facilitates the interaction of naive CD8+ T cells with E-cadherin-expressing dendritic cells that in turn provide cytokine-mediated cues to promote their differentiation into memory-phenotype effector T cells @cp-immunity.bsky.social www.cell.com/immunity/ful...

IFN-induced senescent CD8+ T cells mediate immunotherapy nonresponsiveness in early TNBC, which can be reversed by nicotinamide mononucleotide www.science.org/doi/10.1126/...

Differentiation of naive into memory-phenotype CD8+ T cells does not promote the breakdown of peripheral tolerance in irradiated mice https://www.biorxiv.org/content/10.1101/2025.09.08.672311v1

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social academic.oup.com/jimmunol/adv...

TGFβ limits proximal CD8+ TCR signaling via PTPN22 following strong and moderate agonism @jimmunol.bsky.social academic.oup.com/jimmunol/adv...

The STUB1–CHIC2 complex is a regulator of cytokine receptor expression in CD8+ T cells and provide rationale for inhibiting this pathway to enhance CD8+ T cell-mediated anti-tumor immunity @natimmunol.nature.com @martinlafleur.bsky.social‬ www.nature.com/articles/s41...

Regulation of CD45 isoforms during human effector and memory CD8 T cell differentiation: Implications for T cell nomenclature www.pnas.org/doi/10.1073/...

As someone wrote on Twitter many years ago, "if someone tells you something is unclear, they are -by definition- correct"

A fascinating shift in how we think about PD‑1 from Anandasabapathy's Lab is now out: not only suppressive, but tissue-shaping! 🛑 PD‑1 isn’t just an immune brake. 🟢 It actively drives the formation and maintenance of CD8+ TRM cells in the skin. www.nature.com/articles/s41...

Surprise 😅

Focusing on the Dark Side of the Moon: Involvement of the Nonlesional Skin in Vitiligo doi.org/10.1016/j.ji...

Memory CD8+ T cells have differential cytotoxic capacities across human tissues @sciimmunology.bsky.social www.science.org/doi/10.1126/...

TGF-β and IL-12 conversely orchestrate formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine www.cell.com/iscience/ful...

IL-4 impairs the formation of skin-resident memory CD8+ T cells www.nature.com/articles/s41...

literally